Crystal of egfr extracellular domain and cetuximab fab fragment, and uses thereof

ABSTRACT

The present invention relates to co-crystals of cetuximab Fab in a complex with extracellular domain of EGFR, and structure coordinates obtained from such crystal. Such coordinates are useful for identifying mimetics that bind to the extracellular domain of EGFR. Such mimetics may for example inhibit binding of ligand to EGFR, inhibit activation of EGFR, and/or reduce proliferation of tumor cells.

FIELD OF THE INVENTION

The present invention relates to co-crystals of cetuximab Fab in acomplex with extracellular domain of EGFR, and structure coordinatesobtained from such crystal. Such coordinates are useful for identifyingmimetics, preferably EGFR antagonists, that bind to the extracellulardomain of EGFR. Such mimetics may for example inhibit binding of ligandto EGFR, inhibit activation of EGFR, and/or reduce proliferation oftumor cells.

BACKGROUND OF THE INVENTION

Although normal cells proliferate by the highly controlled activation ofgrowth factor receptor tyrosine kinases (“RTKs”) by their respectiveligands, cancer cells also proliferate by the activation of growthfactor receptors, but lose the careful control of normal proliferation.The loss of control may be caused by numerous factors, such as theoverexpression of growth factors and/or receptors, and autonomousactivation of biochemical pathways regulated by growth factors. Someexamples of RTKs involved in tumorigenesis are the receptors forepidermal growth factor receptor (EGFR) (also known as human EGFreceptor-1 (HER1)), platelet-derived growth factor (PDGFR), insulin-likegrowth factor (IGFR), nerve growth factor (NGFR), and fibroblast growthfactor (FGF). Binding of growth factors to these cell surface receptorsinduces receptor activation, which initiates and modifies signaltransduction pathways and leads to cell proliferation anddifferentiation.

Generally, RTKs have an extracellular region, a transmembranehydrophobic region, and an intracellular region bearing a kinase domain.The first step in the activation of an RTK is ligand-induceddimerization leading to exposure of phosphorylation sites, activation ofthe intracellular kinase domain and recruitment of down-stream signalingmolecules. The most commonly observed mode of RTK dimerization involvesthe “crosslinking” of two receptors having exposed dimerizationinterfaces by binding of a bivalent ligand. For EGFR, structural datapublished in recent years have led to the proposal of quite a differentmechanism. In the absence of ligand, a distinct configuration of thereceptor monomer occludes the dimerization interface of the receptor byburying it in an intramolecular “tether.” Ligand binding induces aconformational change in EGFR that exposes this dimerization site,promoting dimerization and receptor activation.

EGFR is a 170 kD membrane-spanning glycoprotein with an extracellularligand binding domain, a transmembrane region and a cytoplasmic proteintyrosine kinase domain. Examples of ligands that stimulate EGFR includeepidermal growth factor (EGF), transforming growth factor-α (TGF-α),heparin-binding growth factor (HBGF), β-cellulin, and Cripto-1. Bindingof specific ligands results in EGFR autophosphorylation, activation ofthe receptor's cytoplasmic tyrosine kinase domain and initiation ofmultiple signal transduction pathways that regulate tumor growth andsurvival.

Growth factors that activate EGFR are also thought to play a role intumor angiogenesis. Angiogenesis, which refers to the formation ofcapillaries from pre-existing vessels in the embryo and adult organism,is known to be a key element in tumor growth, survival and metastasis.It has been reported that EGFR mediated stimulation of tumor cells leadsto increased expression of the angiogenic factors vascular endothelialgrowth factor (VEGF), interleukin-8 (IL-8), and basic fibroblast growthfactor (bFGF), which can lead to activation of tumor-associated vascularendothelial cells. Stimulation of tumor associated vascular endothelialcells may also occur through activation of their own EGF receptors, bytumor produced growth factors such as TGF-α and EGF.

It has been reported that many human tumors express or overexpress EGFR.Expression of EGFR is correlated with poor prognosis, decreasedsurvival, and/or increased metastasis. EGFR, because of this involvementin tumorigenesis, has been specifically targeted for anticancertherapies. These therapies have predominantly included either amonoclonal antibody that blocks binding of ligand to the extracellulardomain of the receptor or a synthetic tyrosine kinase inhibitor thatacts directly on the intracellular region to prevent signaltransduction.

Cetuximab MAb (ERBITUX®) is a recombinant, human/mouse chimeric,monoclonal antibody composed of the Fv regions of a murine anti-EGFRantibody with human IgG1 heavy and kappa light chain constant regionsand has an approximate molecular weight of 152 kDa. Cetuximab bindsspecifically to the extracellular domain of the human EGFR, and is anEGFR antagonist, which blocks ligand binding to EGFR, prevents receptoractivation, and inhibits growth of tumor cells that express EGFR.Cetuximab has been approved for use in combination with or withoutirinotecan in the treatment of patients with epidermal growth factorreceptor-expressing, metastatic colorectal cancer who are refractory orcan not tolerate irinotecan-based chemotherapy. Cetuximab has been shownto be effective for treatment of psoriasis.

The crystal structure of an EGF-EGFR extracellular domain complex,wherein the receptor domain exists in dimeric form, has been providedOgiso, H. et al., 2002, Cell 110, 775-787. The structure of an EGF-EGFRextracellular domain complex obtained by crystallization at low,non-physiological pH, wherein the receptor exists in monomeric form hasalso been provided Ferguson, K. M. et al., 2003, Mol Cell 11, 507-517.The structure of a transforming growth factor alpha (TGF-α)-EGFRextracellular domain complex in dimeric form has also been determined(Garrett, T. P. et al., 2002, Cell 110, 763-773).

However, the crystal structure of EGFR with an antagonist, particularlycetuximab Fab, has not been previously determined. The inventiondisclosed herein provides for the first time crystals and atomiccoordinates of a complex of an EGFR extracellular domain and cetuximabFab. Accordingly, the present invention provides methods for identifyingpotential mimetics by screening against at least a subset of thecoordinates obtained from such a crystal. Mimetics may be assayed forbiological activities to obtain EGFR antagonists useful for treatment ofEGFR dependent conditions or diseases. EGFR antagonists interact withthe receptor to inhibit EGFR tyrosine kinase activity, withoutlimitation, by blocking ligand binding, inhibiting receptordimerization, ultimately inhibiting receptor substrate phosphorylation,gene activation, and cellular proliferation. Preferably, the antagonistshave substantially similar or improved effectiveness as compared tocetuximab. The antagonists are used for treatment of conditionsassociated with EGFR expression. Such diseases include tumors thatexpress, or overexpress EGFR and which may be stimulated by a ligand ofEGFR. Also included are hyperproliferative diseases stimulated by aligand of EGFR.

SUMMARY OF THE INVENTION

In one aspect, the present invention provides a crystal of areceptor-antibody complex comprising a receptor-antibody complex of anepidermal growth factor receptor (EGFR) extracellular domain andcetuximab Fab, wherein the crystal has a resolution determined by X-raycrystallography of better than about 5.0 Angstroms. Preferably, thecrystal has a resolution determined by X-ray crystallography of betterthan about 4.0 Angstroms, more preferably better than about 3.0Angstroms. Preferably the crystal belongs to space group P2₁ and hasunit cell dimensions a=77.8 Å, b=70.9 Å, c=147.1 Å, and β=02.5°.Preferably, the crystal has atomic coordinates provided in Table 2.

In another aspect, the present invention provides a method for preparinga crystal of a complex of an epidermal growth factor receptor (EGFR)extracellular domain and cetuximab Fab comprising preparing a solutioncontaining the extracellular domain of EGFR and cetuximab Fab fragment,and growing the crystal. Preferably the pH of the solution is about 6.0to about 8.0.

In another aspect, the present invention provides a method ofidentifying a mimetic of cetuximab comprising comparing athree-dimensional structure of the mimetic with a three-dimensionalstructure determined for the above crystal complex. Preferably, thethree dimensional structure of the mimetic is compared with at least asubset of the coordinates provided in Table 2.

In one embodiment, identifying a mimetic is carried out by comparing thethree-dimensional structure of the mimetic against the coordinates of atleast one EGFR amino acid bound by cetuximab Fab. Such EGFR amino acidis selected from the group consisting of Gln 384, Gln 408, Ser 418, Ser440, Lys 465, Ser 468, and Asn 469. In one embodiment, the locations ofatoms of the mimetic that contact EGFR correspond to atoms of cetuximabthat contact EGFR. In yet another embodiment, screening is carried outby comparing a three dimensional structure of a mimetic with the atomiccoordinates of a region of EGFR selected from the group consisting ofabout amino acid residue 350 to about amino acid residue 354, aboutamino acid residue 380 to about amino acid residue 385, about amino acidresidue 405 to about amino acid residue 420, about amino acid residue435 to about amino acid residue 475 and combinations thereof.

The mimetic may be a small molecule, a peptide, or a polypeptide,preferably an antibody or a fragment thereof.

In another aspect of the invention, a mimetic that is an antibody or afragment thereof is identified by introducing one or more substitutionsin at least a single CDR region of cetuximab and/or at non-CDR aminoacids of the antibody that interact with the CDR and affect itsconformation. In one embodiment, at most a single substitution is madein each CDR. In another embodiment, substitution are made solely in CDR3or at amino acids that affect the conformation of CDR3.

In another aspect, the present invention provides the above methodscarried out with use of a computer.

The invention further provides a method for synthesizing the mimetic andassaying its binding or physiological activity to select EGFRantagonists useful for inhibiting EGFR function and treatingEGFR-associated diseases or conditions. In an aspect of the invention, amimetic is provided that inhibits tyrosine kinase activity of thereceptor. In another aspect of the invention, the mimetic inhibitsdimerization of EGFR expressed by a cell. Preferably, the mimetic blocksbinding of EGF to EGFR. Mimetics of the invention bind to EGFR andinhibit EGFR functional activity, preferably to a similar or greaterextent than cetuximab.

In another aspect, the present invention provides a computer-assistedmethod for identifying a mimetic of cetuximab comprising a processor, adata storage system, an input device, and an output device, comprising:inputting into the programmed computer through said input device datacomprising the three-dimensional coordinates of at least a subset of theatoms of EGFR as set out in Table 2; providing a database of chemicaland peptide structures stored in said computer data storage system;selecting from said database, using computer methods, structures havinga portion that is structurally similar to said criteria data set; andoutputting to said output device the selected chemical structures havinga portion similar to said criteria data set.

In another aspect, the present invention provides a machine-readablemedium having stored thereon a plurality of executable instructions toperform a method to identify a mimetic of cetuximab using a crystal of areceptor-antibody complex comprising a receptor-antibody complex of anepidermal growth factor receptor (EGFR) extracellular domain andcetuximab Fab, the method comprising: comparing a three-dimensionalstructure of a mimetic with a three dimensional structure an epidermalgrowth factor receptor (EGFR) extracellular domain and cetuximab Fabhaving an X-ray crystallography resolution of better than about 5.0Angstroms.

Preferably the EGFR coordinates comprise at least a subset of the atomiccoordinates of Table 2. In one embodiment, identifying a mimeticcomprises comparing the three-dimensional structure of a mimetic with athree-dimensional structure of at least one EGFR amino acid bound bycetuximab Fab. In another embodiment identifying a mimetic comprisescomparing a three dimensional structure of a mimetic with the atomiccoordinates of a region of EGFR selected from the group consisting ofabout amino acid residue 350 to about amino acid residue 354, aboutamino acid residue 380 to about amino acid residue 385, about amino acidresidue 405 to about amino acid residue 420, about amino acid residue435 to about amino acid residue 475 and combinations thereof.

In another aspect, the present invention provides a machine-readablemedium having stored thereon a plurality of executable instructions toperform a method for identifying a mimetic of cetuximab, the methodcomprising: introducing in silico substitutions in at least a single CDRregion of cetuximab to obtain a pool of variants; and using a computerand at least a subset of the EGFR coordinates provided in Table 2 toselect a variant with improved EGFR binding characteristics.

In another aspect, the present invention provides a cetuximab mimeticidentified by any of the above methods.

In another aspect, the present invention provides a method of inhibitingEGFR comprising administering the identified mimetic.

In another aspect, the present invention provides a method of treating adisease or condition associated with EGFR expression comprisingadministering the identified mimetic. In one non-limiting embodiment,the present invention provides a method of inhibiting growth of a tumorcell that expresses EGFR comprising administering the above identifiedmimetics. In another embodiment, the present invention provides a methodof treating a hyperproliferative diseases stimulated by a ligand ofEGFR.

In another aspect, the present invention provides a method of treatingpsoriasis comprising administering the above identified mimetics.

BRIEF DESCRIPTION OF THE FIGURES

FIG. 1 provides pictures of the crystals of the present invention. Inthis figure crystals on the left (1 a) are representative of those usedto collect the data and solve the structure. On the right (1 b) areexamples of crystals grown from the same condition except without CdCl₂,which are substantially identical to that obtained in the presence ofCdCl₂.

FIG. 2 provides various characteristics of the crystals of the presentinvention.

FIG. 3 provides crystal structures of EGFR and cetuximab Fab complex.

FIG. 4 provides graphs depicting affinity of cetuximab Fab, and affinityof EGFR ligands for EGFR, and also provides a competition assay.Additional details are provided in the example below having the heading“BIAcore binding studies.”

DETAILED DESCRIPTION OF THE INVENTION

The present invention provides a co-crystal of EGFR extracellular domainand cetuximab Fab fragment with a resolution that is preferably greaterthan about 5 Å, more preferably greater than about 4 Å and mostpreferably greater than about 3 Å. The crystal preferably has a spacegroup P2₁ and unit cell dimensions of a=77.8 Å, b=70.9 Å, c=147.1 Å; andβ=102.5°.

To obtain the crystal for which structural coordinates are shown Table2, the entire extracellular region (i.e., amino acids 1-618 of matureEGFR, including domains I, II, III and IV) is used, plus a C-terminalhexa-histidine tag (Ferguson, K. M. et al., 2000, Embo J 19, 4632-4643;Ferguson, K. M. et al., 2003, Mol Cell 11, 507-517). (See GenBankAccession No. 1NQLA). Cetuximab Fab contains the Fab fragment ofCetuximab, i.e., the heavy and light chain variable region sequences ofmurine antibody M225 (U.S. App. Ser. No. 2004/0006212, incorporatedherein by reference) with human IgG1 C_(H)1 heavy and kappa light chainconstant domains. (Cetuximab includes all three IgG1 heavy chainconstant domains.) The CDR regions of the heavy chain of Cetuximab havethe following sequences: a CDR1 region with a sequence of NY G V H, aCDR2 region with a sequence of V I W S G G N T D Y N T P F T S, and aCDR3 region with a sequence of A L T Y Y D Y E F A Y. The CDR regions ofthe light chain of Cetuximab have the following sequences: a CDR1 regionwith a sequence of R A S Q S I G T N I H, a CDR2 region with a sequenceof Y A S E S I S, and a CDR3 region with a sequence of Q Q N N N W P TT.

The sequences of the proteins in the crystal, i.e., cetuximab Fab andthe extracellular domain of EGFR, are also reported with the atomiccoordinates of Table 2, except for amino acid positions at which theelectron density map was insufficient to place all atoms of the actualamino acid side chain. At those positions, other amino acid side chainsare designated.

Crystallization of the EGFR:cetuximab Fab complex may be carried outfrom a solution of cetuximab Fab and EGFR with various techniques, suchas microbatch, hanging drop, sitting drop, sandwich drop, seeding anddialysis. The solution is prepared by combining EGFR extracellulardomain with cetuximab Fab in a suitable buffer. A standard bufferingagent such as Hepes, Tris, MES and acetate may be used. The buffersystem may also be manipulated by addition of a salt such as sodiumchloride, ammonium sulfate, sodium/potassium phosphate, ammonium acetateamong others. Imidazole may also be used as a buffer. The concentrationof the salt is preferably about 10 mM to about 500 mM, more preferablyabout 25 mM to about 100 mM, and most preferably about 50 mM. The pH ofthe buffer is preferably about 6 to about 8, more preferably about 7 toabout 8. The concentration of the protein in the solution is preferablythat of super-saturation to allow precipitation. The solution mayoptionally contain a protein stabilizing agent.

In one embodiment, the crystal is precipitated by contacting thesolution with a reservoir that reduces the solubility of the proteinsdue to presence of precipitants, i.e., reagents that induceprecipitation. Such contacting may be carried out through vapordiffusion. Examples of precipitants include ammonium sulfate, ethanol,3-ethyl-2,4 pentanediol, and glycols, particularly polyethanol glycol(PEG). The PEG utilized preferably has a molecular weight of about 400to about 20,000, more preferably about 3000 Da, with a concentration ofabout 10% to about 20%, more preferably about 15% (w/v). Someprecipitants may act by making the buffer pH unfavorable for proteinsolubility.

The temperature during crystallization is preferably of about 0° C. toabout 30° C., more preferably about 20° C. to about 30° C., and mostpreferably about 25° C. In addition to generation of structure, thecrystallization technique of the invention may also be used to increasepurity of proteins.

Precipitation may also be carried out in the presence of a heavy metalsuch as cadmium to further improve analysis of the crystal afterprecipitation.

In one embodiment illustrated in the example, about 0.5 μl (ormicroliter) protein at 11 mg/ml in 10 mM Hepes, 50 mM NaCl, pH 7.5 iscontacted with 0.5 μl (or microliter) reservoir solution of about 15%PEG 3350, about 250 mM ammonium sulfate, about 10 mM cadmium chloride,about 100 mM imidazole and about pH 7.5. Essentially the same crystalsare obtained without use of cadmium chloride. Crystals have also beengrown at 15% PEG 3450, 100 mM CaCl₂, 50 mM Sodium acetate, pH 5.0 and15% PEG 3450, 100 mM ammonium acetate, 50 mM sodium citrate, pH 5.0.

The atomic coordinates of the crystal of the present invention aredisclosed in Table 2. The coordinates provide a three dimensionalstructure of the EGFR extracellular domain:cetuximab Fab complex of thecrystal. The cetuximab Fab includes the portion of cetuximab which bindsto the extracellular region of EGFR, and can be used to model theinteraction of cetuximab and EGFR. Accordingly, the crystal and thededuced atomic coordinates allows for studying the binding interactionof cetuximab with EGFR and EGFR inhibition. The three dimensionalstructure further allows for identifying potential mimetics by screeningpotential mimetics against at least part of the structure (a subset ofatoms provided in Table 2).

The three dimensional structure of EGFR:cetuximab Fab complex as definedby atomic coordinates is obtained from the X-ray diffraction pattern ofthe crystal and the electron density map derived therefrom. One methodfor determining the three dimensional structure is by molecularreplacement which involves use of the structure of a closely relatedmolecule or receptor ligand complex. An alternative method employs heavyatom derivatives.

One of skill in the art will also appreciate that the atomic coordinatesprovided are not precise, but are obtained from electron densitymeasured for the crystal. Initial coordinates are determined by matchingthe protein backbone and side chains to the electron density map. Thecoordinates are refined by minimizing the overall energy of the protein(e.g., by adjusting bond lengths and angles), in view of the determinedelectron density. In some locations in the atomic structure, atoms ofamino acid side chains may not be fully resolved due to, for example,solvent interactions and the like. Accordingly, the side chain that ismodeled may differ from the actual side chain at that amino acidposition. For the atomic coordinates set forth in Table 2, Arg 18 of thelight chain and Gln 1 of the heavy chain of cetuximab Fab are modeled asAlanine. The present invention encompasses structures having root meansquare deviations of backbone atoms of not more than about 1.5 Å, ormore preferably not more than about 1.0 Å, or most preferably, not morethan about 0.5 Å for residues of EGFR extracellular domain or cetuximabFab that are used in identifying mimetics. The present inventionencompasses variations within acceptable standards of error in the artfor a crystal with the resolution disclosed herein.

It will also be appreciated that the origin of the atomic coordinates isarbitrarily defined. Accordingly, the same atomic structure can berepresented by sets of coordinates that are numerically different, butthat identify the same atomic positions. The present inventionencompasses such alternative coordinate sets.

Identification of mimetics of cetuximab may be carried out with only asubset of the coordinates provided, such as those of amino acid residuesof EGFR or cetuximab Fab that are associated in the complex.

Potential mimetics are examined against EGFR, particularly one or moreof the above residues, through the use of computer modeling using adocking program. Such computer modeling allows for obtaining a positiveinitial indication of binding before synthesis and testing of thecompound. If the testing shows sufficient interaction, then the compoundmay be synthesized and tested as a potential candidate. There is nolimitation to the source of potential mimetics. For example, potentialmimetics include structural databases of small molecules and otherligands represented in silico, as well as commercially availablelibraries of small molecules that can be similarly modeled. Potentialmimetics further include peptides and macromolecules such as proteins,polypeptides, preferably antibodies or antibody fragments, syntheticpolymer backbones having amino acid-like functional groups, and thelike. Such potential mimetics may have defined structure, or be modeledon the basis of their similarity to other macromolecules of knownstructure. Iterative methods may be employed to vary one or more of thefunctional groups to improve the fit of the potential mimetic with EGFR.Those substances identified as mimetics, if not otherwise available tobe tested for EGFR antagonist activity, may be synthesized.

In preferred embodiments, the locations of at least some atoms ofcetuximab mimetics that contact EGFR correspond to the locations ofatoms of cetuximab that contact EGFR. The correspondence is preferablywithin about 2.0 Å, more preferably within about 1.0 Å, and mostpreferably with about 0.5 Å. The atoms usually interact with EGFR in amanner similar to the corresponding atoms of cetuximab Fab (i.e., polar,basic, acidic, hydrophobic). The mimetics may contain various numbers ofsuch corresponding atoms, and binding of the mimetic to EGFR may becompletely or only partially dependent on such correspondinginteractions. In certain embodiments, such atomic interactions with EGFRmay be supplemented by interactions of other atoms of the mimetic thatalso interact with EGFR. The binding ability of the mimetics can beevaluated by various computer programs as disclosed herein.

Docking may be accomplished by using software such as Quanta and Sybyl(manual model building software), followed by energy minimization andmolecular dynamics with standard molecular mechanics force fields, suchas CHARMM and AMBER. Specialized programs for docking include GRAM,GRID, Flexx, Glide, GOLD, MCSS, DOCK or AUTODOCK (See e.g. U.S. Pat.Nos. 5,856,116 and 6,087,478; Jorgensen W. L., 2004, Science 303,1813-1818). Such procedure includes computer fitting of potentialantagonists to EGFR to determine how the three dimensional structure ofEGFR and the chemical properties of each amino acid interfere with EGFRactivation, and to estimate attraction, repulsion and steric hindranceof the binding. Generally, tighter fits are preferred in that they aremore likely to be effective when administered in vivo, and would be moreselective for EGFR, minimizing binding to other receptors. Many of theseprograms also consider adsorption, distribution, metabolic and excretioncharacteristics of the molecules.

The docking program may be connected to a structure generator (such asSYNOPSIS) to perform de novo screening. An alternative to de novoscreening, is creation of structures based on the binding site such aswith programs including LUDI, SPROUT and BOMB, which allow a user to puta substituent in a binding site and then build up the substituent(Jorgensen W. L., 2004).

One of skill in the art would appreciate that the above screeningmethods may also be carried out manually, by building an actual threedimensional model based on the coordinates, and then determiningdesirable antagonists based on that model visually.

Of particular interest for designing mimetics are those amino acids thatoverlap with the binding site of EGR or TGF-α to EGFR. Such binding mayinterfere with the ligand-induced dimerization of the receptor orinhibit binding of the ligand to EGFR altogether.

Domains I and III of EGFR are responsible for binding of EGF to thereceptor, and are of interest in designing antagonists. Of the aminoacids of EGFR, some are involved in direct hydrogen bonding withcetuximab Fab. These amino acids include Ser 468, Asn 469, Arg 353, Gln384, Gln 408, Ser 418, Ser 440 and/or Lys 465. Ser468 and Asn 469 areinvolved in main-chain hydrogen bonds, i.e., the nature of the sidechain is not directly relevant. Antagonists may be designed to bind to afew, most or none of these amino acids. Other amino acids of EGFR are incontact to some lesser degree with cetuximab Fab. These amino acidsinclude: Pro 349, Arg 353, Leu 382, His 409, Phe 412, Val 417, Ser 418,Ile 438, Gly 441, Lys 443, Ile 466, Ile 467, Gln 471 and Asn 473. Of thenine amino acids between 465 and 473, eight of them are in some contactwith cetuximab Fab. This region of EGFR is also ideal for screening ofantagonists, particularly since residues 467 and 468 are in contact withboth the heavy and light chains of cetuximab.

Cetuximab Fab does not bind to amino acids at positions 325, 346, 348,350, 354-357 and 411, despite these amino acids being involved inEGF/TGF-α binding. Screening may be carried out against these positions,or only for the positions bound by cetuximab Fab, or both. If screeningis carried out based on the binding of cetuximab Fab to EGFR, suchscreening may be carried out in regions of amino acids of about 350 toabout 354, amino acids of about 380 to about 385, amino acids of about405 to about 420, amino acids of about 435 to about 475 and combinationsthereof. One of skill in the art would appreciate that screening maysimply be carried out against domains I and III of EGFR based on thecrystal structure provided, and general area of the binding pocket,without focus on any particular amino acids bound by cetuximab Faband/or ligands.

The mimetics, both peptides and small organic molecules, preferablyantibody and antibody fragments, bind to EGFR and mimic effects ofcetuximab both in vivo and in vitro. In addition to peptides and smallorganic molecules, the mimetic may be a sugar. The mimetic may also be acombination of peptides/small molecules/sugars, such as a peptide havinga synthetic backbone. The mimetic may be designed based on criteria suchas affinity for EGFR, desirable efficacy and/or desirable selectivity.These mimetics have at least a single physiological or binding activityof cetuximab, which activity can be tested by assays provided furtherbelow.

As used herein, “mimetics” include cetuximab mimetics with modificationsthat retain specificity for EGFR. Such modifications include, but arenot limited to, conjugation to an effector molecule such as achemotherapeutic agent (e.g., cisplatin, taxol, doxorubicin) orcytotoxin (e.g., a protein, or a non-protein organic chemotherapeuticagent). The mimetics can be modified by conjugation to detectablereporter moieties. Also included are mimetics with alterations thataffect non-binding characteristics such as half-life (e.g., pegylation).

Proteins and non-protein agents may be conjugated to the mimetics bymethods that are known in the art. Conjugation methods include directlinkage, linkage via covalently attached linkers, and specific bindingpair members (e.g., avidin-biotin). Such methods include, for example,that described by Greenfield et al., Cancer Research 50, 6600-6607(1990) for the conjugation of doxorubicin and those described by Arnonet al., Adv. Exp. Med. Biol. 303, 79-90 (1991) and by Kiseleva et al.,Mol. Biol. (USSR)25, 508-514 (1991) for the conjugation of platinumcompounds.

In one embodiment, a library of small organic molecules is used toscreen for mimetics in silico. In another embodiment, cetuximab is usedas a starting candidate, and varied to generate a cetuximab variant withdesirable properties. Such variant of cetuximab may be a scFv, a Fab,diabody, or IgG. For example, conservative amino acid substitutions maybe made at one or more of residues of cetuximab Fab which bind EGFR:light chain (LC) residues Asn 91, Trp 94; heavy chain (HC) residues Gly54, Tyr 102, Trp 52, Asp 103.

A conservative amino acid substitution is defined as a change in theamino acid composition by way of changing one or two amino acids of apeptide, polypeptide or protein, or fragment thereof. The substitutionis of amino acids with generally similar properties (e.g., acidic,basic, aromatic, size, positively or negatively charged, polarity,non-polarity) such that the substitutions do not substantially alterpeptide, polypeptide or protein characteristics (e.g., charge,isoelectric point, affinity, avidity, conformation, solubility) oractivity. Typical substitutions that may be performed for suchconservative amino acid substitution may be among the groups of aminoacids as follows:

glycine (G), alanine (A), valine (V), leucine (L) and isoleucine (I);aspartic acid (D) and glutamic acid (E);alanine (A), serine (S) and threonine (T);histidine (H), lysine (K) and arginine (R):asparagine (N) and glutamine (Q);phenylalanine (F), tyrosine (Y) and tryptophan (W).

If the binding is not as tight in regard to one or more of the residues,less conservative substitutions may be made at those residues tooptimize the binding. For example, an amino acid with a hydrophilicgroup may be substituted for one with a hydrophobic group.

In one embodiment, a mixture of all or some amino acids is introduced tosynthesize variants of cetuximab randomly at specified positions insilico: Tyr 102 (HC), Trp 52 (HC), and Asp 103 (HC) of cetuximab. Onlythese amino acid residues are involved in side chain hydrogen bonds, andthus are candidates for specific mutations aimed at modifying directinteractions. Such variation, where all 20 amino acids are used, wouldresult in about 20³ variants which can then be screened. If onlyconservative substitutions are made, the variation would be much less,about 3³. Conservative and non-conservative substitutions at otherpositions in the CDRs of cetuximab that do not bind to EGFR directlyshould also be considered. For example, direct interactions betweencontact residues (e.g., main chain—main chain, main chain—side chain,side chain—side chain contacts) can be modified by introducing changesat amino acid positions that affect the position of cetuximab side chainand main chain atoms involved in direct interactions with EGFR. In oneembodiment, at most a single substitution is made in each CDR. Inanother embodiment a single substitution is made in the heavy chain CDR3region of cetuximab.

After such screening and selection, the selected mimetic may besynthesized, and various assays carried out to measure the biological orphysiological activity of the mimetic to select an EGFR antagonist. Apreferred EGFR antagonist has one or more of the following properties:inhibits EGFR tyrosine kinase activity; blocks ligand binding to EGFR;inhibits EGFR dimerization (homodimerization with EGFR orheterodimerization with another EGFR family receptor subunit); inhibitsEGFR substrate phosphorylation; inhibits EGFR mediated gene activation;inhibits growth or proliferation of a cell the expresses EGFR.Preferably, the antagonist has substantially similar or improvedeffectiveness as an EGFR antagonist as compared to Cetuximab.

Tyrosine kinase inhibition can be determined using well-known methods;for example, by measuring the autophosphorylation level of recombinantkinase receptor, and/or phosphorylation of natural or syntheticsubstrates. Thus, phosphorylation assays are useful in determining EGFRantagonists of the present invention. Phosphorylation can be detected,for example, using an antibody specific for phosphotyrosine in an ELISAassay or on a western blot. Some assays for tyrosine kinase activity aredescribed in Panek et al., J. Pharmacol. Exp. Thera. (1997) 283: 1433-44and Batley et al., Life Sci. (1998) 62: 143-50.

In addition, methods for detection of protein expression can be utilizedto determine EGFR antagonists, wherein the proteins being measured areregulated by EGFR tyrosine kinase activity. These methods includeimmunohistochemistry (IHC) for detection of protein expression,fluorescence in situ hybridization (FISH) for detection of geneamplification, competitive radioligand binding assays, solid matrixblotting techniques, such as Northern and Southern blots, reversetranscriptase polymerase chain reaction (RT-PCR) and ELISA. See, e.g.,Grandis et al., Cancer, (1996) 78:1284-92; Shimizu et al., Japan J.Cancer Res., (1994) 85:567-71; Sauter et al., Am. J. Path., (1996)148:1047-53; Collins, Glia, (1995) 15:289-96; Radinsky et al., Clin.Cancer Res., (1995) 1:19-31; Petrides et al., Cancer Res., (1990)50:3934-39; Hoffmann et al., Anticancer Res., (1997) 17:4419-26;Wikstrand et al., Cancer Res., (1995) 55:3140-48.

The ability of a mimetic to block ligand binding can be measured, forexample, by an in vitro competitive assay such as is illustrated in FIG.4. In this assay, a ligand of EGFR such as EGF is immobilized, and abinding assay is carried to determine the effectiveness of the mimeticto competitively inhibit binding of EGFR to the immobilized ligand.

In vivo assays can also be utilized to determine EGFR antagonists. Forexample, receptor tyrosine kinase inhibition can be observed bymitogenic assays using cell lines stimulated with receptor ligand in thepresence and absence of inhibitor. For example, A431cells (American TypeCulture Collection (ATCC), Rockville, Md.) stimulated with EGF can beused to assay EGFR inhibition. Another method involves testing forinhibition of growth of EGFR-expressing tumor cells, using for example,human tumor cells injected into a mouse. See U.S. Pat. No. 6,365,157(Rockwell et al.).

The present invention provides for coordinates of the co-crystal of thepresent invention on a computer readable format such as a magnetic disk,CD-ROM or a hard drive.

In another aspect, the present invention provides methods of treatingEGFR-dependent diseases and conditions in mammals by administering atherapeutically effective amount of a mimetic of cetuximab. One skilledin the art would easily be able to diagnose such conditions anddisorders using known, conventional tests. Treatment means any treatmentof a disease in an animal and includes: (1) preventing the disease fromoccurring in a mammal which may be predisposed to the disease but doesnot yet experience or display symptoms of the disease; e.g., preventionof the outbreak of the clinical symptoms; (2) inhibiting the disease,e.g., arresting its development; or (3) relieving the disease, e.g.,causing regression of the symptoms of the disease. Therapeuticallyeffective amount for the treatment of a disease means that amount which,when administered to a mammal in need thereof, is sufficient to effecttreatment, as defined above, for that disease. A cetuximab mimetic ofthe invention may be administered with an antineoplastic agent such as,for example, a chemotherapeutic.

Cetuximab mimetics of the present invention are useful for treatingtumors that express EGFR. EGFR expressing tumors are characteristicallysensitive to EGF present in their environment, and can further bestimulated by tumor produced EGF or TGF-α. While not intending to bebound to any particular mechanism, the diseases and conditions that maybe treated or prevented by the present methods include, for example,those in which tumor growth is stimulated through an EGFR paracrineand/or autocrine loop. The method is therefore effective for treating asolid tumor that is not vascularized, or is not yet substantiallyvascularized.

In another aspect of the invention, cetuximab mimetics are used toinhibit tumor-associated angiogenesis. EGFR stimulation of vascularendothelium is associated with vascularization of tumors. Typically,vascular endothelium is stimulated in a paracrine fashion by EGF and/orTGF-α from other sources (e.g., tumor cells). Accordingly, the cetuximabmimetics are effective for treating subjects with vascularized tumors orneoplasms.

Tumors that may be treated include primary tumors and metastatic tumors,as well as refractory tumors. Refractory tumors include tumors that failto respond or are resistant to treatment with chemotherapeutic agentsalone, antibodies alone, radiation alone or combinations thereof.Refractory tumors also encompass tumors that appear to be inhibited bytreatment with such agents, but recur up to five years, sometimes up toten years or longer after treatment is discontinued. The tumors mayexpress EGFR at normal levels or they may overexpress EGFR at levels,for example, that are at least 10, 100, or 1000 times normal levels.

Examples of tumor that express EGFR and are stimulated by a ligand ofEGFR include carcinomas, gliomas, sarcomas, adenocarcinomas,adenosarcomas, and adenomas. Such tumors can occur in virtually allparts of the body, including, for example, breast, heart, lung, smallintestine, colon, spleen, kidney, bladder, head and neck, ovary,prostate, brain, pancreas, skin, bone, bone marrow, blood, thymus,uterus, testicles, cervix or liver. Some tumors observed to overexpressEGFR that may be treated according to the present invention include, butare not limited to, colorectal and head and neck tumors, especiallysquamous cell carcinoma of the head and neck, brain tumors such asglioblastomas, and tumors of the lung, breast, pancreas, esophagus,bladder, kidney, ovary, cervix, and prostate. Non-limiting examples oftumors observed to have constitutively active (i.e., unregulated)receptor tyrosine kinase activity include gliomas, non-small-cell lungcarcinomas, ovarian carcinomas and prostate carcinomas. Other examplesof tumors include Kaposi's sarcoma, CNS neoplasms, neuroblastomas,capillary hemangioblastomas, meningiomas and cerebral metastases,melanoma, gastrointestinal and renal carcinomas and sarcomas,rhabdomyosarcoma, glioblastoma, preferably glioblastoma multiforme, andleiomyosarcoma.

The present invention also provides a method of treating a non-cancerhyperproliferative disease in a mammal comprising administering to themammal an effective amount of the antibody of the present invention. Asdisclosed herein, “hyperproliferative disease” is defined as a conditioncaused by excessive growth of non-cancer cells that express a member ofthe EGFR family of receptors. The excess cells generated by ahyperproliferative disease express EGFR at normal levels or they mayoverexpress EGFR.

The types of hyperproliferative diseases that can be treated inaccordance with the invention are any hyperproliferative diseases thatare stimulated by a ligand of EGFR or mutants of such ligands. Examplesof hyperproliferative disease include psoriasis, actinic keratoses, andseborrheic keratoses, warts, keloid scars, and eczema. Also included arehyperproliferative diseases caused by virus infections, such aspapilloma virus infection. For example, psoriasis comes in manydifferent variations and degrees of severity. Different types ofpsoriasis display characteristics such as pus-like blisters (pustularpsoriasis), severe sloughing of the skin (erythrodermic psoriasis),drop-like dots (guttae psoriasis) and smooth inflamed lesions (inversepsoriasis). The treatment of all types of psoriasis (e.g., psoriasisvulgaris, psoriasis pustulosa, psoriasis erythrodermica, psoriasisarthropathica, parapsoriasis, palmoplantar pustulosis) is contemplatedby the invention.

Administering the cetuximab mimetic includes delivering the mimetic to amammal by any method that may achieve the result sought. The term mammalas used herein is intended to include, but is not limited to, humans,laboratory animals, domestic pets and farm animals. The mimetic may beadministered, for example, orally, parenterally (intravenously orintramuscularly), topically, transdermally or by inhalation. Topicaladministration may be preferred for certain hyperproliferativedisorders.

In an embodiment of the invention, cetuximab mimetic can be administeredin combination with one or more other anti-neoplastic agents, such aschemotherapeutic agents. Radiation can also be employed. For examples ofcombination therapies, see, e.g., U.S. Pat. No. 6,217,866 (Schlessingeret al.) (Anti-EGFR antibodies in combination with anti-neoplasticagents); WO 99/60023 (Waksal et al.) (Anti-EGFR antibodies incombination with radiation). Any suitable anti-neoplastic agent can beused, such as a chemotherapeutic agent, radiation or combinationsthereof. The anti-neoplastic agent can be an alkylating agent or ananti-metabolite. Examples of alkylating agents include, but are notlimited to, cisplatin, cyclophosphamide, melphalan, and dacarbazine.Examples of anti-metabolites include, but not limited to, doxorubicin,daunorubicin, paclitaxel, irinotecan (CPT-11), and topotecan. When theagent is radiation, the source of the radiation can be either external(external beam radiation therapy—EBRT) or internal (brachytherapy—BT) tothe patient being treated. The dosage administered depends on numerousfactors, including, for example, the type of agent, the type andseverity tumor being treated and the route of administration of theagent. It should be emphasized, however, that the present invention isnot limited to any particular dose.

For treatment of hyperproliferative disease, the cetuximab mimetic canbe combined with any conventional treatment agent. For example, when thehyperproliferative disease is psoriasis, there are a variety ofconventional systemic and topical agents available. Systemic agents forpsoriasis include methotrexate, and oral retinoids, such as acitretin,etretinate, and isotretinoin. Other systemic treatments of psoriasisinclude hydroxyurea, NSAIDS, sulfasalazine, and 6-thioguanine.Antibiotics and antimicrobials can be used to treat or prevent infectionthat can cause psoriasis to flare and worsen. Topical agents forpsoriasis include anthralin, calcipotriene, coal tar, corticosteroids,retinoids, keratolytics, and tazarotene. Topical steroids are one of themost common therapies prescribed for mild to moderate psoriasis. Topicalsteroids are applied to the surface of the skin, but some are injectedinto the psoriasis lesions.

Hyperproliferative disease treatments further include administration ofthe cetuximab mimetic in combination with phototherapy. Phototherapyincludes administration of any wavelength of light that reduces symptomsof the hyperproliferative disease, as well as photoactivation of achemotherapeutic agent (photochemotherapy). For further discussion oftreatment of hyperproliferative disorders, see WO 02/11677 (Teufel etal.) (Treatment of hyperproliferative diseases with epidermal growthfactor receptor antagonists).

In certain embodiments of the invention, cetuximab mimetics of theinvention can be administered with EGFR antagonists and/or antagonistsof other receptors involved in tumor growth or angiogenesis. Thereceptor antagonists may bind to the receptor or the ligand to blockreceptor-ligand binding, or the receptor antagonists may otherwiseneutralize the receptor tyrosine kinase. Ligands of EGFR include, forexample, EGF, TGF-α amphiregulin, heparin-binding EGF (HB-EGF) andbetacellulin. EGF and TGF-α are thought to be the main endogenousligands that result in EGFR-mediated stimulation, although TGF-α hasbeen shown to be more potent in promoting angiogenesis. Accordingly,EGFR antagonists include antibodies that bind to such ligands andthereby block binding to and activation of EGFR.

The cetuximab mimetic can be used in combination with a VEGFRantagonist. In one embodiment of the invention, a cetuximab mimetic isused in combination with a receptor antagonist that binds specificallyto VEGFR-2/KDR receptor (PCT/US92/01300, filed Feb. 20, 1992; Terman etal., Oncogene 6: 1677-1683 (1991)). In another embodiment of theinvention, a cetuximab mimetic is used in combination with a receptorantagonist that binds specifically to VEGFR-1/Flt-1 receptor (Shibuya M.et al., Oncogene 5, 519-524 (1990)). In another embodiment, a cetuximabmimetic is used in combination with a receptor antagonist that binds toa VEGFR ligand. For example, Avastin® (bevacizumab) is an antibody thatbinds VEGF. Particularly preferred are antigen-binding proteins thatbind to the extracellular domain of VEGFR-1 or VEGFR-2 and block bindingby ligand (VEGF or P1GF), and/or neutralize VEGF-induced or P1GF-inducedactivation. For example, Mab IMC-1121 binds to soluble and cellsurface-expressed KDR. Mab IMC-1121 comprises the V_(H) and V_(L)domains obtained from a human Fab phage display library. (See WO03/075840) In another example, ScFv 6.12 binds to soluble and cellsurface-expressed Flt-1. ScFv 6.12 comprises the V_(H) and V_(L) domainsof mouse monoclonal antibody MAb 6.12. A hybridoma cell line producingMAb 6.12 has been deposited as ATCC number PTA-3344.

In another embodiment, a cetuximab mimetic is administered with anantagonist of insulin-like growth factor receptor (IGFR). In certaintumor cells, inhibition of EGFR function can be compensated byupregulation of other growth factor receptor signaling pathways, andparticularly by IGFR stimulation. Further, inhibition of IGFR signalingresults in increased sensitivity of tumor cells to certain therapeuticagents. Stimulation of either EGFR or IGFR results in phosphorylation ofcommon downstream signal transduction molecules, including Akt andp44/42, although to different extents. Accordingly, in an embodiment ofthe invention, an IGFR antagonist (e.g., an antibody that binds to IGFor IGFR and neutralizes the receptor) is coadministered with a cetuximabmimetic of the invention, thereby blocking a second input into thecommon downstream signaling pathway (e.g., inhibiting activation of Aktand/or p44/42). An example of a human antibody specific for IGFR isIMC-A12 (See WO 2005/016970).

Other examples of growth factor receptors involved in tumorigenesisagainst which antagonists may be directed are the receptors forplatelet-derived growth factor (PDGFR), hepatocyte growth factor (HGFR),nerve growth factor (NGFR), fibroblast growth factor (FGFR), andmacrophage stimulating protein (RON).

The cetuximab mimetics can also be administered with intracellular RTKantagonists that inhibit activity of RTKs or their associated downstreamsignaling elements that are involved in tumor growth or tumor-associatedangiogenesis. The intracellular RTK antagonists are preferably smallmolecules. Some examples of small molecules include organic compounds,organometallic compounds, salts of organic compounds and organometalliccompounds, and inorganic compounds. Atoms in a small molecule are linkedtogether via covalent and ionic bonds; the former is typical for smallorganic compounds such as small molecule tyrosine kinase inhibitors andthe latter is typical of small inorganic compounds. The arrangement ofatoms in a small organic molecule may represent a chain, e.g. acarbon-carbon chain or carbon-heteroatom chain or may represent a ringcontaining carbon atoms, e.g. benzene or a policyclic system, or acombination of carbon and heteroatoms, i.e., heterocycles such as apyrimidine or quinazoline. Although small molecules can have anymolecular weight, they generally include molecules that would otherwisebe considered biological molecules, except their molecular weight is notgreater than 650 D. Small molecules include both compounds found innature, such as hormones, neurotransmitters, nucleotides, amino acids,sugars, lipids, and their derivatives as well as compounds madesynthetically, either by traditional organic synthesis, bio-mediatedsynthesis, or a combination thereof. See e.g. Ganesan, Drug Doscov.Today 7(1): 47-55 (January 2002); Lou, Drug Discov. Today, 6(24):1288-1294 (December 2001).

More preferably, the small molecule to be used as an intracellular RTKantagonist according to the present invention is an intracellular EGFRantagonist that competes with ATP for binding to EGFR's intracellularbinding region having a kinase domain or to proteins involved in thesignal transduction pathways of EGFR activation. Examples of such signaltransduction pathways include the ras-mitogen activated protein kinase(MAPK) pathway, the phosphatidylinositol-3 kinase (P13K)-Akt pathway,the stress-activated protein kinase (SAPK) pathway, and the signaltransducers and activators of transcription (STAT) pathways.Non-limiting examples of proteins involved in such pathways (and towhich a small molecule EGFR antagonist according to the presentinvention can bind) include GRB-2, SOS, Ras, Raf, MEK, MAPK, and matrixmetalloproteinases (MMPs).

One example of a small molecule EGFR antagonist is IRESSA™ (ZD1939),which is a quinozaline derivative that functions as an ATP-mimetic toinhibit EGFR. See U.S. Pat. No. 5,616,582 (Zeneca Limited); WO 96/33980(Zeneca Limited) at p. 4; see also, Rowinsky et al., Abstract 5presented at the 37th Annual Meeting of ASCO, San Francisco, Calif.,12-15 May 2001; Anido et al., Abstract 1712 presented at the 37th AnnualMeeting of ASCO, San Francisco, Calif., 12-15 May 2001. Another exampleof a small molecule EGFR antagonist is TARCEVA™ (OSI-774), which is a4-(substitutedphenylamino)quinozaline derivative[6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenylaminehydrochloride] EGFR inhibitor. See WO 96/30347 (Pfizer Inc.) at, forexample, page 2, line 12 through page 4, line 34 and page 19, lines14-17. See also Moyer et al., Cancer Res., 57: 4838-48 (1997); Pollacket al., J. Pharmacol., 291: 739-48 (1999). TARCEVA™ may function byinhibiting phosphorylation of EGFR and its downstream PI3/Akt and MAP(mitogen activated protein) kinase signal transduction pathwaysresulting in p27-mediated cell-cycle arrest. See Hidalgo et al.,Abstract 281 presented at the 37th Annual Meeting of ASCO, SanFrancisco, Calif., 12-15 May 2001.

Other small molecules are also reported to inhibit EGFR, many of whichare thought to being to the tyrosine kinase domain of an EGFR. Someexamples of such small molecule EGFR antagonists are described in WO91/116051, WO 96/30347, WO 96/33980, WO 97/27199 (Zeneca Limited). WO97/30034 (Zeneca Limited), WO 97/42187 (Zeneca Limited), WO 97/49688(Pfizer Inc.), WO 98/33798 (Warner Lambert Company), WO 00/18761(American Cyanamid Company), and WO 00/31048 (Warner Lambert Company).Examples of specific small molecule EGFR antagonists include C1-1033(Pfizer), which is a quinozaline(N-[4-(3-chloro-4-fluoro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamide)inhibitor of tyrosine kinases, particularly EGFR and is described in WO00/31048 at page 8, lines 22-6; PKI166 (Novartis), which is apyrrolopyrimidine inhibitor of EGFR and is described in WO 97/27199 atpages 10-12; GW2016 (GlaxoSmithKline), which is an inhibitor of EGFR andHER2; EKB569 (Wyeth), which is reported to inhibit the growth of tumorcells that overexpress EGFR or HER2 in vitro and in vivo; AG-1478(Tryphostin), which is a quinazoline small molecule that inhibitssignaling from both EGFR and erbB-2; AG-1478 (Sugen), which isbisubstrate inhibitor that also inhibits protein kinase CK2; PD 153035(Parke-Davis) which is reported to inhibit EGFR kinase activity andtumor growth, induce apoptosis in cells in culture, and enhance thecytotoxicity of cytotoxic chemotherapeutic agents; SPM-924 (SchwarzPharma), which is a tyrosine kinase inhibitor targeted for treatment ofprostrate cancer; CP-546,989 (OSI Pharmaceuticals), which is reportedlyan inhibitor of angiogenesis for treatment of solid tumors; ADL-681,which is a EGFR kinase inhibitor targeted for treatment of cancer; PD158780, which is a pyridopyrimidine that is reported to inhibit thetumor growth rate of A4431 xenografts in mice; CP-358,774, which is aquinzoline that is reported to inhibit autophosphorylation in HN5xenografts in mice; ZD1839, which is a quinzoline that is reported tohave antitumor activity in mouse xenograft models including vulvar,NSCLC, prostrate, ovarian, and colorectal cancers; CGP 59326A, which isa pyrrolopyrimidine that is reported to inhibit growth of EGFR-positivexenografts in mice; PD 165557 (Pfizer); CGP54211 and CGP53353(Novartis), which are dianilnophthalimides. Naturally derived EGFRtyrosine kinase inhibitors include genistein, herbimycin A, quercetin,and erbstatin.

Further small molecules reported to inhibit EGFR and that are thereforewithin the scope of the present invention are tricyclic compounds suchas the compounds described in U.S. Pat. No. 5,679,683; quinazolinederivatives such as the derivatives described in U.S. Pat. No.5,616,582; and indole compounds such as the compounds described in U.S.Pat. No. 5,196,446.

In another embodiment, the EGFR antagonist can be administered incombination with one or more suitable adjuvants, such as, for example,cytokines (IL-10 and IL-13, for example) or other immune stimulators,such as, but not limited to, chemokine, tumor-associated antigens, andpeptides. See, e.g., Larrivée et al., supra. It should be appreciated,however, that administration of only a cetuximab mimetic is sufficientto prevent, inhibit, or reduce the progression of the tumor in atherapeutically effective manner.

For combination therapies, the cetuximab mimetic and anti-neoplasticagent or receptor antagonist may be administered concomitantly orsequentially.

This invention also provides a pharmaceutical composition/formulationcontaining a cetuximab mimetic and a pharmaceutically acceptablecarrier. Carrier as used herein include pharmaceutically acceptablecarriers, excipients, or stabilizers which are nontoxic to the cell ormammal being exposed thereto at the dosages and concentrations employed.Often the physiologically acceptable carrier is an aqueous pH bufferedsolution. Examples of physiologically acceptable carriers includebuffers such as phosphate, citrate and other organic acids; antioxidantsincluding ascorbic acid; low molecular weight (less than about 10residues) polypeptide; proteins, such as serum albumin, gelatin;hydrophilic polymers such as polyvinylpyrrolidone; amino acids such asglycine, glutamine, asparagine, arginine or lysine; monosaccharides,disaccharides, and other carbohydrates including glucose, mannose, ordextrins; chelating agents such as EDTA; sugar alcohols such as mannitolor sorbitol; salt forming counterions such as sodium; and/or nonionicsurfactants such as TWEEN®, polyethylene glycol (PEG), and PLURONICS®.

The active ingredients may also be entrapped in microcapsules prepared,for example, by interfacial polymerization, for example,hydroxymethylcellulose or gelatin-microcapsules andpoly(methylmethacylate) microcapsules, respectively, in colloidal drugdelivery systems (for example, liposomes, albumin microspheres,microemulsions, nano-particles, and nanocapsules) or in macroemulsions.The formulations to be used for in vivo administration must be sterile.This is readily accomplished by filtration through sterile filtrationmembranes. Sustained-release preparations may be prepared. Suitableexamples of sustained-release preparations include semipermeablematrices of solid hydrophobic polymers containing the antibody, whichmatrices are in the form of shaped articles, e.g., films, ormicrocapsules. Examples of sustained-release matrices includepolyesters, hydrogels (for example, poly(2-hydroxyethyl-methacrylate),or poly(vinylalcohol)), polylactides (U.S. Pat. No. 3,773,919),copolymers of L-glutamic acid and γ-ethyl-L-glutamate, non-degradableethylene-vinyl acetate, degradable lactic acid-glycolic acid copolymerssuch as the LUPRON DEPOT® (injectable microspheres composed of lacticacid-glycolic acid copolymer and leuprolide acetate), andpoly-D-(−)-3-hydroxybutyric acid. While polymers such as ethylene-vinylacetate and lactic acid-glycolic acid enable release of molecules forover 100 days, certain hydrogels release proteins for shorter timeperiods.

The present invention also includes kits for inhibiting tumor growthand/or tumor-associated angiogenesis comprising a therapeuticallyeffective amount of a cetuximab mimetic. The kits can further containany suitable antagonist of, for example, another growth factor receptorinvolved in tumorigenesis or angiogenesis (e.g., VEGFR-1/Flt-1, VEGFR-2,PDGFR, IGFR, NGFR, FGFR, etc, as described above). Alternatively, or inaddition, the kits of the present invention can further comprise ananti-neoplastic agent. Examples of suitable anti-neoplastic agents inthe context of the present invention have been described herein. Thekits of the present invention can further comprise an adjuvant; exampleshave also been described above.

Moreover, included within the scope of the present invention is use ofthe present antibodies in vivo and in vitro for investigative ordiagnostic methods, which are well known in the art. The diagnosticmethods include kits, which contain mimetics of the present invention.

Accordingly, the mimetics can be used in vivo and in vitro forinvestigative, diagnostic, prophylactic, or treatment methods, which arewell known in the art. Of course, it is to be understood and expectedthat variations in the principles of invention herein disclosed can bemade by one skilled in the art and it is intended that suchmodifications are to be included within the scope of the presentinvention.

All references mentioned herein are incorporated by reference.

Examples

The following examples are offered for illustrative purposes only, andare not intended to limit the scope of the present invention in any way.

Protein expression and purification. sEGFR was produced and purifiedfrom baculovirus-infected Sf9 cells as described by Ferguson, K. M. etal., 2000, Embo J 19, 4632-4643, and was used without modification ofits glycosylation state. This sEGFR was further purified by sizeexclusion chromatography (SEC) using a SEC250 column (BioRad)pre-equilibrated with 25 mM HEPES, 100 mM NaCl, pH 7.5 and concentratedto 6.2 mg/ml. Cetuximab Fab fragment was prepared by treatment of theIgG protein with papain. The IgG protein (20 mg/ml) was incubated withpapain (1:1000 w:w) at 37° C. for one hour and the digestion wasterminated by addition of iodoacetemide (75 mM final concentration). Thereaction mixture was loaded onto a Protein-A column and the flow-throughfraction containing the Fab fragments was collected and concentrated.The cetuximab Fab was fractionated by SEC and mixed with sEGFR to give atwo fold molar excess of Fab over sEGFR. Excess Fab was separated fromthe sEGFR:Fab complex using the same SEC column. The peak fractionscontaining the sEGFR:Fab complex (as confirmed by SDS-PAGE), wereconcentrated to 11 mg/ml.

Crystallization and data collection. The sEGFR:Fab complex wasbuffer-exchanged into 25 mM HEPES, pH 7.5, containing 50 mM NaCl, andcrystallized by the hanging drop method from a drop containing equalparts of a 78 μM sEGFR:Fab complex solution and reservoir solution of15% PEG3350, 250 mM (NH₄)₂SO₄, 100 mM imidazole, 10 mM CdCl₂, pH 7.5.Streak seeding was used to produce large (0.08×0.08×0.6 mm) singlecrystals. Crystals were cryo-stabilized with a brief exposure to 15%PEG3350, 15% Ethylene Glycol, 250 mM (NH₄)₂SO₄, 100 mM imidazole, 10 mMCdCl₂, pH 7.5, and were flash frozen in liquid nitrogen. Data werecollected at CHESS beamline Al, using an ADSC Quantum-210 CCD detector,and were processed using HKL2000 (See, Otwinowski, Z., and Minor, W.(1997). Processing of X-ray Diffraction Data Collected in OscillationMode. In Macromolecular Crystallography, Volume 276, C. W. Carter Jr.and R. M. Sweet, eds. (New York: Academic Press), pp. 307-326.

Structure determination and refinement. Search models for molecularreplacement were derived from the coordinates of tethered sEGFR (pdb id.1NQL; Ferguson, K. M. et al., 2003) and those of the structure of theFab fragment alone (P. Jeffrey and P. Kussie unpublished data). Aninitial solution was found for a domain I/II fragment (amino acids5-240) combined with a domain III fragment of sEGFR using the dyadoption of MOLREP (The CCP4 Suite: Programs for Protein Crystallography.Acta Cryst. D50, 760-763 (1990)) to search for the best relativeorientation of these two fragments. With the solution for thesefragments fixed it was possible to find a solution for the Fab fragment.Rigid body refinement with CNS was used to optimize the orientation ofthe individual sub-domains of the Fab. Following several rounds of modelbuilding using ‘O’ (Jones, T. A. et al., 1991, Acta Crystallogr A 47 (Pt2), 110-119) and refinement using CNS (Brunger, A. T. et al., 1998, ActaCrystallogr D Biol Crystallogr 54 (Pt 5), 905-921), interpretabledensity for the remaining portions of sEGFR(C-terminal part of domain IIand domain IV) could be seen in composite simulated-annealing omit-maps(calculated with CNS). The final stages of refinement employed TLSrefinement (Winn, M. D. et al., 2001, Acta Crystallogr D BiolCrystallogr 57, 122-133) with anisotropic motion tensors refined foreach of the four domains of sEGFR and each of the domains of the Fab,using REFMAC5 (The CCP4 Suite: Programs for Protein Crystallography.Acta Cryst. D50, 760-763 (1990).

BIAcore binding studies. Surface plasmon resonance binding experiments,performed using a BIAcore 3000 instrument, were performed in 10 mM Hepesbuffer, pH 8.0, that contained 150 mM NaCl, 3 mM EDTA, and 0.005% Tween20 (HBS-EP8) at 25° C. EGF-agonists (200 μg/ml) were coupled to a CM5BIAcore sensor chip using standard amine coupling. Optimal coupling wasobtained in 10 mM sodium acetate at pH 4.0 for EGF and TGFα and at pH6.0 for HB-EGF. Binding of sEGFR to these immobilized ligands wasperformed and analyzed exactly as described in Ferguson, K. M. et al.,2000 (FIG. 4 c). The Fab fragment of cetuximab was coupled to a separatesensor chip using amine coupling. The Fab was diluted to 50 μg/ml in 10mM sodium acetate at pH 5.5 and passed over the activated surface for 5minute at a flow rate 10 μl/minute. The binding of sEGFR to this surfacewas determined exactly as for sEGFR binding to immobilized EGF(Ferguson, K. M. et al., 2000) with the following modifications; a longcontact time was used (10 μl/min for 20 minutes; 200 μl injection) toensure that equilibrium was reached in binding of sEGFR to the surfaceeven at low concentration, the surface was regenerated between datapoints with two 5 μl injections of 10 mM glycine, 1M NaCl (pH 3.0) torapidly remove residual bound sEGFR. This regeneration does not impairthe binding of sEGFR to the Fab; the observed response for a controlsEGFR sample is constant over multiple cycles of binding andregeneration (FIG. 4( a)).

The effect of added Fab upon the binding of sEGFR to immobilized ligandwas determined using the same EGF-agonist chip described above. A seriesof samples were prepared that contained 600 nM sEGFR and increasingamounts of Fab. The fraction of the maximal response in the absence ofadded Fab is plotted for each ligand (FIG. 4( b)).

EGFR:Cetuximab Fab Interface. The following amino acids are involved indirect hydrogen bonds with the Fab (3.25 Å cut-off, calculated using theprogram CONTACT (CCP4)):

Cetuximab* Cetuximab* sEGFR Light Chain Heavy Chain Type Ser 468 Asn 91Main chain - main chain Asn 469 Trp 94 Main chain - main chain Arg 353Gly 54 Side chain - main chain Gln 384 Tyr 102 Side chain - side chainGln 408 Tyr 102 Side chain - side chain Ser 418 Trp 52 Side chain - sidechain Ser 440 Tyr 102 Side chain - main chain Lys 465 Asp 103 Sidechain - side chain *amino acids in the Fab are numbered in a simplesequential manner.Additional amino acids that are close (4 Å cut-off) are shown on thefollowing sequence.

   310        320        330        340        350        360B1 RKVCNGIGIG EFKDSLSINA TNIKHFKNCT SISGDLHILP VAFRGDSFTH TPPLDPQELD   370        380        390        400        410        420   ILKTVKEITG FLLIQAWPEN RTDLHAFENL EIIRGRTKQH GQFSLAVVSL NITSLGLRSL   430        440        450        460        470    KEISDGDVII SGN KNLCYAN TINWKKLFGT SGQKTK IISN RGENSCKA Bold  Fab Heavy chainUnderlined and Italic  Fab Light chain Italic  Both chains of FabThe binding site for cetuximab Fab is partially over-lapping with theligand binding site. The following amino acids are involved in contactto TGFα or EGF, as reported by Garrett et al. and Ogiso et al.

   310        320        330        340        350        360B1 RKVCNGIGIG EFKDSLSINA TNIKHFKNCT SISGDLHILP VAFRGDSFTH TPPLDPQELD   370        380        390        400        410        420   ILKTVKEITG FLLIQAWPEN RTDLHAFENL EIIRGRTKQH GQFSLAVVSL NITSLGLRSL   430        440        450        460        470   KEISDGDVII SGNKNLCYAN TINWKKLFGT SGQKTKIISN RGENSCKA Underlined EGF/TGFα

TABLE 1 Data collection and refinement statistics Data CollectionStatistics^(a) Space group P2₁ Unique cell dimensions a = 77.8 Å, b =70.9 Å, c = 147.1 Å; β = 102.5° X-ray source CHESS A1 Resolution limit2.8 Å Observed/unique 1411,255/38,478 Completeness 99.8 (90.6) R_(sym)^(b) 0.03 (0.33) <I/σ> 17 (5.6) Refinement Statistics Resolution limits500-2.8 Å No. of reflections/no. 38098/1900 test set R factor(R_(free))^(c) 0.22 (0.27) Model Protein sEGFR - aa 1-614 Fab: Lightchain; aa 1-211, Heavy Chain; aa 1-220, 25 saccharide units Total numberof atoms 8131 RMSD bond lengths (Å) 0.028 Å RMSD bond angles (°) 2.63°^(a)Numbers in parentheses refer to last resolution shell ^(b)R_(sym) =Σ|I_(h) − <I_(h)>|/ΣI_(h), where <I_(h)> = average intensity oversymmetry equivalent measurements ^(c)R factor = Σ|F_(o) − F_(c)|/ΣF_(o),where summation is over data used in the refinement; R_(free) includesonly 5% of the data excluded from the refinement

TABLE 2 HEADER HORMONE/GROWTH FACTOR RECEPTOR TITLE STRUCTURE OF THEEXTRACELLULAR DOMAIN OF HUMAN EPIDERMAL TITLE 2 GROWTH FACTOR (EGF)RECEPTOR IN AN COMPLEX WITH IMC-C225 TITLE 3 (CETUXIMBA/ERBITUX). COMPNDMOL_ID: 1; COMPND 2 MOLECULE: EPIDERMAL GROWTH FACTOR RECEPTOR; COMPND 3CHAIN: A; COMPND 4 FRAGMENT: EXTRACELLULAR DOMAIN; COMPND 5 ENGINEERED:YES; COMPND 6 MOL_ID: 2; COMPND 7 MOLECULE: FAB FRAGMENT FROM CETUXIMAB;COMPND 8 CHAIN: C; COMPND 9 CHAIN: D; COMPND 10 SYNONYM: IMC-C225,ERBITUX; COMPND 11 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 ORGANISM_COMMON: HUMAN;SOURCE 4 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA; SOURCE 5EXPRESSION_SYSTEM_COMMON: FALL ARMYWORM; SOURCE 6EXPRESSION_SYSTEM_STRAIN: VIRUS; SOURCE 7 EXPRESSION_SYSTEM_VECTOR_TYPE:BACULOVIRUS; SOURCE 8 MOL_ID: 2; SOURCE PROVIDED BY IMCLONE INC. AS FABFRAGMENT EXPDTA X-RAY DIFFRACTION REMARK 1 REMARK 2 RESOLUTION. 2.80ANGSTROMS. REMARK 3 REFINEMENT. REMARK 3  PROGRAM : REFMAC 5.1.24 REMARK3  AUTHORS : MURSHUDOV, VAGIN, DODSON REMARK 3 REMARK 3   REFINEMENTTARGET: MAXIMUM LIKELIHOOD REMARK 3 REMARK 3  DATA USED IN REFINEMENT.REMARK 3  RESOLUTION RANGE HIGH (ANGSTROMS) :  2.81 REMARK 3  RESOLUTIONRANGE LOW (ANGSTROMS) :  50.00 REMARK 3  DATA CUTOFF (SIGMA(F)) : NONEREMARK 3  COMPLETENESS FOR RANGE (%) :  99.44 REMARK 3  NUMBER OFREFLECTIONS :  36547 REMARK 3 REMARK 3  FIT TO DATA USED IN REFINEMENT.REMARK 3  CROSS-VALIDATION METHOD : THROUGHOUT REMARK 3  FREE R VALUETEST SET SELECTION : RANDOM REMARK 3  R VALUE (WORKING + TEST SET) :0.22623 REMARK 3  R VALUE (WORKING SET) :  0.22396 REMARK 3  FREE RVALUE :  0.26877 REMARK 3  FREE R VALUE TEST SET SIZE (%) :  5.0 REMARK3  FREE R VALUE TEST SET COUNT :  1931 REMARK 3 REMARK 3  FIT IN THEHIGHEST RESOLUTION BIN. REMARK 3  TOTAL NUMBER OF BINS USED :     20REMARK 3  BIN RESOLUTION RANGE HIGH :   2.805 REMARK 3  BIN RESOLUTIONRANGE LOW :   2.878 REMARK 3  REFLECTION IN BIN (WORKING SET) :    2605REMARK 3  BIN R VALUE (WORKING SET) :   0.335 REMARK 3  BIN FREE R VALUESET COUNT :     141 REMARK 3  BIN FREE R VALUE :   0.381 REMARK 3 REMARK3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT. REMARK 3  ALL ATOMS:    8131 REMARK 3 REMARK 3  B VALUES. REMARK 3  FROM WILSON PLOT (A**2): NULL REMARK 3  MEAN B VALUE (OVERALL, A**2) :  7.403 REMARK 3  OVERALLANISOTROPIC B VALUE. REMARK 3   B11 (A**2) : 1.07 REMARK 3   B22 (A**2): 0.32 REMARK 3   B33 (A**2) : −1.83 REMARK 3   B12 (A**2) : 0.00 REMARK3   B13 (A**2) : −1.01 REMARK 3   B23 (A**2) : 0.00 REMARK 3 REMARK 3 ESTIMATED OVERALL COORDINATE ERROR. REMARK 3  ESU BASED ON R VALUE (A): 0.910 REMARK 3  ESU BASED ON FREE R VALUE (A):  0.362 REMARK 3  ESUBASED ON MAXIMUM LIKELIHOOD (A):  0.295 REMARK 3  ESU FOR B VALUES BASEDON MAXIMUM LIKELIHOOD (A**2): 15.477 REMARK 3 REMARK 3 CORRELATIONCOEFFICIENTS. REMARK 3  CORRELATION COEFFICIENT FO-FC :  0.925 REMARK 3 CORRELATION COEFFICIENT FO-FC FREE :  0.888 REMARK 3 REMARK 3  RMSDEVIATIONS FROM IDEAL VALUES COUNT RMS WEIGHT REMARK 3  BOND LENGTHSREFINED ATOMS (A): 8349 ; 0.028 ; 0.021 REMARK 3  BOND LENGTHS OTHERS(A): 7109 ; 0.002 ; 0.020 REMARK 3  BOND ANGLES REFINED ATOMS (DEGREES):11411 ; 2.623 ; 1.993 REMARK 3  BOND ANGLES OTHERS (DEGREES): 16529 ;1.130 ; 3.000 REMARK 3  TORSION ANGLES, PERIOD 1 (DEGREES): 1042 ; 9.222; 5.000 REMARK 3  CHIRAL-CENTER RESTRAINTS (A**3): 1349 ; 0.132 ; 0.200REMARK 3  GENERAL PLANES REFINED ATOMS (A): 9136 ; 0.009 ; 0.020 REMARK3  GENERAL PLANES OTHERS (A): 1532 ; 0.007 ; 0.020 REMARK 3  NON-BONDEDCONTACTS REFINED ATOMS (A): 1896 ; 0.255 ; 0.200 REMARK 3  NON-BONDEDCONTACTS OTHERS (A): 8610 ; 0.250 ; 0.200 REMARK 3  NON-BONDED TORSIONOTHERS (A): 5383 ; 0.106 ; 0.200 REMARK 3  H-BOND (X . . . Y) REFINEDATOMS (A): 146 ; 0.207 ; 0.200 REMARK 3  SYMMETRY VDW REFINED ATOMS (A):11 ; 0.149 ; 0.200 REMARK 3  SYMMETRY VDW OTHERS (A): 51 ; 0.288 ; 0.200REMARK 3  SYMMETRY H-BOND REFINED ATOMS (A): 3 ; 0.346 ; 0.200 REMARK 3REMARK 3  ISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT RMS WEIGHT REMARK 3 MAIN-CHAIN BOND REFINED ATOMS (A**2): 5197 ; 0.717 ; 1.500 REMARK 3 MAIN-CHAIN ANGLE REFINED ATOMS (A**2): 8355 ; 1.289 ; 2.000 REMARK 3 SIDE-CHAIN BOND REFINED ATOMS (A**2): 3152 ; 2.076 ; 3.000 REMARK 3 SIDE-CHAIN ANGLE REFINED ATOMS (A**2): 3056 ; 3.116 ; 4.500 REMARK 3REMARK 3  NCS RESTRAINTS STATISTICS REMARK 3  NUMBER OF NCS GROUPS: NULLREMARK 3 REMARK 3  BULK SOLVENT MODELLING. REMARK 3  METHOD USED:BABINET MODEL WITH MASK REMARK 3  PARAMETERS FOR MASK CALCULATION REMARK3  VDW PROBE RADIUS : 1.40 REMARK 3  ION PROBE RADIUS : 0.80 REMARK 3 SHRINKAGE RADIUS : 0.80 REMARK 3 REMARK 3  OTHER REFINEMENT REMARKS:REMARK 3  HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS REMARK 3LINK  C1 NAG E3281 1.439 ND2 ASN A 328 NAG-ASN LINK  C1 NAG E3371 1.439ND2 ASN A 337 NAG-ASN LINK  C1 NAG E3891 1.439 ND2 ASN A 389 NAG-ASNLINK  C1 NAG E5441 1.439 ND2 ASN A 544 NAG-ASN LINK  C1 NAG E5791 1.439ND2 ASN A 579 NAG-ASN LINK  C1 NAG E 881 1.439 ND2 ASN D  88 NAG-ASNLINK  O3 NAG E 321 N2 NAG E 322 NAG-NAG LINK  O3 NAG E 321 C7 NAG E 322NAG-NAG1 LINK  O3 NAG E 321 O7 NAG E 322 NAG-NAG2 LINK  O2 MAN E 3241.080 O2 MAN E 323 MAN-MAN CISPEP 1 SER C  7 PRO C  8 0.00 CISPEP 2 TYRC 140 PRO C 141 0.00 CISPEP 3 PHE D 152 PRO D 153 0.00 CISPEP 4 GLU D154 PRO D 155 0.00 LINK NAG E3281 NAG E3282 BETA1-4 LINK NAG E3282 MANE3283 BETA1-4 LINK MAN E3283 MAN E3284 BETA1-6 LINK MAN E3284 MAN E3287ALPHA1-3 LINK MAN E3287 MAN E3288 BETA1-2 LINK MAN E3283 MAN E3285ALPHA1-3 LINK MAN E3285 MAN E3286 BETA1-2 LINK MAN E3284 MAN E3289ALPHA1-6 LINK NAG E3371 NAG E3372 ALPHA1-4 LINK NAG E3372 MAN E3373ALPHA1-4 LINK MAN E3373 MAN E3374 BETA1-3 LINK NAG E4201 NAG E4202ALPHA1-4 LINK NAG E4202 MAN E4203 ALPHA1-4 SSBOND 1 CYS A  34 CYS A  7SSBOND 2 CYS A 163 CYS A 133 SSBOND 3 CYS A 175 CYS A 166 SSBOND 4 CYS A183 CYS A 170 SSBOND 5 CYS A 207 CYS A 195 SSBOND 6 CYS A 216 CYS A 208SSBOND 7 CYS A 224 CYS A 212 SSBOND 8 CYS A 236 CYS A 227 SSBOND 9 CYS A283 CYS A 271 SSBOND 10 CYS A 302 CYS A 287 SSBOND 11 CYS A 309 CYS A305 SSBOND 12 CYS A 338 CYS A 313 SSBOND 13 CYS A 499 CYS A 486 SSBOND14 CYS A 511 CYS A 502 SSBOND 15 CYS A 531 CYS A 515 SSBOND 16 CYS A 547CYS A 534 SSBOND 17 CYS A 555 CYS A 538 SSBOND 18 CYS A 567 CYS A 558SSBOND 19 CYS A 593 CYS A 571 SSBOND 20 CYS A 604 CYS A 596 SSBOND 21CYS A 612 CYS A 600 SSBOND 22 CYS A 446 CYS A 475 SSBOND 23 CYS A 482CYS A 491 SSBOND 24 CYS A 199 CYS A 191 SSBOND 25 CYS C  88 CYS C  23SSBOND 26 CYS C 194 CYS C 134 SSBOND 27 CYS D  95 CYS D  22 SSBOND 28CYS D 202 CYS D 146 MODRES NAG E  321 NAG-b-D RENAME MODRES NAG E  322NAG-b-D RENAME MODRES MAN E  323 MAN-b-D RENAME MODRES MAN E  324MAN-b-D RENAME MODRES NAG E 3281 NAG-b-D RENAME MODRES NAG E 3282NAG-b-D RENAME MODRES MAN E 3283 MAN-b-D RENAME MODRES MAN E 3284MAN-b-D RENAME MODRES MAN E 3287 MAN-a-D RENAME MODRES MAN E 3288MAN-b-D RENAME MODRES MAN E 3285 MAN-a-D RENAME MODRES MAN E 3286MAN-b-D RENAME MODRES MAN E 3289 MAN-a-D RENAME MODRES NAG E 3371NAG-b-D RENAME MODRES NAG E 3372 NAG-a-D RENAME MODRES MAN E 3373MAN-a-D RENAME MODRES MAN E 3374 MAN-b-D RENAME MODRES NAG E 3891NAG-b-D RENAME MODRES NAG E 3892 NAG-b-D RENAME MODRES NAG E 4201NAG-b-D RENAME MODRES NAG E 4202 NAG-a-D RENAME MODRES MAN E 4203MAN-a-D RENAME MODRES NAG E 5041 NAG-b-D RENAME MODRES NAG E 5441NAG-b-D RENAME MODRES NAG E 5791 NAG-b-D RENAME MODRES NAG E 881 NAG-b-DRENAME CRYST1  77.823 70.861 147.122 90.00 102.48 90.00 P 1 21 1 SCALE10.012850 0.000000 0.002844 0.00000 SCALE2 0.000000 0.014112 0.0000000.00000 SCALE3 0.000000 0.000000 0.006962 0.00000 ATOM 1 N LEU A 113.360 2.249 11.251 1.00 100.92 N ATOM 3 CA LEU A 1 12.773 1.470 12.3981.00 105.53 C ATOM 5 CB LEU A 1 11.965 0.248 11.865 1.00 108.08 C ATOM 8CG LEU A 1 10.656 −0.207 12.561 1.00 114.07 C ATOM 10 CD1 LEU A 1 9.5790.912 12.805 1.00 118.27 C ATOM 14 CD2 LEU A 1 10.023 −1.358 11.772 1.00115.39 C ATOM 18 C LEU A 1 13.923 1.032 13.354 1.00 103.08 C ATOM 19 OLEU A 1 13.913 1.330 14.572 1.00 105.39 O ATOM 22 N GLU A 2 14.904 0.33312.772 1.00 98.75 N ATOM 24 CA GLU A 2 16.143 −0.038 13.449 1.00 95.06 CATOM 26 CB GLU A 2 16.981 −0.917 12.518 1.00 90.85 C ATOM 29 CG GLU A 218.025 −1.714 13.253 1.00 89.57 C ATOM 32 CD GLU A 2 19.160 −2.20512.358 1.00 88.28 C ATOM 33 OE1 GLU A 2 19.720 −1.403 11.495 1.00 84.21O ATOM 34 OE2 GLU A 2 19.493 −3.427 12.562 1.00 89.66 O ATOM 35 C GLU A2 16.965 1.207 13.819 1.00 92.58 C ATOM 36 O GLU A 2 17.201 2.090 12.9551.00 90.00 O ATOM 37 N GLU A 3 17.396 1.261 15.096 1.00 93.29 N ATOM 39CA GLU A 3 18.416 2.250 15.593 1.00 90.23 C ATOM 41 CB GLU A 3 18.0822.630 17.081 1.00 94.21 C ATOM 44 CG GLU A 3 16.599 3.021 17.380 1.00100.00 C ATOM 47 CD GLU A 3 16.165 2.910 18.872 1.00 105.60 C ATOM 48OE1 GLU A 3 16.983 2.478 19.722 1.00 104.83 O ATOM 49 OE2 GLU A 3 14.9913.253 19.229 1.00 109.98 O ATOM 50 C GLU A 3 19.925 1.714 15.412 1.0084.70 C ATOM 51 O GLU A 3 20.405 0.936 16.274 1.00 85.80 O ATOM 52 N LYSA 4 20.618 2.086 14.305 1.00 79.39 N ATOM 54 CA LYS A 4 21.994 1.60813.949 1.00 74.36 C ATOM 56 CB LYS A 4 22.472 2.211 12.626 1.00 70.99 CATOM 59 CG LYS A 4 21.654 1.834 11.436 1.00 73.21 C ATOM 62 CD LYS A 422.526 1.263 10.289 1.00 71.25 C ATOM 65 CE LYS A 4 21.667 0.401 9.2541.00 75.31 C ATOM 68 NZ LYS A 4 21.491 1.128 7.883 1.00 76.46 N ATOM 72C LYS A 4 23.090 2.043 14.898 1.00 72.83 C ATOM 73 O LYS A 4 23.1693.249 15.216 1.00 73.52 O ATOM 74 N LYS A 5 24.009 1.129 15.248 1.0070.16 N ATOM 76 CA LYS A 5 24.974 1.410 16.328 1.00 68.70 C ATOM 78 CBLYS A 5 25.338 0.124 17.092 1.00 69.57 C ATOM 81 CG LYS A 5 24.052−0.768 17.413 1.00 75.20 C ATOM 84 CD LYS A 5 23.641 −0.893 18.917 1.0079.29 C ATOM 87 CE LYS A 5 22.196 −0.390 19.171 1.00 83.67 C ATOM 90 NZLYS A 5 21.488 −1.198 20.194 1.00 91.94 N ATOM 94 C LYS A 5 26.206 2.15315.828 1.00 64.30 C ATOM 95 O LYS A 5 26.682 1.926 14.749 1.00 61.85 OATOM 96 N VAL A 6 26.724 3.047 16.647 1.00 64.34 N ATOM 98 CA VAL A 627.596 4.114 16.203 1.00 61.78 C ATOM 100 CB VAL A 6 26.890 5.440 16.4681.00 63.52 C ATOM 102 CG1 VAL A 6 27.642 6.564 15.784 1.00 61.56 C ATOM106 CG2 VAL A 6 25.473 5.382 15.997 1.00 66.36 C ATOM 110 C VAL A 628.801 4.255 17.058 1.00 61.00 C ATOM 111 O VAL A 6 28.640 4.254 18.2031.00 63.87 O ATOM 112 N CYS A 7 29.982 4.525 16.546 1.00 58.45 N ATOM114 CA CYS A 7 31.094 4.807 17.432 1.00 59.36 C ATOM 116 CB CYS A 731.943 3.561 17.567 1.00 57.65 C ATOM 119 SG CYS A 7 32.512 2.903 16.0061.00 58.73 S ATOM 120 C CYS A 7 31.926 5.983 16.972 1.00 58.39 C ATOM121 O CYS A 7 31.955 6.264 15.829 1.00 57.51 O ATOM 122 N GLN A 8 32.5856.702 17.874 1.00 61.38 N ATOM 124 CA GLN A 8 33.635 7.683 17.502 1.0061.54 C ATOM 126 CB GLN A 8 34.054 8.482 18.741 1.00 63.20 C ATOM 129 CGGLN A 8 32.927 9.373 19.254 1.00 67.39 C ATOM 132 CD GLN A 8 32.57410.563 18.334 1.00 70.24 C ATOM 133 OE1 GLN A 8 33.273 10.818 17.3351.00 70.24 O ATOM 134 NE2 GLN A 8 31.479 11.300 18.673 1.00 75.33 N ATOM137 C GLN A 8 34.857 6.935 16.978 1.00 60.56 C ATOM 138 O GLN A 8 35.2055.857 17.449 1.00 63.77 O ATOM 139 N GLY A 9 35.579 7.394 16.026 1.0058.91 N ATOM 141 CA GLY A 9 36.720 6.527 15.726 1.00 57.92 C ATOM 144 CGLY A 9 38.036 7.249 15.990 1.00 60.20 C ATOM 145 O GLY A 9 38.259 8.51715.590 1.00 64.00 O ATOM 146 N THR A 10 38.926 6.543 16.652 1.00 59.60 NATOM 148 CA THR A 10 40.369 6.891 16.558 1.00 60.20 C ATOM 150 CB THR A10 41.078 5.669 16.340 1.00 59.09 C ATOM 152 OG1 THR A 10 40.256 4.65816.885 1.00 66.90 O ATOM 154 CG2 THR A 10 42.281 5.634 17.296 1.00 61.60C ATOM 158 C THR A 10 40.998 7.884 15.538 1.00 57.46 C ATOM 159 O THR A10 40.657 7.865 14.372 1.00 55.26 O ATOM 160 N SER A 11 41.945 8.69216.037 1.00 57.21 N ATOM 162 CA SER A 11 42.838 9.479 15.220 1.00 56.01C ATOM 164 CB SER A 11 42.438 10.930 15.303 1.00 58.10 C ATOM 167 OG SERA 11 41.073 11.006 15.003 1.00 58.88 O ATOM 169 C SER A 11 44.237 9.33015.720 1.00 56.12 C ATOM 170 O SER A 11 44.916 10.266 16.008 1.00 56.39O ATOM 171 N ASN A 12 44.687 8.118 15.834 1.00 55.44 N ATOM 173 CA ASN A12 46.051 7.926 16.295 1.00 58.03 C ATOM 175 CB ASN A 12 46.089 6.86517.413 1.00 58.48 C ATOM 178 CG ASN A 12 44.886 6.955 18.346 1.00 59.19C ATOM 179 OD1 ASN A 12 44.347 8.062 18.563 1.00 59.90 O ATOM 180 ND2ASN A 12 44.426 5.784 18.880 1.00 56.12 N ATOM 183 C ASN A 12 47.0847.624 15.172 1.00 57.48 C ATOM 184 O ASN A 12 48.285 7.497 15.459 1.0060.22 O ATOM 185 N LYS A 13 46.655 7.497 13.923 1.00 54.67 N ATOM 187 CALYS A 13 47.614 7.192 12.876 1.00 55.14 C ATOM 189 CB LYS A 13 48.3818.476 12.501 1.00 57.96 C ATOM 192 CG LYS A 13 47.420 9.634 12.179 1.0057.91 C ATOM 195 CD LYS A 13 48.048 10.642 11.298 1.00 60.41 C ATOM 198CE LYS A 13 47.075 11.808 10.983 1.00 63.26 C ATOM 201 NZ LYS A 1347.797 13.059 10.472 1.00 67.44 N ATOM 205 C LYS A 13 48.582 6.09313.297 1.00 56.16 C ATOM 206 O LYS A 13 48.171 4.995 13.766 1.00 56.29 OATOM 207 N LEU A 14 49.880 6.360 13.196 1.00 57.76 N ATOM 209 CA LEU A14 50.813 5.266 13.406 1.00 57.81 C ATOM 211 CB LEU A 14 51.985 5.37512.424 1.00 58.72 C ATOM 214 CG LEU A 14 51.524 5.396 10.955 1.00 56.05C ATOM 216 CD1 LEU A 14 52.683 5.353 9.975 1.00 57.66 C ATOM 220 CD2 LEUA 14 50.536 4.287 10.645 1.00 53.10 C ATOM 224 C LEU A 14 51.243 5.15414.855 1.00 60.01 C ATOM 225 O LEU A 14 52.038 4.261 15.187 1.00 61.31 OATOM 226 N THR A 15 50.731 6.037 15.716 1.00 60.49 N ATOM 228 CA THR A15 50.925 5.854 17.142 1.00 63.51 C ATOM 230 CB THR A 15 50.300 6.95017.944 1.00 64.28 C ATOM 232 OG1 THR A 15 50.825 8.199 17.543 1.00 65.35O ATOM 234 CG2 THR A 15 50.791 6.867 19.429 1.00 69.05 C ATOM 238 C THRA 15 50.397 4.495 17.648 1.00 63.38 C ATOM 239 O THR A 15 49.322 4.01117.232 1.00 61.95 O ATOM 240 N GLN A 16 51.190 3.874 18.517 1.00 66.09 NATOM 242 CA GLN A 16 50.868 2.561 19.107 1.00 66.17 C ATOM 244 CB GLN A16 52.007 1.560 18.862 1.00 67.19 C ATOM 247 CG GLN A 16 51.728 0.21719.455 1.00 66.47 C ATOM 250 CD GLN A 16 52.838 −0.766 19.295 1.00 66.59C ATOM 251 OE1 GLN A 16 53.535 −0.791 18.274 1.00 64.81 O ATOM 252 NE2GLN A 16 52.984 −1.624 20.293 1.00 68.23 N ATOM 255 C GLN A 16 50.6172.737 20.632 1.00 69.21 C ATOM 256 O GLN A 16 51.390 3.422 21.325 1.0073.28 O ATOM 257 N LEU A 17 49.533 2.144 21.148 1.00 67.72 N ATOM 259 CALEU A 17 49.033 2.455 22.486 1.00 69.49 C ATOM 261 CB LEU A 17 47.5042.620 22.478 1.00 67.31 C ATOM 264 CG LEU A 17 46.923 3.591 21.437 1.0064.82 C ATOM 266 CD1 LEU A 17 45.375 3.565 21.397 1.00 62.29 C ATOM 270CD2 LEU A 17 47.487 5.032 21.639 1.00 66.62 C ATOM 274 C LEU A 17 49.4501.295 23.363 1.00 71.74 C ATOM 275 O LEU A 17 48.609 0.497 23.794 1.0071.04 O ATOM 276 N GLY A 18 50.764 1.193 23.572 1.00 73.66 N ATOM 278 CAGLY A 18 51.329 0.265 24.520 1.00 76.87 C ATOM 281 C GLY A 18 51.609−1.038 23.830 1.00 75.65 C ATOM 282 O GLY A 18 51.968 −1.022 22.636 1.0072.82 O ATOM 283 N THR A 19 51.451 −2.140 24.593 1.00 77.55 N ATOM 285CA THR A 19 51.581 −3.516 24.099 1.00 76.35 C ATOM 287 CB THR A 1951.171 −4.562 25.154 1.00 79.33 C ATOM 289 OG1 THR A 19 51.943 −4.42226.343 1.00 83.29 O ATOM 291 CG2 THR A 19 51.574 −5.993 24.734 1.0082.13 C ATOM 295 C THR A 19 50.703 −3.715 22.916 1.00 71.66 C ATOM 296 OTHR A 19 49.617 −3.221 22.854 1.00 69.09 O ATOM 297 N PHE A 20 51.211−4.445 21.952 1.00 71.13 N ATOM 299 CA PHE A 20 50.404 −4.916 20.8731.00 68.02 C ATOM 301 CB PHE A 20 51.089 −6.099 20.219 1.00 69.47 C ATOM304 CG PHE A 20 52.300 −5.752 19.353 1.00 70.89 C ATOM 305 CD1 PHE A 2053.413 −6.599 19.350 1.00 74.82 C ATOM 307 CE1 PHE A 20 54.500 −6.33418.562 1.00 76.46 C ATOM 309 CZ PHE A 20 54.491 −5.207 17.726 1.00 74.93C ATOM 311 CE2 PHE A 20 53.391 −4.360 17.707 1.00 69.96 C ATOM 313 CD2PHE A 20 52.303 −4.641 18.517 1.00 69.30 C ATOM 315 C PHE A 20 49.083−5.409 21.417 1.00 67.44 C ATOM 316 O PHE A 20 48.034 −5.063 20.903 1.0063.96 O ATOM 317 N GLU A 21 49.124 −6.245 22.449 1.00 71.20 N ATOM 319CA GLU A 21 47.872 −6.628 23.125 1.00 71.94 C ATOM 321 CB GLU A 2148.020 −7.643 24.239 1.00 75.53 C ATOM 324 CG GLU A 21 46.614 −8.01724.681 1.00 77.19 C ATOM 327 CD GLU A 21 46.443 −9.456 25.095 1.00 84.24C ATOM 328 OE1 GLU A 21 46.760 −9.761 26.300 1.00 86.94 O ATOM 329 OE2GLU A 21 45.962 −10.251 24.217 1.00 85.07 O ATOM 330 C GLU A 21 47.004−5.473 23.632 1.00 71.25 C ATOM 331 O GLU A 21 45.855 −5.383 23.189 1.0069.23 O ATOM 332 N ASP A 22 47.496 −4.605 24.525 1.00 73.11 N ATOM 334CA ASP A 22 46.671 −3.422 24.914 1.00 72.68 C ATOM 336 CB ASP A 2247.456 −2.386 25.699 1.00 75.14 C ATOM 339 CG ASP A 22 48.062 −2.91926.931 1.00 79.93 C ATOM 340 OD1 ASP A 22 47.490 −3.833 27.552 1.0082.29 O ATOM 341 OD2 ASP A 22 49.142 −2.460 27.345 1.00 83.24 O ATOM 342C ASP A 22 46.054 −2.652 23.717 1.00 68.07 C ATOM 343 O ASP A 22 44.945−2.133 23.790 1.00 67.64 O ATOM 344 N HIS A 23 46.807 −2.553 22.638 1.0065.04 N ATOM 346 CA HIS A 23 46.409 −1.772 21.532 1.00 61.33 C ATOM 348CB HIS A 23 47.586 −1.723 20.576 1.00 60.16 C ATOM 351 CG HIS A 2347.430 −0.802 19.398 1.00 57.41 C ATOM 352 ND1 HIS A 23 47.673 0.55219.463 1.00 58.45 N ATOM 354 CE1 HIS A 23 47.519 1.098 18.275 1.00 53.82C ATOM 356 NE2 HIS A 23 47.197 0.141 17.433 1.00 55.61 N ATOM 358 CD2HIS A 23 47.171 −1.062 18.100 1.00 54.92 C ATOM 360 C HIS A 23 45.178−2.497 21.012 1.00 59.61 C ATOM 361 O HIS A 23 44.118 −1.917 20.865 1.0059.40 O ATOM 362 N PHE A 24 45.286 −3.789 20.800 1.00 59.94 N ATOM 364CA PHE A 24 44.165 −4.543 20.272 1.00 58.09 C ATOM 366 CB PHE A 2444.597 −5.974 19.965 1.00 58.40 C ATOM 369 CG PHE A 24 43.471 −6.88419.627 1.00 56.74 C ATOM 370 CD1 PHE A 24 43.023 −6.988 18.340 1.0054.72 C ATOM 372 CE1 PHE A 24 41.961 −7.863 18.065 1.00 55.93 C ATOM 374CZ PHE A 24 41.358 −8.614 19.113 1.00 55.91 C ATOM 376 CE2 PHE A 2441.803 −8.486 20.339 1.00 56.90 C ATOM 378 CD2 PHE A 24 42.844 −7.63420.609 1.00 56.82 C ATOM 380 C PHE A 24 42.939 −4.503 21.203 1.00 59.52C ATOM 381 O PHE A 24 41.843 −4.307 20.754 1.00 58.02 O ATOM 382 N LEU A25 43.108 −4.645 22.501 1.00 63.07 N ATOM 384 CA LEU A 25 41.933 −4.66623.381 1.00 65.30 C ATOM 386 CB LEU A 25 42.314 −4.821 24.840 1.00 68.45C ATOM 389 CG LEU A 25 43.082 −6.114 25.072 1.00 72.33 C ATOM 391 CD1LEU A 25 43.607 −6.190 26.513 1.00 78.48 C ATOM 395 CD2 LEU A 25 42.279−7.433 24.705 1.00 72.81 C ATOM 399 C LEU A 25 41.117 −3.401 23.190 1.0064.01 C ATOM 400 O LEU A 25 39.876 −3.424 23.279 1.00 63.70 O ATOM 401 NSER A 26 41.826 −2.309 22.885 1.00 63.31 N ATOM 403 CA SER A 26 41.237−0.975 22.871 1.00 63.14 C ATOM 405 CB SER A 26 42.233 0.064 23.416 1.0064.86 C ATOM 408 OG SER A 26 42.684 0.916 22.406 1.00 65.68 O ATOM 410 CSER A 26 40.693 −0.634 21.502 1.00 59.23 C ATOM 411 O SER A 26 39.6660.067 21.392 1.00 58.89 O ATOM 412 N LEU A 27 41.375 −1.155 20.478 1.0056.73 N ATOM 414 CA LEU A 27 40.789 −1.286 19.177 1.00 53.81 C ATOM 416CB LEU A 27 41.575 −2.211 18.289 1.00 52.35 C ATOM 419 CG LEU A 2741.132 −2.136 16.819 1.00 49.44 C ATOM 421 CD1 LEU A 27 41.376 −0.79716.298 1.00 46.75 C ATOM 425 CD2 LEU A 27 41.881 −3.150 15.889 1.0049.11 C ATOM 429 C LEU A 27 39.461 −1.911 19.358 1.00 54.56 C ATOM 430 OLEU A 27 38.466 −1.407 18.837 1.00 55.41 O ATOM 431 N GLN A 28 39.456−3.009 20.096 1.00 55.62 N ATOM 433 CA GLN A 28 38.281 −3.800 20.2971.00 56.39 C ATOM 435 CB GLN A 28 38.618 −5.091 21.063 1.00 59.09 C ATOM438 CG GLN A 28 37.773 −6.291 20.641 1.00 60.00 C ATOM 441 CD GLN A 2838.007 −7.567 21.488 1.00 64.33 C ATOM 442 OE1 GLN A 28 38.723 −7.56322.480 1.00 64.48 O ATOM 443 NE2 GLN A 28 37.405 −8.649 21.059 1.0065.54 N ATOM 446 C GLN A 28 37.210 −3.034 21.026 1.00 57.59 C ATOM 447 OGLN A 28 36.029 −3.157 20.656 1.00 57.19 O ATOM 448 N ARG A 29 37.594−2.271 22.063 1.00 59.69 N ATOM 450 CA ARG A 29 36.584 −1.653 22.9711.00 62.22 C ATOM 452 CB ARG A 29 37.133 −1.079 24.311 1.00 64.71 C ATOM461 C ARG A 29 35.845 −0.627 22.145 1.00 60.09 C ATOM 462 O ARG A 2934.649 −0.509 22.287 1.00 61.92 O ATOM 463 N MET A 30 36.547 0.03121.226 1.00 57.09 N ATOM 465 CA MET A 30 35.975 1.057 20.390 1.00 55.26C ATOM 467 CB MET A 30 37.106 1.794 19.716 1.00 53.16 C ATOM 470 CG META 30 36.722 2.870 18.699 1.00 51.84 C ATOM 473 SD MET A 30 35.550 4.07119.326 1.00 54.54 S ATOM 474 CE MET A 30 36.573 5.055 20.420 1.00 55.60C ATOM 478 C MET A 30 35.059 0.480 19.332 1.00 53.92 C ATOM 479 O MET A30 33.907 0.863 19.200 1.00 55.74 O ATOM 480 N PHE A 31 35.550 −0.46818.559 1.00 52.04 N ATOM 482 CA PHE A 31 34.781 −0.943 17.430 1.00 49.68C ATOM 484 CB PHE A 31 35.756 −1.193 16.273 1.00 47.66 C ATOM 487 CG PHEA 31 36.433 0.085 15.783 1.00 46.71 C ATOM 488 CD1 PHE A 31 37.781 0.30515.979 1.00 46.45 C ATOM 490 CE1 PHE A 31 38.321 1.541 15.566 1.00 47.62C ATOM 492 CZ PHE A 31 37.509 2.502 14.959 1.00 44.30 C ATOM 494 CE2 PHEA 31 36.194 2.278 14.788 1.00 42.28 C ATOM 496 CD2 PHE A 31 35.663 1.10415.190 1.00 44.72 C ATOM 498 C PHE A 31 33.789 −2.089 17.673 1.00 50.47C ATOM 499 O PHE A 31 33.081 −2.417 16.777 1.00 48.38 O ATOM 500 N ASN A32 33.613 −2.585 18.890 1.00 53.44 N ATOM 502 CA ASN A 32 32.885 −3.79419.024 1.00 56.24 C ATOM 504 CB ASN A 32 32.747 −4.260 20.430 1.00 59.73C ATOM 507 CG ASN A 32 32.163 −5.711 20.520 1.00 62.37 C ATOM 508 OD1ASN A 32 32.440 −6.605 19.743 1.00 58.57 O ATOM 509 ND2 ASN A 32 31.353−5.911 21.504 1.00 72.53 N ATOM 512 C ASN A 32 31.558 −3.958 18.295 1.0058.05 C ATOM 513 O ASN A 32 31.416 −4.866 17.436 1.00 59.26 O ATOM 514 NASN A 33 30.525 −3.217 18.586 1.00 60.46 N ATOM 516 CA ASN A 33 29.286−3.562 17.838 1.00 61.41 C ATOM 518 CB ASN A 33 28.089 −3.573 18.7891.00 65.21 C ATOM 521 CG ASN A 33 28.127 −4.776 19.664 1.00 67.90 C ATOM522 OD1 ASN A 33 28.491 −5.890 19.232 1.00 63.09 O ATOM 523 ND2 ASN A 3327.793 −4.578 20.898 1.00 73.36 N ATOM 526 C ASN A 33 29.053 −2.69216.659 1.00 59.01 C ATOM 527 O ASN A 33 27.930 −2.561 16.195 1.00 60.95O ATOM 528 N CYS A 34 30.114 −2.094 16.167 1.00 55.98 N ATOM 530 CA CYSA 34 29.963 −0.850 15.449 1.00 55.77 C ATOM 532 CB CYS A 34 31.281−0.106 15.502 1.00 54.43 C ATOM 535 SG CYS A 34 31.232 1.564 14.851 1.0057.88 S ATOM 536 C CYS A 34 29.476 −0.995 13.995 1.00 54.12 C ATOM 537 OCYS A 34 30.046 −1.728 13.154 1.00 52.55 O ATOM 538 N GLU A 35 28.408−0.279 13.701 1.00 54.92 N ATOM 540 CA GLU A 35 27.854 −0.268 12.3531.00 54.01 C ATOM 542 CB GLU A 35 26.296 −0.439 12.423 1.00 57.63 C ATOM545 CG GLU A 35 25.807 −1.904 12.595 1.00 60.04 C ATOM 548 CD GLU A 3524.265 −2.089 12.755 1.00 66.48 C ATOM 549 OE1 GLU A 35 23.430 −1.28312.291 1.00 69.81 O ATOM 550 OE2 GLU A 35 23.846 −3.086 13.360 1.0069.46 O ATOM 551 C GLU A 35 28.366 0.985 11.531 1.00 50.84 C ATOM 552 OGLU A 35 28.835 0.861 10.394 1.00 47.39 O ATOM 553 N VAL A 36 28.2982.154 12.164 1.00 51.35 N ATOM 555 CA VAL A 36 28.759 3.440 11.634 1.0049.75 C ATOM 557 CB VAL A 36 27.613 4.468 11.651 1.00 52.18 C ATOM 559CG1 VAL A 36 28.075 5.785 11.084 1.00 50.62 C ATOM 563 CG2 VAL A 3626.441 3.964 10.857 1.00 53.96 C ATOM 567 C VAL A 36 29.898 4.062 12.4541.00 48.86 C ATOM 568 O VAL A 36 29.810 4.215 13.664 1.00 50.58 O ATOM569 N VAL A 37 30.955 4.440 11.786 1.00 46.36 N ATOM 571 CA VAL A 3732.030 5.169 12.417 1.00 46.84 C ATOM 573 CB VAL A 37 33.361 4.63711.878 1.00 44.64 C ATOM 575 CG1 VAL A 37 34.537 5.214 12.638 1.00 45.69C ATOM 579 CG2 VAL A 37 33.372 3.171 11.950 1.00 43.09 C ATOM 583 C VALA 37 31.876 6.682 12.091 1.00 47.84 C ATOM 584 O VAL A 37 32.128 7.15010.959 1.00 47.48 O ATOM 585 N LEU A 38 31.406 7.446 13.057 1.00 49.78 NATOM 587 CA LEU A 38 31.412 8.917 12.977 1.00 50.77 C ATOM 589 CB LEU A38 31.068 9.494 14.341 1.00 53.03 C ATOM 592 CG LEU A 38 29.739 9.09314.919 1.00 54.79 C ATOM 594 CD1 LEU A 38 29.401 10.042 16.017 1.0057.99 C ATOM 598 CD2 LEU A 38 28.708 9.110 13.851 1.00 54.29 C ATOM 602C LEU A 38 32.752 9.540 12.550 1.00 49.42 C ATOM 603 O LEU A 38 32.74810.523 11.843 1.00 50.78 O ATOM 604 N GLY A 39 33.862 8.991 13.049 1.0048.45 N ATOM 606 CA GLY A 39 35.219 9.454 12.840 1.00 47.35 C ATOM 609 CGLY A 39 35.961 8.563 11.878 1.00 45.06 C ATOM 610 O GLY A 39 35.4098.141 10.867 1.00 45.58 O ATOM 611 N ASN A 40 37.225 8.286 12.136 1.0044.47 N ATOM 613 CA ASN A 40 37.921 7.385 11.256 1.00 42.80 C ATOM 615CB ASN A 40 39.282 7.891 10.781 1.00 43.45 C ATOM 618 CG ASN A 40 39.4299.389 10.797 1.00 44.32 C ATOM 619 OD1 ASN A 40 38.929 10.062 9.935 1.0045.99 O ATOM 620 ND2 ASN A 40 40.205 9.897 11.734 1.00 44.54 N ATOM 623C ASN A 40 38.159 6.049 11.918 1.00 42.57 C ATOM 624 O ASN A 40 38.2115.931 13.148 1.00 44.09 O ATOM 625 N LEU A 41 38.390 5.082 11.046 1.0040.76 N ATOM 627 CA LEU A 41 38.610 3.727 11.369 1.00 40.75 C ATOM 629CB LEU A 41 37.822 2.850 10.400 1.00 39.36 C ATOM 632 CG LEU A 41 38.0901.346 10.561 1.00 40.49 C ATOM 634 CD1 LEU A 41 37.763 0.779 11.990 1.0044.00 C ATOM 638 CD2 LEU A 41 37.247 0.567 9.646 1.00 41.86 C ATOM 642 CLEU A 41 40.058 3.488 11.150 1.00 40.97 C ATOM 643 O LEU A 41 40.5253.672 10.045 1.00 41.21 O ATOM 644 N GLU A 42 40.785 3.046 12.166 1.0042.33 N ATOM 646 CA GLU A 42 42.201 2.775 12.003 1.00 42.70 C ATOM 648CB GLU A 42 43.020 3.721 12.808 1.00 44.36 C ATOM 651 CG GLU A 42 42.6955.159 12.455 1.00 47.91 C ATOM 654 CD GLU A 42 43.418 6.201 13.308 1.0051.77 C ATOM 655 OE1 GLU A 42 43.332 6.066 14.581 1.00 51.29 O ATOM 656OE2 GLU A 42 44.027 7.154 12.688 1.00 51.12 O ATOM 657 C GLU A 42 42.4861.426 12.488 1.00 43.28 C ATOM 658 O GLU A 42 42.282 1.164 13.667 1.0045.62 O ATOM 659 N ILE A 43 42.979 0.557 11.605 1.00 42.12 N ATOM 661 CAILE A 43 43.421 −0.746 12.046 1.00 42.21 C ATOM 663 CB ILE A 43 42.633−1.771 11.341 1.00 40.74 C ATOM 665 CG1 ILE A 43 41.166 −1.548 11.6681.00 39.80 C ATOM 668 CD1 ILE A 43 40.301 −1.940 10.641 1.00 39.39 CATOM 672 CG2 ILE A 43 43.052 −3.107 11.840 1.00 43.58 C ATOM 676 C ILE A43 44.919 −0.912 11.876 1.00 42.70 C ATOM 677 O ILE A 43 45.477 −0.69410.858 1.00 42.81 O ATOM 678 N THR A 44 45.555 −1.355 12.916 1.00 44.98N ATOM 680 CA THR A 44 46.888 −0.922 13.235 1.00 46.86 C ATOM 682 CB THRA 44 46.703 0.473 13.748 1.00 47.31 C ATOM 684 OG1 THR A 44 46.847 1.36912.637 1.00 48.62 O ATOM 686 CG2 THR A 44 47.744 0.877 14.643 1.00 49.36C ATOM 690 C THR A 44 47.609 −1.798 14.277 1.00 49.13 C ATOM 691 O THR A44 47.102 −2.055 15.380 1.00 49.25 O ATOM 692 N TYR A 45 48.794 −2.25813.899 1.00 50.28 N ATOM 694 CA TYR A 45 49.613 −3.069 14.773 1.00 52.93C ATOM 696 CB TYR A 45 50.095 −2.247 15.992 1.00 55.11 C ATOM 699 CG TYRA 45 50.992 −1.106 15.593 1.00 55.23 C ATOM 700 CD1 TYR A 45 50.5300.165 15.617 1.00 54.89 C ATOM 702 CE1 TYR A 45 51.299 1.209 15.259 1.0054.93 C ATOM 704 CZ TYR A 45 52.553 0.999 14.808 1.00 56.32 C ATOM 705OH TYR A 45 53.273 2.109 14.459 1.00 62.09 O ATOM 707 CE2 TYR A 4553.066 −0.250 14.754 1.00 56.10 C ATOM 709 CD2 TYR A 45 52.279 −1.30615.143 1.00 56.61 C ATOM 711 C TYR A 45 48.946 −4.393 15.189 1.00 53.13C ATOM 712 O TYR A 45 49.477 −5.102 16.030 1.00 56.05 O ATOM 713 N VAL A46 47.843 −4.775 14.559 1.00 50.80 N ATOM 715 CA VAL A 46 47.215 −6.03914.908 1.00 51.76 C ATOM 717 CB VAL A 46 45.861 −6.206 14.238 1.00 49.39C ATOM 719 CG1 VAL A 46 45.204 −7.480 14.608 1.00 50.02 C ATOM 723 CG2VAL A 46 44.963 −5.087 14.699 1.00 51.23 C ATOM 727 C VAL A 46 48.118−7.153 14.509 1.00 53.22 C ATOM 728 O VAL A 46 48.496 −7.203 13.361 1.0053.23 O ATOM 729 N GLN A 47 48.430 −8.050 15.436 1.00 56.14 N ATOM 731CA GLN A 47 49.344 −9.151 15.162 1.00 59.49 C ATOM 733 CB GLN A 4750.283 −9.340 16.373 1.00 63.39 C ATOM 736 CG GLN A 47 51.212 −8.13016.701 1.00 64.49 C ATOM 739 CD GLN A 47 52.252 −7.834 15.592 1.00 64.62C ATOM 740 OE1 GLN A 47 52.947 −8.741 15.096 1.00 64.30 O ATOM 741 NE2GLN A 47 52.335 −6.564 15.191 1.00 65.38 N ATOM 744 C GLN A 47 48.684−10.517 14.730 1.00 60.25 C ATOM 745 O GLN A 47 47.461 −10.670 14.7101.00 59.39 O ATOM 746 N ARG A 48 49.500 −11.502 14.381 1.00 62.64 N ATOM748 CA ARG A 48 48.950 −12.787 13.940 1.00 64.49 C ATOM 750 CB ARG A 4850.048 −13.799 13.534 1.00 67.77 C ATOM 753 CG ARG A 48 50.278 −13.82212.038 1.00 68.04 C ATOM 756 CD ARG A 48 51.286 −14.816 11.673 1.0074.89 C ATOM 759 NE ARG A 48 50.712 −15.969 10.921 1.00 78.86 N ATOM 761CZ ARG A 48 50.734 −17.271 11.322 1.00 76.74 C ATOM 762 NH1 ARG A 4851.286 −17.691 12.474 1.00 78.50 N ATOM 765 NH2 ARG A 48 50.196 −18.15910.526 1.00 78.65 N ATOM 768 C ARG A 48 48.077 −13.463 14.977 1.00 65.82C ATOM 769 O ARG A 48 48.387 −13.433 16.148 1.00 69.06 O ATOM 770 N ASNA 49 47.020 −14.120 14.508 1.00 64.58 N ATOM 772 CA ASN A 49 46.070−14.867 15.340 1.00 65.41 C ATOM 774 CB ASN A 49 46.724 −16.066 16.0151.00 69.43 C ATOM 777 CG ASN A 49 47.310 −16.988 15.043 1.00 70.04 CATOM 778 OD1 ASN A 49 46.635 −17.426 14.102 1.00 68.58 O ATOM 779 ND2ASN A 49 48.587 −17.271 15.207 1.00 73.31 N ATOM 782 C ASN A 49 45.334−14.079 16.368 1.00 64.69 C ATOM 783 O ASN A 49 44.878 −14.646 17.3551.00 66.94 O ATOM 784 N TYR A 50 45.214 −12.785 16.166 1.00 61.48 N ATOM786 CA TYR A 50 44.278 −12.059 16.973 1.00 62.03 C ATOM 788 CB TYR A 5044.795 −10.662 17.261 1.00 61.43 C ATOM 791 CG TYR A 50 45.768 −10.55618.432 1.00 64.24 C ATOM 792 CD1 TYR A 50 47.030 −11.118 18.363 1.0065.32 C ATOM 794 CE1 TYR A 50 47.922 −10.989 19.436 1.00 69.50 C ATOM796 CZ TYR A 50 47.553 −10.279 20.561 1.00 70.19 C ATOM 797 OH TYR A 5048.425 −10.156 21.594 1.00 74.47 O ATOM 799 CE2 TYR A 50 46.328 −9.70520.642 1.00 67.54 C ATOM 801 CD2 TYR A 50 45.446 −9.818 19.573 1.0064.01 C ATOM 803 C TYR A 50 42.992 −11.996 16.156 1.00 59.86 C ATOM 804O TYR A 50 43.082 −11.703 15.011 1.00 57.85 O ATOM 805 N ASP A 51 41.818−12.223 16.752 1.00 61.02 N ATOM 807 CA ASP A 51 40.540 −12.225 16.0371.00 59.60 C ATOM 809 CB ASP A 51 39.472 −12.905 16.896 1.00 62.57 CATOM 812 CG ASP A 51 38.272 −13.445 16.079 1.00 61.90 C ATOM 813 OD1 ASPA 51 38.043 −13.027 14.914 1.00 53.66 O ATOM 814 OD2 ASP A 51 37.498−14.330 16.570 1.00 65.06 O ATOM 815 C ASP A 51 40.013 −10.838 15.7751.00 57.33 C ATOM 816 O ASP A 51 39.564 −10.219 16.717 1.00 59.76 O ATOM817 N LEU A 52 39.985 −10.397 14.519 1.00 54.26 N ATOM 819 CA LEU A 5239.331 −9.145 14.121 1.00 52.34 C ATOM 821 CB LEU A 52 40.110 −8.41513.029 1.00 49.67 C ATOM 824 CG LEU A 52 41.456 −7.893 13.423 1.00 50.34C ATOM 826 CD1 LEU A 52 42.092 −7.459 12.115 1.00 49.85 C ATOM 830 CD2LEU A 52 41.305 −6.728 14.427 1.00 50.52 C ATOM 834 C LEU A 52 37.948−9.321 13.542 1.00 51.96 C ATOM 835 O LEU A 52 37.444 −8.450 12.848 1.0050.66 O ATOM 836 N SER A 53 37.293 −10.399 13.864 1.00 54.16 N ATOM 838CA SER A 53 36.003 −10.618 13.274 1.00 54.53 C ATOM 840 CB SER A 5335.526 −12.042 13.555 1.00 56.90 C ATOM 843 OG SER A 53 35.460 −12.20314.922 1.00 58.05 O ATOM 845 C SER A 53 34.947 −9.619 13.758 1.00 55.01C ATOM 846 O SER A 53 33.897 −9.595 13.168 1.00 56.80 O ATOM 847 N PHE A54 35.168 −8.820 14.802 1.00 54.98 N ATOM 849 CA PHE A 54 34.142 −7.84515.190 1.00 55.18 C ATOM 851 CB PHE A 54 34.467 −7.156 16.478 1.00 55.26C ATOM 854 CG PHE A 54 35.840 −6.619 16.535 1.00 53.23 C ATOM 855 CD1PHE A 54 36.104 −5.318 16.141 1.00 55.25 C ATOM 857 CE1 PHE A 54 37.420−4.754 16.207 1.00 53.92 C ATOM 859 CZ PHE A 54 38.446 −5.524 16.6711.00 56.11 C ATOM 861 CE2 PHE A 54 38.166 −6.881 17.085 1.00 54.50 CATOM 863 CD2 PHE A 54 36.883 −7.395 16.974 1.00 53.07 C ATOM 865 C PHE A54 33.936 −6.763 14.167 1.00 54.02 C ATOM 866 O PHE A 54 32.946 −6.01614.274 1.00 56.54 O ATOM 867 N LEU A 55 34.895 −6.616 13.233 1.00 51.66N ATOM 869 CA LEU A 55 34.779 −5.672 12.103 1.00 48.92 C ATOM 871 CB LEUA 55 36.115 −5.550 11.426 1.00 46.55 C ATOM 874 CG LEU A 55 37.205−5.064 12.318 1.00 46.74 C ATOM 876 CD1 LEU A 55 38.490 −5.184 11.6211.00 45.91 C ATOM 880 CD2 LEU A 55 36.9.62 −3.616 12.600 1.00 47.82 CATOM 884 C LEU A 55 33.821 −6.095 10.989 1.00 48.78 C ATOM 885 O LEU A55 33.656 −5.390 9.989 1.00 49.08 O ATOM 886 N LYS A 56 33.230 −7.27411.090 1.00 50.51 N ATOM 888 CA LYS A 56 32.248 −7.667 10.096 1.00 50.35C ATOM 890 CB LYS A 56 31.836 −9.114 10.238 1.00 52.48 C ATOM 893 CG LYSA 56 32.973 −10.132 10.110 1.00 53.73 C ATOM 896 CD LYS A 56 32.484−11.607 9.798 1.00 58.55 C ATOM 899 CE LYS A 56 33.628 −12.680 9.3901.00 59.21 C ATOM 902 NZ LYS A 56 33.071 −13.963 8.832 1.00 61.23 N ATOM906 C LYS A 56 31.048 −6.741 10.221 1.00 50.84 C ATOM 907 O LYS A 5630.296 −6.625 9.287 1.00 51.82 O ATOM 908 N THR A 57 30.905 −6.03611.339 1.00 51.04 N ATOM 910 CA THR A 57 29.736 −5.205 11.583 1.00 52.25C ATOM 912 CB THR A 57 29.699 −4.985 13.031 1.00 53.38 C ATOM 914 OG1THR A 57 29.273 −6.173 13.594 1.00 54.50 O ATOM 916 CG2 THR A 57 28.567−4.211 13.417 1.00 58.64 C ATOM 920 C THR A 57 29.757 −3.823 10.876 1.0050.73 C ATOM 921 O THR A 57 28.726 −3.142 10.690 1.00 50.93 O ATOM 922 NILE A 58 30.947 −3.412 10.510 1.00 48.03 N ATOM 924 CA ILE A 58 31.102−2.105 10.062 1.00 47.21 C ATOM 926 CB ILE A 58 32.545 −1.755 10.0921.00 45.62 C ATOM 928 CG1 ILE A 58 32.947 −1.611 11.543 1.00 47.30 CATOM 931 CD1 ILE A 58 34.411 −1.176 11.687 1.00 48.07 C ATOM 935 CG2 ILEA 58 32.779 −0.361 9.424 1.00 45.43 C ATOM 939 C ILE A 58 30.472 −1.9468.683 1.00 46.76 C ATOM 940 O ILE A 58 30.884 −2.571 7.729 1.00 46.94 OATOM 941 N GLN A 59 29.457 −1.091 8.633 1.00 47.32 N ATOM 943 CA GLN A59 28.765 −0.744 7.433 1.00 46.32 C ATOM 945 CB GLN A 59 27.308 −0.5357.789 1.00 49.40 C ATOM 948 CG GLN A 59 26.460 −1.801 7.748 1.00 50.88 CATOM 951 CD GLN A 59 25.154 −1.630 8.490 1.00 56.62 C ATOM 952 OE1 GLN A59 24.282 −0.851 8.084 1.00 61.17 O ATOM 953 NE2 GLN A 59 25.029 −2.3199.621 1.00 62.39 N ATOM 956 C GLN A 59 29.328 0.491 6.793 1.00 43.74 CATOM 957 O GLN A 59 29.321 0.621 5.609 1.00 42.04 O ATOM 958 N GLU A 6029.790 1.437 7.575 1.00 43.80 N ATOM 960 CA GLU A 60 30.199 2.713 6.9641.00 43.43 C ATOM 962 CB GLU A 60 28.983 3.525 6.485 1.00 45.57 C ATOM965 CG GLU A 60 27.904 3.828 7.486 1.00 49.95 C ATOM 968 CD GLU A 6026.781 4.755 6.943 1.00 55.76 C ATOM 969 OE1 GLU A 60 25.747 4.155 6.4841.00 53.00 O ATOM 970 OE2 GLU A 60 26.933 6.058 7.002 1.00 55.62 O ATOM971 C GLU A 60 31.110 3.560 7.813 1.00 41.36 C ATOM 972 O GLU A 6031.060 3.489 8.959 1.00 41.52 O ATOM 973 N VAL A 61 31.956 4.343 7.1711.00 40.34 N ATOM 975 CA VAL A 61 32.955 5.212 7.787 1.00 40.06 C ATOM977 CB VAL A 61 34.383 4.620 7.589 1.00 38.27 C ATOM 979 CG1 VAL A 6135.479 5.597 8.136 1.00 38.94 C ATOM 983 CG2 VAL A 61 34.453 3.245 8.2461.00 36.00 C ATOM 987 C VAL A 61 32.892 6.673 7.263 1.00 41.13 C ATOM988 O VAL A 61 33.035 7.009 6.073 1.00 40.36 O ATOM 989 N ALA A 6232.717 7.588 8.167 1.00 43.43 N ATOM 991 CA ALA A 62 32.644 8.993 7.7411.00 44.23 C ATOM 993 CB ALA A 62 32.068 9.827 8.844 1.00 45.33 C ATOM997 C ALA A 62 34.000 9.548 7.301 1.00 42.41 C ATOM 998 O ALA A 6234.058 10.357 6.397 1.00 43.72 O ATOM 999 N GLY A 63 35.062 9.160 7.9841.00 41.42 N ATOM 1001 CA GLY A 63 36.337 9.844 7.875 1.00 41.84 C ATOM1004 C GLY A 63 37.229 9.070 6.951 1.00 40.75 C ATOM 1005 O GLY A 6336.820 8.695 5.882 1.00 40.21 O ATOM 1006 N TYR A 64 38.425 8.717 7.3591.00 40.83 N ATOM 1008 CA TYR A 64 39.185 7.771 6.561 1.00 39.12 C ATOM1010 CB TYR A 64 40.559 8.330 6.344 1.00 40.77 C ATOM 1013 CG TYR A 6441.366 8.605 7.595 1.00 40.87 C ATOM 1014 CD1 TYR A 64 42.182 7.6178.184 1.00 42.70 C ATOM 1016 CE1 TYR A 64 42.969 7.892 9.305 1.00 44.16C ATOM 1018 CZ TYR A 64 42.910 9.171 9.833 1.00 42.92 C ATOM 1019 OH TYRA 64 43.627 9.512 10.935 1.00 43.56 O ATOM 1021 CE2 TYR A 64 42.09010.108 9.279 1.00 43.84 C ATOM 1023 CD2 TYR A 64 41.353 9.838 8.153 1.0043.12 C ATOM 1025 C TYR A 64 39.325 6.394 7.210 1.00 39.09 C ATOM 1026 OTYR A 64 39.007 6.183 8.369 1.00 40.13 O ATOM 1027 N VAL A 65 39.8335.469 6.425 1.00 37.79 N ATOM 1029 CA VAL A 65 40.165 4.157 6.845 1.0037.58 C ATOM 1031 CB VAL A 65 39.451 3.155 5.959 1.00 36.44 C ATOM 1033CG1 VAL A 65 39.941 1.695 6.176 1.00 35.49 C ATOM 1037 CG2 VAL A 6538.020 3.234 6.276 1.00 38.10 C ATOM 1041 C VAL A 65 41.665 4.017 6.6811.00 38.37 C ATOM 1042 O VAL A 65 42.169 4.112 5.579 1.00 38.62 O ATOM1043 N LEU A 66 42.377 3.760 7.760 1.00 38.89 N ATOM 1045 CA LEU A 6643.750 3.428 7.621 1.00 40.32 C ATOM 1047 CB LEU A 66 44.519 4.432 8.4051.00 42.88 C ATOM 1050 CG LEU A 66 45.904 4.043 8.875 1.00 45.09 C ATOM1052 CD1 LEU A 66 46.821 3.880 7.728 1.00 44.69 C ATOM 1056 CD2 LEU A 6646.373 5.153 9.836 1.00 48.02 C ATOM 1060 C LEU A 66 44.042 2.058 8.1551.00 40.80 C ATOM 1061 O LEU A 66 43.832 1.757 9.314 1.00 42.77 O ATOM1062 N ILE A 67 44.576 1.198 7.326 1.00 40.95 N ATOM 1064 CA ILE A 6745.001 −0.132 7.747 1.00 40.61 C ATOM 1066 CB ILE A 67 44.324 −1.1136.861 1.00 39.42 C ATOM 1068 CG1 ILE A 67 42.836 −1.076 7.096 1.00 37.05C ATOM 1071 CD1 ILE A 67 42.129 −1.575 5.966 1.00 36.61 C ATOM 1075 CG2ILE A 67 44.845 −2.486 7.132 1.00 42.01 C ATOM 1079 C ILE A 67 46.526−0.226 7.596 1.00 42.09 C ATOM 1080 O ILE A 67 47.035 −0.356 6.481 1.0042.06 O ATOM 1081 N ALA A 68 47.252 −0.097 8.693 1.00 43.71 N ATOM 1083CA ALA A 68 48.691 −0.174 8.634 1.00 46.04 C ATOM 1085 CB ALA A 6849.231 1.175 8.518 1.00 46.74 C ATOM 1089 C ALA A 68 49.421 −0.962 9.7711.00 48.21 C ATOM 1090 O ALA A 68 48.939 −1.126 10.901 1.00 47.90 O ATOM1091 N LEU A 69 50.597 −1.464 9.396 1.00 50.08 N ATOM 1093 CA LEU A 6951.542 −2.143 10.292 1.00 52.36 C ATOM 1095 CB LEU A 69 52.199 −1.12711.234 1.00 53.98 C ATOM 1098 CG LEU A 69 52.815 0.105 10.537 1.00 54.54C ATOM 1100 CD1 LEU A 69 53.048 1.269 11.481 1.00 55.84 C ATOM 1104 CD2LEU A 69 54.114 −0.210 9.926 1.00 56.72 C ATOM 1108 C LEU A 69 50.917−3.355 10.993 1.00 51.43 C ATOM 1109 O LEU A 69 51.253 −3.718 12.1021.00 52.82 O ATOM 1110 N ASN A 70 50.034 −3.989 10.254 1.00 49.53 N ATOM1112 CA ASN A 70 49.288 −5.146 10.709 1.00 49.78 C ATOM 1114 CB ASN A 7047.887 −5.148 10.071 1.00 47.45 C ATOM 1117 CG ASN A 70 47.025 −4.05410.557 1.00 45.01 C ATOM 1118 OD1 ASN A 70 46.654 −4.043 11.719 1.0045.13 O ATOM 1119 ND2 ASN A 70 46.719 −3.102 9.690 1.00 43.78 N ATOM1122 C ASN A 70 49.990 −6.380 10.192 1.00 51.18 C ATOM 1123 O ASN A 7050.449 −6.375 9.044 1.00 50.13 O ATOM 1124 N THR A 71 50.106 −7.42511.001 1.00 53.00 N ATOM 1126 CA THR A 71 50.513 −8.709 10.427 1.0055.45 C ATOM 1128 CB THR A 71 51.718 −9.356 11.116 1.00 58.70 C ATOM1130 OG1 THR A 71 51.432 −9.593 12.492 1.00 59.65 O ATOM 1132 CG2 THR A71 52.909 −8.463 11.068 1.00 60.02 C ATOM 1136 C THR A 71 49.382 −9.71410.440 1.00 55.26 C ATOM 1137 O THR A 71 49.550 −10.818 9.952 1.00 55.74O ATOM 1138 N VAL A 72 48.242 −9.316 11.005 1.00 53.94 N ATOM 1140 CAVAL A 72 47.114 −10.219 11.120 1.00 53.04 C ATOM 1142 CB VAL A 72 45.909−9.515 11.839 1.00 51.69 C ATOM 1144 CG1 VAL A 72 45.385 −8.312 11.0591.00 47.61 C ATOM 1148 CG2 VAL A 72 44.786 −10.530 12.214 1.00 51.56 CATOM 1152 C VAL A 72 46.800 −10.776 9.727 1.00 51.50 C ATOM 1153 O VAL A72 46.932 −10.096 8.734 1.00 50.25 O ATOM 1154 N GLU A 73 46.456 −12.0479.672 1.00 53.42 N ATOM 1156 CA GLU A 73 46.307 −12.720 8.413 1.00 53.56C ATOM 1158 CB GLU A 73 46.091 −14.219 8.575 1.00 55.45 C ATOM 1161 CGGLU A 73 46.005 −14.829 7.190 1.00 57.21 C ATOM 1164 CD GLU A 73 46.159−16.328 7.121 1.00 65.02 C ATOM 1165 OE1 GLU A 73 46.539 −16.914 8.2481.00 68.29 O ATOM 1166 OE2 GLU A 73 45.894 −16.869 5.933 1.00 62.47 OATOM 1167 C GLU A 73 45.169 −12.057 7.647 1.00 51.07 C ATOM 1168 O GLU A73 45.351 −11.655 6.539 1.00 49.97 O ATOM 1169 N ARG A 74 44.011 −11.8888.257 1.00 50.85 N ATOM 1171 CA ARG A 74 42.877 −11.303 7.545 1.00 49.00C ATOM 1173 CB ARG A 74 41.874 −12.437 7.294 1.00 49.93 C ATOM 1176 CGARG A 74 40.411 −12.118 7.396 1.00 51.98 C ATOM 1179 CD ARG A 74 39.468−13.326 7.038 1.00 54.93 C ATOM 1182 NE ARG A 74 39.084 −13.105 5.6451.00 59.31 N ATOM 1184 CZ ARG A 74 38.269 −13.895 4.959 1.00 62.52 CATOM 1185 NH1 ARG A 74 37.762 −14.941 5.616 1.00 65.45 N ATOM 1188 NH2ARG A 74 37.967 −13.648 3.635 1.00 58.43 N ATOM 1191 C ARG A 74 42.266−10.058 8.264 1.00 46.63 C ATOM 1192 O ARG A 74 42.386 −9.919 9.436 1.0046.29 O ATOM 1193 N ILE A 75 41.684 −9.133 7.517 1.00 44.98 N ATOM 1195CA ILE A 75 40.955 −7.991 8.086 1.00 43.65 C ATOM 1197 CB ILE A 7541.725 −6.736 7.884 1.00 42.04 C ATOM 1199 CG1 ILE A 75 42.831 −6.6848.929 1.00 43.21 C ATOM 1202 CD1 ILE A 75 44.040 −5.756 8.633 1.00 42.89C ATOM 1206 CG2 ILE A 75 40.805 −5.538 8.084 1.00 42.87 C ATOM 1210 CILE A 75 39.538 −7.913 7.476 1.00 42.35 C ATOM 1211 O ILE A 75 39.350−7.353 6.451 1.00 39.45 O ATOM 1212 N PRO A 76 38.576 −8.592 8.099 1.0043.86 N ATOM 1213 CA PRO A 76 37.285 −8.857 7.461 1.00 43.31 C ATOM 1215CB PRO A 76 36.796 −10.049 8.210 1.00 43.97 C ATOM 1218 CG PRO A 7637.340 −9.772 9.568 1.00 45.76 C ATOM 1221 CD PRO A 76 38.691 −9.2479.406 1.00 44.45 C ATOM 1224 C PRO A 76 36.324 −7.728 7.568 1.00 42.78 CATOM 1225 O PRO A 76 35.396 −7.831 8.333 1.00 45.44 O ATOM 1226 N LEU A77 36.535 −6.697 6.748 1.00 41.49 N ATOM 1228 CA LEU A 77 35.641 −5.5676.537 1.00 39.87 C ATOM 1230 CB LEU A 77 36.546 −4.409 6.198 1.00 38.77C ATOM 1233 CG LEU A 77 37.158 −3.827 7.512 1.00 41.18 C ATOM 1235 CD1LEU A 77 38.215 −2.809 7.271 1.00 41.61 C ATOM 1239 CD2 LEU A 77 36.111−3.156 8.502 1.00 40.56 C ATOM 1243 C LEU A 77 34.637 −5.929 5.427 1.0041.28 C ATOM 1244 O LEU A 77 34.447 −5.251 4.413 1.00 42.53 O ATOM 1245N GLU A 78 33.972 −7.055 5.647 1.00 43.65 N ATOM 1247 CA GLU A 78 33.051−7.679 4.726 1.00 44.72 C ATOM 1249 CB GLU A 78 32.625 −9.074 5.243 1.0047.90 C ATOM 1252 CG GLU A 78 33.638 −10.261 5.125 1.00 49.04 C ATOM1255 CD GLU A 78 33.290 −11.463 6.010 1.00 57.37 C ATOM 1256 OE1 GLU A78 32.198 −11.438 6.698 1.00 60.60 O ATOM 1257 OE2 GLU A 78 34.099−12.458 6.053 1.00 64.67 O ATOM 1258 C GLU A 78 31.804 −6.852 4.471 1.0045.32 C ATOM 1259 O GLU A 78 31.180 −7.118 3.483 1.00 48.23 O ATOM 1260N ASN A 79 31.427 −5.864 5.300 1.00 45.00 N ATOM 1262 CA ASN A 79 30.167−5.128 5.064 1.00 45.06 C ATOM 1264 CB ASN A 79 29.175 −5.520 6.123 1.0047.94 C ATOM 1267 CG ASN A 79 28.893 −7.032 6.112 1.00 46.44 C ATOM 1268OD1 ASN A 79 28.282 −7.536 5.190 1.00 48.09 O ATOM 1269 ND2 ASN A 7929.350 −7.723 7.101 1.00 45.47 N ATOM 1272 C ASN A 79 30.263 −3.5724.936 1.00 44.03 C ATOM 1273 O ASN A 79 29.243 −2.882 4.734 1.00 44.31 OATOM 1274 N LEU A 80 31.505 −3.086 4.968 1.00 41.14 N ATOM 1276 CA LEU A80 31.853 −1.726 4.783 1.00 39.81 C ATOM 1278 CB LEU A 80 33.381 −1.6074.910 1.00 35.95 C ATOM 1281 CG LEU A 80 33.900 −0.184 4.736 1.00 39.21C ATOM 1283 CD1 LEU A 80 33.164 0.825 5.606 1.00 37.81 C ATOM 1287 CD2LEU A 80 35.397 0.048 4.966 1.00 41.93 C ATOM 1291 C LEU A 80 31.377−1.250 3.421 1.00 40.93 C ATOM 1292 O LEU A 80 32.049 −1.496 2.469 1.0042.60 O ATOM 1293 N GLN A 81 30.255 −0.537 3.300 1.00 42.84 N ATOM 1295CA GLN A 81 29.796 −0.098 1.984 1.00 43.93 C ATOM 1297 CB GLN A 8128.269 0.058 1.841 1.00 46.43 C ATOM 1300 CG GLN A 81 27.410 −0.7702.822 1.00 53.59 C ATOM 1303 CD GLN A 81 25.871 −0.694 2.613 1.00 59.31C ATOM 1304 OE1 GLN A 81 25.397 −0.526 1.466 1.00 64.23 O ATOM 1305 NE2GLN A 81 25.105 −0.867 3.707 1.00 58.31 N ATOM 1308 C GLN A 81 30.4271.192 1.574 1.00 43.10 C ATOM 1309 O GLN A 81 30.390 1.526 0.406 1.0044.40 O ATOM 1310 N ILE A 82 30.926 1.983 2.500 1.00 42.20 N ATOM 1312CA ILE A 82 31.227 3.374 2.148 1.00 41.78 C ATOM 1314 CB ILE A 82 29.9524.210 2.093 1.00 43.88 C ATOM 1316 CG1 ILE A 82 30.226 5.693 1.936 1.0044.99 C ATOM 1319 CD1 ILE A 82 28.980 6.417 1.322 1.00 47.81 C ATOM 1323CG2 ILE A 82 29.181 4.105 3.300 1.00 46.56 C ATOM 1327 C ILE A 82 32.1234.000 3.099 1.00 40.42 C ATOM 1328 O ILE A 82 31.890 3.965 4.277 1.0040.10 O ATOM 1329 N ILE A 83 33.149 4.590 2.559 1.00 40.78 N ATOM 1331CA ILE A 83 33.982 5.550 3.268 1.00 41.60 C ATOM 1333 CB ILE A 83 35.4725.198 2.997 1.00 40.44 C ATOM 1335 CG1 ILE A 83 35.765 3.848 3.622 1.0040.01 C ATOM 1338 CD1 ILE A 83 36.743 3.034 2.815 1.00 42.41 C ATOM 1342CG2 ILE A 83 36.410 6.236 3.487 1.00 38.30 C ATOM 1346 C ILE A 83 33.6696.893 2.695 1.00 42.50 C ATOM 1347 O ILE A 83 33.999 7.150 1.579 1.0043.19 O ATOM 1348 N ARG A 84 33.018 7.761 3.415 1.00 44.85 N ATOM 1350CA ARG A 84 32.956 9.181 2.954 1.00 47.16 C ATOM 1352 CB ARG A 84 31.9579.935 3.837 1.00 48.61 C ATOM 1355 CG ARG A 84 30.620 9.238 4.016 1.0046.73 C ATOM 1358 CD ARG A 84 29.729 9.845 5.062 1.00 47.11 C ATOM 1361NE ARG A 84 28.625 8.937 5.218 1.00 49.65 N ATOM 1363 CZ ARG A 84 27.5428.873 4.460 1.00 52.43 C ATOM 1364 NH1 ARG A 84 27.321 9.737 3.523 1.0056.44 N ATOM 1367 NH2 ARG A 84 26.651 7.905 4.649 1.00 56.44 N ATOM 1370C ARG A 84 34.366 9.791 3.133 1.00 47.81 C ATOM 1371 O ARG A 84 35.1199.296 3.931 1.00 49.72 O ATOM 1372 N GLY A 85 34.798 10.845 2.512 1.0049.39 N ATOM 1374 CA GLY A 85 36.098 11.343 3.004 1.00 49.30 C ATOM 1377C GLY A 85 36.067 12.641 3.784 1.00 51.38 C ATOM 1378 O GLY A 85 36.67213.702 3.350 1.00 54.87 O ATOM 1379 N ASN A 86 35.350 12.634 4.894 1.0050.44 N ATOM 1381 CA ASN A 86 35.247 13.909 5.616 1.00 53.16 C ATOM 1383CB ASN A 86 34.137 13.970 6.662 1.00 54.49 C ATOM 1386 CG ASN A 8632.855 13.473 6.133 1.00 56.57 C ATOM 1387 OD1 ASN A 86 32.589 13.5164.880 1.00 57.07 O ATOM 1388 ND2 ASN A 86 32.041 12.937 7.053 1.00 58.10N ATOM 1391 C ASN A 86 36.544 14.299 6.243 1.00 52.27 C ATOM 1392 O ASNA 86 36.736 15.441 6.387 1.00 54.97 O ATOM 1393 N MET A 87 37.376 13.3556.672 1.00 49.69 N ATOM 1395 CA MET A 87 38.812 13.569 6.874 1.00 50.28C ATOM 1397 CB MET A 87 39.369 13.214 8.246 1.00 50.21 C ATOM 1400 CGMET A 87 38.562 13.459 9.436 1.00 54.83 C ATOM 1403 SD MET A 87 39.25914.846 10.126 1.00 63.81 S ATOM 1404 CE MET A 87 38.913 15.937 8.8311.00 64.30 C ATOM 1408 C MET A 87 39.563 12.647 5.990 1.00 48.04 C ATOM1409 O MET A 87 39.001 11.677 5.499 1.00 46.37 O ATOM 1410 N TYR A 8840.857 12.939 5.889 1.00 49.45 N ATOM 1412 CA TYR A 88 41.828 12.1885.123 1.00 49.57 C ATOM 1414 CB TYR A 88 42.405 13.024 3.985 1.00 50.98C ATOM 1417 CG TYR A 88 41.429 13.553 2.930 1.00 53.15 C ATOM 1418 CD1TYR A 88 41.227 14.877 2.711 1.00 57.66 C ATOM 1420 CE1 TYR A 88 40.40015.281 1.763 1.00 56.97 C ATOM 1422 CZ TYR A 88 39.767 14.410 0.984 1.0052.93 C ATOM 1423 OH TYR A 88 38.880 14.736 0.021 1.00 53.52 O ATOM 1425CE2 TYR A 88 39.952 13.177 1.150 1.00 52.34 C ATOM 1427 CD2 TYR A 8840.787 12.717 2.112 1.00 54.43 C ATOM 1429 C TYR A 88 43.005 11.7725.994 1.00 50.38 C ATOM 1430 O TYR A 88 43.540 12.623 6.636 1.00 51.81 OATOM 1431 N TYR A 89 43.461 10.494 6.003 1.00 49.68 N ATOM 1433 CA TYR A89 44.851 10.226 6.458 1.00 51.12 C ATOM 1435 CB TYR A 89 45.199 8.7936.230 1.00 48.69 C ATOM 1438 CG TYR A 89 46.550 8.377 6.698 1.00 49.97 CATOM 1439 CD1 TYR A 89 46.788 8.184 7.998 1.00 52.94 C ATOM 1441 CE1 TYRA 89 48.046 7.787 8.456 1.00 54.76 C ATOM 1443 CZ TYR A 89 49.063 7.5657.595 1.00 53.29 C ATOM 1444 OH TYR A 89 50.254 7.164 8.142 1.00 54.86 OATOM 1446 CE2 TYR A 89 48.855 7.728 6.279 1.00 52.09 C ATOM 1448 CD2 TYRA 89 47.581 8.133 5.832 1.00 52.11 C ATOM 1450 C TYR A 89 45.758 11.1215.592 1.00 54.75 C ATOM 1451 O TYR A 89 45.311 11.553 4.499 1.00 57.07 OATOM 1452 N GLU A 90 46.990 11.416 6.012 1.00 56.38 N ATOM 1454 CA GLU A90 47.978 12.129 5.116 1.00 58.43 C ATOM 1456 CB GLU A 90 49.394 11.4435.224 1.00 60.02 C ATOM 1459 CG GLU A 90 49.655 10.346 4.183 1.00 63.93C ATOM 1462 CD GLU A 90 51.108 9.763 4.087 1.00 72.04 C ATOM 1463 OE1GLU A 90 52.082 10.496 4.526 1.00 73.67 O ATOM 1464 OE2 GLU A 90 51.2468.551 3.534 1.00 70.25 O ATOM 1465 C GLU A 90 47.584 12.478 3.607 1.0056.72 C ATOM 1466 O GLU A 90 47.069 11.643 2.909 1.00 53.74 O ATOM 1467N ASN A 91 47.844 13.712 3.136 1.00 59.85 N ATOM 1469 CA ASN A 91 47.84614.086 1.691 1.00 61.10 C ATOM 1471 CB ASN A 91 48.956 13.309 0.852 1.0062.38 C ATOM 1474 CG ASN A 91 50.403 13.342 1.452 1.00 66.43 C ATOM 1475OD1 ASN A 91 51.269 14.148 1.040 1.00 66.35 O ATOM 1476 ND2 ASN A 9150.692 12.379 2.344 1.00 68.77 N ATOM 1479 C ASN A 91 46.511 13.7351.008 1.00 57.87 C ATOM 1480 O ASN A 91 46.489 13.144 −0.104 1.00 58.73O ATOM 1481 N SER A 92 45.373 13.936 1.639 1.00 54.13 N ATOM 1483 CA SERA 92 44.142 13.510 0.901 1.00 50.01 C ATOM 1485 CB SER A 92 43.99114.441 −0.308 1.00 53.39 C ATOM 1488 OG SER A 92 44.397 13.795 −1.4791.00 55.51 O ATOM 1490 C SER A 92 43.861 11.994 0.390 1.00 45.90 C ATOM1491 O SER A 92 43.244 11.776 −0.632 1.00 45.63 O ATOM 1492 N TYR A 9344.238 11.012 1.185 1.00 44.30 N ATOM 1494 CA TYR A 93 43.804 9.6370.991 1.00 42.94 C ATOM 1496 CB TYR A 93 44.955 8.620 1.158 1.00 41.72 CATOM 1499 CG TYR A 93 46.166 8.787 0.278 1.00 43.87 C ATOM 1500 CD1 TYRA 93 47.407 9.146 0.829 1.00 46.10 C ATOM 1502 CE1 TYR A 93 48.541 9.3270.012 1.00 50.76 C ATOM 1504 CZ TYR A 93 48.439 9.139 −1.371 1.00 48.97C ATOM 1505 OH TYR A 93 49.527 9.284 −2.159 1.00 51.85 O ATOM 1507 CE2TYR A 93 47.228 8.775 −1.937 1.00 47.04 C ATOM 1509 CD2 TYR A 93 46.0878.588 −1.104 1.00 44.48 C ATOM 1511 C TYR A 93 42.754 9.357 2.068 1.0042.52 C ATOM 1512 O TYR A 93 43.009 9.539 3.289 1.00 42.34 O ATOM 1513 NALA A 94 41.585 8.947 1.581 1.00 42.12 N ATOM 1515 CA ALA A 94 40.4678.458 2.386 1.00 41.29 C ATOM 1517 CB ALA A 94 39.124 8.712 1.688 1.0041.93 C ATOM 1521 C ALA A 94 40.538 7.046 2.741 1.00 36.58 C ATOM 1522 OALA A 94 39.832 6.652 3.648 1.00 38.88 O ATOM 1523 N LEU A 95 41.3226.287 1.976 1.00 37.35 N ATOM 1525 CA LEU A 95 41.677 4.889 2.345 1.0036.53 C ATOM 1527 CB LEU A 95 40.838 3.878 1.575 1.00 35.59 C ATOM 1530CG LEU A 95 41.249 2.405 1.730 1.00 38.72 C ATOM 1532 CD1 LEU A 9540.952 1.856 3.092 1.00 38.41 C ATOM 1536 CD2 LEU A 95 40.553 1.5380.725 1.00 40.76 C ATOM 1540 C LEU A 95 43.155 4.620 2.097 1.00 36.96 CATOM 1541 O LEU A 95 43.702 4.902 1.040 1.00 36.85 O ATOM 1542 N ALA A96 43.811 4.030 3.064 1.00 36.75 N ATOM 1544 CA ALA A 96 45.256 3.9542.964 1.00 39.78 C ATOM 1546 CB ALA A 96 45.925 5.164 3.605 1.00 41.49 CATOM 1550 C ALA A 96 45.666 2.689 3.629 1.00 40.17 C ATOM 1551 O ALA A96 45.306 2.465 4.723 1.00 39.98 O ATOM 1552 N VAL A 97 46.352 1.8272.908 1.00 41.75 N ATOM 1554 CA VAL A 97 46.585 0.484 3.341 1.00 42.09 CATOM 1556 CB VAL A 97 45.788 −0.476 2.463 1.00 41.49 C ATOM 1558 CG1 VALA 97 46.026 −1.918 2.852 1.00 42.14 C ATOM 1562 CG2 VAL A 97 44.323−0.177 2.615 1.00 41.22 C ATOM 1566 C VAL A 97 48.086 0.352 3.161 1.0044.34 C ATOM 1567 O VAL A 97 48.554 0.134 2.051 1.00 45.40 O ATOM 1568 NLEU A 98 48.818 0.528 4.272 1.00 45.17 N ATOM 1570 CA LEU A 98 50.2760.703 4.325 1.00 46.32 C ATOM 1572 CB LEU A 98 50.596 2.056 4.941 1.0047.45 C ATOM 1575 CG LEU A 98 49.900 3.267 4.427 1.00 46.46 C ATOM 1577CD1 LEU A 98 50.711 4.432 4.845 1.00 49.07 C ATOM 1581 CD2 LEU A 9849.904 3.181 2.962 1.00 49.37 C ATOM 1585 C LEU A 98 51.052 −0.301 5.1901.00 46.58 C ATOM 1586 O LEU A 98 50.744 −0.562 6.346 1.00 44.34 O ATOM1587 N SER A 99 52.121 −0.774 4.585 1.00 48.54 N ATOM 1589 CA SER A 9953.196 −1.505 5.215 1.00 51.61 C ATOM 1591 CB SER A 99 54.303 −0.5295.593 1.00 54.70 C ATOM 1594 OG SER A 99 53.951 0.131 6.737 1.00 56.30 OATOM 1596 C SER A 99 52.781 −2.478 6.314 1.00 50.51 C ATOM 1597 O SER A99 53.385 −2.555 7.367 1.00 51.44 O ATOM 1598 N ASN A 100 51.810 −3.3015.909 1.00 48.91 N ATOM 1600 CA ASN A 100 51.163 −4.336 6.673 1.00 48.16C ATOM 1602 CB ASN A 100 49.731 −4.596 6.150 1.00 45.34 C ATOM 1605 CGASN A 100 48.753 −3.488 6.537 1.00 43.98 C ATOM 1606 OD1 ASN A 10048.493 −3.220 7.752 1.00 44.49 O ATOM 1607 ND2 ASN A 100 48.219 −2.8205.529 1.00 40.05 N ATOM 1610 C ASN A 100 51.948 −5.611 6.590 1.00 50.03C ATOM 1611 O ASN A 100 51.466 −6.581 6.059 1.00 49.67 O ATOM 1612 N TYRA 101 53.167 −5.561 7.095 1.00 52.63 N ATOM 1614 CA TYR A 101 54.057−6.682 7.206 1.00 55.81 C ATOM 1616 CB TYR A 101 54.935 −6.876 5.9571.00 57.44 C ATOM 1619 CG TYR A 101 55.910 −5.739 5.711 1.00 61.09 CATOM 1620 CD1 TYR A 101 57.282 −5.915 5.822 1.00 65.26 C ATOM 1622 CE1TYR A 101 58.178 −4.835 5.598 1.00 67.71 C ATOM 1624 CZ TYR A 101 57.689−3.571 5.279 1.00 66.52 C ATOM 1625 OH TYR A 101 58.504 −2.489 5.0801.00 66.74 O ATOM 1627 CE2 TYR A 101 56.339 −3.370 5.169 1.00 63.37 CATOM 1629 CD2 TYR A 101 55.450 −4.453 5.380 1.00 61.79 C ATOM 1631 C TYRA 101 54.922 −6.375 8.399 1.00 59.02 C ATOM 1632 O TYR A 101 54.849−5.281 8.984 1.00 59.11 O ATOM 1633 N ASP A 102 55.740 −7.351 8.775 1.0062.99 N ATOM 1635 CA ASP A 102 56.695 −7.200 9.858 1.00 66.01 C ATOM1637 CB ASP A 102 56.193 −7.849 11.169 1.00 66.35 C ATOM 1640 CG ASP A102 56.362 −9.374 11.239 1.00 70.03 C ATOM 1641 OD1 ASP A 102 56.452−10.092 10.212 1.00 73.62 O ATOM 1642 OD2 ASP A 102 56.400 −9.961 12.3401.00 72.18 O ATOM 1643 C ASP A 102 58.069 −7.681 9.459 1.00 69.88 C ATOM1644 O ASP A 102 58.284 −8.255 8.390 1.00 69.60 O ATOM 1645 N ALA A 10359.005 −7.382 10.340 1.00 73.77 N ATOM 1647 CA ALA A 103 60.390 −7.78610.188 1.00 78.79 C ATOM 1649 CB ALA A 103 61.234 −7.388 11.471 1.0082.44 C ATOM 1653 C ALA A 103 60.469 −9.265 9.936 1.00 80.28 C ATOM 1654O ALA A 103 61.349 −9.677 9.202 1.00 83.58 O ATOM 1655 N ASN A 10459.535 −10.036 10.519 1.00 78.84 N ATOM 1657 CA ASN A 104 59.562 −11.51710.518 1.00 81.30 C ATOM 1659 CB ASN A 104 58.700 −12.058 11.667 1.0080.83 C ATOM 1662 CG ASN A 104 59.503 −12.368 12.896 1.00 85.11 C ATOM1663 OD1 ASN A 104 60.124 −13.432 12.973 1.00 88.51 O ATOM 1664 ND2 ASNA 104 59.490 −11.439 13.881 1.00 83.35 N ATOM 1667 C ASN A 104 59.156−12.295 9.262 1.00 80.02 C ATOM 1668 O ASN A 104 59.059 −13.525 9.3601.00 81.89 O ATOM 1669 N ALA A 105 58.967 −11.613 8.120 1.00 77.36 NATOM 1671 CA ALA A 105 58.482 −12.224 6.874 1.00 76.38 C ATOM 1673 CBALA A 105 59.452 −13.356 6.374 1.00 80.34 C ATOM 1677 C ALA A 105 57.000−12.731 6.961 1.00 73.17 C ATOM 1678 O ALA A 105 56.718 −13.889 6.7001.00 73.97 O ATOM 1679 N THR A 106 56.081 −11.824 7.298 1.00 69.66 NATOM 1681 CA THR A 106 54.660 −12.097 7.532 1.00 66.80 C ATOM 1683 CBTHR A 106 54.420 −12.371 9.047 1.00 68.37 C ATOM 1685 OG1 THR A 10655.307 −13.390 9.523 1.00 72.58 O ATOM 1687 CG2 THR A 106 52.978 −12.9139.329 1.00 67.58 C ATOM 1691 C THR A 106 53.902 −10.812 7.270 1.00 62.45C ATOM 1692 O THR A 106 54.416 −9.762 7.574 1.00 62.25 O ATOM 1693 N GLYA 107 52.673 −10.886 6.782 1.00 58.72 N ATOM 1695 CA GLY A 107 51.864−9.712 6.675 1.00 55.00 C ATOM 1698 C GLY A 107 50.400 −9.905 6.384 1.0053.15 C ATOM 1699 O GLY A 107 49.843 −10.953 6.433 1.00 53.80 O ATOM1700 N LEU A 108 49.751 −8.814 6.049 1.00 52.41 N ATOM 1702 CA LEU A 10848.340 −8.814 5.782 1.00 50.68 C ATOM 1704 CB LEU A 108 47.813 −7.3955.753 1.00 47.39 C ATOM 1707 CG LEU A 108 46.336 −7.409 5.418 1.00 45.14C ATOM 1709 CD1 LEU A 108 45.449 −8.110 6.475 1.00 45.32 C ATOM 1713 CD2LEU A 108 45.931 −5.996 5.325 1.00 43.71 C ATOM 1717 C LEU A 108 48.153−9.472 4.422 1.00 52.50 C ATOM 1718 O LEU A 108 48.849 −9.151 3.447 1.0055.00 O ATOM 1719 N LYS A 109 47.179 −10.355 4.355 1.00 52.74 N ATOM1721 CA LYS A 109 46.955 −11.238 3.229 1.00 53.15 C ATOM 1723 CB LYS A109 47.638 −12.559 3.644 1.00 55.47 C ATOM 1726 CG LYS A 109 47.261−13.758 2.850 1.00 58.35 C ATOM 1729 CD LYS A 109 47.898 −15.038 3.3481.00 64.60 C ATOM 1732 CE LYS A 109 47.531 −16.247 2.344 1.00 68.67 CATOM 1735 NZ LYS A 109 48.322 −17.517 2.627 1.00 71.64 N ATOM 1739 C LYSA 109 45.472 −11.376 3.326 1.00 51.57 C ATOM 1740 O LYS A 109 45.043−11.938 4.301 1.00 55.49 O ATOM 1741 N GLU A 110 44.629 −10.868 2.4821.00 48.33 N ATOM 1743 CA GLU A 110 43.162 −10.946 2.841 1.00 47.27 CATOM 1745 CB GLU A 110 42.668 −12.235 3.564 1.00 48.52 C ATOM 1748 CGGLU A 110 42.930 −13.571 2.828 1.00 52.86 C ATOM 1751 CD GLU A 11042.513 −14.864 3.570 1.00 55.78 C ATOM 1752 OE1 GLU A 110 41.488 −14.8544.321 1.00 53.35 O ATOM 1753 OE2 GLU A 110 43.190 −15.927 3.337 1.0063.72 O ATOM 1754 C GLU A 110 42.519 −9.791 3.590 1.00 44.72 C ATOM 1755O GLU A 110 42.327 −9.843 4.769 1.00 44.16 O ATOM 1756 N LEU A 11142.058 −8.851 2.780 1.00 42.81 N ATOM 1758 CA LEU A 111 41.322 −7.6843.153 1.00 41.48 C ATOM 1760 CB LEU A 111 42.164 −6.445 2.787 1.00 40.76C ATOM 1763 CG LEU A 111 41.578 −5.068 2.935 1.00 39.62 C ATOM 1765 CD1LEU A 111 41.011 −4.863 4.331 1.00 41.72 C ATOM 1769 CD2 LEU A 11142.691 −4.060 2.710 1.00 39.92 C ATOM 1773 C LEU A 111 40.103 −7.6452.272 1.00 41.38 C ATOM 1774 O LEU A 111 40.014 −6.823 1.395 1.00 42.26O ATOM 1775 N PRO A 112 39.179 −8.521 2.525 1.00 41.64 N ATOM 1776 CAPRO A 112 38.060 −8.786 1.640 1.00 42.53 C ATOM 1778 CB PRO A 112 37.638−10.175 2.115 1.00 44.60 C ATOM 1781 CG PRO A 112 37.805 −10.066 3.5881.00 43.64 C ATOM 1784 CD PRO A 112 39.114 −9.318 3.760 1.00 43.26 CATOM 1787 C PRO A 112 36.845 −7.849 1.760 1.00 42.22 C ATOM 1788 O PRO A112 35.765 −8.273 2.247 1.00 43.92 O ATOM 1789 N MET A 113 36.976 −6.6501.225 1.00 41.57 N ATOM 1791 CA MET A 113 35.973 −5.586 1.353 1.00 41.49C ATOM 1793 CB MET A 113 36.676 −4.230 1.468 1.00 40.58 C ATOM 1796 CGMET A 113 37.824 −4.291 2.459 1.00 41.70 C ATOM 1799 SD MET A 113 38.645−2.730 2.961 1.00 44.40 S ATOM 1800 CE MET A 113 38.085 −1.709 1.7801.00 48.11 C ATOM 1804 C MET A 113 35.088 −5.639 0.146 1.00 42.26 C ATOM1805 O MET A 113 35.080 −4.740 −0.708 1.00 42.73 O ATOM 1806 N ARG A 11434.344 −6.726 0.053 1.00 42.70 N ATOM 1808 CA ARG A 114 33.513 −6.960−1.108 1.00 43.40 C ATOM 1810 CB ARG A 114 33.165 −8.423 −1.136 1.0045.30 C ATOM 1813 CG ARG A 114 32.163 −8.694 −0.123 1.00 48.87 C ATOM1816 CD ARG A 114 32.431 −9.967 0.498 1.00 54.37 C ATOM 1819 NE ARG A114 31.551 −10.186 1.603 1.00 56.34 N ATOM 1821 CZ ARG A 114 31.514−11.297 2.263 1.00 55.48 C ATOM 1822 NH1 ARG A 114 32.344 −12.304 1.9821.00 51.37 N ATOM 1825 NH2 ARG A 114 30.674 −11.331 3.277 1.00 60.58 NATOM 1828 C ARG A 114 32.209 −6.193 −1.176 1.00 42.43 C ATOM 1829 O ARGA 114 31.422 −6.405 −2.096 1.00 43.72 O ATOM 1830 N ASN A 115 31.936−5.385 −0.165 1.00 41.74 N ATOM 1832 CA ASN A 115 30.800 −4.474 −0.1831.00 42.25 C ATOM 1834 CB ASN A 115 29.944 −4.676 1.039 1.00 43.29 CATOM 1837 CG ASN A 115 29.106 −5.845 0.914 1.00 44.56 C ATOM 1838 OD1ASN A 115 28.419 −6.041 −0.040 1.00 47.36 O ATOM 1839 ND2 ASN A 11529.181 −6.668 1.865 1.00 52.65 N ATOM 1842 C ASN A 115 31.177 −3.013−0.329 1.00 40.39 C ATOM 1843 O ASN A 115 30.332 −2.226 −0.638 1.0041.23 O ATOM 1844 N LEU A 116 32.440 −2.683 −0.159 1.00 38.95 N ATOM1846 CA LEU A 116 32.917 −1.357 −0.384 1.00 39.18 C ATOM 1848 CB LEU A116 34.415 −1.245 −0.029 1.00 37.99 C ATOM 1851 CG LEU A 116 34.9610.166 −0.304 1.00 38.33 C ATOM 1853 CD1 LEU A 116 34.239 1.149 0.5631.00 39.42 C ATOM 1857 CD2 LEU A 116 36.421 0.263 −0.035 1.00 38.20 CATOM 1861 C LEU A 116 32.611 −0.853 −1.839 1.00 40.77 C ATOM 1862 O LEUA 116 33.220 −1.240 −2.811 1.00 41.13 O ATOM 1863 N GLN A 117 31.6410.020 −1.950 1.00 41.94 N ATOM 1865 CA GLN A 117 31.185 0.433 −3.2281.00 44.45 C ATOM 1867 CB GLN A 117 29.790 −0.099 −3.459 1.00 46.41 CATOM 1870 CG GLN A 117 29.915 −1.437 −4.132 1.00 50.06 C ATOM 1873 CDGLN A 117 28.659 −2.188 −4.162 1.00 54.73 C ATOM 1874 OE1 GLN A 11727.898 −2.178 −3.185 1.00 56.09 O ATOM 1875 NE2 GLN A 117 28.436 −2.883−5.252 1.00 56.36 N ATOM 1878 C GLN A 117 31.319 1.908 −3.539 1.00 44.91C ATOM 1879 O GLN A 117 31.561 2.178 −4.686 1.00 47.48 O ATOM 1880 N GLUA 118 31.246 2.824 −2.567 1.00 43.90 N ATOM 1882 CA GLU A 118 31.6304.203 −2.827 1.00 44.87 C ATOM 1884 CB GLU A 118 30.338 5.058 −3.0071.00 48.13 C ATOM 1887 CG GLU A 118 30.326 6.583 −3.040 1.00 50.77 CATOM 1890 CD GLU A 118 30.632 7.244 −4.365 1.00 56.86 C ATOM 1891 OE1GLU A 118 31.202 6.589 −5.234 1.00 65.98 O ATOM 1892 OE2 GLU A 11830.462 8.468 −4.540 1.00 58.62 O ATOM 1893 C GLU A 118 32.606 4.742−1.785 1.00 42.40 C ATOM 1894 O GLU A 118 32.534 4.414 −0.641 1.00 40.40O ATOM 1895 N ILE A 119 33.550 5.555 −2.272 1.00 42.58 N ATOM 1897 CAILE A 119 34.382 6.462 −1.481 1.00 41.49 C ATOM 1899 CB ILE A 119 35.8846.155 −1.688 1.00 40.87 C ATOM 1901 CG1 ILE A 119 36.283 4.839 −1.0431.00 40.15 C ATOM 1904 CD1 ILE A 119 37.837 4.504 −1.293 1.00 40.31 CATOM 1908 CG2 ILE A 119 36.808 7.251 −1.096 1.00 40.44 C ATOM 1912 C ILEA 119 34.012 7.873 −1.961 1.00 41.94 C ATOM 1913 O ILE A 119 34.4418.325 −3.039 1.00 44.53 O ATOM 1914 N LEU A 120 33.182 8.572 −1.200 1.0042.54 N ATOM 1916 CA LEU A 120 32.619 9.831 −1.705 1.00 46.08 C ATOM1918 CB LEU A 120 31.798 10.529 −0.657 1.00 47.62 C ATOM 1921 CG LEU A120 30.428 10.004 −0.329 1.00 50.88 C ATOM 1923 CD1 LEU A 120 29.76311.116 0.529 1.00 54.37 C ATOM 1927 CD2 LEU A 120 29.652 9.701 −1.6101.00 50.49 C ATOM 1931 C LEU A 120 33.658 10.830 −2.141 1.00 46.27 CATOM 1932 O LEU A 120 33.462 11.522 −3.112 1.00 48.50 O ATOM 1933 N HISA 121 34.737 10.906 −1.361 1.00 45.34 N ATOM 1935 CA HIS A 121 35.89111.734 −1.632 1.00 45.38 C ATOM 1937 CB HIS A 121 35.889 12.961 −0.7961.00 47.60 C ATOM 1940 CG HIS A 121 34.582 13.616 −0.646 1.00 47.72 CATOM 1941 ND1 HIS A 121 34.347 14.891 −1.097 1.00 49.72 N ATOM 1943 CE1HIS A 121 33.129 15.251 −0.758 1.00 50.90 C ATOM 1945 NE2 HIS A 12132.577 14.277 −0.081 1.00 49.78 N ATOM 1947 CD2 HIS A 121 33.480 13.2480.038 1.00 47.09 C ATOM 1949 C HIS A 121 37.208 11.131 −1.263 1.00 44.24C ATOM 1950 O HIS A 121 37.331 10.470 −0.247 1.00 43.40 O ATOM 1951 NGLY A 122 38.215 11.496 −2.036 1.00 46.45 N ATOM 1953 CA GLY A 12239.568 11.184 −1.687 1.00 46.38 C ATOM 1956 C GLY A 122 40.066 10.056−2.530 1.00 46.66 C ATOM 1957 O GLY A 122 39.309 9.308 −3.132 1.00 44.50O ATOM 1958 N ALA A 123 41.369 9.924 −2.491 1.00 47.30 N ATOM 1960 CAALA A 123 42.029 8.889 −3.172 1.00 47.38 C ATOM 1962 CB ALA A 123 43.2739.481 −3.863 1.00 49.98 C ATOM 1966 C ALA A 123 42.350 7.675 −2.244 1.0044.62 C ATOM 1967 O ALA A 123 41.818 7.512 −1.158 1.00 43.85 O ATOM 1968N VAL A 124 43.114 6.733 −2.791 1.00 45.41 N ATOM 1970 CA VAL A 12443.423 5.507 −2.138 1.00 43.66 C ATOM 1972 CB VAL A 124 42.721 4.412−2.827 1.00 42.78 C ATOM 1974 CG1 VAL A 124 43.053 3.093 −2.159 1.0044.72 C ATOM 1978 CG2 VAL A 124 41.231 4.593 −2.655 1.00 42.04 C ATOM1982 C VAL A 124 44.902 5.256 −2.142 1.00 44.48 C ATOM 1983 O VAL A 12445.611 5.612 −3.083 1.00 46.68 O ATOM 1984 N ARG A 125 45.391 4.622−1.099 1.00 43.14 N ATOM 1986 CA ARG A 125 46.761 4.216 −1.137 1.0044.94 C ATOM 1988 CB ARG A 125 47.589 5.115 −0.277 1.00 47.27 C ATOM1991 CG ARG A 125 49.029 4.742 −0.264 1.00 51.74 C ATOM 1994 CD ARG A125 49.897 5.906 0.139 1.00 57.79 C ATOM 1997 NE ARG A 125 51.268 5.694−0.336 1.00 64.37 N ATOM 1999 CZ ARG A 125 52.378 5.749 0.419 1.00 67.82C ATOM 2000 NH1 ARG A 125 52.312 6.066 1.746 1.00 67.17 N ATOM 2003 NH2ARG A 125 53.565 5.492 −0.178 1.00 68.87 N ATOM 2006 C ARG A 125 46.9362.808 −0.655 1.00 43.08 C ATOM 2007 O ARG A 125 46.596 2.460 0.469 1.0039.00 O ATOM 2008 N PHE A 126 47.508 2.011 −1.552 1.00 44.38 N ATOM 2010CA PHE A 126 48.137 0.783 −1.167 1.00 44.03 C ATOM 2012 CB PHE A 12647.510 −0.344 −1.926 1.00 43.71 C ATOM 2015 CG PHE A 126 46.218 −0.807−1.391 1.00 40.01 C ATOM 2016 CD1 PHE A 126 45.108 −0.080 −1.549 1.0040.92 C ATOM 2018 CE1 PHE A 126 43.887 −0.550 −1.063 1.00 39.27 C ATOM2020 CZ PHE A 126 43.775 −1.763 −0.456 1.00 38.94 C ATOM 2022 CE2 PHE A126 44.833 −2.509 −0.371 1.00 42.57 C ATOM 2024 CD2 PHE A 126 46.088−2.034 −0.854 1.00 42.75 C ATOM 2026 C PHE A 126 49.648 0.852 −1.4651.00 46.82 C ATOM 2027 O PHE A 126 50.036 1.090 −2.614 1.00 47.64 O ATOM2028 N SER A 127 50.476 0.631 −0.423 1.00 47.70 N ATOM 2030 CA SER A 12751.910 0.385 −0.566 1.00 51.19 C ATOM 2032 CB SER A 127 52.649 1.696−0.466 1.00 54.02 C ATOM 2035 OG SER A 127 53.034 1.883 0.885 1.00 57.27O ATOM 2037 C SER A 127 52.481 −0.594 0.485 1.00 51.56 C ATOM 2038 O SERA 127 52.047 −0.628 1.604 1.00 49.36 O ATOM 2039 N ASN A 128 53.468−1.391 0.078 1.00 54.77 N ATOM 2041 CA ASN A 128 54.264 −2.229 0.9681.00 56.21 C ATOM 2043 CB ASN A 128 55.137 −1.373 1.877 1.00 58.23 CATOM 2046 CG ASN A 128 56.046 −0.407 1.097 1.00 62.17 C ATOM 2047 OD1ASN A 128 57.182 −0.758 0.790 1.00 66.14 O ATOM 2048 ND2 ASN A 12855.556 0.817 0.799 1.00 58.01 N ATOM 2051 C ASN A 128 53.402 −3.2281.755 1.00 54.35 C ATOM 2052 O ASN A 128 53.461 −3.340 2.990 1.00 53.42O ATOM 2053 N ASN A 129 52.624 −3.990 0.999 1.00 53.03 N ATOM 2055 CAASN A 129 51.809 −5.034 1.562 1.00 51.72 C ATOM 2057 CB ASN A 129 50.355−4.712 1.281 1.00 48.91 C ATOM 2060 CG ASN A 129 49.950 −3.386 1.8771.00 48.71 C ATOM 2061 OD1 ASN A 129 49.956 −3.219 3.097 1.00 46.84 OATOM 2062 ND2 ASN A 129 49.620 −2.425 1.021 1.00 49.70 N ATOM 2065 C ASNA 129 52.142 −6.394 0.988 1.00 53.27 C ATOM 2066 O ASN A 129 51.301−6.990 0.376 1.00 52.88 O ATOM 2067 N PRO A 130 53.322 −6.931 1.248 1.0055.86 N ATOM 2068 CA PRO A 130 53.849 −8.030 0.441 1.00 58.30 C ATOM2070 CB PRO A 130 55.334 −8.067 0.806 1.00 61.57 C ATOM 2073 CG PRO A130 55.422 −7.439 2.170 1.00 61.58 C ATOM 2076 CD PRO A 130 54.194−6.614 2.386 1.00 57.72 C ATOM 2079 C PRO A 130 53.194 −9.378 0.718 1.0058.29 C ATOM 2080 O PRO A 130 53.617 −10.382 0.197 1.00 60.97 O ATOM2081 N ALA A 131 52.151 −9.438 1.513 1.00 55.73 N ATOM 2083 CA ALA A 13151.452 −10.692 1.621 1.00 54.80 C ATOM 2085 CB ALA A 131 51.407 −11.0733.006 1.00 54.50 C ATOM 2089 C ALA A 131 50.056 −10.559 1.046 1.00 52.04C ATOM 2090 O ALA A 131 49.305 −11.499 1.010 1.00 52.22 O ATOM 2091 NLEU A 132 49.731 −9.399 0.527 1.00 50.22 N ATOM 2093 CA LEU A 132 48.347−9.100 0.235 1.00 48.25 C ATOM 2095 CB LEU A 132 48.111 −7.577 0.0941.00 46.58 C ATOM 2098 CG LEU A 132 46.693 −7.049 −0.140 1.00 42.72 CATOM 2100 CD1 LEU A 132 45.792 −7.428 0.981 1.00 41.93 C ATOM 2104 CD2LEU A 132 46.701 −5.522 −0.330 1.00 41.41 C ATOM 2108 C LEU A 132 47.923−9.826 −1.003 1.00 49.53 C ATOM 2109 O LEU A 132 48.735 −10.093 −1.8831.00 51.28 O ATOM 2110 N CYS A 133 46.636 −10.148 −1.031 1.00 49.32 NATOM 2112 CA CYS A 133 46.017 −10.944 −2.085 1.00 51.07 C ATOM 2114 CBCYS A 133 45.605 −12.286 −1.533 1.00 51.93 C ATOM 2117 SG CYS A 13347.113 −13.311 −1.525 1.00 58.93 S ATOM 2118 C CYS A 133 44.814 −10.287−2.732 1.00 49.03 C ATOM 2119 O CYS A 133 44.089 −9.538 −2.070 1.0047.78 O ATOM 2120 N ASN A 134 44.660 −10.569 −4.026 1.00 48.89 N ATOM2122 CA ASN A 134 43.496 −10.312 −4.800 1.00 47.55 C ATOM 2124 CB ASN A134 42.304 −11.082 −4.237 1.00 46.96 C ATOM 2127 CG ASN A 134 42.563−12.593 −4.084 1.00 49.52 C ATOM 2128 OD1 ASN A 134 42.816 −13.265−5.038 1.00 51.07 O ATOM 2129 ND2 ASN A 134 42.457 −13.112 −2.870 1.0048.52 N ATOM 2132 C ASN A 134 43.169 −8.832 −5.039 1.00 45.92 C ATOM2133 O ASN A 134 42.597 −8.494 −6.061 1.00 45.65 O ATOM 2134 N VAL A 13543.530 −7.933 −4.135 1.00 45.56 N ATOM 2136 CA VAL A 135 42.985 −6.552−4.156 1.00 43.82 C ATOM 2138 CB VAL A 135 43.400 −5.780 −2.932 1.0042.47 C ATOM 2140 CG1 VAL A 135 43.037 −4.266 −3.017 1.00 41.77 C ATOM2144 CG2 VAL A 135 42.786 −6.384 −1.737 1.00 41.35 C ATOM 2148 C VAL A135 43.493 −5.880 −5.431 1.00 45.40 C ATOM 2149 O VAL A 135 42.723−5.205 −6.070 1.00 45.40 O ATOM 2150 N GLU A 136 44.755 −6.158 −5.7961.00 46.87 N ATOM 2152 CA GLU A 136 45.404 −5.750 −7.035 1.00 49.44 CATOM 2154 CB GLU A 136 46.677 −6.586 −7.316 1.00 52.90 C ATOM 2157 CGGLU A 136 47.654 −6.085 −8.413 1.00 57.64 C ATOM 2160 CD GLU A 13648.784 −7.097 −8.714 1.00 66.03 C ATOM 2161 OE1 GLU A 136 49.015 −7.981−7.798 1.00 68.30 O ATOM 2162 OE2 GLU A 136 49.415 −7.041 −9.837 1.0070.61 O ATOM 2163 C GLU A 136 44.526 −5.895 −8.238 1.00 50.26 C ATOM2164 O GLU A 136 44.781 −5.226 −9.234 1.00 52.27 O ATOM 2165 N SER A 13743.516 −6.745 −8.189 1.00 49.34 N ATOM 2167 CA SER A 137 42.673 −6.934−9.365 1.00 51.02 C ATOM 2169 CB SER A 137 42.120 −8.342 −9.390 1.0051.77 C ATOM 2172 OG SER A 137 41.372 −8.537 −8.213 1.00 49.79 O ATOM2174 C SER A 137 41.521 −5.953 −9.408 1.00 49.35 C ATOM 2175 O SER A 13740.737 −5.909 −10.335 1.00 50.09 O ATOM 2176 N ILE A 138 41.427 −5.128−8.420 1.00 47.68 N ATOM 2178 CA ILE A 138 40.207 −4.429 −8.272 1.0047.46 C ATOM 2180 CB ILE A 138 39.947 −4.236 −6.830 1.00 45.92 C ATOM2182 CG1 ILE A 138 39.161 −5.479 −6.402 1.00 50.04 C ATOM 2185 CD1 ILE A138 38.907 −5.482 −4.979 1.00 52.31 C ATOM 2189 CG2 ILE A 138 39.130−3.036 −6.535 1.00 44.29 C ATOM 2193 C ILE A 138 40.270 −3.168 −9.0141.00 48.13 C ATOM 2194 O ILE A 138 41.305 −2.535 −9.060 1.00 49.23 OATOM 2195 N GLN A 139 39.110 −2.834 −9.567 1.00 48.49 N ATOM 2197 CA GLNA 139 38.826 −1.708 −10.439 1.00 48.81 C ATOM 2199 CB GLN A 139 37.724−2.104 −11.446 1.00 50.08 C ATOM 2202 CG GLN A 139 38.234 −3.051 −12.5881.00 52.30 C ATOM 2205 CD GLN A 139 37.175 −3.535 −13.588 1.00 54.29 CATOM 2206 OE1 GLN A 139 36.906 −2.864 −14.560 1.00 59.63 O ATOM 2207 NE2GLN A 139 36.617 −4.708 −13.361 1.00 52.60 N ATOM 2210 C GLN A 13938.326 −0.553 −9.603 1.00 48.02 C ATOM 2211 O GLN A 139 37.130 −0.409−9.361 1.00 48.86 O ATOM 2212 N TRP A 140 39.238 0.279 −9.138 1.00 47.32N ATOM 2214 CA TRP A 140 38.876 1.416 −8.309 1.00 45.95 C ATOM 2216 CBTRP A 140 40.180 2.000 −7.785 1.00 46.14 C ATOM 2219 CG TRP A 140 40.8850.963 −6.994 1.00 46.00 C ATOM 2220 CD1 TRP A 140 41.802 0.118 −7.4511.00 49.63 C ATOM 2222 NE1 TRP A 140 42.183 −0.754 −6.450 1.00 52.24 NATOM 2224 CE2 TRP A 140 41.481 −0.469 −5.318 1.00 45.13 C ATOM 2225 CD2TRP A 140 40.644 0.601 −5.619 1.00 46.06 C ATOM 2226 CE3 TRP A 14039.843 1.122 −4.603 1.00 47.07 C ATOM 2228 CZ3 TRP A 140 39.902 0.531−3.331 1.00 46.32 C ATOM 2230 CH2 TRP A 140 40.751 −0.540 −3.099 1.0044.90 C ATOM 2232 CZ2 TRP A 140 41.559 −1.032 −4.085 1.00 44.06 C ATOM2234 C TRP A 140 37.958 2.468 −8.988 1.00 46.64 C ATOM 2235 O TRP A 14037.156 3.152 −8.417 1.00 47.16 O ATOM 2236 N ARG A 141 38.039 2.549−10.251 1.00 49.56 N ATOM 2238 CA ARG A 141 37.281 3.487 −11.006 1.0051.70 C ATOM 2240 CB ARG A 141 37.690 3.287 −12.479 1.00 54.96 C ATOM2243 CG ARG A 141 37.314 4.259 −13.453 1.00 59.89 C ATOM 2246 CD ARG A141 37.332 3.683 −14.883 1.00 68.80 C ATOM 2249 NE ARG A 141 36.9254.702 −15.900 1.00 76.88 N ATOM 2251 CZ ARG A 141 36.168 4.420 −16.9811.00 79.58 C ATOM 2252 NH1 ARG A 141 35.680 3.165 −17.156 1.00 77.54 NATOM 2255 NH2 ARG A 141 35.910 5.388 −17.889 1.00 83.87 N ATOM 2258 CARG A 141 35.805 3.315 −10.714 1.00 51.04 C ATOM 2259 O ARG A 141 35.0774.284 −10.763 1.00 52.62 O ATOM 2260 N ASP A 142 35.337 2.129 −10.3541.00 50.38 N ATOM 2262 CA ASP A 142 33.936 2.014 −9.928 1.00 50.96 CATOM 2264 CB ASP A 142 33.502 0.590 −9.927 1.00 51.24 C ATOM 2267 CG ASPA 142 32.027 0.437 −9.613 1.00 56.27 C ATOM 2268 OD1 ASP A 142 31.5900.872 −8.537 1.00 64.27 O ATOM 2269 OD2 ASP A 142 31.195 −0.113 −10.3331.00 62.04 O ATOM 2270 C ASP A 142 33.730 2.575 −8.491 1.00 48.89 C ATOM2271 O ASP A 142 32.639 3.015 −8.113 1.00 47.96 O ATOM 2272 N ILE A 14334.781 2.510 −7.685 1.00 47.20 N ATOM 2274 CA ILE A 143 34.745 2.956−6.294 1.00 44.55 C ATOM 2276 CB ILE A 143 35.712 2.142 −5.533 1.0042.17 C ATOM 2278 CG1 ILE A 143 35.086 0.768 −5.327 1.00 40.78 C ATOM2281 CD1 ILE A 143 36.133 −0.301 −5.046 1.00 40.44 C ATOM 2285 CG2 ILE A143 36.018 2.787 −4.247 1.00 41.34 C ATOM 2289 C ILE A 143 35.044 4.401−6.069 1.00 44.56 C ATOM 2290 O ILE A 143 34.327 5.095 −5.380 1.00 44.62O ATOM 2291 N VAL A 144 36.124 4.863 −6.630 1.00 45.00 N ATOM 2293 CAVAL A 144 36.509 6.218 −6.403 1.00 45.50 C ATOM 2295 CB VAL A 144 38.0286.287 −6.507 1.00 45.97 C ATOM 2297 CG1 VAL A 144 38.574 7.708 −6.4911.00 48.38 C ATOM 2301 CG2 VAL A 144 38.596 5.619 −5.328 1.00 43.75 CATOM 2305 C VAL A 144 35.797 7.249 −7.293 1.00 48.79 C ATOM 2306 O VAL A144 35.338 7.047 −8.422 1.00 49.84 O ATOM 2307 N SER A 145 35.723 8.445−6.763 1.00 51.81 N ATOM 2309 CA SER A 145 35.288 9.568 −7.616 1.0054.78 C ATOM 2311 CB SER A 145 34.926 10.760 −6.750 1.00 54.47 C ATOM2314 OG SER A 145 34.427 11.741 −7.626 1.00 59.24 O ATOM 2316 C SER A145 36.287 9.966 −8.735 1.00 56.23 C ATOM 2317 O SER A 145 37.469 10.176−8.515 1.00 55.05 O ATOM 2318 N SER A 146 35.814 10.152 −9.935 1.0058.67 N ATOM 2320 CA SER A 146 36.764 10.567 −10.927 1.00 61.98 C ATOM2322 CB SER A 146 36.061 10.701 −12.244 1.00 65.22 C ATOM 2325 OG SER A146 35.229 11.815 −12.148 1.00 69.73 O ATOM 2327 C SER A 146 37.58611.851 −10.591 1.00 63.73 C ATOM 2328 O SER A 146 38.718 12.001 −11.0611.00 66.06 O ATOM 2329 N ASP A 147 37.110 12.782 −9.776 1.00 63.35 NATOM 2331 CA ASP A 147 38.047 13.855 −9.448 1.00 64.51 C ATOM 2333 CBASP A 147 37.388 14.938 −8.643 1.00 65.88 C ATOM 2336 CG ASP A 14736.191 15.484 −9.315 1.00 70.56 C ATOM 2337 OD1 ASP A 147 36.324 15.944−10.449 1.00 76.86 O ATOM 2338 OD2 ASP A 147 35.062 15.475 −8.799 1.0074.60 O ATOM 2339 C ASP A 147 39.320 13.451 −8.694 1.00 61.87 C ATOM2340 O ASP A 147 40.181 14.271 −8.574 1.00 64.00 O ATOM 2341 N PHE A 14839.443 12.235 −8.160 1.00 58.00 N ATOM 2343 CA PHE A 148 40.589 11.831−7.323 1.00 55.65 C ATOM 2345 CB PHE A 148 40.100 11.392 −5.912 1.0052.67 C ATOM 2348 CG PHE A 148 39.418 12.463 −5.124 1.00 52.51 C ATOM2349 CD1 PHE A 148 38.059 12.760 −5.313 1.00 55.87 C ATOM 2351 CE1 PHE A148 37.408 13.812 −4.627 1.00 53.04 C ATOM 2353 CZ PHE A 148 38.10014.471 −3.764 1.00 53.77 C ATOM 2355 CE2 PHE A 148 39.466 14.202 −3.5531.00 50.27 C ATOM 2357 CD2 PHE A 148 40.105 13.203 −4.221 1.00 53.15 CATOM 2359 C PHE A 148 41.411 10.674 −7.958 1.00 55.84 C ATOM 2360 O PHEA 148 42.390 10.172 −7.375 1.00 54.76 O ATOM 2361 N LEU A 149 40.99210.208 −9.141 1.00 57.46 N ATOM 2363 CA LEU A 149 41.756 9.207 −9.9021.00 57.20 C ATOM 2365 CB LEU A 149 41.124 8.951 −11.285 1.00 58.59 CATOM 2368 CG LEU A 149 39.781 8.163 −11.362 1.00 57.42 C ATOM 2370 CD1LEU A 149 39.542 7.556 −12.713 1.00 59.65 C ATOM 2374 CD2 LEU A 14939.590 7.015 −10.313 1.00 54.35 C ATOM 2378 C LEU A 149 43.154 9.743−10.028 1.00 59.44 C ATOM 2379 O LEU A 149 44.122 9.110 −9.706 1.0057.88 O ATOM 2380 N SER A 150 43.237 10.997 −10.427 1.00 63.31 N ATOM2382 CA SER A 150 44.517 11.658 −10.439 1.00 65.95 C ATOM 2384 CB SER A150 44.345 13.107 −10.848 1.00 69.04 C ATOM 2387 OG SER A 150 44.46813.155 −12.260 1.00 74.02 O ATOM 2389 C SER A 150 45.359 11.553 −9.1651.00 64.15 C ATOM 2390 O SER A 150 46.550 11.630 −9.276 1.00 66.94 OATOM 2391 N ASN A 151 44.802 11.413 −7.962 1.00 60.55 N ATOM 2393 CA ASNA 151 45.676 11.373 −6.785 1.00 59.05 C ATOM 2395 CB ASN A 151 45.28012.526 −5.824 1.00 58.72 C ATOM 2398 CG ASN A 151 45.979 13.869 −6.2021.00 65.21 C ATOM 2399 OD1 ASN A 151 45.616 14.591 −7.128 1.00 66.28 OATOM 2400 ND2 ASN A 151 47.026 14.157 −5.506 1.00 72.90 N ATOM 2403 CASN A 151 45.879 9.943 −6.181 1.00 55.44 C ATOM 2404 O ASN A 151 46.4719.774 −5.128 1.00 53.43 O ATOM 2405 N MET A 152 45.499 8.901 −6.932 1.0054.65 N ATOM 2407 CA MET A 152 45.653 7.496 −6.467 1.00 52.66 C ATOM2409 CB MET A 152 44.910 6.533 −7.366 1.00 51.86 C ATOM 2412 CG MET A152 43.443 6.813 −7.552 1.00 52.03 C ATOM 2415 SD MET A 152 42.338 6.049−6.388 1.00 50.06 S ATOM 2416 CE MET A 152 42.743 4.273 −6.557 1.0048.82 C ATOM 2420 C MET A 152 47.124 7.024 −6.371 1.00 54.06 C ATOM 2421O MET A 152 47.951 7.492 −7.134 1.00 56.68 O ATOM 2422 N SER A 15347.449 6.144 −5.399 1.00 52.56 N ATOM 2424 CA SER A 153 48.828 5.589−5.246 1.00 54.12 C ATOM 2426 CB SER A 153 49.601 6.341 −4.187 1.0054.43 C ATOM 2429 OG SER A 153 50.968 6.247 −4.512 1.00 56.90 O ATOM2431 C SER A 153 48.953 4.069 −4.949 1.00 52.77 C ATOM 2432 O SER A 15349.268 3.659 −3.817 1.00 52.35 O ATOM 2433 N MET A 154 48.749 3.276−5.995 1.00 52.33 N ATOM 2435 CA MET A 154 48.550 1.862 −5.893 1.0050.75 C ATOM 2437 CB MET A 154 47.455 1.440 −6.811 1.00 49.97 C ATOM2440 CG MET A 154 46.216 2.318 −6.656 1.00 50.89 C ATOM 2443 SD MET A154 45.282 1.929 −5.148 1.00 58.01 S ATOM 2444 CE MET A 154 45.749 3.387−4.448 1.00 57.15 C ATOM 2448 C MET A 154 49.802 1.157 −6.255 1.00 52.92C ATOM 2449 O MET A 154 50.276 1.278 −7.330 1.00 54.18 O ATOM 2450 N ASPA 155 50.346 0.414 −5.315 1.00 53.59 N ATOM 2452 CA ASP A 155 51.559−0.296 −5.564 1.00 57.73 C ATOM 2454 CB ASP A 155 52.786 0.526 −5.1951.00 60.70 C ATOM 2457 CG ASP A 155 54.088 −0.300 −5.273 1.00 67.99 CATOM 2458 OD1 ASP A 155 54.469 −0.830 −6.389 1.00 70.11 O ATOM 2459 OD2ASP A 155 54.773 −0.487 −4.215 1.00 74.44 O ATOM 2460 C ASP A 155 51.489−1.670 −4.882 1.00 56.85 C ATOM 2461 O ASP A 155 51.675 −1.845 −3.6621.00 55.16 O ATOM 2462 N PHE A 156 51.232 −2.651 −5.733 1.00 57.62 NATOM 2464 CA PHE A 156 50.904 −3.965 −5.298 1.00 57.25 C ATOM 2466 CBPHE A 156 49.701 −4.410 −6.080 1.00 55.63 C ATOM 2469 CG PHE A 15648.424 −3.817 −5.645 1.00 51.82 C ATOM 2470 CD1 PHE A 156 47.824 −2.852−6.408 1.00 48.57 C ATOM 2472 CE1 PHE A 156 46.643 −2.329 −6.067 1.0048.09 C ATOM 2474 CZ PHE A 156 46.005 −2.746 −4.921 1.00 49.29 C ATOM2476 CE2 PHE A 156 46.573 −3.759 −4.128 1.00 49.85 C ATOM 2478 CD2 PHE A156 47.775 −4.298 −4.513 1.00 51.25 C ATOM 2480 C PHE A 156 52.031−4.922 −5.663 1.00 62.02 C ATOM 2481 O PHE A 156 52.258 −5.121 −6.8621.00 65.96 O ATOM 2482 N GLN A 157 52.711 −5.558 −4.693 1.00 63.64 NATOM 2484 CA GLN A 157 53.730 −6.585 −5.019 1.00 67.83 C ATOM 2486 CBGLN A 157 55.158 −6.019 −5.121 1.00 71.20 C ATOM 2489 CG GLN A 15755.232 −4.741 −5.955 1.00 74.76 C ATOM 2492 CD GLN A 157 56.512 −3.922−5.738 1.00 81.43 C ATOM 2493 OE1 GLN A 157 57.596 −4.501 −5.524 1.0084.93 O ATOM 2494 NE2 GLN A 157 56.394 −2.570 −5.832 1.00 80.80 N ATOM2497 C GLN A 157 53.694 −7.701 −3.995 1.00 67.85 C ATOM 2498 O GLN A 15754.239 −7.549 −2.884 1.00 68.89 O ATOM 2499 N ASN A 158 53.049 −8.824−4.343 1.00 67.34 N ATOM 2501 CA ASN A 158 52.985 −9.931 −3.387 1.0066.37 C ATOM 2503 CB ASN A 158 51.748 −10.825 −3.573 1.00 65.25 C ATOM2506 CG ASN A 158 51.555 −11.805 −2.408 1.00 65.80 C ATOM 2507 OD1 ASN A158 52.434 −12.615 −2.126 1.00 69.30 O ATOM 2508 ND2 ASN A 158 50.396−11.749 −1.760 1.00 62.84 N ATOM 2511 C ASN A 158 54.252 −10.683 −3.6071.00 68.88 C ATOM 2512 O ASN A 158 54.482 −11.075 −4.714 1.00 71.15 OATOM 2513 N HIS A 159 55.079 −10.768 −2.562 1.00 68.92 N ATOM 2515 CAHIS A 159 56.367 −11.474 −2.511 1.00 72.75 C ATOM 2517 CB HIS A 15957.529 −10.454 −2.416 1.00 74.34 C ATOM 2525 C HIS A 159 56.430 −12.503−1.321 1.00 73.55 C ATOM 2526 O HIS A 159 57.483 −13.106 −1.060 1.0077.25 O ATOM 2527 N LEU A 160 55.312 −12.726 −0.620 1.00 70.71 N ATOM2529 CA LEU A 160 55.300 −13.613 0.558 1.00 71.96 C ATOM 2531 CB LEU A160 54.955 −12.858 1.835 1.00 69.16 C ATOM 2534 CG LEU A 160 56.170−12.018 2.242 1.00 72.49 C ATOM 2536 CD1 LEU A 160 55.879 −11.038 3.4171.00 70.29 C ATOM 2540 CD2 LEU A 160 57.406 −12.963 2.560 1.00 78.18 CATOM 2544 C LEU A 160 54.436 −14.860 0.466 1.00 72.80 C ATOM 2545 O LEUA 160 54.715 −15.905 1.146 1.00 76.27 O ATOM 2546 N GLY A 161 53.426−14.830 −0.387 1.00 70.92 N ATOM 2548 CA GLY A 161 52.682 −16.052 −0.5881.00 71.53 C ATOM 2551 C GLY A 161 52.337 −16.324 −2.010 1.00 72.10 CATOM 2552 O GLY A 161 52.925 −15.725 −2.936 1.00 73.91 O ATOM 2553 N SERA 162 51.354 −17.218 −2.151 1.00 71.50 N ATOM 2555 CA SER A 162 50.850−17.612 −3.430 1.00 71.80 C ATOM 2557 CB SER A 162 51.072 −19.072 −3.6311.00 75.27 C ATOM 2560 OG SER A 162 49.976 −19.671 −3.029 1.00 75.08 OATOM 2562 C SER A 162 49.382 −17.287 −3.697 1.00 68.40 C ATOM 2563 O SERA 162 49.076 −17.118 −4.826 1.00 71.58 O ATOM 2564 N CYS A 163 48.443−17.195 −2.785 1.00 64.77 N ATOM 2566 CA CYS A 163 47.190 −16.558 −3.2481.00 62.32 C ATOM 2568 CB CYS A 163 47.482 −15.350 −4.121 1.00 60.54 CATOM 2571 SG CYS A 163 48.195 −14.039 −3.164 1.00 65.07 S ATOM 2572 CCYS A 163 46.203 −17.327 −4.092 1.00 62.09 C ATOM 2573 O CYS A 16346.486 −17.842 −5.125 1.00 64.63 O ATOM 2574 N GLN A 164 44.966 −17.252−3.712 1.00 59.87 N ATOM 2576 CA GLN A 164 43.963 −17.875 −4.490 1.0059.87 C ATOM 2578 CB GLN A 164 42.775 −18.151 −3.577 1.00 58.78 C ATOM2581 CG GLN A 164 43.135 −19.114 −2.394 1.00 60.45 C ATOM 2584 CD GLN A164 42.289 −18.848 −1.173 1.00 58.32 C ATOM 2585 OE1 GLN A 164 41.246−19.446 −1.065 1.00 62.19 O ATOM 2586 NE2 GLN A 164 42.706 −17.902−0.272 1.00 60.77 N ATOM 2589 C GLN A 164 43.615 −17.003 −5.717 1.0058.68 C ATOM 2590 O GLN A 164 44.054 −15.875 −5.910 1.00 55.31 O ATOM2591 N LYS A 165 42.840 −17.597 −6.587 1.00 60.41 N ATOM 2593 CA LYS A165 42.374 −16.938 −7.780 1.00 59.80 C ATOM 2595 CB LYS A 165 42.587−17.888 −8.966 1.00 63.00 C ATOM 2598 CG LYS A 165 44.023 −18.081 −9.3471.00 64.02 C ATOM 2601 CD LYS A 165 44.046 −18.676 −10.685 1.00 70.24 CATOM 2604 CE LYS A 165 45.354 −19.359 −10.979 1.00 75.93 C ATOM 2607 NZLYS A 165 45.322 −20.005 −12.321 1.00 78.93 N ATOM 2611 C LYS A 16540.898 −16.505 −7.632 1.00 57.91 C ATOM 2612 O LYS A 165 40.082 −17.115−6.894 1.00 57.15 O ATOM 2613 N CYS A 166 40.574 −15.429 −8.331 1.0056.63 N ATOM 2615 CA CYS A 166 39.229 −14.949 −8.421 1.00 56.14 C ATOM2617 CB CYS A 166 39.265 −13.725 −9.280 1.00 56.07 C ATOM 2620 SG CYS A166 39.966 −12.314 −8.384 1.00 60.17 S ATOM 2621 C CYS A 166 38.278−15.928 −9.059 1.00 58.20 C ATOM 2622 O CYS A 166 38.612 −16.593 −9.9931.00 60.87 O ATOM 2623 N ASP A 167 37.054 −15.995 −8.604 1.00 58.01 NATOM 2625 CA ASP A 167 36.071 −16.803 −9.313 1.00 62.21 C ATOM 2627 CBASP A 167 34.731 −16.757 −8.577 1.00 61.75 C ATOM 2630 CG ASP A 16733.981 −18.042 −8.691 1.00 67.21 C ATOM 2631 OD1 ASP A 167 33.252−18.146 −9.682 1.00 71.66 O ATOM 2632 OD2 ASP A 167 34.098 −19.030−7.887 1.00 71.36 O ATOM 2633 C ASP A 167 35.907 −16.370 −10.772 1.0064.34 C ATOM 2634 O ASP A 167 35.932 −15.189 −11.077 1.00 64.04 O ATOM2635 N PRO A 168 35.733 −17.276 −11.712 1.00 69.18 N ATOM 2636 CA PRO A168 35.529 −16.843 −13.117 1.00 71.67 C ATOM 2638 CB PRO A 168 35.482−18.135 −13.880 1.00 75.31 C ATOM 2641 CG PRO A 168 34.937 −19.094−12.867 1.00 75.75 C ATOM 2644 CD PRO A 168 35.648 −18.736 −11.577 1.0072.39 C ATOM 2647 C PRO A 168 34.190 −16.113 −13.277 1.00 72.13 C ATOM2648 O PRO A 168 33.980 −15.434 −14.273 1.00 74.17 O ATOM 2649 N SER A169 33.333 −16.243 −12.263 1.00 70.78 N ATOM 2651 CA SER A 169 32.029−15.649 −12.196 1.00 70.36 C ATOM 2653 CB SER A 169 31.448 −16.185−10.906 1.00 69.09 C ATOM 2656 OG SER A 169 30.162 −15.740 −10.627 1.0069.59 O ATOM 2658 C SER A 169 32.176 −14.099 −12.189 1.00 68.96 C ATOM2659 O SER A 169 31.369 −13.354 −12.767 1.00 69.80 O ATOM 2660 N CYS A170 33.235 −13.645 −11.522 1.00 66.34 N ATOM 2662 CA CYS A 170 33.585−12.257 −11.389 1.00 64.17 C ATOM 2664 CB CYS A 170 35.009 −12.194−10.803 1.00 62.64 C ATOM 2667 SG CYS A 170 35.099 −12.706 −9.064 1.0065.28 S ATOM 2668 C CYS A 170 33.626 −11.532 −12.691 1.00 64.97 C ATOM2669 O CYS A 170 34.036 −12.154 −13.644 1.00 67.60 O ATOM 2670 N PRO A171 33.293 −10.224 −12.709 1.00 63.33 N ATOM 2671 CA PRO A 171 33.587−9.309 −13.840 1.00 63.95 C ATOM 2673 CB PRO A 171 32.709 −8.083 −13.5451.00 62.43 C ATOM 2676 CG PRO A 171 32.618 −8.081 −12.137 1.00 60.40 CATOM 2679 CD PRO A 171 32.609 −9.504 −11.624 1.00 60.72 C ATOM 2682 CPRO A 171 35.056 −8.844 −13.952 1.00 62.28 C ATOM 2683 O PRO A 17135.613 −8.339 −12.977 1.00 58.36 O ATOM 2684 N ASN A 172 35.651 −9.053−15.137 1.00 64.60 N ATOM 2686 CA ASN A 172 37.014 −8.626 −15.469 1.0064.03 C ATOM 2688 CB ASN A 172 37.092 −7.107 −15.494 1.00 63.31 C ATOM2691 CG ASN A 172 36.067 −6.493 −16.417 1.00 64.86 C ATOM 2692 OD1 ASN A172 36.063 −6.769 −17.588 1.00 68.52 O ATOM 2693 ND2 ASN A 172 35.183−5.689 −15.884 1.00 63.98 N ATOM 2696 C ASN A 172 38.072 −9.188 −14.5251.00 62.11 C ATOM 2697 O ASN A 172 39.141 −8.611 −14.391 1.00 60.44 OATOM 2698 N GLY A 173 37.760 −10.330 −13.891 1.00 61.90 N ATOM 2700 CAGLY A 173 38.676 −11.067 −13.029 1.00 60.44 C ATOM 2703 C GLY A 17338.962 −10.365 −11.733 1.00 56.68 C ATOM 2704 O GLY A 173 39.958 −10.665−11.056 1.00 54.88 O ATOM 2705 N SER A 174 38.081 −9.436 −11.392 1.0054.92 N ATOM 2707 CA SER A 174 38.350 −8.556 −10.289 1.00 53.27 C ATOM2709 CB SER A 174 38.094 −7.084 −10.657 1.00 54.14 C ATOM 2712 OG SER A174 37.408 −6.922 −11.890 1.00 61.12 O ATOM 2714 C SER A 174 37.560−8.949 −9.069 1.00 51.33 C ATOM 2715 O SER A 174 36.354 −9.118 −9.1281.00 51.96 O ATOM 2716 N CYS A 175 38.277 −9.140 −7.965 1.00 50.14 NATOM 2718 CA CYS A 175 37.716 −9.660 −6.724 1.00 49.06 C ATOM 2720 CBCYS A 175 37.668 −11.161 −6.785 1.00 51.08 C ATOM 2723 SG CYS A 17539.237 −11.989 −6.497 1.00 54.98 S ATOM 2724 C CYS A 175 38.552 −9.228−5.541 1.00 46.28 C ATOM 2725 O CYS A 175 39.663 −8.727 −5.713 1.0045.60 O ATOM 2726 N TRP A 176 38.009 −9.415 −4.342 1.00 44.79 N ATOM2728 CA TRP A 176 38.693 −9.052 −3.078 1.00 42.74 C ATOM 2730 CB TRP A176 37.714 −8.389 −2.131 1.00 40.96 C ATOM 2733 CG TRP A 176 37.119−7.038 −2.642 1.00 40.42 C ATOM 2734 CD1 TRP A 176 35.982 −6.870 −3.3261.00 39.92 C ATOM 2736 NE1 TRP A 176 35.755 −5.544 −3.560 1.00 41.12 NATOM 2738 CE2 TRP A 176 36.782 −4.827 −3.009 1.00 41.59 C ATOM 2739 CD2TRP A 176 37.639 −5.735 −2.393 1.00 38.66 C ATOM 2740 CE3 TRP A 17638.790 −5.256 −1.764 1.00 39.18 C ATOM 2742 CZ3 TRP A 176 39.040 −3.931−1.766 1.00 36.89 C ATOM 2744 CH2 TRP A 176 38.161 −3.054 −2.364 1.0040.57 C ATOM 2746 CZ2 TRP A 176 37.023 −3.483 −3.010 1.00 40.72 C ATOM2748 C TRP A 176 39.264 −10.290 −2.369 1.00 43.56 C ATOM 2749 O TRP A176 39.952 −10.188 −1.370 1.00 42.95 O ATOM 2750 N GLY A 177 38.981−11.465 −2.907 1.00 45.37 N ATOM 2752 CA GLY A 177 39.457 −12.658 −2.3121.00 45.99 C ATOM 2755 C GLY A 177 38.797 −13.810 −2.985 1.00 49.26 CATOM 2756 O GLY A 177 38.184 −13.706 −4.041 1.00 50.81 O ATOM 2757 N ALAA 178 38.914 −14.939 −2.328 1.00 50.26 N ATOM 2759 CA ALA A 178 38.527−16.179 −2.908 1.00 53.28 C ATOM 2761 CB ALA A 178 39.129 −17.222 −2.1291.00 55.32 C ATOM 2765 C ALA A 178 37.029 −16.275 −2.878 1.00 53.36 CATOM 2766 O ALA A 178 36.440 −15.593 −2.110 1.00 50.54 O ATOM 2767 N GLYA 179 36.414 −17.067 −3.747 1.00 55.92 N ATOM 2769 CA GLY A 179 34.974−17.248 −3.736 1.00 57.34 C ATOM 2772 C GLY A 179 34.100 −16.268 −4.4951.00 56.65 C ATOM 2773 O GLY A 179 34.480 −15.136 −4.759 1.00 53.03 OATOM 2774 N GLU A 180 32.925 −16.772 −4.873 1.00 59.51 N ATOM 2776 CAGLU A 180 31.983 −16.075 −5.712 1.00 60.69 C ATOM 2778 CB GLU A 18030.822 −16.977 −6.100 1.00 64.23 C ATOM 2781 CG GLU A 180 30.038 −16.423−7.273 1.00 69.05 C ATOM 2784 CD GLU A 180 28.984 −17.373 −7.882 1.0079.34 C ATOM 2785 OE1 GLU A 180 27.807 −16.913 −7.924 1.00 83.24 O ATOM2786 OE2 GLU A 180 29.287 −18.553 −8.346 1.00 85.62 O ATOM 2787 C GLU A180 31.425 −14.874 −4.965 1.00 58.20 C ATOM 2788 O GLU A 180 31.056−13.872 −5.585 1.00 55.67 O ATOM 2789 N GLU A 181 31.338 −15.008 −3.6391.00 57.72 N ATOM 2791 CA GLU A 181 30.851 −13.919 −2.784 1.00 56.13 CATOM 2793 CB GLU A 181 30.543 −14.432 −1.393 1.00 56.53 C ATOM 2796 CGGLU A 181 31.761 −14.311 −0.500 1.00 56.15 C ATOM 2799 CD GLU A 18131.764 −15.221 0.695 1.00 58.93 C ATOM 2800 OE1 GLU A 181 30.689 −15.7990.952 1.00 63.12 O ATOM 2801 OE2 GLU A 181 32.849 −15.341 1.348 1.0058.06 O ATOM 2802 C GLU A 181 31.802 −12.698 −2.640 1.00 52.53 C ATOM2803 O GLU A 181 31.385 −11.655 −2.106 1.00 51.74 O ATOM 2804 N ASN A182 33.061 −12.845 −3.073 1.00 51.13 N ATOM 2806 CA ASN A 182 34.102−11.813 −2.936 1.00 47.84 C ATOM 2808 CB ASN A 182 35.396 −12.431 −2.3921.00 46.56 C ATOM 2811 CG ASN A 182 35.351 −12.667 −0.891 1.00 46.60 CATOM 2812 OD1 ASN A 182 34.761 −11.922 −0.093 1.00 45.34 O ATOM 2813 ND2ASN A 182 36.004 −13.707 −0.499 1.00 47.84 N ATOM 2816 C ASN A 18234.383 −11.183 −4.272 1.00 47.77 C ATOM 2817 O ASN A 182 35.383 −10.470−4.441 1.00 45.91 O ATOM 2818 N CYS A 183 33.503 −11.480 −5.236 1.0050.13 N ATOM 2820 CA CYS A 183 33.545 −10.849 −6.567 1.00 51.09 C ATOM2822 CB CYS A 183 32.578 −11.504 −7.579 1.00 53.48 C ATOM 2825 SG CYS A183 33.164 −13.146 −8.334 1.00 63.64 S ATOM 2826 C CYS A 183 33.204−9.376 −6.289 1.00 48.00 C ATOM 2827 O CYS A 183 32.345 −9.091 −5.4541.00 45.84 O ATOM 2828 N GLN A 184 33.937 −8.507 −6.987 1.00 46.92 NATOM 2830 CA GLN A 184 33.621 −7.097 −7.082 1.00 47.29 C ATOM 2832 CBGLN A 184 34.702 −6.286 −7.837 1.00 45.60 C ATOM 2835 CG GLN A 18434.313 −4.821 −8.086 1.00 46.53 C ATOM 2838 CD GLN A 184 35.490 −3.732−8.235 1.00 45.39 C ATOM 2839 OE1 GLN A 184 36.557 −3.993 −8.815 1.0043.19 O ATOM 2840 NE2 GLN A 184 35.226 −2.509 −7.721 1.00 41.52 N ATOM2843 C GLN A 184 32.209 −6.922 −7.643 1.00 49.85 C ATOM 2844 O GLN A 18431.887 −7.418 −8.732 1.00 53.03 O ATOM 2845 N LYS A 185 31.342 −6.271−6.868 1.00 49.27 N ATOM 2847 CA LYS A 185 30.086 −5.798 −7.441 1.0051.63 C ATOM 2849 CB LYS A 185 29.023 −5.620 −6.343 1.00 52.06 C ATOM2852 CG LYS A 185 28.517 −6.901 −5.629 1.00 53.93 C ATOM 2855 CD LYS A185 28.156 −6.583 −4.065 1.00 53.03 C ATOM 2858 CE LYS A 185 28.695−7.612 −3.059 1.00 49.07 C ATOM 2861 NZ LYS A 185 27.572 −8.323 −2.5401.00 54.03 N ATOM 2865 C LYS A 185 30.318 −4.457 −8.218 1.00 50.18 CATOM 2866 O LYS A 185 30.983 −3.581 −7.726 1.00 49.13 O ATOM 2867 N LEUA 186 29.780 −4.279 −9.412 1.00 52.33 N ATOM 2869 CA LEU A 186 29.967−3.001 −10.114 1.00 52.28 C ATOM 2871 CB LEU A 186 30.613 −3.131 −11.4931.00 53.18 C ATOM 2874 CG LEU A 186 32.019 −3.758 −11.492 1.00 52.36 CATOM 2876 CD1 LEU A 186 32.537 −4.107 −12.914 1.00 54.00 C ATOM 2880 CD2LEU A 186 33.021 −2.930 −10.768 1.00 48.37 C ATOM 2884 C LEU A 18628.654 −2.280 −10.199 1.00 54.66 C ATOM 2885 O LEU A 186 27.611 −2.903−10.407 1.00 56.57 O ATOM 2886 N THR A 187 28.725 −0.964 −9.972 1.0054.57 N ATOM 2888 CA THR A 187 27.587 −0.095 −10.035 1.00 57.60 C ATOM2890 CB THR A 187 27.054 0.099 −8.609 1.00 56.84 C ATOM 2892 OG1 THR A187 28.131 0.506 −7.763 1.00 56.81 O ATOM 2894 CG2 THR A 187 26.549−1.189 −7.960 1.00 55.84 C ATOM 2898 C THR A 187 27.833 1.310 −10.6621.00 59.12 C ATOM 2899 O THR A 187 26.885 2.106 −10.684 1.00 60.17 OATOM 2900 N LYS A 188 29.051 1.629 −11.153 1.00 59.07 N ATOM 2902 CA LYSA 188 29.350 2.969 −11.776 1.00 60.11 C ATOM 2904 CB LYS A 188 30.4303.762 −10.957 1.00 57.60 C ATOM 2907 CG LYS A 188 30.704 5.336 −11.2081.00 53.08 C ATOM 2910 CD LYS A 188 31.704 6.033 −10.139 1.00 50.46 CATOM 2913 CE LYS A 188 32.508 7.420 −10.695 1.00 62.36 C ATOM 2916 NZLYS A 188 32.092 9.158 −10.925 1.00 56.57 N ATOM 2920 C LYS A 188 29.7712.735 −13.239 1.00 63.34 C ATOM 2921 O LYS A 188 29.111 3.149 −14.1571.00 66.50 O ATOM 2922 N ILE A 189 30.843 1.998 −13.440 1.00 63.68 NATOM 2924 CA ILE A 189 31.424 1.690 −14.765 1.00 67.03 C ATOM 2926 CBILE A 189 32.738 0.990 −14.377 1.00 65.88 C ATOM 2928 CG1 ILE A 18933.814 2.078 −14.376 1.00 68.15 C ATOM 2931 CD1 ILE A 189 34.948 1.628−13.491 1.00 70.37 C ATOM 2935 CG2 ILE A 189 33.099 −0.237 −15.182 1.0066.88 C ATOM 2939 C ILE A 189 30.607 0.832 −15.788 1.00 70.02 C ATOM2940 O ILE A 189 30.992 0.629 −16.920 1.00 72.11 O ATOM 2941 N ILE A 19029.476 0.336 −15.338 1.00 70.44 N ATOM 2943 CA ILE A 190 28.701 −0.687−15.994 1.00 72.98 C ATOM 2945 CB ILE A 190 28.515 −1.794 −14.937 1.0070.63 C ATOM 2947 CG1 ILE A 190 29.637 −2.783 −15.140 1.00 71.22 C ATOM2950 CD1 ILE A 190 29.307 −4.255 −14.645 1.00 76.22 C ATOM 2954 CG2 ILEA 190 27.125 −2.377 −14.917 1.00 71.99 C ATOM 2958 C ILE A 190 27.366−0.090 −16.413 1.00 76.24 C ATOM 2959 O ILE A 190 26.564 −0.726 −17.1191.00 79.79 O ATOM 2960 N CYS A 191 27.136 1.143 −15.996 1.00 75.30 NATOM 2962 CA CYS A 191 25.844 1.785 −16.157 1.00 78.23 C ATOM 2964 CBCYS A 191 25.752 2.923 −15.123 1.00 76.32 C ATOM 2967 SG CYS A 19126.102 2.238 −13.446 1.00 74.45 S ATOM 2968 C CYS A 191 25.605 2.255−17.601 1.00 81.91 C ATOM 2969 O CYS A 191 26.543 2.581 −18.338 1.0082.17 O ATOM 2970 N ALA A 192 24.346 2.227 −18.012 1.00 84.89 N ATOM2972 CA ALA A 192 23.966 2.868 −19.251 1.00 89.58 C ATOM 2974 CB ALA A192 22.450 2.842 −19.400 1.00 93.30 C ATOM 2978 C ALA A 192 24.506 4.339−19.275 1.00 89.64 C ATOM 2979 O ALA A 192 24.639 4.980 −18.201 1.0085.53 O ATOM 2980 N GLN A 193 24.836 4.846 −20.484 1.00 93.10 N ATOM2982 CA GLN A 193 25.353 6.215 −20.616 1.00 94.09 C ATOM 2984 CB GLN A193 25.538 6.634 −22.098 1.00 99.22 C ATOM 2987 CG GLN A 193 26.1638.062 −22.297 1.00 99.92 C ATOM 2990 CD GLN A 193 25.933 8.638 −23.6921.00 108.02 C ATOM 2991 OE1 GLN A 193 25.886 7.901 −24.675 1.00 115.13 OATOM 2992 NE2 GLN A 193 25.800 9.955 −23.788 1.00 112.64 N ATOM 2995 CGLN A 193 24.388 7.177 −19.901 1.00 94.51 C ATOM 2996 O GLN A 193 24.8278.100 −19.208 1.00 92.51 O ATOM 2997 N GLN A 194 23.086 6.891 −20.0501.00 97.35 N ATOM 2999 CA GLN A 194 21.973 7.735 −19.591 1.00 99.21 CATOM 3001 CB GLN A 194 20.667 7.116 −20.142 1.00 103.46 C ATOM 3008 CGLN A 194 21.839 8.015 −18.057 1.00 95.71 C ATOM 3009 O GLN A 194 21.0138.809 −17.645 1.00 97.16 O ATOM 3010 N CYS A 195 22.633 7.364 −17.2161.00 91.62 N ATOM 3012 CA CYS A 195 22.490 7.526 −15.791 1.00 88.83 CATOM 3014 CB CYS A 195 22.917 6.292 −15.017 1.00 85.27 C ATOM 3017 SGCYS A 195 21.902 4.815 −15.196 1.00 90.56 S ATOM 3018 C CYS A 195 23.4128.598 −15.346 1.00 86.94 C ATOM 3019 O CYS A 195 24.607 8.599 −15.6801.00 85.07 O ATOM 3020 N SER A 196 22.858 9.456 −14.507 1.00 87.22 NATOM 3022 CA SER A 196 23.627 10.438 −13.814 1.00 85.77 C ATOM 3024 CBSER A 196 22.648 11.354 −13.047 1.00 87.93 C ATOM 3027 OG SER A 19622.540 11.018 −11.651 1.00 86.76 O ATOM 3029 C SER A 196 24.677 9.843−12.839 1.00 81.16 C ATOM 3030 O SER A 196 25.573 10.557 −12.395 1.0081.13 O ATOM 3031 N GLY A 197 24.538 8.580 −12.438 1.00 78.73 N ATOM3033 CA GLY A 197 25.334 8.000 −11.342 1.00 73.56 C ATOM 3036 C GLY A197 24.830 6.601 −11.007 1.00 72.09 C ATOM 3037 O GLY A 197 23.864 6.111−11.623 1.00 75.94 O ATOM 3038 N ARG A 198 25.480 5.936 −10.068 1.0067.34 N ATOM 3040 CA ARG A 198 25.152 4.530 −9.712 1.00 65.41 C ATOM3042 CB ARG A 198 24.991 4.402 −8.192 1.00 63.68 C ATOM 3045 CG ARG A198 26.212 4.737 −7.348 1.00 57.45 C ATOM 3048 CD ARG A 198 27.428 4.201−7.931 1.00 54.35 C ATOM 3051 NE ARG A 198 28.605 4.632 −7.227 1.0049.75 N ATOM 3053 CZ ARG A 198 29.670 3.892 −7.060 1.00 48.00 C ATOM3054 NH1 ARG A 198 29.696 2.647 −7.498 1.00 51.64 N ATOM 3057 NH2 ARG A198 30.717 4.384 −6.450 1.00 45.20 N ATOM 3060 C ARG A 198 23.916 3.831−10.309 1.00 67.96 C ATOM 3061 O ARG A 198 22.865 4.429 −10.482 1.0069.74 O ATOM 3062 N CYS A 199 24.066 2.517 −10.533 1.00 68.17 N ATOM3064 CA CYS A 199 22.980 1.584 −11.035 1.00 70.76 C ATOM 3066 CB CYS A199 23.028 1.453 −12.552 1.00 73.17 C ATOM 3069 SG CYS A 199 24.6200.814 −13.123 1.00 70.86 S ATOM 3070 C CYS A 199 23.083 0.184 −10.3851.00 68.65 C ATOM 3071 O CYS A 199 23.915 −0.044 −9.450 1.00 65.70 OATOM 3072 N ARG A 200 22.214 −0.730 −10.837 1.00 70.83 N ATOM 3074 CAARG A 200 22.179 −2.148 −10.359 1.00 69.39 C ATOM 3076 CB ARG A 20021.098 −2.232 −9.299 1.00 70.45 C ATOM 3079 CG ARG A 200 19.798 −1.633−9.740 1.00 73.74 C ATOM 3082 CD ARG A 200 18.746 −1.838 −8.754 1.0076.36 C ATOM 3085 NE ARG A 200 17.429 −1.744 −9.348 1.00 82.84 N ATOM3087 CZ ARG A 200 16.411 −2.522 −9.015 1.00 86.81 C ATOM 3088 NH1 ARG A200 16.540 −3.467 −8.083 1.00 85.55 N ATOM 3091 NH2 ARG A 200 15.245−2.346 −9.616 1.00 92.94 N ATOM 3094 C ARG A 200 21.932 −3.214 −11.4671.00 71.45 C ATOM 3095 O ARG A 200 21.777 −4.416 −11.236 1.00 71.97 OATOM 3096 N GLY A 201 21.869 −2.714 −12.673 1.00 73.31 N ATOM 3098 CAGLY A 201 21.586 −3.476 −13.847 1.00 77.37 C ATOM 3101 C GLY A 20122.227 −2.705 −14.954 1.00 78.01 C ATOM 3102 O GLY A 201 22.616 −1.565−14.732 1.00 76.98 O ATOM 3103 N LYS A 202 22.386 −3.322 −16.117 1.0080.54 N ATOM 3105 CA LYS A 202 23.135 −2.699 −17.185 1.00 81.72 C ATOM3107 CB LYS A 202 23.959 −3.720 −18.012 1.00 81.81 C ATOM 3114 C LYS A202 22.129 −1.884 −17.999 1.00 86.87 C ATOM 3115 O LYS A 202 22.526−1.153 −18.906 1.00 88.82 O ATOM 3116 N SER A 203 20.842 −1.953 −17.6131.00 89.89 N ATOM 3118 CA SER A 203 19.704 −1.280 −18.316 1.00 94.97 CATOM 3120 CB SER A 203 18.414 −2.065 −18.031 1.00 98.06 C ATOM 3123 OGSER A 203 18.209 −2.178 −16.619 1.00 96.46 O ATOM 3125 C SER A 20319.442 0.215 −17.938 1.00 94.60 C ATOM 3126 O SER A 203 19.990 0.716−16.921 1.00 89.96 O ATOM 3127 N PRO A 204 18.628 0.908 −18.767 1.0099.08 N ATOM 3128 CA PRO A 204 18.061 2.235 −18.420 1.00 99.90 C ATOM3130 CB PRO A 204 17.375 2.695 −19.710 1.00 105.95 C ATOM 3133 CG PRO A204 17.293 1.497 −20.624 1.00 108.00 C ATOM 3136 CD PRO A 204 18.2770.493 −20.142 1.00 103.68 C ATOM 3139 C PRO A 204 17.048 2.246 −17.2731.00 100.16 C ATOM 3140 O PRO A 204 17.060 3.133 −16.434 1.00 98.31 OATOM 3141 N SER A 205 16.173 1.267 −17.206 1.00 102.97 N ATOM 3143 CASER A 205 15.376 1.118 −15.992 1.00 103.18 C ATOM 3145 CB SER A 20514.395 −0.004 −16.148 1.00 107.04 C ATOM 3148 OG SER A 205 15.123 −1.122−16.565 1.00 106.57 O ATOM 3150 C SER A 205 16.237 0.823 −14.770 1.0097.64 C ATOM 3151 O SER A 205 15.875 1.164 −13.651 1.00 97.84 O ATOM3152 N ASP A 206 17.401 0.227 −14.948 1.00 94.14 N ATOM 3154 CA ASP A206 18.244 −0.075 −13.781 1.00 88.73 C ATOM 3156 CB ASP A 206 19.266−1.183 −14.155 1.00 86.17 C ATOM 3162 C ASP A 206 18.926 1.144 −13.0991.00 84.68 C ATOM 3163 O ASP A 206 19.810 0.969 −12.300 1.00 80.94 OATOM 3164 N CYS A 207 18.545 2.373 −13.378 1.00 86.84 N ATOM 3166 CA CYSA 207 19.279 3.512 −12.786 1.00 84.84 C ATOM 3168 CB CYS A 207 19.0064.782 −13.567 1.00 88.15 C ATOM 3171 SG CYS A 207 19.830 4.949 −15.1771.00 93.16 S ATOM 3172 C CYS A 207 18.945 3.809 −11.311 1.00 82.80 CATOM 3173 O CYS A 207 17.821 3.524 −10.885 1.00 85.48 O ATOM 3174 N CYSA 208 19.915 4.385 −10.561 1.00 78.90 N ATOM 3176 CA CYS A 208 19.7494.786 −9.117 1.00 76.99 C ATOM 3178 CB CYS A 208 20.959 4.473 −8.2001.00 71.82 C ATOM 3181 SG CYS A 208 21.335 2.712 −7.852 1.00 71.46 SATOM 3182 C CYS A 208 19.496 6.275 −9.006 1.00 77.75 C ATOM 3183 O CYS A208 20.107 7.074 −9.710 1.00 76.69 O ATOM 3184 N HIS A 209 18.607 6.637−8.092 1.00 79.28 N ATOM 3186 CA HIS A 209 18.280 8.040 −7.879 1.0081.28 C ATOM 3188 CB HIS A 209 17.372 8.223 −6.680 1.00 82.57 C ATOM3191 CG HIS A 209 16.907 9.628 −6.497 1.00 86.38 C ATOM 3192 ND1 HIS A209 15.853 10.170 −7.198 1.00 94.24 N ATOM 3194 CE1 HIS A 209 15.65511.421 −6.809 1.00 96.56 C ATOM 3196 NE2 HIS A 209 16.568 11.718 −5.9021.00 91.93 N ATOM 3198 CD2 HIS A 209 17.357 10.610 −5.691 1.00 86.90 CATOM 3200 C HIS A 209 19.551 8.845 −7.694 1.00 78.10 C ATOM 3201 O HIS A209 20.510 8.343 −7.144 1.00 73.89 O ATOM 3202 N ASN A 210 19.543 10.089−8.168 1.00 80.56 N ATOM 3204 CA ASN A 210 20.717 10.936 −8.164 1.0078.95 C ATOM 3206 CB ASN A 210 20.251 12.335 −8.576 1.00 83.73 C ATOM3209 CG ASN A 210 21.408 13.355 −8.850 1.00 85.95 C ATOM 3210 OD1 ASN A210 22.542 13.249 −8.323 1.00 81.95 O ATOM 3211 ND2 ASN A 210 21.06514.416 −9.643 1.00 92.19 N ATOM 3214 C ASN A 210 21.360 10.886 −6.7581.00 75.18 C ATOM 3215 O ASN A 210 22.583 10.777 −6.639 1.00 72.10 OATOM 3216 N GLN A 211 20.516 10.873 −5.716 1.00 75.07 N ATOM 3218 CA GLNA 211 20.930 10.869 −4.335 1.00 71.75 C ATOM 3220 CB GLN A 211 19.72811.029 −3.403 1.00 73.99 C ATOM 3223 CG GLN A 211 18.918 12.325 −3.5751.00 77.34 C ATOM 3226 CD GLN A 211 19.620 13.572 −3.094 1.00 73.73 CATOM 3227 OE1 GLN A 211 20.318 13.552 −2.113 1.00 70.44 O ATOM 3228 NE2GLN A 211 19.431 14.657 −3.802 1.00 77.44 N ATOM 3231 C GLN A 211 21.6909.671 −3.809 1.00 68.89 C ATOM 3232 O GLN A 211 22.103 9.730 −2.654 1.0068.37 O ATOM 3233 N CYS A 212 21.895 8.585 −4.561 1.00 68.32 N ATOM 3235CA CYS A 212 22.445 7.341 −3.952 1.00 65.45 C ATOM 3237 CB CYS A 21221.877 6.071 −4.588 1.00 66.69 C ATOM 3240 SG CYS A 212 20.095 5.933−4.285 1.00 74.19 S ATOM 3241 C CYS A 212 23.942 7.262 −3.984 1.00 61.86C ATOM 3242 O CYS A 212 24.613 7.907 −4.833 1.00 61.22 O ATOM 3243 N ALAA 213 24.468 6.458 −3.056 1.00 59.19 N ATOM 3245 CA ALA A 213 25.8776.519 −2.765 1.00 56.34 C ATOM 3247 CB ALA A 213 26.105 6.720 −1.3921.00 55.01 C ATOM 3251 C ALA A 213 26.611 5.295 −3.245 1.00 54.74 C ATOM3252 O ALA A 213 27.718 5.456 −3.821 1.00 54.91 O ATOM 3253 N ALA A 21426.052 4.111 −3.043 1.00 54.09 N ATOM 3255 CA ALA A 214 26.786 2.893−3.436 1.00 52.51 C ATOM 3257 CB ALA A 214 26.982 2.055 −2.300 1.0050.79 C ATOM 3261 C ALA A 214 26.086 2.088 −4.486 1.00 55.33 C ATOM 3262O ALA A 214 26.726 1.278 −5.148 1.00 55.72 O ATOM 3263 N GLY A 21524.783 2.329 −4.653 1.00 58.27 N ATOM 3265 CA GLY A 215 23.914 1.484−5.445 1.00 60.72 C ATOM 3268 C GLY A 215 22.512 1.447 −4.858 1.00 63.18C ATOM 3269 O GLY A 215 22.195 2.220 −3.951 1.00 62.63 O ATOM 3270 N CYSA 216 21.657 0.574 −5.394 1.00 65.69 N ATOM 3272 CA CYS A 216 20.2580.586 −4.964 1.00 69.24 C ATOM 3274 CB CYS A 216 19.535 1.716 −5.6501.00 72.29 C ATOM 3277 SG CYS A 216 19.657 1.623 −7.430 1.00 74.13 SATOM 3278 C CYS A 216 19.447 −0.665 −5.227 1.00 71.77 C ATOM 3279 O CYSA 216 19.886 −1.583 −5.916 1.00 71.93 O ATOM 3280 N THR A 217 18.233−0.626 −4.696 1.00 73.98 N ATOM 3282 CA THR A 217 17.304 −1.724 −4.6651.00 76.58 C ATOM 3284 CB THR A 217 16.933 −1.861 −3.231 1.00 76.60 CATOM 3286 OG1 THR A 217 18.073 −2.376 −2.558 1.00 71.61 O ATOM 3288 CG2THR A 217 15.797 −2.863 −2.987 1.00 81.96 C ATOM 3292 C THR A 217 16.089−1.360 −5.465 1.00 81.10 C ATOM 3293 O THR A 217 15.039 −1.958 −5.3101.00 84.07 O ATOM 3294 N GLY A 218 16.232 −0.341 −6.305 1.00 81.30 NATOM 3296 CA GLY A 218 15.083 0.262 −6.937 1.00 86.06 C ATOM 3299 C GLYA 218 15.298 1.697 −7.356 1.00 85.69 C ATOM 3300 O GLY A 218 16.3232.320 −7.062 1.00 81.26 O ATOM 3301 N PRO A 219 14.270 2.229 −8.003 1.0090.50 N ATOM 3302 CA PRO A 219 14.353 3.496 −8.749 1.00 91.95 C ATOM3304 CB PRO A 219 12.956 3.600 −9.384 1.00 98.27 C ATOM 3307 CG PRO A219 12.042 2.762 −8.489 1.00 99.76 C ATOM 3310 CD PRO A 219 12.909 1.656−8.018 1.00 95.47 C ATOM 3313 C PRO A 219 14.624 4.769 −7.946 1.00 90.33C ATOM 3314 O PRO A 219 15.405 5.591 −8.349 1.00 88.23 O ATOM 3315 N ARGA 220 13.981 4.904 −6.810 1.00 91.91 N ATOM 3317 CA ARG A 220 13.7386.217 −6.233 1.00 93.99 C ATOM 3319 CB ARG A 220 12.218 6.360 −5.9041.00 100.22 C ATOM 3322 CG ARG A 220 11.634 5.167 −5.100 1.00 102.19 CATOM 3325 CD ARG A 220 10.103 5.144 −4.836 1.00 109.43 C ATOM 3328 NEARG A 220 9.740 3.785 −4.386 1.00 111.00 N ATOM 3330 CZ ARG A 220 8.5053.358 −4.091 1.00 115.28 C ATOM 3331 NH1 ARG A 220 7.446 4.179 −4.1771.00 118.66 N ATOM 3334 NH2 ARG A 220 8.347 2.087 −3.696 1.00 114.53 NATOM 3337 C ARG A 220 14.631 6.612 −5.014 1.00 89.71 C ATOM 3338 O ARG A220 15.450 5.829 −4.543 1.00 86.23 O ATOM 3339 N GLU A 221 14.468 7.873−4.587 1.00 90.79 N ATOM 3341 CA GLU A 221 14.998 8.469 −3.350 1.0088.14 C ATOM 3343 CB GLU A 221 14.054 9.612 −2.885 1.00 92.21 C ATOM3346 CG GLU A 221 13.975 10.853 −3.765 1.00 95.00 C ATOM 3349 CD GLU A221 12.697 10.962 −4.627 1.00 103.69 C ATOM 3350 OE1 GLU A 221 12.3209.931 −5.267 1.00 106.17 O ATOM 3351 OE2 GLU A 221 12.071 12.079 −4.7021.00 106.53 O ATOM 3352 C GLU A 221 15.116 7.478 −2.181 1.00 86.16 CATOM 3353 O GLU A 221 16.103 7.484 −1.457 1.00 82.16 O ATOM 3354 N SER A222 14.086 6.661 −1.965 1.00 89.43 N ATOM 3356 CA SER A 222 14.027 5.806−0.769 1.00 88.57 C ATOM 3358 CB SER A 222 12.580 5.683 −0.281 1.0093.94 C ATOM 3361 OG SER A 222 11.809 4.919 −1.194 1.00 96.86 O ATOM3363 C SER A 222 14.640 4.395 −0.949 1.00 85.65 C ATOM 3364 O SER A 22214.676 3.619 0.016 1.00 85.41 O ATOM 3365 N ASP A 223 15.135 4.061−2.150 1.00 83.69 N ATOM 3367 CA ASP A 223 15.657 2.711 −2.417 1.0080.96 C ATOM 3369 CB ASP A 223 15.185 2.195 −3.776 1.00 83.33 C ATOM3372 CG ASP A 223 13.703 2.299 −3.944 1.00 89.14 C ATOM 3373 OD1 ASP A223 12.981 1.875 −3.024 1.00 91.08 O ATOM 3374 OD2 ASP A 223 13.1652.800 −4.951 1.00 92.92 O ATOM 3375 C ASP A 223 17.171 2.672 −2.346 1.0075.27 C ATOM 3376 O ASP A 223 17.825 1.737 −2.855 1.00 73.21 O ATOM 3377N CYS A 224 17.746 3.656 −1.683 1.00 72.71 N ATOM 3379 CA CYS A 22419.181 3.736 −1.655 1.00 67.99 C ATOM 3381 CB CYS A 224 19.598 5.080−1.135 1.00 67.67 C ATOM 3384 SG CYS A 224 19.506 6.395 −2.344 1.0070.46 S ATOM 3385 C CYS A 224 19.754 2.694 −0.764 1.00 64.94 C ATOM 3386O CYS A 224 19.110 2.246 0.162 1.00 65.66 O ATOM 3387 N LEU A 225 20.9792.321 −1.078 1.00 61.70 N ATOM 3389 CA LEU A 225 21.782 1.447 −0.2451.00 59.61 C ATOM 3391 CB LEU A 225 22.986 0.868 −1.023 1.00 56.35 CATOM 3394 CG LEU A 225 22.685 −0.402 −1.891 1.00 56.31 C ATOM 3396 CD1LEU A 225 23.880 −0.866 −2.679 1.00 51.61 C ATOM 3400 CD2 LEU A 22522.126 −1.570 −1.021 1.00 56.37 C ATOM 3404 C LEU A 225 22.260 2.2960.878 1.00 59.46 C ATOM 3405 O LEU A 225 22.097 1.964 2.032 1.00 60.50 OATOM 3406 N VAL A 226 22.876 3.410 0.501 1.00 59.46 N ATOM 3408 CA VAL A226 23.450 4.366 1.417 1.00 58.35 C ATOM 3410 CB VAL A 226 25.010 4.1971.616 1.00 54.93 C ATOM 3412 CG1 VAL A 226 25.384 4.755 2.905 1.00 57.11C ATOM 3416 CG2 VAL A 226 25.449 2.804 1.665 1.00 54.18 C ATOM 3420 CVAL A 226 23.165 5.729 0.779 1.00 59.60 C ATOM 3421 O VAL A 226 22.9585.810 −0.407 1.00 60.42 O ATOM 3422 N CYS A 227 23.138 6.793 1.574 1.0060.27 N ATOM 3424 CA CYS A 227 22.873 8.110 1.052 1.00 62.07 C ATOM 3426CB CYS A 227 22.091 8.926 2.031 1.00 64.54 C ATOM 3429 SG CYS A 22720.427 8.315 2.115 1.00 71.77 S ATOM 3430 C CYS A 227 24.164 8.781 0.8911.00 59.58 C ATOM 3431 O CYS A 227 25.088 8.519 1.662 1.00 57.51 O ATOM3432 N ARG A 228 24.235 9.677 −0.087 1.00 60.72 N ATOM 3434 CA ARG A 22825.465 10.401 −0.289 1.00 58.88 C ATOM 3436 CB ARG A 228 25.938 10.420−1.728 1.00 58.79 C ATOM 3439 CG ARG A 228 25.066 10.857 −2.770 1.0060.60 C ATOM 3442 CD ARG A 228 25.870 11.291 −4.034 1.00 60.85 C ATOM3445 NE ARG A 228 25.464 12.688 −4.273 1.00 66.58 N ATOM 3447 CZ ARG A228 25.007 13.147 −5.391 1.00 68.99 C ATOM 3448 NH1 ARG A 228 24.95012.391 −6.479 1.00 73.85 N ATOM 3451 NH2 ARG A 228 24.612 14.369 −5.4381.00 73.63 N ATOM 3454 C ARG A 228 25.487 11.753 0.315 1.00 60.04 C ATOM3455 O ARG A 228 26.542 12.340 0.407 1.00 59.64 O ATOM 3456 N LYS A 22924.352 12.222 0.791 1.00 62.48 N ATOM 3458 CA LYS A 229 24.353 13.4421.549 1.00 63.66 C ATOM 3460 CB LYS A 229 23.648 14.573 0.792 1.00 67.05C ATOM 3463 CG LYS A 229 24.518 15.066 −0.385 1.00 67.47 C ATOM 3466 CDLYS A 229 23.831 16.061 −1.381 1.00 73.70 C ATOM 3469 CE LYS A 22924.848 16.474 −2.543 1.00 75.33 C ATOM 3472 NZ LYS A 229 24.415 17.315−3.811 1.00 79.07 N ATOM 3476 C LYS A 229 23.794 13.092 2.898 1.00 63.63C ATOM 3477 O LYS A 229 24.536 12.696 3.782 1.00 61.98 O ATOM 3478 N PHEA 230 22.501 13.163 3.054 1.00 66.52 N ATOM 3480 CA PHE A 230 21.90612.856 4.332 1.00 68.08 C ATOM 3482 CB PHE A 230 21.322 14.129 4.9061.00 71.57 C ATOM 3485 CG PHE A 230 22.344 15.070 5.540 1.00 72.46 CATOM 3486 CD1 PHE A 230 22.787 16.209 4.888 1.00 74.10 C ATOM 3488 CE1PHE A 230 23.692 17.117 5.502 1.00 74.49 C ATOM 3490 CZ PHE A 230 24.14616.887 6.773 1.00 74.16 C ATOM 3492 CE2 PHE A 230 23.716 15.748 7.4431.00 73.51 C ATOM 3494 CD2 PHE A 230 22.800 14.859 6.831 1.00 74.05 CATOM 3496 C PHE A 230 20.816 11.770 4.136 1.00 69.44 C ATOM 3497 O PHE A230 20.160 11.708 3.069 1.00 71.17 O ATOM 3498 N ARG A 231 20.676 10.8915.130 1.00 68.61 N ATOM 3500 CA ARG A 231 19.584 9.915 5.195 1.00 70.29C ATOM 3502 CB ARG A 231 20.074 8.526 5.708 1.00 67.41 C ATOM 3511 C ARGA 231 18.552 10.519 6.134 1.00 74.06 C ATOM 3512 O ARG A 231 18.92211.069 7.149 1.00 73.47 O ATOM 3513 N ASP A 232 17.274 10.431 5.798 1.0078.37 N ATOM 3515 CA ASP A 232 16.234 10.971 6.662 1.00 84.33 C ATOM3517 CB ASP A 232 15.144 11.728 5.891 1.00 88.64 C ATOM 3520 CG ASP A232 14.232 12.510 6.806 1.00 92.77 C ATOM 3521 OD1 ASP A 232 14.28512.270 8.018 1.00 92.46 O ATOM 3522 OD2 ASP A 232 13.441 13.392 6.4171.00 96.60 O ATOM 3523 C ASP A 232 15.612 9.869 7.492 1.00 87.11 C ATOM3524 O ASP A 232 15.962 9.695 8.668 1.00 88.04 O ATOM 3525 N GLU A 23314.665 9.150 6.910 1.00 89.56 N ATOM 3527 CA GLU A 233 13.976 8.1177.627 1.00 91.75 C ATOM 3529 CB GLU A 233 12.599 8.613 8.111 1.00 97.99C ATOM 3532 CG GLU A 233 12.519 8.786 9.622 1.00 100.66 C ATOM 3535 CDGLU A 233 11.380 9.704 10.061 1.00 109.45 C ATOM 3536 OE1 GLU A 23310.502 9.995 9.208 1.00 113.90 O ATOM 3537 OE2 GLU A 233 11.348 10.14411.258 1.00 112.63 O ATOM 3538 C GLU A 233 13.901 7.127 6.539 1.00 90.22C ATOM 3539 O GLU A 233 12.882 6.953 5.916 1.00 94.09 O ATOM 3540 N ALAA 234 15.026 6.560 6.197 1.00 85.19 N ATOM 3542 CA ALA A 234 15.0255.743 4.982 1.00 84.82 C ATOM 3544 CB ALA A 234 13.817 4.741 5.027 1.0088.93 C ATOM 3548 C ALA A 234 15.060 6.514 3.595 1.00 84.64 C ATOM 3549O ALA A 234 15.340 5.900 2.543 1.00 83.37 O ATOM 3550 N THR A 235 14.7907.827 3.601 1.00 85.96 N ATOM 3552 CA THR A 235 14.869 8.675 2.402 1.0085.56 C ATOM 3554 CB THR A 235 13.751 9.674 2.489 1.00 90.41 C ATOM 3556OG1 THR A 235 12.551 8.977 2.820 1.00 94.00 O ATOM 3558 CG2 THR A 23513.455 10.298 1.155 1.00 91.65 C ATOM 3562 C THR A 235 16.208 9.4132.264 1.00 81.37 C ATOM 3563 O THR A 235 16.840 9.680 3.237 1.00 80.40 OATOM 3564 N CYS A 236 16.631 9.764 1.059 1.00 80.26 N ATOM 3566 CA CYS A236 17.911 10.456 0.845 1.00 76.60 C ATOM 3568 CB CYS A 236 18.705 9.695−0.191 1.00 73.69 C ATOM 3571 SG CYS A 236 19.452 8.145 0.356 1.00 71.68S ATOM 3572 C CYS A 236 17.771 11.919 0.358 1.00 78.31 C ATOM 3573 O CYSA 236 17.255 12.169 −0.717 1.00 80.49 O ATOM 3574 N LYS A 237 18.29512.873 1.114 1.00 77.15 N ATOM 3576 CA LYS A 237 18.017 14.294 0.8791.00 79.48 C ATOM 3578 CB LYS A 237 17.178 14.842 2.038 1.00 82.43 CATOM 3581 CG LYS A 237 16.038 13.951 2.407 1.00 84.83 C ATOM 3584 CD LYSA 237 15.070 14.580 3.357 1.00 90.16 C ATOM 3587 CE LYS A 237 13.74613.819 3.358 1.00 94.88 C ATOM 3590 NZ LYS A 237 12.689 14.539 4.1031.00 102.61 N ATOM 3594 C LYS A 237 19.292 15.106 0.759 1.00 76.46 CATOM 3595 O LYS A 237 20.312 14.741 1.276 1.00 72.36 O ATOM 3596 N ASP A238 19.216 16.234 0.079 1.00 78.98 N ATOM 3598 CA ASP A 238 20.32117.193 0.047 1.00 77.64 C ATOM 3600 CB ASP A 238 19.975 18.348 −0.8951.00 81.85 C ATOM 3603 CG ASP A 238 19.772 17.891 −2.338 1.00 82.50 CATOM 3604 OD1 ASP A 238 20.406 16.888 −2.690 1.00 80.05 O ATOM 3605 OD2ASP A 238 19.015 18.454 −3.170 1.00 84.38 O ATOM 3606 C ASP A 238 20.64117.763 1.424 1.00 76.62 C ATOM 3607 O ASP A 238 21.770 18.114 1.707 1.0073.74 O ATOM 3608 N THR A 239 19.645 17.833 2.290 1.00 79.33 N ATOM 3610CA THR A 239 19.820 18.465 3.586 1.00 80.08 C ATOM 3612 CB THR A 23919.799 20.008 3.363 1.00 84.18 C ATOM 3614 OG1 THR A 239 20.373 20.6854.484 1.00 83.41 O ATOM 3616 CG2 THR A 239 18.371 20.544 3.222 1.0088.96 C ATOM 3620 C THR A 239 18.769 18.064 4.591 1.00 82.04 C ATOM 3621O THR A 239 17.690 17.627 4.250 1.00 84.18 O ATOM 3622 N CYS A 24019.076 18.261 5.847 1.00 82.76 N ATOM 3624 CA CYS A 240 18.073 18.0466.850 1.00 87.41 C ATOM 3626 CB CYS A 240 18.686 17.977 8.227 1.00 85.89C ATOM 3629 SG CYS A 240 19.820 16.589 8.264 1.00 84.87 S ATOM 3630 CCYS A 240 17.039 19.132 6.784 1.00 93.59 C ATOM 3631 O CYS A 240 17.35620.313 6.683 1.00 95.73 O ATOM 3632 N PRO A 241 15.780 18.740 6.812 1.0055.04 N ATOM 3633 CA PRO A 241 14.682 19.707 6.985 1.00 56.88 C ATOM3635 CB PRO A 241 13.431 18.836 7.235 1.00 58.19 C ATOM 3638 CG PRO A241 13.919 17.393 7.321 1.00 57.06 C ATOM 3641 CD PRO A 241 15.28117.357 6.687 1.00 54.91 C ATOM 3644 C PRO A 241 14.936 20.540 8.198 1.0057.83 C ATOM 3645 O PRO A 241 15.201 20.028 9.281 1.00 57.58 O ATOM 3646N PRO A 242 14.852 21.827 8.038 1.00 58.40 N ATOM 3647 CA PRO A 24215.392 22.690 9.071 1.00 59.18 C ATOM 3649 CB PRO A 242 15.812 23.9298.325 1.00 59.59 C ATOM 3652 CG PRO A 242 15.087 23.771 6.931 1.00 60.42C ATOM 3655 CD PRO A 242 14.198 22.555 6.961 1.00 58.64 C ATOM 3658 CPRO A 242 14.349 22.986 10.097 1.00 60.49 C ATOM 3659 O PRO A 242 13.16922.609 9.956 1.00 58.83 O ATOM 3660 N LEU A 243 14.859 23.681 11.1131.00 61.42 N ATOM 3662 CA LEU A 243 14.198 23.925 12.387 1.00 63.21 CATOM 3664 CB LEU A 243 15.253 24.301 13.402 1.00 63.51 C ATOM 3667 CGLEU A 243 16.030 23.016 13.747 1.00 64.54 C ATOM 3669 CD1 LEU A 24317.404 23.380 14.430 1.00 64.32 C ATOM 3673 CD2 LEU A 243 15.119 21.98914.577 1.00 64.65 C ATOM 3677 C LEU A 243 13.212 25.037 12.331 1.0064.28 C ATOM 3678 O LEU A 243 12.271 25.089 13.119 1.00 65.42 O ATOM3679 N MET A 244 13.425 25.919 11.372 1.00 63.70 N ATOM 3681 CA MET A244 12.606 27.066 11.251 1.00 65.18 C ATOM 3683 CB MET A 244 13.31228.151 11.980 1.00 65.81 C ATOM 3686 CG MET A 244 13.551 27.784 13.4121.00 66.25 C ATOM 3689 SD MET A 244 13.078 29.142 14.347 1.00 72.32 SATOM 3690 CE MET A 244 11.731 28.403 15.295 1.00 73.17 C ATOM 3694 C META 244 12.399 27.474 9.833 1.00 65.08 C ATOM 3695 O MET A 244 13.31227.447 9.054 1.00 63.58 O ATOM 3696 N LEU A 245 11.177 27.876 9.529 1.0067.08 N ATOM 3698 CA LEU A 245 10.803 28.355 8.241 1.00 67.76 C ATOM3700 CB LEU A 245 9.739 27.435 7.703 1.00 68.55 C ATOM 3703 CG LEU A 24510.253 26.021 7.432 1.00 67.01 C ATOM 3705 CD1 LEU A 245 9.067 25.1107.212 1.00 68.07 C ATOM 3709 CD2 LEU A 245 11.186 25.963 6.238 1.0065.23 C ATOM 3713 C LEU A 245 10.185 29.719 8.344 1.00 70.42 C ATOM 3714O LEU A 245 9.435 29.957 9.281 1.00 71.97 O ATOM 3715 N TYR A 246 10.45730.590 7.355 1.00 70.54 N ATOM 3717 CA TYR A 246 9.619 31.746 7.100 1.0072.93 C ATOM 3719 CB TYR A 246 10.028 32.498 5.833 1.00 72.99 C ATOM3722 CG TYR A 246 9.424 33.903 5.785 1.00 76.04 C ATOM 3723 CD1 TYR A246 10.123 34.980 6.284 1.00 76.12 C ATOM 3725 CE1 TYR A 246 9.59536.220 6.294 1.00 78.89 C ATOM 3727 CZ TYR A 246 8.358 36.417 5.810 1.0080.72 C ATOM 3728 OH TYR A 246 7.871 37.715 5.849 1.00 84.16 O ATOM 3730CE2 TYR A 246 7.616 35.344 5.325 1.00 79.96 C ATOM 3732 CD2 TYR A 2468.134 34.126 5.310 1.00 76.25 C ATOM 3734 C TYR A 246 8.167 31.318 6.9501.00 75.65 C ATOM 3735 O TYR A 246 7.842 30.513 6.113 1.00 75.18 O ATOM3736 N ASN A 247 7.289 31.893 7.749 1.00 79.06 N ATOM 3738 CA ASN A 2475.865 31.606 7.710 1.00 81.97 C ATOM 3740 CB ASN A 247 5.369 31.4859.144 1.00 83.33 C ATOM 3743 CG ASN A 247 4.117 30.711 9.248 1.00 86.35C ATOM 3744 OD1 ASN A 247 3.048 31.184 8.805 1.00 90.91 O ATOM 3745 ND2ASN A 247 4.212 29.494 9.824 1.00 83.97 N ATOM 3748 C ASN A 247 5.15232.746 7.008 1.00 84.93 C ATOM 3749 O ASN A 247 5.206 33.878 7.458 1.0085.90 O ATOM 3750 N PRO A 248 4.500 32.451 5.903 1.00 86.39 N ATOM 3751CA PRO A 248 3.782 33.478 5.096 1.00 90.09 C ATOM 3753 CB PRO A 2483.144 32.675 3.968 1.00 90.03 C ATOM 3756 CG PRO A 248 3.918 31.3163.957 1.00 86.36 C ATOM 3759 CD PRO A 248 4.423 31.092 5.346 1.00 84.43C ATOM 3762 C PRO A 248 2.673 34.251 5.837 1.00 94.90 C ATOM 3763 O PROA 248 2.511 35.494 5.688 1.00 96.88 O ATOM 3764 N THR A 249 1.905 33.4916.619 1.00 96.37 N ATOM 3766 CA THR A 249 0.842 34.054 7.446 1.00 101.00C ATOM 3768 CB THR A 249 −0.184 32.930 7.919 1.00 102.23 C ATOM 3770 OG1THR A 249 −1.321 32.895 7.044 1.00 104.68 O ATOM 3772 CG2 THR A 249−0.848 33.250 9.282 1.00 105.46 C ATOM 3776 C THR A 249 1.457 34.8428.633 1.00 100.86 C ATOM 3777 O THR A 249 1.021 35.972 8.921 1.00 104.58O ATOM 3778 N THR A 250 2.463 34.262 9.304 1.00 96.81 N ATOM 3780 CA THRA 250 3.064 34.893 10.490 1.00 95.38 C ATOM 3782 CB THR A 250 3.97333.896 11.305 1.00 91.35 C ATOM 3784 OG1 THR A 250 3.395 32.584 11.4011.00 90.19 O ATOM 3786 CG2 THR A 250 4.032 34.315 12.723 1.00 91.91 CATOM 3790 C THR A 250 3.893 36.124 10.108 1.00 94.90 C ATOM 3791 O THR A250 4.075 37.028 10.936 1.00 96.04 O ATOM 3792 N TYR A 251 4.380 36.1568.861 1.00 93.34 N ATOM 3794 CA TYR A 251 5.414 37.103 8.412 1.00 92.01C ATOM 3796 CB TYR A 251 4.905 38.559 8.423 1.00 95.71 C ATOM 3799 CGTYR A 251 3.736 38.867 7.485 1.00 100.54 C ATOM 3800 CD1 TYR A 251 2.41538.810 7.927 1.00 103.41 C ATOM 3802 CE1 TYR A 251 1.387 39.090 7.0791.00 106.88 C ATOM 3804 CZ TYR A 251 1.655 39.462 5.781 1.00 106.57 CATOM 3805 OH TYR A 251 0.633 39.762 4.918 1.00 110.34 O ATOM 3807 CE2TYR A 251 2.937 39.552 5.333 1.00 102.86 C ATOM 3809 CD2 TYR A 251 3.96239.262 6.165 1.00 100.61 C ATOM 3811 C TYR A 251 6.699 36.995 9.259 1.0088.23 C ATOM 3812 O TYR A 251 7.362 37.985 9.536 1.00 88.44 O ATOM 3813N GLN A 252 7.059 35.806 9.697 1.00 84.91 N ATOM 3815 CA GLN A 252 8.32535.701 10.397 1.00 81.92 C ATOM 3817 CB GLN A 252 8.134 36.158 11.8401.00 82.92 C ATOM 3820 CG GLN A 252 7.289 35.204 12.679 1.00 84.45 CATOM 3823 CD GLN A 252 6.830 35.822 13.980 1.00 88.01 C ATOM 3824 OE1GLN A 252 7.570 36.606 14.587 1.00 89.53 O ATOM 3825 NE2 GLN A 252 5.60335.504 14.406 1.00 89.99 N ATOM 3828 C GLN A 252 8.961 34.304 10.3271.00 78.33 C ATOM 3829 O GLN A 252 8.474 33.408 9.676 1.00 76.85 O ATOM3830 N MET A 253 10.095 34.153 10.987 1.00 76.53 N ATOM 3832 CA MET A253 10.666 32.843 11.258 1.00 74.03 C ATOM 3834 CB MET A 253 12.13732.999 11.601 1.00 71.87 C ATOM 3837 CG MET A 253 12.931 33.489 10.4351.00 71.14 C ATOM 3840 SD MET A 253 12.878 32.239 9.059 1.00 75.45 SATOM 3841 CE MET A 253 12.407 33.204 7.938 1.00 75.10 C ATOM 3845 C META 253 9.874 32.178 12.387 1.00 75.06 C ATOM 3846 O MET A 253 9.69732.729 13.464 1.00 76.02 O ATOM 3847 N ASP A 254 9.369 30.994 12.0981.00 75.32 N ATOM 3849 CA ASP A 254 8.560 30.212 13.023 1.00 76.65 CATOM 3851 CB ASP A 254 7.086 30.304 12.587 1.00 79.52 C ATOM 3854 CG ASPA 254 6.174 30.884 13.663 1.00 82.89 C ATOM 3855 OD1 ASP A 254 6.56330.843 14.866 1.00 82.32 O ATOM 3856 OD2 ASP A 254 5.037 31.370 13.3761.00 86.13 O ATOM 3857 C ASP A 254 9.022 28.724 13.021 1.00 74.63 C ATOM3858 O ASP A 254 9.382 28.192 11.985 1.00 73.66 O ATOM 3859 N VAL A 2558.988 28.059 14.174 1.00 74.49 N ATOM 3861 CA VAL A 255 9.301 26.61214.277 1.00 72.81 C ATOM 3863 CB VAL A 255 8.787 25.976 15.627 1.0073.73 C ATOM 3865 CG1 VAL A 255 9.722 24.890 16.070 1.00 72.16 C ATOM3869 CG2 VAL A 255 8.622 27.020 16.785 1.00 76.62 C ATOM 3873 C VAL A255 8.707 25.762 13.148 1.00 72.23 C ATOM 3874 O VAL A 255 7.497 25.70812.977 1.00 73.53 O ATOM 3875 N ASN A 256 9.566 25.088 12.389 1.00 70.27N ATOM 3877 CA ASN A 256 9.101 24.122 11.380 1.00 70.31 C ATOM 3879 CBASN A 256 10.182 23.791 10.348 1.00 67.62 C ATOM 3882 CG ASN A 256 9.85822.537 9.502 1.00 65.90 C ATOM 3883 OD1 ASN A 256 8.855 21.859 9.7091.00 65.23 O ATOM 3884 ND2 ASN A 256 10.740 22.225 8.558 1.00 63.09 NATOM 3887 C ASN A 256 8.719 22.844 12.077 1.00 71.03 C ATOM 3888 O ASN A256 9.570 22.241 12.710 1.00 68.99 O ATOM 3889 N PRO A 257 7.457 22.42411.954 1.00 74.05 N ATOM 3890 CA PRO A 257 7.007 21.212 12.660 1.0074.85 C ATOM 3892 CB PRO A 257 5.467 21.181 12.420 1.00 77.52 C ATOM3895 CG PRO A 257 5.247 21.916 11.101 1.00 78.04 C ATOM 3898 CD PRO A257 6.380 23.014 11.114 1.00 76.18 C ATOM 3901 C PRO A 257 7.711 19.97112.080 1.00 72.67 C ATOM 3902 O PRO A 257 8.226 19.202 12.894 1.00 73.12O ATOM 3903 N GLU A 258 7.762 19.793 10.752 1.00 71.09 N ATOM 3905 CAGLU A 258 8.441 18.626 10.148 1.00 68.98 C ATOM 3907 CB GLU A 258 8.10018.532 8.631 1.00 68.15 C ATOM 3914 C GLU A 258 9.997 18.534 10.399 1.0066.74 C ATOM 3915 O GLU A 258 10.638 17.563 9.979 1.00 65.05 O ATOM 3916N GLY A 259 10.584 19.518 11.105 1.00 66.61 N ATOM 3918 CA GLY A 25912.031 19.749 11.122 1.00 64.31 C ATOM 3921 C GLY A 259 12.826 18.78711.970 1.00 63.46 C ATOM 3922 O GLY A 259 12.237 18.134 12.863 1.0064.80 O ATOM 3923 N LYS A 260 14.148 18.732 11.713 1.00 61.22 N ATOM3925 CA LYS A 260 15.061 17.684 12.239 1.00 59.87 C ATOM 3927 CB LYS A260 15.012 16.435 11.361 1.00 58.96 C ATOM 3930 CG LYS A 260 13.63515.850 11.292 1.00 61.80 C ATOM 3933 CD LYS A 260 13.592 14.414 10.8211.00 63.51 C ATOM 3936 CE LYS A 260 12.464 14.188 9.801 1.00 64.20 CATOM 3939 NZ LYS A 260 11.982 12.820 9.961 1.00 68.50 N ATOM 3943 C LYSA 260 16.528 18.103 12.418 1.00 57.61 C ATOM 3944 O LYS A 260 17.01718.961 11.792 1.00 57.42 O ATOM 3945 N TYR A 261 17.211 17.436 13.3051.00 56.94 N ATOM 3947 CA TYR A 261 18.543 17.762 13.716 1.00 55.87 CATOM 3949 CB TYR A 261 18.663 17.429 15.213 1.00 56.86 C ATOM 3952 CGTYR A 261 17.714 18.203 16.097 1.00 58.81 C ATOM 3953 CD1 TYR A 26116.747 17.586 16.878 1.00 62.63 C ATOM 3955 CE1 TYR A 261 15.864 18.33817.722 1.00 63.21 C ATOM 3957 CZ TYR A 261 15.972 19.694 17.733 1.0064.10 C ATOM 3958 OH TYR A 261 15.188 20.526 18.498 1.00 67.69 O ATOM3960 CE2 TYR A 261 16.924 20.311 16.958 1.00 64.45 C ATOM 3962 CD2 TYR A261 17.785 19.570 16.154 1.00 61.93 C ATOM 3964 C TYR A 261 19.49616.898 12.904 1.00 54.12 C ATOM 3965 O TYR A 261 19.153 15.858 12.4221.00 53.80 O ATOM 3966 N SER A 262 20.729 17.298 12.811 1.00 53.84 NATOM 3968 CA SER A 262 21.669 16.598 12.024 1.00 53.32 C ATOM 3970 CBSER A 262 22.452 17.594 11.178 1.00 52.59 C ATOM 3973 OG SER A 26223.776 17.761 11.661 1.00 53.41 O ATOM 3975 C SER A 262 22.566 15.72712.939 1.00 54.56 C ATOM 3976 O SER A 262 23.248 16.220 13.815 1.0055.50 O ATOM 3977 N PHE A 263 22.561 14.423 12.719 1.00 55.44 N ATOM3979 CA PHE A 263 23.483 13.544 13.407 1.00 58.17 C ATOM 3981 CB PHE A263 22.733 12.590 14.327 1.00 59.86 C ATOM 3984 CG PHE A 263 23.61311.673 15.142 1.00 61.87 C ATOM 3985 CD1 PHE A 263 24.705 12.159 15.8261.00 62.54 C ATOM 3987 CE1 PHE A 263 25.441 11.352 16.570 1.00 64.60 CATOM 3989 CZ PHE A 263 25.119 10.015 16.657 1.00 67.48 C ATOM 3991 CE2PHE A 263 24.039 9.515 16.003 1.00 65.99 C ATOM 3993 CD2 PHE A 26323.287 10.334 15.264 1.00 63.61 C ATOM 3995 C PHE A 263 24.214 12.76412.367 1.00 58.42 C ATOM 3996 O PHE A 263 23.644 11.903 11.736 1.0057.38 O ATOM 3997 N GLY A 264 25.513 13.051 12.319 1.00 60.11 N ATOM3999 CA GLY A 264 26.439 12.853 11.228 1.00 59.81 C ATOM 4002 C GLY A264 25.990 12.114 10.022 1.00 58.59 C ATOM 4003 O GLY A 264 26.20810.919 9.926 1.00 61.26 O ATOM 4004 N ALA A 265 25.426 12.803 9.068 1.0056.84 N ATOM 4006 CA ALA A 265 24.939 12.139 7.818 1.00 55.65 C ATOM4008 CB ALA A 265 25.948 11.151 7.134 1.00 55.54 C ATOM 4012 C ALA A 26523.642 11.468 8.026 1.00 54.37 C ATOM 4013 O ALA A 265 23.287 10.6207.246 1.00 54.14 O ATOM 4014 N THR A 266 22.924 11.936 9.029 1.00 54.84N ATOM 4016 CA THR A 266 21.622 11.451 9.350 1.00 54.78 C ATOM 4018 CBTHR A 266 21.814 10.371 10.300 1.00 56.35 C ATOM 4020 OG1 THR A 26621.628 9.203 9.556 1.00 55.31 O ATOM 4022 CG2 THR A 266 20.782 10.29311.424 1.00 58.51 C ATOM 4026 C THR A 266 20.750 12.549 9.891 1.00 55.45C ATOM 4027 O THR A 266 21.247 13.566 10.359 1.00 55.61 O ATOM 4028 NCYS A 267 19.445 12.342 9.755 1.00 55.64 N ATOM 4030 CA CYS A 267 18.43213.347 10.049 1.00 56.01 C ATOM 4032 CB CYS A 267 17.598 13.692 8.8311.00 54.41 C ATOM 4035 SG CYS A 267 18.513 14.786 7.754 1.00 52.64 SATOM 4036 C CYS A 267 17.547 12.698 11.016 1.00 57.94 C ATOM 4037 O CYSA 267 17.059 11.627 10.716 1.00 58.45 O ATOM 4038 N VAL A 268 17.27313.378 12.130 1.00 59.39 N ATOM 4040 CA VAL A 268 16.860 12.719 13.3441.00 61.02 C ATOM 4042 CB VAL A 268 18.164 12.290 14.042 1.00 61.46 CATOM 4044 CG1 VAL A 268 18.230 12.613 15.536 1.00 61.61 C ATOM 4048 CG2VAL A 268 18.399 10.822 13.748 1.00 62.00 C ATOM 4052 C VAL A 268 16.00013.647 14.197 1.00 62.66 C ATOM 4053 O VAL A 268 16.450 14.752 14.4581.00 62.80 O ATOM 4054 N LYS A 269 14.799 13.212 14.646 1.00 63.83 NATOM 4056 CA LYS A 269 13.909 14.122 15.410 1.00 65.02 C ATOM 4058 CBLYS A 269 12.413 13.700 15.399 1.00 65.91 C ATOM 4065 C LYS A 269 14.39814.338 16.842 1.00 65.84 C ATOM 4066 O LYS A 269 14.126 15.373 17.4381.00 65.90 O ATOM 4067 N LYS A 270 15.099 13.359 17.404 1.00 66.46 NATOM 4069 CA LYS A 270 15.659 13.544 18.749 1.00 67.95 C ATOM 4071 CBLYS A 270 14.794 12.868 19.835 1.00 68.78 C ATOM 4078 C LYS A 270 17.11813.048 18.735 1.00 67.52 C ATOM 4079 O LYS A 270 17.418 12.037 18.0931.00 67.82 O ATOM 4080 N CYS A 271 18.029 13.792 19.378 1.00 67.18 NATOM 4082 CA CYS A 271 19.404 13.329 19.533 1.00 67.14 C ATOM 4084 CBCYS A 271 20.298 14.392 20.163 1.00 67.37 C ATOM 4087 SG CYS A 27120.613 15.867 19.148 1.00 64.80 S ATOM 4088 C CYS A 271 19.474 12.05920.385 1.00 69.08 C ATOM 4089 O CYS A 271 18.591 11.760 21.157 1.0069.41 O ATOM 4090 N PRO A 272 20.500 11.265 20.163 1.00 70.38 N ATOM4091 CA PRO A 272 20.849 10.151 21.051 1.00 72.24 C ATOM 4093 CB PRO A272 22.117 9.577 20.427 1.00 72.83 C ATOM 4096 CG PRO A 272 22.33910.261 19.105 1.00 71.30 C ATOM 4099 CD PRO A 272 21.334 11.334 18.9501.00 69.52 C ATOM 4102 C PRO A 272 21.148 10.500 22.518 1.00 74.35 CATOM 4103 O PRO A 272 21.335 11.680 22.899 1.00 72.50 O ATOM 4104 N ALAA 273 21.207 9.460 23.360 1.00 76.92 N ATOM 4106 CA ALA A 273 21.3369.770 24.770 1.00 79.31 C ATOM 4108 CB ALA A 273 21.267 8.471 25.7041.00 81.70 C ATOM 4112 C ALA A 273 22.660 10.549 24.920 1.00 80.08 CATOM 4113 O ALA A 273 23.657 10.214 24.269 1.00 81.25 O ATOM 4114 N ALAA 274 22.643 11.606 25.731 1.00 80.37 N ATOM 4116 CA ALA A 274 23.87312.309 26.180 1.00 80.79 C ATOM 4118 CB ALA A 274 24.953 11.284 26.7091.00 82.92 C ATOM 4122 C ALA A 274 24.467 13.290 25.124 1.00 79.12 CATOM 4123 O ALA A 274 25.525 13.931 25.359 1.00 80.24 O ATOM 4124 N TYRA 275 23.770 13.426 23.984 1.00 76.37 N ATOM 4126 CA TYR A 275 24.05914.488 23.006 1.00 73.46 C ATOM 4128 CB TYR A 275 23.851 13.945 21.5891.00 72.66 C ATOM 4131 CG TYR A 275 24.943 13.029 21.067 1.00 73.61 CATOM 4132 CD1 TYR A 275 24.814 11.666 21.160 1.00 75.81 C ATOM 4134 CE1TYR A 275 25.821 10.768 20.623 1.00 78.82 C ATOM 4136 CZ TYR A 27526.949 11.265 19.972 1.00 77.14 C ATOM 4137 OH TYR A 275 27.922 10.37819.496 1.00 74.15 O ATOM 4139 CE2 TYR A 275 27.068 12.649 19.842 1.0076.49 C ATOM 4141 CD2 TYR A 275 26.066 13.529 20.396 1.00 74.32 C ATOM4143 C TYR A 275 23.253 15.819 23.224 1.00 70.60 C ATOM 4144 O TYR A 27522.179 15.869 23.817 1.00 69.08 O ATOM 4145 N VAL A 276 23.819 16.88722.710 1.00 68.49 N ATOM 4147 CA VAL A 276 23.309 18.203 22.896 1.0066.88 C ATOM 4149 CB VAL A 276 24.361 19.009 23.644 1.00 67.40 C ATOM4151 CG1 VAL A 276 24.077 20.468 23.538 1.00 66.99 C ATOM 4155 CG2 VAL A276 24.424 18.581 25.105 1.00 69.12 C ATOM 4159 C VAL A 276 23.11918.799 21.516 1.00 65.33 C ATOM 4160 O VAL A 276 23.945 18.554 20.6481.00 64.97 O ATOM 4161 N VAL A 277 22.077 19.608 21.316 1.00 64.18 NATOM 4163 CA VAL A 277 21.895 20.312 20.051 1.00 63.43 C ATOM 4165 CBVAL A 277 20.423 20.537 19.793 1.00 63.64 C ATOM 4167 CG1 VAL A 27720.178 21.579 18.660 1.00 63.81 C ATOM 4171 CG2 VAL A 277 19.719 19.23219.503 1.00 63.12 C ATOM 4175 C VAL A 277 22.591 21.672 20.042 1.0063.46 C ATOM 4176 O VAL A 277 22.630 22.344 20.998 1.00 64.27 O ATOM4177 N THR A 278 23.107 22.065 18.912 1.00 64.13 N ATOM 4179 CA THR A278 23.883 23.273 18.716 1.00 65.38 C ATOM 4181 CB THR A 278 24.92422.973 17.652 1.00 65.09 C ATOM 4183 OG1 THR A 278 25.926 22.130 18.2191.00 66.18 O ATOM 4185 CG2 THR A 278 25.683 24.189 17.208 1.00 67.03 CATOM 4189 C THR A 278 22.963 24.272 18.124 1.00 66.33 C ATOM 4190 O THRA 278 21.894 23.912 17.678 1.00 66.13 O ATOM 4191 N ASP A 279 23.38725.530 18.075 1.00 68.38 N ATOM 4193 CA ASP A 279 22.622 26.565 17.3711.00 69.35 C ATOM 4195 CB ASP A 279 23.231 27.974 17.663 1.00 70.17 CATOM 4198 CG ASP A 279 22.622 28.619 18.927 1.00 74.12 C ATOM 4199 OD1ASP A 279 21.509 28.147 19.255 1.00 80.61 O ATOM 4200 OD2 ASP A 27923.129 29.541 19.668 1.00 75.22 O ATOM 4201 C ASP A 279 22.387 26.33315.837 1.00 68.57 C ATOM 4202 O ASP A 279 21.493 26.966 15.271 1.0069.77 O ATOM 4203 N HIS A 280 23.158 25.484 15.155 1.00 67.36 N ATOM4205 CA HIS A 280 22.837 25.161 13.757 1.00 66.40 C ATOM 4207 CB HIS A280 24.111 24.930 12.934 1.00 67.43 C ATOM 4210 CG HIS A 280 25.04426.101 12.966 1.00 75.84 C ATOM 4211 ND1 HIS A 280 24.803 27.271 12.2461.00 83.72 N ATOM 4213 CE1 HIS A 280 25.755 28.167 12.529 1.00 86.54 CATOM 4215 NE2 HIS A 280 26.613 27.618 13.393 1.00 86.77 N ATOM 4217 CD2HIS A 280 26.187 26.325 13.689 1.00 82.80 C ATOM 4219 C HIS A 280 21.92823.935 13.660 1.00 63.82 C ATOM 4220 O HIS A 280 21.670 23.449 12.5831.00 62.82 O ATOM 4221 N GLY A 281 21.454 23.433 14.786 1.00 62.07 NATOM 4223 CA GLY A 281 20.711 22.192 14.803 1.00 60.37 C ATOM 4226 C GLYA 281 21.450 20.874 14.599 1.00 58.17 C ATOM 4227 O GLY A 281 20.87219.957 14.053 1.00 54.70 O ATOM 4228 N SER A 282 22.674 20.769 15.0991.00 58.36 N ATOM 4230 CA SER A 282 23.451 19.518 14.988 1.00 59.80 CATOM 4232 CB SER A 282 24.823 19.766 14.377 1.00 59.16 C ATOM 4235 OGSER A 282 25.214 21.051 14.795 1.00 62.95 O ATOM 4237 C SER A 282 23.67318.870 16.322 1.00 60.81 C ATOM 4238 O SER A 282 23.983 19.548 17.2751.00 61.77 O ATOM 4239 N CYS A 283 23.563 17.547 16.351 1.00 61.19 NATOM 4241 CA CYS A 283 23.886 16.751 17.517 1.00 62.86 C ATOM 4243 CBCYS A 283 23.288 15.378 17.378 1.00 62.70 C ATOM 4246 SG CYS A 28321.524 15.593 17.275 1.00 63.42 S ATOM 4247 C CYS A 283 25.378 16.64317.738 1.00 64.27 C ATOM 4248 O CYS A 283 26.086 15.979 17.042 1.0064.51 O ATOM 4249 N VAL A 284 25.827 17.322 18.756 1.00 65.87 N ATOM4251 CA VAL A 284 27.194 17.333 19.161 1.00 67.25 C ATOM 4253 CB VAL A284 27.645 18.783 19.075 1.00 66.98 C ATOM 4255 CG1 VAL A 284 28.28719.308 20.427 1.00 69.20 C ATOM 4259 CG2 VAL A 284 28.515 18.989 17.8471.00 65.40 C ATOM 4263 C VAL A 284 27.288 16.742 20.591 1.00 69.52 CATOM 4264 O VAL A 284 26.303 16.509 21.280 1.00 68.60 O ATOM 4265 N ARGA 285 28.494 16.492 21.043 1.00 72.61 N ATOM 4267 CA ARG A 285 28.67915.718 22.271 1.00 75.24 C ATOM 4269 CB ARG A 285 30.043 15.046 22.2221.00 77.38 C ATOM 4272 CG ARG A 285 30.241 14.309 20.879 1.00 77.58 CATOM 4275 CD ARG A 285 31.506 13.520 20.741 1.00 79.64 C ATOM 4278 NEARG A 285 31.750 12.663 21.889 1.00 81.81 N ATOM 4280 CZ ARG A 28532.836 11.910 21.998 1.00 88.43 C ATOM 4281 NH1 ARG A 285 33.742 11.91621.013 1.00 89.46 N ATOM 4284 NH2 ARG A 285 33.035 11.135 23.078 1.0092.89 N ATOM 4287 C ARG A 285 28.524 16.617 23.501 1.00 75.88 C ATOM4288 O ARG A 285 27.908 16.216 24.524 1.00 76.68 O ATOM 4289 N ALA A 28629.080 17.833 23.386 1.00 75.41 N ATOM 4291 CA ALA A 286 29.095 18.80524.477 1.00 74.95 C ATOM 4293 CB ALA A 286 30.314 18.614 25.312 1.0077.22 C ATOM 4297 C ALA A 286 29.079 20.218 23.942 1.00 73.45 C ATOM4298 O ALA A 286 29.676 20.530 22.894 1.00 72.96 O ATOM 4299 N CYS A 28728.406 21.073 24.681 1.00 72.05 N ATOM 4301 CA CYS A 287 28.399 22.46824.351 1.00 71.75 C ATOM 4303 CB CYS A 287 27.642 23.229 25.427 1.0071.31 C ATOM 4306 SG CYS A 287 25.875 22.940 25.188 1.00 73.43 S ATOM4307 C CYS A 287 29.768 23.066 24.284 1.00 72.75 C ATOM 4308 O CYS A 28730.617 22.701 25.063 1.00 73.85 O ATOM 4309 N GLY A 288 29.938 24.05123.398 1.00 72.69 N ATOM 4311 CA GLY A 288 31.088 24.947 23.428 1.0074.02 C ATOM 4314 C GLY A 288 31.303 25.704 24.750 1.00 75.81 C ATOM4315 O GLY A 288 30.500 25.659 25.739 1.00 76.26 O ATOM 4316 N ALA A 28932.440 26.388 24.813 1.00 77.00 N ATOM 4318 CA ALA A 289 32.570 27.52325.728 1.00 76.07 C ATOM 4320 CB ALA A 289 34.065 27.885 25.926 1.0078.28 C ATOM 4324 C ALA A 289 31.802 28.638 25.003 1.00 73.43 C ATOM4325 O ALA A 289 31.441 28.499 23.823 1.00 72.51 O ATOM 4326 N GLU A 29031.556 29.741 25.680 1.00 71.93 N ATOM 4328 CA GLU A 290 30.674 30.78425.138 1.00 69.93 C ATOM 4330 CB GLU A 290 30.933 31.060 23.638 1.0069.55 C ATOM 4337 C GLU A 290 29.204 30.388 25.378 1.00 68.43 C ATOM4338 O GLU A 290 28.304 31.263 25.434 1.00 66.42 O ATOM 4339 N SER A 29128.965 29.076 25.564 1.00 68.05 N ATOM 4341 CA SER A 291 27.586 28.56125.670 1.00 66.93 C ATOM 4343 CB SER A 291 27.133 27.982 24.310 1.0066.63 C ATOM 4346 OG SER A 291 27.904 26.832 23.974 1.00 70.01 O ATOM4348 C SER A 291 27.418 27.540 26.790 1.00 65.49 C ATOM 4349 O SER A 29128.386 27.171 27.433 1.00 65.82 O ATOM 4350 N TYR A 292 26.187 27.09927.003 1.00 63.29 N ATOM 4352 CA TYR A 292 25.873 26.244 28.114 1.0063.59 C ATOM 4354 CB TYR A 292 25.605 27.105 29.361 1.00 63.27 C ATOM4357 CG TYR A 292 24.345 27.900 29.346 1.00 61.34 C ATOM 4358 CD1 TYR A292 23.232 27.426 29.953 1.00 61.28 C ATOM 4360 CE1 TYR A 292 22.06428.124 29.961 1.00 62.43 C ATOM 4362 CZ TYR A 292 21.969 29.333 29.3171.00 63.33 C ATOM 4363 OH TYR A 292 20.753 30.010 29.369 1.00 61.75 OATOM 4365 CE2 TYR A 292 23.089 29.833 28.659 1.00 61.75 C ATOM 4367 CD2TYR A 292 24.269 29.109 28.695 1.00 61.15 C ATOM 4369 C TYR A 292 24.68025.364 27.824 1.00 63.55 C ATOM 4370 O TYR A 292 23.902 25.665 26.9441.00 61.46 O ATOM 4371 N GLU A 293 24.514 24.283 28.594 1.00 65.22 NATOM 4373 CA GLU A 293 23.421 23.337 28.343 1.00 64.96 C ATOM 4375 CBGLU A 293 23.822 21.946 28.802 1.00 66.42 C ATOM 4378 CG GLU A 29322.814 20.850 28.461 1.00 66.78 C ATOM 4381 CD GLU A 293 23.357 19.45328.686 1.00 68.32 C ATOM 4382 OE1 GLU A 293 24.573 19.284 28.917 1.0066.66 O ATOM 4383 OE2 GLU A 293 22.541 18.514 28.585 1.00 72.49 O ATOM4384 C GLU A 293 22.180 23.740 29.062 1.00 64.18 C ATOM 4385 O GLU A 29322.258 24.258 30.131 1.00 64.53 O ATOM 4386 N MET A 294 21.037 23.44428.482 1.00 64.06 N ATOM 4388 CA MET A 294 19.735 23.773 29.048 1.0064.77 C ATOM 4390 CB MET A 294 19.444 25.230 28.817 1.00 64.63 C ATOM4393 CG MET A 294 19.548 25.564 27.386 1.00 65.21 C ATOM 4396 SD MET A294 18.161 26.233 26.768 1.00 67.82 S ATOM 4397 CE MET A 294 18.22527.967 27.430 1.00 68.39 C ATOM 4401 C MET A 294 18.693 22.959 28.3351.00 65.12 C ATOM 4402 O MET A 294 19.053 22.135 27.553 1.00 66.70 OATOM 4403 N GLU A 295 17.409 23.178 28.560 1.00 66.08 N ATOM 4405 CA GLUA 295 16.403 22.270 28.025 1.00 66.85 C ATOM 4407 CB GLU A 295 16.10521.144 29.030 1.00 68.03 C ATOM 4410 CG GLU A 295 15.320 19.987 28.4201.00 70.00 C ATOM 4413 CD GLU A 295 15.183 18.715 29.276 1.00 72.37 CATOM 4414 OE1 GLU A 295 15.186 18.767 30.490 1.00 69.76 O ATOM 4415 OE2GLU A 295 15.049 17.605 28.700 1.00 77.58 O ATOM 4416 C GLU A 295 15.12022.957 27.586 1.00 67.10 C ATOM 4417 O GLU A 295 14.683 23.903 28.1551.00 66.08 O ATOM 4418 N GLU A 296 14.521 22.402 26.557 1.00 68.39 NATOM 4420 CA GLU A 296 13.398 22.997 25.876 1.00 69.98 C ATOM 4422 CBGLU A 296 13.906 24.045 24.880 1.00 69.31 C ATOM 4425 CG GLU A 29612.939 25.175 24.543 1.00 71.32 C ATOM 4428 CD GLU A 296 13.505 26.31723.613 1.00 72.51 C ATOM 4429 OE1 GLU A 296 14.592 26.270 22.931 1.0067.50 O ATOM 4430 OE2 GLU A 296 12.790 27.333 23.556 1.00 76.03 O ATOM4431 C GLU A 296 12.649 21.830 25.194 1.00 71.02 C ATOM 4432 O GLU A 29613.163 21.119 24.332 1.00 69.99 O ATOM 4433 N ASP A 297 11.435 21.62125.654 1.00 72.87 N ATOM 4435 CA ASP A 297 10.564 20.526 25.225 1.0074.19 C ATOM 4437 CB ASP A 297 9.775 20.856 23.925 1.00 74.54 C ATOM4440 CG ASP A 297 8.253 20.479 24.078 1.00 78.91 C ATOM 4441 OD1 ASP A297 7.709 19.556 23.383 1.00 80.68 O ATOM 4442 OD2 ASP A 297 7.52821.033 24.964 1.00 83.36 O ATOM 4443 C ASP A 297 11.184 19.131 25.2121.00 73.07 C ATOM 4444 O ASP A 297 10.949 18.325 24.330 1.00 72.94 OATOM 4445 N GLY A 298 11.922 18.833 26.251 1.00 72.78 N ATOM 4447 CA GLYA 298 12.585 17.537 26.330 1.00 72.97 C ATOM 4450 C GLY A 298 13.75417.408 25.377 1.00 71.57 C ATOM 4451 O GLY A 298 14.020 16.324 24.8681.00 72.37 O ATOM 4452 N VAL A 299 14.432 18.524 25.111 1.00 70.39 NATOM 4454 CA VAL A 299 15.601 18.557 24.223 1.00 68.75 C ATOM 4456 CBVAL A 299 15.264 19.209 22.862 1.00 68.23 C ATOM 4458 CG1 VAL A 29916.357 18.967 21.894 1.00 67.60 C ATOM 4462 CG2 VAL A 299 13.917 18.71622.298 1.00 68.94 C ATOM 4466 C VAL A 299 16.718 19.382 24.871 1.0067.74 C ATOM 4467 O VAL A 299 16.573 20.574 25.068 1.00 66.87 O ATOM4468 N ARG A 300 17.821 18.729 25.220 1.00 67.57 N ATOM 4470 CA ARG A300 19.013 19.425 25.667 1.00 66.47 C ATOM 4472 CB ARG A 300 19.95718.390 26.324 1.00 67.22 C ATOM 4481 C ARG A 300 19.626 20.231 24.4371.00 64.86 C ATOM 4482 O ARG A 300 19.911 19.629 23.366 1.00 63.66 OATOM 4483 N LYS A 301 19.757 21.576 24.594 1.00 63.56 N ATOM 4485 CA LYSA 301 20.400 22.506 23.623 1.00 62.09 C ATOM 4487 CB LYS A 301 19.36523.446 23.014 1.00 61.81 C ATOM 4490 CG LYS A 301 18.004 22.874 22.9451.00 62.27 C ATOM 4493 CD LYS A 301 17.127 23.599 21.987 1.00 62.22 CATOM 4496 CE LYS A 301 15.767 22.883 21.889 1.00 64.18 C ATOM 4499 NZLYS A 301 14.711 23.900 21.583 1.00 68.36 N ATOM 4503 C LYS A 301 21.47423.415 24.208 1.00 61.40 C ATOM 4504 O LYS A 301 21.486 23.655 25.3641.00 61.73 O ATOM 4505 N CYS A 302 22.354 23.943 23.380 1.00 60.84 NATOM 4507 CA CYS A 302 23.324 24.956 23.768 1.00 61.35 C ATOM 4509 CBCYS A 302 24.550 24.881 22.905 1.00 60.99 C ATOM 4512 SG CYS A 30225.368 23.314 23.146 1.00 67.99 S ATOM 4513 C CYS A 302 22.794 26.27523.482 1.00 60.63 C ATOM 4514 O CYS A 302 22.523 26.536 22.363 1.0062.04 O ATOM 4515 N ALA A 303 22.657 27.119 24.472 1.00 60.94 N ATOM4517 CA ALA A 303 22.390 28.522 24.292 1.00 60.90 C ATOM 4519 CB ALA A303 21.236 28.950 25.251 1.00 60.91 C ATOM 4523 C ALA A 303 23.72329.290 24.565 1.00 61.01 C ATOM 4524 O ALA A 303 24.608 28.755 25.1621.00 61.07 O ATOM 4525 N LYS A 304 23.867 30.532 24.114 1.00 61.74 NATOM 4527 CA LYS A 304 25.101 31.306 24.314 1.00 62.76 C ATOM 4529 CBLYS A 304 25.383 32.328 23.177 1.00 62.14 C ATOM 4536 C LYS A 304 24.98132.007 25.672 1.00 63.58 C ATOM 4537 O LYS A 304 23.927 32.573 26.0161.00 62.97 O ATOM 4538 N CYS A 305 26.067 31.947 26.441 1.00 64.37 NATOM 4540 CA CYS A 305 26.054 32.434 27.809 1.00 64.66 C ATOM 4542 CBCYS A 305 27.392 32.217 28.470 1.00 65.21 C ATOM 4545 SG CYS A 30527.739 30.498 28.766 1.00 63.94 S ATOM 4546 C CYS A 305 25.781 33.87827.864 1.00 64.83 C ATOM 4547 O CYS A 305 26.343 34.630 27.095 1.0064.68 O ATOM 4548 N GLU A 306 24.936 34.253 28.814 1.00 66.05 N ATOM4550 CA GLU A 306 24.524 35.644 29.001 1.00 66.80 C ATOM 4552 CB GLU A306 23.563 35.751 30.202 1.00 66.67 C ATOM 4559 C GLU A 306 25.81236.489 29.193 1.00 67.43 C ATOM 4560 O GLU A 306 26.353 37.052 28.1771.00 68.24 O ATOM 4561 N GLY A 307 26.321 36.534 30.441 1.00 65.77 NATOM 4563 CA GLY A 307 27.647 37.068 30.683 1.00 65.67 C ATOM 4566 C GLYA 307 28.789 36.058 30.514 1.00 65.77 C ATOM 4567 O GLY A 307 28.74935.218 29.655 1.00 66.29 O ATOM 4568 N PRO A 308 29.826 36.129 31.3451.00 65.73 N ATOM 4569 CA PRO A 308 30.736 34.998 31.452 1.00 65.66 CATOM 4571 CB PRO A 308 31.671 35.399 32.609 1.00 66.34 C ATOM 4574 CGPRO A 308 31.364 36.818 32.999 1.00 65.33 C ATOM 4577 CD PRO A 30830.197 37.256 32.246 1.00 65.52 C ATOM 4580 C PRO A 308 29.978 33.70831.807 1.00 64.49 C ATOM 4581 O PRO A 308 29.013 33.700 32.535 1.0063.44 O ATOM 4582 N CYS A 309 30.438 32.594 31.299 1.00 64.85 N ATOM4584 CA CYS A 309 29.805 31.354 31.627 1.00 64.54 C ATOM 4586 CB CYS A309 30.386 30.212 30.830 1.00 65.21 C ATOM 4589 SG CYS A 309 29.78830.212 29.155 1.00 66.57 S ATOM 4590 C CYS A 309 29.997 31.025 33.0321.00 64.83 C ATOM 4591 O CYS A 309 30.976 31.344 33.634 1.00 65.61 OATOM 4592 N ARG A 310 29.058 30.285 33.547 1.00 60.31 N ATOM 4594 CA ARGA 310 29.113 29.882 34.923 1.00 57.41 C ATOM 4596 CB ARG A 310 27.79929.192 35.275 1.00 58.70 C ATOM 4599 CG ARG A 310 27.864 28.223 36.4491.00 59.00 C ATOM 4602 CD ARG A 310 26.495 27.931 37.089 1.00 61.96 CATOM 4605 NE ARG A 310 26.526 28.291 38.498 1.00 59.13 N ATOM 4607 CZARG A 310 26.658 27.437 39.485 1.00 58.19 C ATOM 4608 NH1 ARG A 31026.733 26.108 39.288 1.00 62.56 N ATOM 4611 NH2 ARG A 310 26.687 27.93940.688 1.00 54.22 N ATOM 4614 C ARG A 310 30.266 28.956 35.092 1.0056.38 C ATOM 4615 O ARG A 310 30.384 27.970 34.367 1.00 60.06 O ATOM4616 N LYS A 311 31.077 29.253 36.067 1.00 52.95 N ATOM 4618 CA LYS A311 32.237 28.466 36.405 1.00 53.16 C ATOM 4620 CB LYS A 311 33.48929.100 35.809 1.00 53.22 C ATOM 4623 CG LYS A 311 34.691 28.185 35.6361.00 54.72 C ATOM 4626 CD LYS A 311 35.994 28.877 36.020 1.00 54.84 CATOM 4629 CE LYS A 311 37.190 28.137 35.562 1.00 55.94 C ATOM 4632 NZLYS A 311 37.492 28.559 34.153 1.00 61.52 N ATOM 4636 C LYS A 311 32.37028.399 37.919 1.00 51.04 C ATOM 4637 O LYS A 311 32.461 29.412 38.6261.00 48.96 O ATOM 4638 N VAL A 312 32.389 27.190 38.441 1.00 52.10 NATOM 4640 CA VAL A 312 32.387 27.022 39.879 1.00 49.43 C ATOM 4642 CBVAL A 312 31.419 25.856 40.214 1.00 51.43 C ATOM 4644 CG1 VAL A 31231.644 25.299 41.629 1.00 51.31 C ATOM 4648 CG2 VAL A 312 29.941 26.30340.019 1.00 51.87 C ATOM 4652 C VAL A 312 33.810 26.792 40.321 1.0047.46 C ATOM 4653 O VAL A 312 34.534 26.134 39.633 1.00 48.81 O ATOM4654 N CYS A 313 34.224 27.342 41.452 1.00 45.64 N ATOM 4656 CA CYS A313 35.603 27.139 41.985 1.00 46.21 C ATOM 4658 CB CYS A 313 36.53328.305 41.639 1.00 45.10 C ATOM 4661 SG CYS A 313 36.511 28.703 39.8431.00 55.46 S ATOM 4662 C CYS A 313 35.674 26.972 43.482 1.00 44.15 CATOM 4663 O CYS A 313 35.043 27.684 44.222 1.00 44.97 O ATOM 4664 N ASNA 314 36.502 26.078 43.951 1.00 44.46 N ATOM 4666 CA ASN A 314 36.81725.995 45.346 1.00 42.36 C ATOM 4668 CB ASN A 314 37.915 24.968 45.5531.00 43.90 C ATOM 4671 CG ASN A 314 37.515 23.563 45.052 1.00 46.81 CATOM 4672 OD1 ASN A 314 36.465 23.016 45.453 1.00 50.58 O ATOM 4673 ND2ASN A 314 38.309 23.026 44.099 1.00 49.45 N ATOM 4676 C ASN A 314 37.27827.306 45.972 1.00 40.41 C ATOM 4677 O ASN A 314 37.974 28.140 45.3851.00 40.47 O ATOM 4678 N GLY A 315 36.860 27.494 47.209 1.00 39.42 NATOM 4680 CA GLY A 315 37.329 28.597 47.998 1.00 36.84 C ATOM 4683 C GLYA 315 38.633 28.342 48.697 1.00 36.39 C ATOM 4684 O GLY A 315 39.32127.340 48.580 1.00 36.34 O ATOM 4685 N ILE A 316 38.975 29.319 49.4831.00 35.62 N ATOM 4687 CA ILE A 316 40.197 29.200 50.208 1.00 36.69 CATOM 4689 CB ILE A 316 40.615 30.542 50.613 1.00 34.84 C ATOM 4691 CG1ILE A 316 41.327 31.048 49.383 1.00 37.92 C ATOM 4694 CD1 ILE A 31641.400 32.434 49.319 1.00 40.69 C ATOM 4698 CG2 ILE A 316 41.647 30.48551.734 1.00 34.92 C ATOM 4702 C ILE A 316 40.093 28.246 51.344 1.0037.13 C ATOM 4703 O ILE A 316 39.246 28.398 52.197 1.00 36.17 O ATOM4704 N GLY A 317 40.969 27.271 51.351 1.00 38.50 N ATOM 4706 CA GLY A317 40.937 26.289 52.410 1.00 40.78 C ATOM 4709 C GLY A 317 40.86424.924 51.786 1.00 43.80 C ATOM 4710 O GLY A 317 41.628 23.995 52.1491.00 46.54 O ATOM 4711 N ILE A 318 40.026 24.860 50.760 1.00 43.85 NATOM 4713 CA ILE A 318 39.762 23.645 49.983 1.00 46.17 C ATOM 4715 CBILE A 318 38.287 23.658 49.611 1.00 45.60 C ATOM 4717 CG1 ILE A 31837.441 23.639 50.888 1.00 43.98 C ATOM 4720 CD1 ILE A 318 36.125 24.13750.662 1.00 43.89 C ATOM 4724 CG2 ILE A 318 38.020 22.487 48.661 1.0047.89 C ATOM 4728 C ILE A 318 40.520 23.509 48.639 1.00 47.63 C ATOM4729 O ILE A 318 40.833 24.543 48.012 1.00 46.75 O ATOM 4730 N GLY A 31940.735 22.254 48.176 1.00 49.13 N ATOM 4732 CA GLY A 319 41.097 21.97646.806 1.00 49.93 C ATOM 4735 C GLY A 319 42.480 22.498 46.473 1.0050.82 C ATOM 4736 O GLY A 319 43.460 22.255 47.179 1.00 50.60 O ATOM4737 N GLU A 320 42.574 23.195 45.349 1.00 51.94 N ATOM 4739 CA GLU A320 43.811 23.859 44.916 1.00 52.89 C ATOM 4741 CB GLU A 320 43.50424.771 43.735 1.00 53.88 C ATOM 4744 CG GLU A 320 42.802 24.123 42.5551.00 59.54 C ATOM 4747 CD GLU A 320 41.252 24.262 42.562 1.00 63.07 CATOM 4748 OE1 GLU A 320 40.603 24.715 43.485 1.00 57.30 O ATOM 4749 OE2GLU A 320 40.630 23.836 41.573 1.00 75.97 O ATOM 4750 C GLU A 320 44.34224.781 46.010 1.00 50.87 C ATOM 4751 O GLU A 320 45.521 25.097 46.0221.00 52.50 O ATOM 4752 N TYR A 321 43.445 25.243 46.893 1.00 47.74 NATOM 4754 CA TYR A 321 43.796 25.996 48.048 1.00 45.39 C ATOM 4756 CBTYR A 321 42.903 27.163 48.113 1.00 43.88 C ATOM 4759 CG TYR A 32142.549 27.735 46.790 1.00 47.78 C ATOM 4760 CD1 TYR A 321 41.299 27.54546.250 1.00 51.91 C ATOM 4762 CE1 TYR A 321 40.963 28.042 45.044 1.0054.97 C ATOM 4764 CZ TYR A 321 41.861 28.800 44.366 1.00 58.00 C ATOM4765 OH TYR A 321 41.452 29.315 43.136 1.00 61.65 O ATOM 4767 CE2 TYR A321 43.129 29.019 44.881 1.00 55.75 C ATOM 4769 CD2 TYR A 321 43.46128.453 46.077 1.00 54.38 C ATOM 4771 C TYR A 321 43.715 25.308 49.3981.00 45.37 C ATOM 4772 O TYR A 321 43.438 25.950 50.371 1.00 42.50 OATOM 4773 N LYS A 322 44.043 24.018 49.489 1.00 49.57 N ATOM 4775 CA LYSA 322 44.267 23.354 50.814 1.00 50.70 C ATOM 4777 CB LYS A 322 44.61921.795 50.737 1.00 52.77 C ATOM 4784 C LYS A 322 45.384 24.199 51.5131.00 49.99 C ATOM 4785 O LYS A 322 46.427 24.525 50.921 1.00 51.02 OATOM 4786 N ASP A 323 45.144 24.600 52.746 1.00 48.30 N ATOM 4788 CA ASPA 323 46.253 25.036 53.583 1.00 47.80 C ATOM 4790 CB ASP A 323 47.44224.075 53.481 1.00 51.14 C ATOM 4793 CG ASP A 323 47.180 22.729 54.1091.00 53.64 C ATOM 4794 OD1 ASP A 323 46.376 22.621 55.075 1.00 52.75 OATOM 4795 OD2 ASP A 323 47.796 21.713 53.701 1.00 58.75 O ATOM 4796 CASP A 323 46.770 26.367 53.240 1.00 45.65 C ATOM 4797 O ASP A 323 47.82126.714 53.723 1.00 47.47 O ATOM 4798 N SER A 324 46.044 27.125 52.4381.00 43.32 N ATOM 4800 CA SER A 324 46.390 28.510 52.161 1.00 41.79 CATOM 4802 CB SER A 324 46.201 28.796 50.677 1.00 42.47 C ATOM 4805 OGSER A 324 45.674 27.663 50.062 1.00 45.77 O ATOM 4807 C SER A 324 45.53729.476 52.905 1.00 37.75 C ATOM 4808 O SER A 324 44.411 29.412 52.7731.00 37.31 O ATOM 4809 N LEU A 325 46.096 30.432 53.610 1.00 37.13 NATOM 4811 CA LEU A 325 45.334 31.298 54.493 1.00 35.04 C ATOM 4813 CBLEU A 325 46.238 32.059 55.405 1.00 35.20 C ATOM 4816 CG LEU A 32547.124 31.230 56.304 1.00 38.21 C ATOM 4818 CD1 LEU A 325 48.006 32.08857.155 1.00 38.14 C ATOM 4822 CD2 LEU A 325 46.216 30.335 57.130 1.0038.92 C ATOM 4826 C LEU A 325 44.533 32.325 53.776 1.00 33.99 C ATOM4827 O LEU A 325 43.445 32.619 54.178 1.00 32.49 O ATOM 4828 N SER A 32645.048 32.884 52.693 1.00 35.06 N ATOM 4830 CA SER A 326 44.248 33.88351.961 1.00 32.80 C ATOM 4832 CB SER A 326 44.583 35.203 52.587 1.0031.79 C ATOM 4835 OG SER A 326 44.971 36.156 51.666 1.00 32.01 O ATOM4837 C SER A 326 44.404 33.929 50.432 1.00 33.06 C ATOM 4838 O SER A 32645.192 33.247 49.857 1.00 33.84 O ATOM 4839 N ILE A 327 43.595 34.72549.773 1.00 32.82 N ATOM 4841 CA ILE A 327 43.767 34.943 48.360 1.0034.47 C ATOM 4843 CB ILE A 327 42.689 35.862 47.848 1.00 34.82 C ATOM4845 CG1 ILE A 327 41.498 35.102 47.344 1.00 36.75 C ATOM 4848 CD1 ILE A327 40.210 35.936 47.450 1.00 39.37 C ATOM 4852 CG2 ILE A 327 43.07236.537 46.591 1.00 38.67 C ATOM 4856 C ILE A 327 45.050 35.640 48.3201.00 34.57 C ATOM 4857 O ILE A 327 45.288 36.446 49.182 1.00 34.42 OATOM 4858 N ASN A 328 45.886 35.347 47.332 1.00 36.41 N ATOM 4860 CA ASNA 328 47.298 35.754 47.372 1.00 37.37 C ATOM 4862 CB ASN A 328 48.00235.038 48.522 1.00 37.48 C ATOM 4865 CG ASN A 328 48.542 33.692 48.1731.00 39.49 C ATOM 4866 OD1 ASN A 328 49.033 33.448 47.064 1.00 46.88 OATOM 4867 ND2 ASN A 328 48.542 32.803 49.165 1.00 39.97 N ATOM 4870 CASN A 328 48.051 35.653 46.050 1.00 39.52 C ATOM 4871 O ASN A 328 47.56935.036 45.117 1.00 40.76 O ATOM 4872 N ALA A 329 49.204 36.297 45.9221.00 41.21 N ATOM 4874 CA ALA A 329 49.894 36.340 44.585 1.00 44.38 CATOM 4876 CB ALA A 329 51.307 36.867 44.702 1.00 46.80 C ATOM 4880 C ALAA 329 49.981 35.028 43.836 1.00 45.40 C ATOM 4881 O ALA A 329 49.79934.986 42.642 1.00 45.54 O ATOM 4882 N THR A 330 50.308 33.986 44.5771.00 45.70 N ATOM 4884 CA THR A 330 50.416 32.677 44.025 1.00 48.70 CATOM 4886 CB THR A 330 50.997 31.669 45.089 1.00 49.87 C ATOM 4888 OG1THR A 330 52.331 32.048 45.543 1.00 51.51 O ATOM 4890 CG2 THR A 33051.204 30.298 44.458 1.00 50.43 C ATOM 4894 C THR A 330 49.057 32.21243.479 1.00 47.89 C ATOM 4895 O THR A 330 48.914 31.950 42.295 1.0051.27 O ATOM 4896 N ASN A 331 48.053 32.168 44.321 1.00 44.82 N ATOM4898 CA ASN A 331 46.806 31.518 43.978 1.00 43.96 C ATOM 4900 CB ASN A331 46.163 30.942 45.241 1.00 41.18 C ATOM 4903 CG ASN A 331 45.82532.001 46.294 1.00 38.02 C ATOM 4904 OD1 ASN A 331 45.247 33.040 46.0211.00 35.91 O ATOM 4905 ND2 ASN A 331 46.133 31.684 47.528 1.00 38.74 NATOM 4908 C ASN A 331 45.750 32.358 43.246 1.00 44.04 C ATOM 4909 O ASNA 331 44.746 31.828 42.838 1.00 43.86 O ATOM 4910 N ILE A 332 45.93033.662 43.099 1.00 43.98 N ATOM 4912 CA ILE A 332 44.823 34.466 42.6321.00 42.84 C ATOM 4914 CB ILE A 332 45.126 35.929 42.836 1.00 42.58 CATOM 4916 CG1 ILE A 332 44.037 36.797 42.283 1.00 44.23 C ATOM 4919 CD1ILE A 332 43.052 37.052 43.195 1.00 43.72 C ATOM 4923 CG2 ILE A 33246.249 36.384 42.012 1.00 47.11 C ATOM 4927 C ILE A 332 44.578 34.12841.178 1.00 45.50 C ATOM 4928 O ILE A 332 43.489 34.240 40.691 1.0045.59 O ATOM 4929 N LYS A 333 45.597 33.700 40.442 1.00 49.20 N ATOM4931 CA LYS A 333 45.375 33.357 39.021 1.00 51.11 C ATOM 4933 CB LYS A333 46.690 33.013 38.339 1.00 54.36 C ATOM 4936 CG LYS A 333 47.40631.694 38.725 1.00 57.01 C ATOM 4939 CD LYS A 333 48.821 31.590 37.9591.00 62.54 C ATOM 4942 CE LYS A 333 49.910 30.629 38.656 1.00 65.67 CATOM 4945 NZ LYS A 333 50.727 29.668 37.638 1.00 68.40 N ATOM 4949 C LYSA 333 44.323 32.280 38.822 1.00 50.34 C ATOM 4950 O LYS A 333 43.58232.338 37.868 1.00 51.26 O ATOM 4951 N HIS A 334 44.258 31.317 39.7381.00 49.08 N ATOM 4953 CA HIS A 334 43.312 30.206 39.685 1.00 49.27 CATOM 4955 CB HIS A 334 43.659 29.165 40.744 1.00 48.44 C ATOM 4958 CGHIS A 334 44.980 28.524 40.539 1.00 53.18 C ATOM 4959 ND1 HIS A 33445.158 27.442 39.698 1.00 59.88 N ATOM 4961 CE1 HIS A 334 46.441 27.11939.674 1.00 62.27 C ATOM 4963 NE2 HIS A 334 47.095 27.941 40.481 1.0059.52 N ATOM 4965 CD2 HIS A 334 46.199 28.819 41.045 1.00 54.75 C ATOM4967 C HIS A 334 41.853 30.601 39.909 1.00 47.75 C ATOM 4968 O HIS A 33440.986 29.750 39.847 1.00 48.67 O ATOM 4969 N PHE A 335 41.579 31.87440.217 1.00 46.14 N ATOM 4971 CA PHE A 335 40.196 32.413 40.254 1.0044.55 C ATOM 4973 CB PHE A 335 40.053 33.427 41.378 1.00 41.24 C ATOM4976 CG PHE A 335 40.055 32.827 42.681 1.00 39.32 C ATOM 4977 CD1 PHE A335 41.223 32.551 43.307 1.00 39.57 C ATOM 4979 CE1 PHE A 335 41.22231.936 44.525 1.00 40.84 C ATOM 4981 CZ PHE A 335 40.043 31.617 45.1041.00 41.14 C ATOM 4983 CE2 PHE A 335 38.863 31.842 44.455 1.00 40.09 CATOM 4985 CD2 PHE A 335 38.876 32.428 43.255 1.00 40.14 C ATOM 4987 CPHE A 335 39.687 33.101 38.960 1.00 46.58 C ATOM 4988 O PHE A 335 38.62033.706 39.041 1.00 45.62 O ATOM 4989 N LYS A 336 40.399 32.984 37.8191.00 48.98 N ATOM 4991 CA LYS A 336 40.046 33.678 36.590 1.00 51.49 CATOM 4993 CB LYS A 336 41.121 33.576 35.481 1.00 53.28 C ATOM 5000 C LYSA 336 38.721 33.111 36.086 1.00 53.24 C ATOM 5001 O LYS A 336 38.57831.885 35.942 1.00 55.91 O ATOM 5002 N ASN A 337 37.749 33.990 35.8371.00 52.95 N ATOM 5004 CA ASN A 337 36.461 33.566 35.321 1.00 54.28 CATOM 5006 CB ASN A 337 36.652 32.725 34.105 1.00 57.90 C ATOM 5009 CGASN A 337 37.513 33.373 33.127 1.00 61.13 C ATOM 5010 OD1 ASN A 33737.278 34.525 32.791 1.00 60.64 O ATOM 5011 ND2 ASN A 337 38.553 32.66232.664 1.00 67.20 N ATOM 5014 C ASN A 337 35.581 32.785 36.259 1.0052.45 C ATOM 5015 O ASN A 337 34.540 32.290 35.832 1.00 52.89 O ATOM5016 N CYS A 338 35.970 32.691 37.527 1.00 49.80 N ATOM 5018 CA CYS A338 35.126 32.034 38.473 1.00 49.56 C ATOM 5020 CB CYS A 338 35.80331.803 39.799 1.00 47.52 C ATOM 5023 SG CYS A 338 37.211 30.611 39.5081.00 59.20 S ATOM 5024 C CYS A 338 33.979 32.932 38.628 1.00 47.35 CATOM 5025 O CYS A 338 34.130 34.149 38.726 1.00 46.23 O ATOM 5026 N THRA 339 32.834 32.301 38.627 1.00 46.93 N ATOM 5028 CA THR A 339 31.59932.968 38.809 1.00 47.23 C ATOM 5030 CB THR A 339 30.770 32.593 37.6221.00 50.51 C ATOM 5032 OG1 THR A 339 30.642 33.782 36.857 1.00 53.34 OATOM 5034 CG2 THR A 339 29.337 32.064 37.962 1.00 50.61 C ATOM 5038 CTHR A 339 30.930 32.648 40.135 1.00 45.18 C ATOM 5039 O THR A 339 30.24733.470 40.689 1.00 44.47 O ATOM 5040 N SER A 340 31.129 31.439 40.6321.00 45.15 N ATOM 5042 CA SER A 340 30.623 31.025 41.933 1.00 43.31 CATOM 5044 CB SER A 340 29.379 30.132 41.733 1.00 45.83 C ATOM 5047 OGSER A 340 29.249 29.081 42.698 1.00 44.04 O ATOM 5049 C SER A 340 31.70230.248 42.678 1.00 41.72 C ATOM 5050 O SER A 340 32.352 29.358 42.1301.00 43.56 O ATOM 5051 N ILE A 341 31.840 30.554 43.938 1.00 38.97 NATOM 5053 CA ILE A 341 32.891 30.013 44.722 1.00 38.11 C ATOM 5055 CBILE A 341 33.577 31.124 45.410 1.00 36.26 C ATOM 5057 CG1 ILE A 34134.447 31.785 44.365 1.00 37.48 C ATOM 5060 CD1 ILE A 341 34.986 32.99744.783 1.00 39.65 C ATOM 5064 CG2 ILE A 341 34.370 30.578 46.573 1.0036.38 C ATOM 5068 C ILE A 341 32.279 29.147 45.704 1.00 38.22 C ATOM5069 O ILE A 341 31.424 29.588 46.497 1.00 36.50 O ATOM 5070 N SER A 34232.702 27.897 45.679 1.00 40.02 N ATOM 5072 CA SER A 342 32.138 26.94646.612 1.00 41.56 C ATOM 5074 CB SER A 342 31.753 25.639 45.909 1.0044.24 C ATOM 5077 OG SER A 342 32.513 24.550 46.357 1.00 49.61 O ATOM5079 C SER A 342 33.114 26.871 47.782 1.00 39.51 C ATOM 5080 O SER A 34234.143 26.269 47.719 1.00 40.40 O ATOM 5081 N GLY A 343 32.762 27.57848.840 1.00 38.27 N ATOM 5083 CA GLY A 343 33.645 27.834 49.938 1.0037.00 C ATOM 5086 C GLY A 343 33.681 29.322 50.263 1.00 35.53 C ATOM5087 O GLY A 343 32.754 30.074 49.877 1.00 34.59 O ATOM 5088 N ASP A 34434.775 29.727 50.970 1.00 34.54 N ATOM 5090 CA ASP A 344 34.920 31.07051.544 1.00 32.00 C ATOM 5092 CB ASP A 344 35.234 30.977 53.032 1.0031.72 C ATOM 5095 CG ASP A 344 34.574 29.830 53.703 1.00 34.32 C ATOM5096 OD1 ASP A 344 33.317 29.772 53.622 1.00 41.66 O ATOM 5097 OD2 ASP A344 35.178 28.928 54.346 1.00 35.55 O ATOM 5098 C ASP A 344 36.02531.826 50.797 1.00 30.48 C ATOM 5099 O ASP A 344 36.853 31.209 50.2041.00 31.17 O ATOM 5100 N LEU A 345 35.995 33.146 50.824 1.00 28.65 NATOM 5102 CA LEU A 345 37.056 33.969 50.344 1.00 29.65 C ATOM 5104 CBLEU A 345 36.479 34.951 49.381 1.00 31.28 C ATOM 5107 CG LEU A 34536.877 35.111 47.916 1.00 34.49 C ATOM 5109 CD1 LEU A 345 37.260 33.82547.393 1.00 39.14 C ATOM 5113 CD2 LEU A 345 35.690 35.571 47.155 1.0033.77 C ATOM 5117 C LEU A 345 37.580 34.737 51.548 1.00 29.18 C ATOM5118 O LEU A 345 36.784 35.296 52.295 1.00 29.37 O ATOM 5119 N HIS A 34638.882 34.655 51.810 1.00 29.00 N ATOM 5121 CA HIS A 346 39.552 35.40952.838 1.00 28.13 C ATOM 5123 CB HIS A 346 40.486 34.542 53.655 1.0029.47 C ATOM 5126 CG HIS A 346 39.875 33.338 54.278 1.00 30.10 C ATOM5127 ND1 HIS A 346 38.833 33.396 55.118 1.00 35.14 N ATOM 5129 CE1 HIS A346 38.538 32.196 55.572 1.00 35.47 C ATOM 5131 NE2 HIS A 346 39.39131.361 55.089 1.00 32.97 N ATOM 5133 CD2 HIS A 346 40.268 32.060 54.3111.00 36.36 C ATOM 5135 C HIS A 346 40.552 36.345 52.173 1.00 29.15 CATOM 5136 O HIS A 346 41.448 35.896 51.405 1.00 29.88 O ATOM 5137 N ILEA 347 40.509 37.629 52.497 1.00 28.56 N ATOM 5139 CA ILE A 347 41.53738.505 52.005 1.00 28.80 C ATOM 5141 CB ILE A 347 40.914 39.548 51.1751.00 28.20 C ATOM 5143 CG1 ILE A 347 40.355 38.876 49.939 1.00 28.97 CATOM 5146 CD1 ILE A 347 39.286 39.729 49.225 1.00 31.16 C ATOM 5150 CG2ILE A 347 41.951 40.589 50.781 1.00 29.70 C ATOM 5154 C ILE A 347 42.24839.072 53.183 1.00 28.89 C ATOM 5155 O ILE A 347 41.697 39.924 53.8101.00 29.99 O ATOM 5156 N LEU A 348 43.443 38.605 53.524 1.00 30.00 NATOM 5158 CA LEU A 348 44.077 39.025 54.787 1.00 30.57 C ATOM 5160 CBLEU A 348 44.555 37.886 55.605 1.00 30.53 C ATOM 5163 CG LEU A 34843.596 36.715 55.576 1.00 31.50 C ATOM 5165 CD1 LEU A 348 44.246 35.48256.211 1.00 32.92 C ATOM 5169 CD2 LEU A 348 42.330 37.083 56.215 1.0031.99 C ATOM 5173 C LEU A 348 45.246 39.881 54.475 1.00 32.43 C ATOM5174 O LEU A 348 45.607 39.970 53.337 1.00 34.49 O ATOM 5175 N PRO A 34945.778 40.592 55.455 1.00 32.87 N ATOM 5176 CA PRO A 349 46.973 41.38155.264 1.00 33.99 C ATOM 5178 CB PRO A 349 47.271 41.886 56.659 1.0034.22 C ATOM 5181 CG PRO A 349 45.966 42.137 57.153 1.00 34.18 C ATOM5184 CD PRO A 349 45.163 40.881 56.755 1.00 32.82 C ATOM 5187 C PRO A349 48.124 40.614 54.726 1.00 35.54 C ATOM 5188 O PRO A 349 48.89341.228 53.933 1.00 37.23 O ATOM 5189 N VAL A 350 48.295 39.356 55.1241.00 35.44 N ATOM 5191 CA VAL A 350 49.450 38.608 54.559 1.00 37.52 CATOM 5193 CB VAL A 350 49.454 37.117 54.856 1.00 37.63 C ATOM 5195 CG1VAL A 350 50.325 36.871 55.983 1.00 39.53 C ATOM 5199 CG2 VAL A 35048.030 36.560 55.008 1.00 35.14 C ATOM 5203 C VAL A 350 49.551 38.67253.016 1.00 37.28 C ATOM 5204 O VAL A 350 50.644 38.668 52.452 1.0037.00 O ATOM 5205 N ALA A 351 48.386 38.692 52.387 1.00 34.61 N ATOM5207 CA ALA A 351 48.304 38.858 50.982 1.00 35.88 C ATOM 5209 CB ALA A351 46.880 39.055 50.584 1.00 34.44 C ATOM 5213 C ALA A 351 49.13640.024 50.514 1.00 37.47 C ATOM 5214 O ALA A 351 50.006 39.864 49.7101.00 38.97 O ATOM 5215 N PHE A 352 48.843 41.210 51.010 1.00 37.79 NATOM 5217 CA PHE A 352 49.495 42.407 50.491 1.00 39.28 C ATOM 5219 CBPHE A 352 48.674 43.607 50.839 1.00 37.35 C ATOM 5222 CG PHE A 35247.296 43.459 50.390 1.00 35.68 C ATOM 5223 CD1 PHE A 352 46.310 43.14651.249 1.00 35.62 C ATOM 5225 CE1 PHE A 352 45.040 42.971 50.821 1.0035.56 C ATOM 5227 CZ PHE A 352 44.760 43.037 49.504 1.00 37.20 C ATOM5229 CE2 PHE A 352 45.774 43.277 48.616 1.00 38.11 C ATOM 5231 CD2 PHE A352 47.016 43.468 49.070 1.00 38.39 C ATOM 5233 C PHE A 352 50.91242.564 50.942 1.00 42.10 C ATOM 5234 O PHE A 352 51.661 43.264 50.3081.00 45.13 O ATOM 5235 N ARG A 353 51.318 41.916 52.018 1.00 42.10 NATOM 5237 CA ARG A 353 52.706 42.048 52.408 1.00 44.35 C ATOM 5239 CBARG A 353 52.810 42.476 53.863 1.00 44.18 C ATOM 5242 CG ARG A 35352.838 41.475 54.889 1.00 45.56 C ATOM 5245 CD ARG A 353 52.340 41.99356.328 1.00 46.05 C ATOM 5248 NE ARG A 353 51.908 40.792 57.076 1.0048.23 N ATOM 5250 CZ ARG A 353 50.904 40.702 57.958 1.00 49.69 C ATOM5251 NH1 ARG A 353 50.159 41.766 58.367 1.00 48.00 N ATOM 5254 NH2 ARG A353 50.644 39.490 58.462 1.00 51.85 N ATOM 5257 C ARG A 353 53.60640.883 52.034 1.00 45.87 C ATOM 5258 O ARG A 353 54.793 40.995 52.1131.00 49.79 O ATOM 5259 N GLY A 354 53.077 39.819 51.471 1.00 44.58 NATOM 5261 CA GLY A 354 53.844 38.608 51.326 1.00 45.57 C ATOM 5264 C GLYA 354 54.077 37.881 52.646 1.00 45.59 C ATOM 5265 O GLY A 354 53.79538.404 53.757 1.00 44.40 O ATOM 5266 N ASP A 355 54.560 36.657 52.4891.00 47.02 N ATOM 5268 CA ASP A 355 54.875 35.747 53.559 1.00 49.26 CATOM 5270 CB ASP A 355 53.675 34.810 53.761 1.00 47.45 C ATOM 5273 CGASP A 355 53.819 33.857 54.999 1.00 52.55 C ATOM 5274 OD1 ASP A 35554.748 33.966 55.843 1.00 52.58 O ATOM 5275 OD2 ASP A 355 52.964 32.94555.218 1.00 57.12 O ATOM 5276 C ASP A 355 56.184 34.963 53.184 1.0052.90 C ATOM 5277 O ASP A 355 56.230 34.283 52.193 1.00 53.38 O ATOM5278 N SER A 356 57.257 35.097 53.951 1.00 55.22 N ATOM 5280 CA SER A356 58.449 34.379 53.620 1.00 59.39 C ATOM 5282 CB SER A 356 59.69335.013 54.276 1.00 62.91 C ATOM 5285 OG SER A 356 59.657 34.911 55.6881.00 63.67 O ATOM 5287 C SER A 356 58.280 32.920 54.042 1.00 59.92 CATOM 5288 O SER A 356 58.935 31.998 53.497 1.00 62.62 O ATOM 5289 N PHEA 357 57.411 32.695 55.015 1.00 57.30 N ATOM 5291 CA PHE A 357 57.30331.355 55.591 1.00 58.59 C ATOM 5293 CB PHE A 357 56.605 31.427 56.9641.00 57.36 C ATOM 5296 CG PHE A 357 57.294 32.421 57.919 1.00 60.90 CATOM 5297 CD1 PHE A 357 56.748 33.697 58.164 1.00 59.90 C ATOM 5299 CE1PHE A 357 57.381 34.597 59.001 1.00 62.61 C ATOM 5301 CZ PHE A 35758.620 34.277 59.612 1.00 66.42 C ATOM 5303 CE2 PHE A 357 59.197 33.03459.358 1.00 70.78 C ATOM 5305 CD2 PHE A 357 58.530 32.102 58.516 1.0068.20 C ATOM 5307 C PHE A 357 56.638 30.400 54.612 1.00 57.26 C ATOM5308 O PHE A 357 56.959 29.213 54.566 1.00 59.38 O ATOM 5309 N THR A 35855.781 30.990 53.792 1.00 53.74 N ATOM 5311 CA THR A 358 54.993 30.31752.788 1.00 52.07 C ATOM 5313 CB THR A 358 53.638 30.968 52.871 1.0048.69 C ATOM 5315 OG1 THR A 358 52.917 30.251 53.847 1.00 49.41 O ATOM5317 CG2 THR A 358 52.782 30.701 51.766 1.00 49.09 C ATOM 5321 C THR A358 55.512 30.469 51.384 1.00 52.42 C ATOM 5322 O THR A 358 54.93629.873 50.469 1.00 50.78 O ATOM 5323 N HIS A 359 56.595 31.258 51.2521.00 53.66 N ATOM 5325 CA HIS A 359 57.166 31.739 49.989 1.00 54.99 CATOM 5327 CB HIS A 359 57.756 30.604 49.243 1.00 57.50 C ATOM 5330 CGHIS A 359 58.370 29.588 50.107 1.00 58.68 C ATOM 5331 ND1 HIS A 35959.709 29.584 50.363 1.00 63.58 N ATOM 5333 CE1 HIS A 359 60.000 28.53951.119 1.00 64.70 C ATOM 5335 NE2 HIS A 359 58.883 27.896 51.392 1.0061.34 N ATOM 5337 CD2 HIS A 359 57.855 28.510 50.738 1.00 58.13 C ATOM5339 C HIS A 359 56.194 32.451 49.042 1.00 52.38 C ATOM 5340 O HIS A 35956.192 32.210 47.892 1.00 53.48 O ATOM 5341 N THR A 360 55.402 33.35949.534 1.00 50.00 N ATOM 5343 CA THR A 360 54.434 34.040 48.722 1.0048.70 C ATOM 5345 CB THR A 360 53.195 33.835 49.430 1.00 45.16 C ATOM5347 OG1 THR A 360 52.938 32.444 49.359 1.00 46.70 O ATOM 5349 CG2 THR A360 52.036 34.453 48.731 1.00 44.91 C ATOM 5353 C THR A 360 54.78635.512 48.561 1.00 48.92 C ATOM 5354 O THR A 360 54.978 36.188 49.5331.00 48.33 O ATOM 5355 N PRO A 361 55.010 35.986 47.351 1.00 50.79 NATOM 5356 CA PRO A 361 55.426 37.375 47.190 1.00 51.83 C ATOM 5358 CBPRO A 361 55.759 37.484 45.706 1.00 54.65 C ATOM 5361 CG PRO A 36155.333 36.260 45.089 1.00 54.61 C ATOM 5364 CD PRO A 361 55.017 35.24846.088 1.00 52.35 C ATOM 5367 C PRO A 361 54.285 38.263 47.500 1.0048.71 C ATOM 5368 O PRO A 361 53.182 37.783 47.427 1.00 47.40 O ATOM5369 N PRO A 362 54.507 39.526 47.794 1.00 48.27 N ATOM 5370 CA PRO A362 53.421 40.468 47.950 1.00 46.05 C ATOM 5372 CB PRO A 362 54.16241.791 48.029 1.00 47.43 C ATOM 5375 CG PRO A 362 55.417 41.523 47.7891.00 49.64 C ATOM 5378 CD PRO A 362 55.780 40.167 48.028 1.00 50.35 CATOM 5381 C PRO A 362 52.473 40.437 46.765 1.00 45.74 C ATOM 5382 O PROA 362 52.943 40.284 45.696 1.00 49.40 O ATOM 5383 N LEU A 363 51.18940.595 46.966 1.00 44.33 N ATOM 5385 CA LEU A 363 50.174 40.533 45.9201.00 44.66 C ATOM 5387 CB LEU A 363 48.831 40.112 46.510 1.00 41.08 CATOM 5390 CG LEU A 363 47.517 40.078 45.722 1.00 40.32 C ATOM 5392 CD1LEU A 363 47.505 39.026 44.654 1.00 41.76 C ATOM 5396 CD2 LEU A 36346.293 39.759 46.643 1.00 37.90 C ATOM 5400 C LEU A 363 49.957 41.90445.321 1.00 46.91 C ATOM 5401 O LEU A 363 49.602 42.858 46.011 1.0046.28 O ATOM 5402 N ASP A 364 50.142 41.990 44.006 1.00 50.07 N ATOM5404 CA ASP A 364 49.742 43.191 43.278 1.00 50.91 C ATOM 5406 CB ASP A364 50.197 43.079 41.819 1.00 54.23 C ATOM 5409 CG ASP A 364 49.88144.322 40.987 1.00 56.02 C ATOM 5410 OD1 ASP A 364 49.213 45.282 41.5021.00 50.42 O ATOM 5411 OD2 ASP A 364 50.278 44.378 39.776 1.00 60.00 OATOM 5412 C ASP A 364 48.221 43.399 43.404 1.00 47.27 C ATOM 5413 O ASPA 364 47.433 42.672 42.883 1.00 45.88 O ATOM 5414 N PRO A 365 47.82144.436 44.058 1.00 46.25 N ATOM 5415 CA PRO A 365 46.404 44.751 44.1661.00 45.25 C ATOM 5417 CB PRO A 365 46.408 46.030 44.972 1.00 45.77 CATOM 5420 CG PRO A 365 47.706 45.971 45.683 1.00 46.71 C ATOM 5423 CDPRO A 365 48.660 45.428 44.709 1.00 47.17 C ATOM 5426 C PRO A 365 45.61045.003 42.889 1.00 47.18 C ATOM 5427 O PRO A 365 44.431 44.806 43.0031.00 46.77 O ATOM 5428 N GLN A 366 46.155 45.502 41.778 1.00 50.90 NATOM 5430 CA GLN A 366 45.415 45.498 40.507 1.00 52.74 C ATOM 5432 CBGLN A 366 46.289 45.759 39.264 1.00 56.32 C ATOM 5439 C GLN A 366 44.77944.131 40.329 1.00 51.62 C ATOM 5440 O GLN A 366 43.737 44.006 39.6861.00 53.12 O ATOM 5441 N GLU A 367 45.392 43.090 40.873 1.00 49.93 NATOM 5443 CA GLU A 367 44.957 41.743 40.530 1.00 49.07 C ATOM 5445 CBGLU A 367 46.016 40.748 40.955 1.00 49.47 C ATOM 5448 CG GLU A 36747.254 40.827 40.170 1.00 55.32 C ATOM 5451 CD GLU A 367 47.521 39.53739.415 1.00 65.30 C ATOM 5452 OE1 GLU A 367 47.045 39.472 38.236 1.0071.91 O ATOM 5453 OE2 GLU A 367 48.219 38.601 39.984 1.00 69.48 O ATOM5454 C GLU A 367 43.609 41.341 41.121 1.00 44.37 C ATOM 5455 O GLU A 36743.026 40.320 40.783 1.00 43.44 O ATOM 5456 N LEU A 368 43.146 42.12242.045 1.00 41.59 N ATOM 5458 CA LEU A 368 41.862 41.872 42.622 1.0039.34 C ATOM 5460 CB LEU A 368 41.649 42.755 43.821 1.00 37.40 C ATOM5463 CG LEU A 368 42.571 42.306 44.922 1.00 37.05 C ATOM 5465 CD1 LEU A368 42.591 43.311 46.006 1.00 37.85 C ATOM 5469 CD2 LEU A 368 42.13640.982 45.456 1.00 37.21 C ATOM 5473 C LEU A 368 40.775 42.088 41.6121.00 40.58 C ATOM 5474 O LEU A 368 39.749 41.513 41.759 1.00 39.88 OATOM 5475 N ASP A 369 41.013 42.861 40.558 1.00 44.30 N ATOM 5477 CA ASPA 369 40.101 42.958 39.417 1.00 46.16 C ATOM 5479 CB ASP A 369 40.75243.678 38.251 1.00 50.23 C ATOM 5482 CG ASP A 369 41.010 45.227 38.5061.00 55.84 C ATOM 5483 OD1 ASP A 369 40.507 45.849 39.505 1.00 57.91 OATOM 5484 OD2 ASP A 369 41.782 45.893 37.753 1.00 60.79 O ATOM 5485 CASP A 369 39.621 41.612 38.939 1.00 45.71 C ATOM 5486 O ASP A 369 38.53141.537 38.475 1.00 46.84 O ATOM 5487 N ILE A 370 40.412 40.553 39.0671.00 45.58 N ATOM 5489 CA ILE A 370 40.011 39.148 38.769 1.00 46.13 CATOM 5491 CB ILE A 370 41.135 38.210 39.219 1.00 46.46 C ATOM 5493 CG1ILE A 370 42.075 37.803 38.072 1.00 50.66 C ATOM 5496 CD1 ILE A 37043.582 37.835 38.532 1.00 51.51 C ATOM 5500 CG2 ILE A 370 40.622 36.94939.735 1.00 47.70 C ATOM 5504 C ILE A 370 38.727 38.626 39.419 1.0043.97 C ATOM 5505 O ILE A 370 37.935 37.986 38.824 1.00 45.31 O ATOM5506 N LEU A 371 38.532 38.885 40.675 1.00 41.68 N ATOM 5508 CA LEU A371 37.290 38.530 41.354 1.00 39.69 C ATOM 5510 CB LEU A 371 37.47638.789 42.863 1.00 37.02 C ATOM 5513 CG LEU A 371 38.785 38.136 43.3521.00 36.34 C ATOM 5515 CD1 LEU A 371 39.215 38.574 44.651 1.00 34.34 CATOM 5519 CD2 LEU A 371 38.586 36.658 43.371 1.00 38.01 C ATOM 5523 CLEU A 371 36.031 39.257 40.875 1.00 40.31 C ATOM 5524 O LEU A 371 34.96238.940 41.363 1.00 38.85 O ATOM 5525 N LYS A 372 36.131 40.222 39.9591.00 42.21 N ATOM 5527 CA LYS A 372 34.932 40.898 39.422 1.00 43.84 CATOM 5529 CB LYS A 372 35.285 41.942 38.377 1.00 46.36 C ATOM 5532 CGLYS A 372 35.513 43.305 38.954 1.00 47.88 C ATOM 5535 CD LYS A 37236.436 44.155 38.058 1.00 51.39 C ATOM 5538 CE LYS A 372 36.918 45.44938.779 1.00 53.07 C ATOM 5541 NZ LYS A 372 38.090 46.150 38.045 1.0059.80 N ATOM 5545 C LYS A 372 33.950 39.980 38.766 1.00 44.83 C ATOM5546 O LYS A 372 32.860 40.345 38.495 1.00 45.62 O ATOM 5547 N THR A 37334.355 38.775 38.458 1.00 46.35 N ATOM 5549 CA THR A 373 33.487 37.81537.799 1.00 47.94 C ATOM 5551 CB THR A 373 34.382 36.802 37.192 1.0048.66 C ATOM 5553 OG1 THR A 373 35.052 37.419 36.130 1.00 51.06 O ATOM5555 CG2 THR A 373 33.564 35.865 36.391 1.00 55.55 C ATOM 5559 C THR A373 32.508 37.084 38.700 1.00 45.96 C ATOM 5560 O THR A 373 31.61736.372 38.216 1.00 48.41 O ATOM 5561 N VAL A 374 32.706 37.253 39.9981.00 42.63 N ATOM 5563 CA VAL A 374 32.140 36.424 41.020 1.00 40.86 CATOM 5565 CB VAL A 374 33.088 36.339 42.283 1.00 38.33 C ATOM 5567 CG1VAL A 374 32.534 35.381 43.293 1.00 37.92 C ATOM 5571 CG2 VAL A 37434.458 35.804 41.921 1.00 38.98 C ATOM 5575 C VAL A 374 30.751 36.89341.416 1.00 40.06 C ATOM 5576 O VAL A 374 30.539 38.005 41.826 1.0039.99 O ATOM 5577 N LYS A 375 29.823 35.983 41.353 1.00 40.81 N ATOM5579 CA LYS A 375 28.452 36.273 41.649 1.00 42.35 C ATOM 5581 CB LYS A375 27.541 35.795 40.477 1.00 46.59 C ATOM 5584 CG LYS A 375 27.77736.549 39.090 1.00 50.24 C ATOM 5587 CD LYS A 375 26.669 36.227 38.0591.00 57.80 C ATOM 5590 CE LYS A 375 27.128 36.178 36.545 1.00 62.46 CATOM 5593 NZ LYS A 375 26.016 36.062 35.526 1.00 61.68 N ATOM 5597 C LYSA 375 28.008 35.654 42.952 1.00 40.06 C ATOM 5598 O LYS A 375 27.17336.205 43.624 1.00 39.08 O ATOM 5599 N GLU A 376 28.528 34.503 43.3091.00 39.23 N ATOM 5601 CA GLU A 376 28.081 33.914 44.552 1.00 39.53 CATOM 5603 CB GLU A 376 26.947 32.867 44.334 1.00 41.78 C ATOM 5606 CGGLU A 376 27.373 31.519 43.819 1.00 44.47 C ATOM 5609 CD GLU A 37626.253 30.494 43.764 1.00 47.77 C ATOM 5610 OE1 GLU A 376 25.436 30.49544.646 1.00 51.29 O ATOM 5611 OE2 GLU A 376 26.180 29.681 42.851 1.0049.03 O ATOM 5612 C GLU A 376 29.214 33.326 45.341 1.00 37.53 C ATOM5613 O GLU A 376 30.135 32.819 44.752 1.00 38.28 O ATOM 5614 N LEU A 37729.159 33.465 46.662 1.00 35.71 N ATOM 5616 CA LEU A 377 29.980 32.69547.555 1.00 35.03 C ATOM 5618 CB LEU A 377 30.888 33.582 48.445 1.0032.95 C ATOM 5621 CG LEU A 377 31.383 34.875 47.722 1.00 32.32 C ATOM5623 CD1 LEU A 377 32.373 35.705 48.488 1.00 30.13 C ATOM 5627 CD2 LEU A377 32.034 34.537 46.491 1.00 36.27 C ATOM 5631 C LEU A 377 29.00131.854 48.361 1.00 36.88 C ATOM 5632 O LEU A 377 28.064 32.351 48.9831.00 37.14 O ATOM 5633 N THR A 378 29.199 30.548 48.278 1.00 38.82 NATOM 5635 CA THR A 378 28.558 29.513 49.108 1.00 39.57 C ATOM 5637 CBTHR A 378 29.221 28.290 48.593 1.00 41.13 C ATOM 5639 OG1 THR A 37828.353 27.866 47.593 1.00 41.94 O ATOM 5641 CG2 THR A 378 29.395 27.05649.550 1.00 44.08 C ATOM 5645 C THR A 378 28.753 29.721 50.604 1.0037.78 C ATOM 5646 O THR A 378 27.843 29.535 51.415 1.00 36.72 O ATOM5647 N GLY A 379 29.962 30.195 50.908 1.00 36.56 N ATOM 5649 CA GLY A379 30.487 30.357 52.264 1.00 35.72 C ATOM 5652 C GLY A 379 30.46831.774 52.761 1.00 33.26 C ATOM 5653 O GLY A 379 29.453 32.421 52.7441.00 34.48 O ATOM 5654 N PHE A 380 31.604 32.269 53.181 1.00 31.43 NATOM 5656 CA PHE A 380 31.641 33.606 53.748 1.00 30.14 C ATOM 5658 CBPHE A 380 31.949 33.563 55.237 1.00 29.78 C ATOM 5661 CG PHE A 38033.326 33.040 55.606 1.00 28.19 C ATOM 5662 CD1 PHE A 380 34.468 33.85655.512 1.00 26.22 C ATOM 5664 CE1 PHE A 380 35.680 33.405 55.974 1.0025.15 C ATOM 5666 CZ PHE A 380 35.755 32.140 56.510 1.00 26.34 C ATOM5668 CE2 PHE A 380 34.631 31.325 56.573 1.00 27.52 C ATOM 5670 CD2 PHE A380 33.459 31.771 56.148 1.00 27.63 C ATOM 5672 C PHE A 380 32.64934.455 53.086 1.00 28.80 C ATOM 5673 O PHE A 380 33.535 33.928 52.4141.00 30.25 O ATOM 5674 N LEU A 381 32.580 35.737 53.345 1.00 26.76 NATOM 5676 CA LEU A 381 33.462 36.629 52.687 1.00 27.56 C ATOM 5678 CBLEU A 381 32.671 37.545 51.773 1.00 27.59 C ATOM 5681 CG LEU A 38133.418 38.759 51.282 1.00 28.54 C ATOM 5683 CD1 LEU A 381 34.748 38.29850.721 1.00 30.46 C ATOM 5687 CD2 LEU A 381 32.616 39.439 50.209 1.0032.21 C ATOM 5691 C LEU A 381 34.189 37.411 53.743 1.00 27.21 C ATOM5692 O LEU A 381 33.594 38.246 54.431 1.00 28.39 O ATOM 5693 N LEU A 38235.471 37.202 53.868 1.00 26.93 N ATOM 5695 CA LEU A 382 36.188 37.83854.953 1.00 27.83 C ATOM 5697 CB LEU A 382 36.849 36.750 55.764 1.0028.01 C ATOM 5700 CG LEU A 382 37.909 37.206 56.753 1.00 29.87 C ATOM5702 CD1 LEU A 382 37.249 38.057 57.829 1.00 31.23 C ATOM 5706 CD2 LEU A382 38.571 36.020 57.423 1.00 29.60 C ATOM 5710 C LEU A 382 37.23938.826 54.424 1.00 27.94 C ATOM 5711 O LEU A 382 38.189 38.425 53.7701.00 28.55 O ATOM 5712 N ILE A 383 37.106 40.104 54.738 1.00 28.44 NATOM 5714 CA ILE A 383 37.992 41.136 54.168 1.00 29.01 C ATOM 5716 CBILE A 383 37.182 42.076 53.298 1.00 30.11 C ATOM 5718 CG1 ILE A 38336.362 41.266 52.311 1.00 31.00 C ATOM 5721 CD1 ILE A 383 35.938 42.13651.127 1.00 32.70 C ATOM 5725 CG2 ILE A 383 38.119 43.072 52.508 1.0029.84 C ATOM 5729 C ILE A 383 38.695 41.952 55.210 1.00 28.25 C ATOM5730 O ILE A 383 38.130 42.865 55.743 1.00 27.90 O ATOM 5731 N GLN A 38439.944 41.635 55.486 1.00 28.72 N ATOM 5733 CA GLN A 384 40.640 42.23256.611 1.00 28.78 C ATOM 5735 CB GLN A 384 41.213 41.148 57.429 1.0028.34 C ATOM 5738 CG GLN A 384 40.192 40.473 58.315 1.00 27.69 C ATOM5741 CD GLN A 384 40.787 39.489 59.310 1.00 25.79 C ATOM 5742 OE1 GLN A384 41.947 39.167 59.277 1.00 29.42 O ATOM 5743 NE2 GLN A 384 39.99739.070 60.220 1.00 29.85 N ATOM 5746 C GLN A 384 41.735 43.122 56.0731.00 30.69 C ATOM 5747 O GLN A 384 42.402 43.817 56.826 1.00 33.98 OATOM 5748 N ALA A 385 41.892 43.164 54.756 1.00 30.13 N ATOM 5750 CA ALAA 385 42.856 44.036 54.126 1.00 30.49 C ATOM 5752 CB ALA A 385 44.24243.332 54.044 1.00 30.62 C ATOM 5756 C ALA A 385 42.348 44.372 52.7281.00 31.09 C ATOM 5757 O ALA A 385 41.586 43.598 52.083 1.00 30.22 OATOM 5758 N TRP A 386 42.808 45.504 52.232 1.00 32.17 N ATOM 5760 CA TRPA 386 42.343 45.986 50.991 1.00 33.08 C ATOM 5762 CB TRP A 386 40.90346.412 51.231 1.00 32.74 C ATOM 5765 CG TRP A 386 40.173 46.579 50.0121.00 36.40 C ATOM 5766 CD1 TRP A 386 39.885 47.756 49.354 1.00 40.08 CATOM 5768 NE1 TRP A 386 39.158 47.478 48.227 1.00 40.21 N ATOM 5770 CE2TRP A 386 39.049 46.114 48.114 1.00 40.12 C ATOM 5771 CD2 TRP A 38639.676 45.539 49.213 1.00 35.62 C ATOM 5772 CE3 TRP A 386 39.657 44.17449.339 1.00 34.88 C ATOM 5774 CZ3 TRP A 386 39.049 43.446 48.400 1.0037.08 C ATOM 5776 CH2 TRP A 386 38.429 44.025 47.329 1.00 39.08 C ATOM5778 CZ2 TRP A 386 38.425 45.359 47.159 1.00 42.51 C ATOM 5780 C TRP A386 43.127 47.177 50.563 1.00 34.61 C ATOM 5781 O TRP A 386 43.39048.039 51.341 1.00 37.82 O ATOM 5782 N PRO A 387 43.434 47.332 49.3201.00 36.03 N ATOM 5783 CA PRO A 387 44.281 48.435 48.949 1.00 38.07 CATOM 5785 CB PRO A 387 44.323 48.312 47.443 1.00 39.84 C ATOM 5788 CGPRO A 387 43.252 47.516 47.081 1.00 38.50 C ATOM 5791 CD PRO A 38742.989 46.569 48.156 1.00 36.66 C ATOM 5794 C PRO A 387 43.736 49.78449.409 1.00 39.23 C ATOM 5795 O PRO A 387 42.603 50.184 49.169 1.0039.83 O ATOM 5796 N GLU A 388 44.573 50.483 50.137 1.00 41.44 N ATOM5798 CA GLU A 388 44.233 51.765 50.763 1.00 43.29 C ATOM 5800 CB GLU A388 45.383 52.255 51.622 1.00 45.21 C ATOM 5803 CG GLU A 388 45.56751.443 52.897 1.00 45.28 C ATOM 5806 CD GLU A 388 46.796 51.891 53.6541.00 52.65 C ATOM 5807 OE1 GLU A 388 47.893 51.297 53.459 1.00 53.52 OATOM 5808 OE2 GLU A 388 46.653 52.891 54.420 1.00 57.96 O ATOM 5809 CGLU A 388 43.796 52.887 49.862 1.00 45.35 C ATOM 5810 O GLU A 388 43.06353.764 50.284 1.00 45.89 O ATOM 5811 N ASN A 389 44.170 52.836 48.6091.00 47.38 N ATOM 5813 CA ASN A 389 43.678 53.842 47.663 1.00 50.51 CATOM 5815 CB ASN A 389 44.805 54.240 46.668 1.00 54.16 C ATOM 5818 CGASN A 389 45.254 53.045 45.796 1.00 56.14 C ATOM 5819 OD1 ASN A 38945.805 52.052 46.328 1.00 62.07 O ATOM 5820 ND2 ASN A 389 44.886 53.05544.521 1.00 57.83 N ATOM 5823 C ASN A 389 42.455 53.391 46.860 1.0049.44 C ATOM 5824 O ASN A 389 42.303 53.859 45.756 1.00 52.95 O ATOM5825 N ARG A 390 41.611 52.494 47.344 1.00 46.09 N ATOM 5827 CA ARG A390 40.371 52.217 46.649 1.00 46.76 C ATOM 5829 CB ARG A 390 40.23450.742 46.244 1.00 45.10 C ATOM 5832 CG ARG A 390 41.217 50.172 45.2851.00 47.34 C ATOM 5835 CD ARG A 390 41.438 50.956 43.977 1.00 53.54 CATOM 5838 NE ARG A 390 40.695 50.412 42.824 1.00 53.39 N ATOM 5840 CZARG A 390 39.518 50.880 42.393 1.00 54.47 C ATOM 5841 NH1 ARG A 39038.862 51.878 43.014 1.00 59.31 N ATOM 5844 NH2 ARG A 390 38.951 50.32541.362 1.00 52.63 N ATOM 5847 C ARG A 390 39.172 52.536 47.545 1.0046.14 C ATOM 5848 O ARG A 390 38.999 51.940 48.589 1.00 44.17 O ATOM5849 N THR A 391 38.283 53.411 47.114 1.00 48.34 N ATOM 5851 CA THR A391 37.246 53.899 48.039 1.00 47.56 C ATOM 5853 CB THR A 391 36.64555.201 47.543 1.00 50.22 C ATOM 5855 OG1 THR A 391 35.870 54.878 46.4031.00 51.02 O ATOM 5857 CG2 THR A 391 37.689 56.203 47.035 1.00 51.77 CATOM 5861 C THR A 391 36.102 52.893 48.239 1.00 45.74 C ATOM 5862 O THRA 391 35.269 53.087 49.121 1.00 45.03 O ATOM 5863 N ASP A 392 36.05251.812 47.467 1.00 44.71 N ATOM 5865 CA ASP A 392 35.129 50.743 47.8331.00 42.13 C ATOM 5867 CB ASP A 392 33.840 50.977 47.144 1.00 43.91 CATOM 5870 CG ASP A 392 33.994 51.000 45.722 1.00 45.23 C ATOM 5871 OD1ASP A 392 35.000 50.496 45.229 1.00 45.27 O ATOM 5872 OD2 ASP A 39233.161 51.519 45.017 1.00 46.76 O ATOM 5873 C ASP A 392 35.663 49.38547.506 1.00 40.51 C ATOM 5874 O ASP A 392 36.837 49.268 47.180 1.0042.21 O ATOM 5875 N LEU A 393 34.839 48.351 47.691 1.00 39.13 N ATOM5877 CA LEU A 393 35.208 46.964 47.389 1.00 37.38 C ATOM 5879 CB LEU A393 34.402 45.992 48.238 1.00 35.46 C ATOM 5882 CG LEU A 393 34.42546.226 49.733 1.00 34.54 C ATOM 5884 CD1 LEU A 393 33.565 45.205 50.4541.00 34.20 C ATOM 5888 CD2 LEU A 393 35.810 46.075 50.173 1.00 34.63 CATOM 5892 C LEU A 393 34.967 46.666 45.901 1.00 38.22 C ATOM 5893 O LEUA 393 34.103 45.865 45.572 1.00 38.13 O ATOM 5894 N HIS A 394 35.75247.300 45.025 1.00 38.65 N ATOM 5896 CA HIS A 394 35.460 47.287 43.6071.00 40.24 C ATOM 5898 CB HIS A 394 36.506 48.073 42.878 1.00 41.20 CATOM 5901 CG HIS A 394 37.873 47.539 43.061 1.00 43.28 C ATOM 5902 ND1HIS A 394 38.577 47.684 44.242 1.00 44.16 N ATOM 5904 CE1 HIS A 39439.754 47.091 44.108 1.00 44.04 C ATOM 5906 NE2 HIS A 394 39.820 46.53542.906 1.00 44.28 N ATOM 5908 CD2 HIS A 394 38.649 46.787 42.240 1.0044.56 C ATOM 5910 C HIS A 394 35.397 45.864 43.053 1.00 39.79 C ATOM5911 O HIS A 394 34.658 45.565 42.118 1.00 39.77 O ATOM 5912 N ALA A 39536.186 44.971 43.639 1.00 38.62 N ATOM 5914 CA ALA A 395 36.342 43.67543.038 1.00 38.76 C ATOM 5916 CB ALA A 395 37.493 43.036 43.581 1.0037.86 C ATOM 5920 C ALA A 395 35.102 42.811 43.228 1.00 38.35 C ATOM5921 O ALA A 395 34.964 41.819 42.513 1.00 39.40 O ATOM 5922 N PHE A 39634.194 43.239 44.111 1.00 36.67 N ATOM 5924 CA PHE A 396 32.986 42.52044.416 1.00 36.80 C ATOM 5926 CB PHE A 396 32.934 42.244 45.922 1.0035.11 C ATOM 5929 CG PHE A 396 34.060 41.284 46.399 1.00 34.66 C ATOM5930 CD1 PHE A 396 35.141 41.734 47.116 1.00 31.86 C ATOM 5932 CE1 PHE A396 36.149 40.871 47.508 1.00 30.93 C ATOM 5934 CZ PHE A 396 36.11239.574 47.201 1.00 31.65 C ATOM 5936 CE2 PHE A 396 35.056 39.084 46.5281.00 33.87 C ATOM 5938 CD2 PHE A 396 34.020 39.942 46.097 1.00 34.52 CATOM 5940 C PHE A 396 31.709 43.215 43.939 1.00 38.98 C ATOM 5941 O PHEA 396 30.598 42.884 44.347 1.00 40.05 O ATOM 5942 N GLU A 397 31.82844.157 43.030 1.00 41.06 N ATOM 5944 CA GLU A 397 30.664 44.849 42.4951.00 43.09 C ATOM 5946 CB GLU A 397 31.192 45.871 41.507 1.00 45.95 CATOM 5949 CG GLU A 397 31.738 45.211 40.255 1.00 49.91 C ATOM 5952 CDGLU A 397 32.326 46.179 39.236 1.00 58.00 C ATOM 5953 OE1 GLU A 39731.536 46.971 38.642 1.00 63.84 O ATOM 5954 OE2 GLU A 397 33.574 46.09838.994 1.00 59.87 O ATOM 5955 C GLU A 397 29.588 43.961 41.771 1.0044.36 C ATOM 5956 O GLU A 397 28.513 44.449 41.344 1.00 45.29 O ATOM5957 N ASN A 398 29.882 42.681 41.554 1.00 43.83 N ATOM 5959 CA ASN A398 28.902 41.797 40.905 1.00 44.75 C ATOM 5961 CB ASN A 398 29.48641.235 39.638 1.00 46.12 C ATOM 5964 CG ASN A 398 29.691 42.290 38.6131.00 46.75 C ATOM 5965 OD1 ASN A 398 28.812 43.035 38.309 1.00 50.16 OATOM 5966 ND2 ASN A 398 30.866 42.371 38.097 1.00 47.71 N ATOM 5969 CASN A 398 28.408 40.673 41.794 1.00 43.09 C ATOM 5970 O ASN A 398 27.63239.847 41.387 1.00 44.84 O ATOM 5971 N LEU A 399 28.830 40.707 43.0331.00 40.07 N ATOM 5973 CA LEU A 399 28.488 39.731 43.975 1.00 38.64 CATOM 5975 CB LEU A 399 29.387 39.940 45.179 1.00 35.59 C ATOM 5978 CGLEU A 399 29.067 39.022 46.299 1.00 34.56 C ATOM 5980 CD1 LEU A 39929.351 37.598 45.883 1.00 36.89 C ATOM 5984 CD2 LEU A 399 29.858 39.41447.436 1.00 34.33 C ATOM 5988 C LEU A 399 27.014 39.935 44.321 1.0041.17 C ATOM 5989 O LEU A 399 26.567 40.998 44.836 1.00 42.73 O ATOM5990 N GLU A 400 26.261 38.884 44.057 1.00 42.86 N ATOM 5992 CA GLU A400 24.817 38.875 44.151 1.00 44.43 C ATOM 5994 CB GLU A 400 24.27738.174 42.923 1.00 46.71 C ATOM 5997 CG GLU A 400 24.484 39.044 41.7191.00 50.19 C ATOM 6000 CD GLU A 400 24.161 38.401 40.366 1.00 56.20 CATOM 6001 OE1 GLU A 400 23.095 37.786 40.242 1.00 56.23 O ATOM 6002 OE2GLU A 400 24.980 38.579 39.408 1.00 58.34 O ATOM 6003 C GLU A 400 24.31638.192 45.421 1.00 43.67 C ATOM 6004 O GLU A 400 23.233 38.518 45.8851.00 44.99 O ATOM 6005 N ILE A 401 25.130 37.306 46.011 1.00 41.83 NATOM 6007 CA ILE A 401 24.737 36.490 47.162 1.00 40.84 C ATOM 6009 CBILE A 401 23.734 35.422 46.710 1.00 42.90 C ATOM 6011 CG1 ILE A 40123.449 34.429 47.814 1.00 43.25 C ATOM 6014 CD1 ILE A 401 22.256 33.58647.448 1.00 45.27 C ATOM 6018 CG2 ILE A 401 24.253 34.643 45.619 1.0044.73 C ATOM 6022 C ILE A 401 25.897 35.831 47.895 1.00 38.33 C ATOM6023 O ILE A 401 26.794 35.247 47.303 1.00 37.78 O ATOM 6024 N ILE A 40225.857 35.927 49.206 1.00 37.64 N ATOM 6026 CA ILE A 402 26.758 35.21950.099 1.00 35.89 C ATOM 6028 CB ILE A 402 27.313 36.190 51.117 1.0033.76 C ATOM 6030 CG1 ILE A 402 28.327 37.122 50.428 1.00 33.45 C ATOM6033 CD1 ILE A 402 28.729 38.356 51.238 1.00 30.73 C ATOM 6037 CG2 ILE A402 27.959 35.445 52.248 1.00 33.22 C ATOM 6041 C ILE A 402 25.87234.221 50.789 1.00 38.27 C ATOM 6042 O ILE A 402 25.042 34.590 51.6111.00 40.21 O ATOM 6043 N ARG A 403 25.961 32.954 50.440 1.00 39.72 NATOM 6045 CA ARG A 403 25.029 31.971 51.036 1.00 41.41 C ATOM 6047 CBARG A 403 25.094 30.665 50.280 1.00 42.06 C ATOM 6050 CG ARG A 40324.566 30.759 48.913 1.00 42.50 C ATOM 6053 CD ARG A 403 24.271 29.36148.306 1.00 45.57 C ATOM 6056 NE ARG A 403 23.861 29.447 46.910 1.0046.93 N ATOM 6058 CZ ARG A 403 22.741 30.008 46.512 1.00 49.93 C ATOM6059 NH1 ARG A 403 21.876 30.503 47.387 1.00 52.29 N ATOM 6062 NH2 ARG A403 22.461 30.068 45.235 1.00 52.68 N ATOM 6065 C ARG A 403 25.27231.712 52.541 1.00 40.44 C ATOM 6066 O ARG A 403 24.332 31.432 53.2621.00 41.87 O ATOM 6067 N GLY A 404 26.520 31.772 52.979 1.00 38.47 NATOM 6069 CA GLY A 404 26.841 31.694 54.394 1.00 38.72 C ATOM 6072 C GLYA 404 26.779 30.296 55.021 1.00 40.86 C ATOM 6073 O GLY A 404 26.52830.097 56.219 1.00 42.25 O ATOM 6074 N ARG A 405 26.982 29.284 54.2041.00 41.64 N ATOM 6076 CA ARG A 405 26.955 27.903 54.687 1.00 43.01 CATOM 6078 CB ARG A 405 27.068 27.061 53.455 1.00 44.80 C ATOM 6081 CGARG A 405 25.790 26.999 52.727 1.00 46.83 C ATOM 6084 CD ARG A 40525.923 26.159 51.460 1.00 49.83 C ATOM 6087 NE ARG A 405 24.656 26.20250.690 1.00 54.46 N ATOM 6089 CZ ARG A 405 24.534 25.597 49.539 1.0055.52 C ATOM 6090 NH1 ARG A 405 25.589 24.930 49.073 1.00 55.71 N ATOM6093 NH2 ARG A 405 23.379 25.608 48.890 1.00 59.28 N ATOM 6096 C ARG A405 28.043 27.497 55.659 1.00 40.66 C ATOM 6097 O ARG A 405 27.88126.744 56.531 1.00 41.11 O ATOM 6098 N THR A 406 29.194 27.962 55.3511.00 40.05 N ATOM 6100 CA THR A 406 30.381 28.035 56.186 1.00 40.02 CATOM 6102 CB THR A 406 31.557 27.731 55.244 1.00 39.43 C ATOM 6104 OG1THR A 406 31.310 26.463 54.715 1.00 43.84 O ATOM 6106 CG2 THR A 40632.910 27.424 55.938 1.00 43.39 C ATOM 6110 C THR A 406 30.393 29.47556.679 1.00 37.35 C ATOM 6111 O THR A 406 29.970 30.388 55.965 1.0036.01 O ATOM 6112 N LYS A 407 30.744 29.669 57.936 1.00 38.03 N ATOM6114 CA LYS A 407 30.913 31.032 58.480 1.00 37.24 C ATOM 6116 CB LYS A407 29.808 31.396 59.427 1.00 38.61 C ATOM 6119 CG LYS A 407 28.40831.305 58.843 1.00 39.27 C ATOM 6122 CD LYS A 407 27.467 30.706 59.8641.00 41.05 C ATOM 6125 CE LYS A 407 26.150 30.400 59.316 1.00 44.32 CATOM 6128 NZ LYS A 407 25.229 31.288 60.019 1.00 52.24 N ATOM 6132 C LYSA 407 32.218 31.114 59.237 1.00 37.24 C ATOM 6133 O LYS A 407 32.84930.135 59.489 1.00 40.60 O ATOM 6134 N GLN A 408 32.674 32.299 59.5521.00 36.38 N ATOM 6136 CA GLN A 408 33.979 32.465 60.158 1.00 34.55 CATOM 6138 CB GLN A 408 34.581 33.801 59.825 1.00 32.09 C ATOM 6141 CGGLN A 408 35.948 33.899 60.498 1.00 31.64 C ATOM 6144 CD GLN A 40836.473 35.248 60.620 1.00 30.23 C ATOM 6145 OE1 GLN A 408 35.772 36.22160.467 1.00 39.71 O ATOM 6146 NE2 GLN A 408 37.680 35.336 60.852 1.0026.16 N ATOM 6149 C GLN A 408 33.734 32.402 61.666 1.00 35.59 C ATOM6150 O GLN A 408 32.869 33.106 62.167 1.00 34.95 O ATOM 6151 N HIS A 40934.501 31.551 62.338 1.00 35.68 N ATOM 6153 CA HIS A 409 34.305 31.23963.709 1.00 36.96 C ATOM 6155 CB HIS A 409 34.594 32.495 64.525 1.0036.30 C ATOM 6158 CG HIS A 409 35.974 32.999 64.388 1.00 32.03 C ATOM6159 ND1 HIS A 409 37.046 32.335 64.885 1.00 36.03 N ATOM 6161 CE1 HIS A409 38.149 32.995 64.602 1.00 32.96 C ATOM 6163 NE2 HIS A 409 37.82334.099 63.993 1.00 29.44 N ATOM 6165 CD2 HIS A 409 36.464 34.108 63.8191.00 33.90 C ATOM 6167 C HIS A 409 32.898 30.688 63.922 1.00 38.45 CATOM 6168 O HIS A 409 32.282 30.785 64.967 1.00 39.82 O ATOM 6169 N GLYA 410 32.341 30.135 62.879 1.00 39.18 N ATOM 6171 CA GLY A 410 30.94829.727 62.974 1.00 40.64 C ATOM 6174 C GLY A 410 30.003 30.872 63.1231.00 39.89 C ATOM 6175 O GLY A 410 28.908 30.596 63.288 1.00 40.91 OATOM 6176 N ASN A 411 30.443 32.129 63.096 1.00 39.05 N ATOM 6178 CA ASNA 411 29.582 33.303 63.276 1.00 39.30 C ATOM 6180 CB ASN A 411 30.17634.429 64.213 1.00 39.22 C ATOM 6183 CG ASN A 411 30.202 34.049 65.6931.00 44.51 C ATOM 6184 OD1 ASN A 411 29.929 32.909 65.994 1.00 52.63 OATOM 6185 ND2 ASN A 411 30.548 34.986 66.614 1.00 41.99 N ATOM 6188 CASN A 411 29.312 33.940 61.907 1.00 37.22 C ATOM 6189 O ASN A 411 28.19433.948 61.435 1.00 37.23 O ATOM 6190 N PHE A 412 30.342 34.474 61.2781.00 34.68 N ATOM 6192 CA PHE A 412 30.135 35.478 60.287 1.00 33.77 CATOM 6194 CB PHE A 412 31.294 36.438 60.393 1.00 32.92 C ATOM 6197 CGPHE A 412 31.440 37.028 61.750 1.00 33.90 C ATOM 6198 CD1 PHE A 41232.607 36.831 62.507 1.00 34.35 C ATOM 6200 CE1 PHE A 412 32.708 37.35363.793 1.00 31.85 C ATOM 6202 CZ PHE A 412 31.688 38.084 64.275 1.0033.72 C ATOM 6204 CE2 PHE A 412 30.575 38.290 63.552 1.00 33.28 C ATOM6206 CD2 PHE A 412 30.419 37.748 62.306 1.00 32.58 C ATOM 6208 C PHE A412 30.053 34.983 58.856 1.00 33.95 C ATOM 6209 O PHE A 412 30.86534.164 58.410 1.00 34.69 O ATOM 6210 N SER A 413 29.101 35.512 58.0881.00 34.35 N ATOM 6212 CA SER A 413 29.154 35.319 56.617 1.00 33.33 CATOM 6214 CB SER A 413 27.803 34.919 56.082 1.00 34.29 C ATOM 6217 OGSER A 413 26.927 35.986 56.195 1.00 34.47 O ATOM 6219 C SER A 413 29.71136.474 55.800 1.00 31.62 C ATOM 6220 O SER A 413 29.980 36.268 54.6791.00 30.19 O ATOM 6221 N LEU A 414 29.810 37.698 56.361 1.00 32.41 NATOM 6223 CA LEU A 414 30.474 38.882 55.716 1.00 31.11 C ATOM 6225 CBLEU A 414 29.458 39.830 55.119 1.00 32.13 C ATOM 6228 CG LEU A 41429.895 41.226 54.590 1.00 33.57 C ATOM 6230 CD1 LEU A 414 31.044 41.17653.529 1.00 33.54 C ATOM 6234 CD2 LEU A 414 28.737 41.998 53.991 1.0034.32 C ATOM 6238 C LEU A 414 31.241 39.660 56.755 1.00 30.16 C ATOM6239 O LEU A 414 30.616 40.240 57.603 1.00 31.21 O ATOM 6240 N ALA A 41532.565 39.668 56.721 1.00 28.59 N ATOM 6242 CA ALA A 415 33.347 40.42157.709 1.00 28.16 C ATOM 6244 CB ALA A 415 34.171 39.540 58.506 1.0027.51 C ATOM 6248 C ALA A 415 34.233 41.399 56.975 1.00 28.12 C ATOM6249 O ALA A 415 34.998 41.005 56.099 1.00 28.60 O ATOM 6250 N VAL A 41634.077 42.689 57.294 1.00 28.48 N ATOM 6252 CA VAL A 416 34.865 43.76856.701 1.00 27.99 C ATOM 6254 CB VAL A 416 33.940 44.600 55.867 1.0028.89 C ATOM 6256 CG1 VAL A 416 34.667 45.745 55.232 1.00 29.37 C ATOM6260 CG2 VAL A 416 33.294 43.709 54.828 1.00 29.55 C ATOM 6264 C VAL A416 35.492 44.588 57.822 1.00 27.40 C ATOM 6265 O VAL A 416 34.78845.252 58.514 1.00 28.63 O ATOM 6266 N VAL A 417 36.805 44.579 57.9821.00 26.45 N ATOM 6268 CA VAL A 417 37.390 45.086 59.181 1.00 27.04 CATOM 6270 CB VAL A 417 37.707 43.940 60.175 1.00 27.03 C ATOM 6272 CG1VAL A 417 38.177 44.508 61.435 1.00 31.02 C ATOM 6276 CG2 VAL A 41736.616 43.085 60.494 1.00 25.94 C ATOM 6280 C VAL A 417 38.700 45.84958.959 1.00 27.79 C ATOM 6281 O VAL A 417 39.729 45.304 58.592 1.0028.44 O ATOM 6282 N SER A 418 38.659 47.118 59.304 1.00 29.69 N ATOM6284 CA SER A 418 39.783 48.037 59.273 1.00 29.96 C ATOM 6286 CB SER A418 40.834 47.559 60.216 1.00 30.43 C ATOM 6289 OG SER A 418 41.77048.555 60.517 1.00 34.34 O ATOM 6291 C SER A 418 40.320 48.213 57.8891.00 30.06 C ATOM 6292 O SER A 418 41.441 48.007 57.668 1.00 30.27 OATOM 6293 N LEU A 419 39.473 48.581 56.934 1.00 30.95 N ATOM 6295 CA LEUA 419 39.881 49.016 55.578 1.00 30.62 C ATOM 6297 CB LEU A 419 38.97448.380 54.560 1.00 29.76 C ATOM 6300 CG LEU A 419 38.564 46.915 54.6921.00 27.89 C ATOM 6302 CD1 LEU A 419 37.844 46.349 53.455 1.00 26.37 CATOM 6306 CD2 LEU A 419 39.796 46.136 54.942 1.00 30.27 C ATOM 6310 CLEU A 419 39.787 50.520 55.513 1.00 31.84 C ATOM 6311 O LEU A 419 39.24851.129 56.415 1.00 34.04 O ATOM 6312 N ASN A 420 40.347 51.141 54.5051.00 32.95 N ATOM 6314 CA ASN A 420 40.409 52.602 54.421 1.00 35.62 CATOM 6316 CB ASN A 420 41.682 53.008 53.739 1.00 37.74 C ATOM 6319 CGASN A 420 41.961 54.452 53.815 1.00 40.33 C ATOM 6320 OD1 ASN A 42041.713 55.072 54.796 1.00 41.29 O ATOM 6321 ND2 ASN A 420 42.543 54.99152.774 1.00 42.87 N ATOM 6324 C ASN A 420 39.322 53.016 53.519 1.0038.01 C ATOM 6325 O ASN A 420 39.319 54.112 53.010 1.00 41.16 O ATOM6326 N ILE A 421 38.383 52.103 53.301 1.00 37.63 N ATOM 6328 CA ILE A421 37.280 52.252 52.393 1.00 38.22 C ATOM 6330 CB ILE A 421 36.76750.873 52.179 1.00 36.26 C ATOM 6332 CG1 ILE A 421 36.784 50.662 50.7241.00 40.93 C ATOM 6335 CD1 ILE A 421 36.644 49.237 50.423 1.00 45.47 CATOM 6339 CG2 ILE A 421 35.404 50.467 52.732 1.00 34.04 C ATOM 6343 CILE A 421 36.263 53.290 52.797 1.00 40.58 C ATOM 6344 O ILE A 421 36.20353.706 53.954 1.00 42.88 O ATOM 6345 N THR A 422 35.511 53.755 51.8141.00 42.92 N ATOM 6347 CA THR A 422 34.541 54.868 51.949 1.00 44.98 CATOM 6349 CB THR A 422 34.870 55.912 50.914 1.00 47.73 C ATOM 6351 OG1THR A 422 36.200 56.430 51.181 1.00 49.14 O ATOM 6353 CG2 THR A 42233.950 57.054 51.018 1.00 49.95 C ATOM 6357 C THR A 422 33.106 54.41851.763 1.00 44.41 C ATOM 6358 O THR A 422 32.230 54.898 52.433 1.0046.45 O ATOM 6359 N SER A 423 32.878 53.462 50.889 1.00 42.64 N ATOM6361 CA SER A 423 31.626 52.762 50.831 1.00 41.79 C ATOM 6363 CB SER A423 30.874 53.300 49.666 1.00 44.68 C ATOM 6366 OG SER A 423 31.65553.146 48.490 1.00 46.25 O ATOM 6368 C SER A 423 31.838 51.294 50.5601.00 38.94 C ATOM 6369 O SER A 423 32.862 50.907 50.044 1.00 37.59 OATOM 6370 N LEU A 424 30.846 50.468 50.858 1.00 38.17 N ATOM 6372 CA LEUA 424 31.038 49.034 50.632 1.00 36.68 C ATOM 6374 CB LEU A 424 29.94948.233 51.394 1.00 35.68 C ATOM 6377 CG LEU A 424 30.177 48.127 52.9161.00 36.14 C ATOM 6379 CD1 LEU A 424 28.913 47.658 53.776 1.00 34.01 CATOM 6383 CD2 LEU A 424 31.441 47.302 53.250 1.00 33.86 C ATOM 6387 CLEU A 424 31.090 48.724 49.078 1.00 36.95 C ATOM 6388 O LEU A 424 31.90948.010 48.555 1.00 33.92 O ATOM 6389 N GLY A 425 30.182 49.314 48.3641.00 38.75 N ATOM 6391 CA GLY A 425 30.155 49.084 46.969 1.00 40.99 CATOM 6394 C GLY A 425 29.443 47.814 46.622 1.00 41.20 C ATOM 6395 O GLYA 425 29.472 47.443 45.460 1.00 44.17 O ATOM 6396 N LEU A 426 28.80547.141 47.566 1.00 40.36 N ATOM 6398 CA LEU A 426 28.240 45.842 47.2581.00 39.92 C ATOM 6400 CB LEU A 426 28.082 45.026 48.527 1.00 37.76 CATOM 6403 CG LEU A 426 29.426 44.744 49.170 1.00 36.86 C ATOM 6405 CD1LEU A 426 29.176 43.892 50.403 1.00 38.68 C ATOM 6409 CD2 LEU A 42630.381 44.023 48.252 1.00 35.23 C ATOM 6413 C LEU A 426 26.932 46.00146.557 1.00 42.18 C ATOM 6414 O LEU A 426 25.894 45.526 47.046 1.0044.29 O ATOM 6415 N ARG A 427 26.948 46.648 45.405 1.00 43.67 N ATOM6417 CA ARG A 427 25.710 47.033 44.753 1.00 46.27 C ATOM 6419 CB ARG A427 25.952 48.098 43.700 1.00 48.95 C ATOM 6422 CG ARG A 427 26.78147.687 42.500 1.00 51.08 C ATOM 6425 CD ARG A 427 26.942 48.830 41.4621.00 53.68 C ATOM 6428 NE ARG A 427 27.600 49.930 42.126 1.00 52.90 NATOM 6430 CZ ARG A 427 28.907 49.974 42.333 1.00 54.16 C ATOM 6431 NH1ARG A 427 29.687 49.026 41.855 1.00 56.67 N ATOM 6434 NH2 ARG A 42729.469 50.978 42.973 1.00 53.42 N ATOM 6437 C ARG A 427 24.921 45.92344.137 1.00 46.88 C ATOM 6438 O ARG A 427 23.864 46.167 43.683 1.0049.33 O ATOM 6439 N SER A 428 25.423 44.709 44.079 1.00 45.62 N ATOM6441 CA SER A 428 24.656 43.644 43.465 1.00 46.68 C ATOM 6443 CB SER A428 25.514 42.826 42.506 1.00 45.99 C ATOM 6446 OG SER A 428 25.83443.593 41.362 1.00 47.96 O ATOM 6448 C SER A 428 24.148 42.720 44.4861.00 45.95 C ATOM 6449 O SER A 428 23.366 41.806 44.178 1.00 48.53 OATOM 6450 N LEU A 429 24.620 42.903 45.703 1.00 44.50 N ATOM 6452 CA LEUA 429 24.329 41.963 46.753 1.00 43.25 C ATOM 6454 CB LEU A 429 25.19742.215 47.923 1.00 40.85 C ATOM 6457 CG LEU A 429 25.039 41.129 48.9661.00 40.60 C ATOM 6459 CD1 LEU A 429 25.400 39.734 48.410 1.00 40.92 CATOM 6463 CD2 LEU A 429 25.895 41.522 50.121 1.00 38.94 C ATOM 6467 CLEU A 429 22.889 42.116 47.185 1.00 45.57 C ATOM 6468 O LEU A 429 22.51643.074 47.852 1.00 46.09 O ATOM 6469 N LYS A 430 22.079 41.148 46.8011.00 46.89 N ATOM 6471 CA LYS A 430 20.729 41.149 47.203 1.00 49.09 CATOM 6473 CB LYS A 430 19.848 40.867 46.020 1.00 52.17 C ATOM 6476 CGLYS A 430 20.075 41.767 44.775 1.00 56.42 C ATOM 6479 CD LYS A 43020.040 43.323 45.059 1.00 58.97 C ATOM 6482 CE LYS A 430 19.311 44.13843.898 1.00 64.18 C ATOM 6485 NZ LYS A 430 18.517 45.353 44.422 1.0067.30 N ATOM 6489 C LYS A 430 20.482 40.120 48.287 1.00 48.70 C ATOM6490 O LYS A 430 19.396 40.095 48.817 1.00 52.84 O ATOM 6491 N GLU A 43121.402 39.237 48.636 1.00 45.66 N ATOM 6493 CA GLU A 431 20.996 38.24249.591 1.00 44.87 C ATOM 6495 CB GLU A 431 20.319 37.086 48.889 1.0046.51 C ATOM 6498 CG GLU A 431 20.122 35.923 49.821 1.00 47.21 C ATOM6501 CD GLU A 431 19.206 34.813 49.314 1.00 54.73 C ATOM 6502 OE1 GLU A431 18.587 34.845 48.198 1.00 57.66 O ATOM 6503 OE2 GLU A 431 19.06133.865 50.108 1.00 58.94 O ATOM 6504 C GLU A 431 22.172 37.745 50.3121.00 42.74 C ATOM 6505 O GLU A 431 23.201 37.454 49.714 1.00 40.52 OATOM 6506 N ILE A 432 22.020 37.676 51.635 1.00 43.15 N ATOM 6508 CA ILEA 432 22.953 36.946 52.541 1.00 40.67 C ATOM 6510 CB ILE A 432 23.65637.901 53.551 1.00 38.41 C ATOM 6512 CG1 ILE A 432 24.459 38.988 52.8131.00 36.41 C ATOM 6515 CD1 ILE A 432 24.835 40.134 53.667 1.00 34.20 CATOM 6519 CG2 ILE A 432 24.583 37.096 54.405 1.00 37.20 C ATOM 6523 CILE A 432 22.159 35.884 53.298 1.00 42.12 C ATOM 6524 O ILE A 432 21.58936.182 54.330 1.00 43.01 O ATOM 6525 N SER A 433 22.116 34.665 52.7671.00 43.12 N ATOM 6527 CA SER A 433 21.267 33.580 53.285 1.00 45.85 CATOM 6529 CB SER A 433 21.474 32.275 52.493 1.00 46.97 C ATOM 6532 OGSER A 433 21.513 32.412 51.072 1.00 47.67 O ATOM 6534 C SER A 433 21.41433.251 54.795 1.00 45.97 C ATOM 6535 O SER A 433 20.426 33.093 55.5431.00 49.16 O ATOM 6536 N ASP A 434 22.636 33.142 55.246 1.00 43.68 NATOM 6538 CA ASP A 434 22.897 32.829 56.616 1.00 44.35 C ATOM 6540 CBASP A 434 23.092 31.311 56.710 1.00 46.18 C ATOM 6543 CG ASP A 43422.775 30.720 58.098 1.00 49.52 C ATOM 6544 OD1 ASP A 434 22.139 31.35058.999 1.00 50.92 O ATOM 6545 OD2 ASP A 434 23.167 29.561 58.374 1.0053.17 O ATOM 6546 C ASP A 434 24.121 33.598 57.103 1.00 41.73 C ATOM6547 O ASP A 434 24.857 34.175 56.338 1.00 39.17 O ATOM 6548 N GLY A 43524.301 33.626 58.413 1.00 43.10 N ATOM 6550 CA GLY A 435 25.468 34.23059.044 1.00 41.52 C ATOM 6553 C GLY A 435 25.300 35.685 59.493 1.0040.59 C ATOM 6554 O GLY A 435 24.326 36.283 59.093 1.00 42.87 O ATOM6555 N ASP A 436 26.244 36.248 60.256 1.00 38.15 N ATOM 6557 CA ASP A436 26.162 37.608 60.633 1.00 37.69 C ATOM 6559 CB ASP A 436 26.45137.759 62.063 1.00 38.84 C ATOM 6562 CG ASP A 436 25.542 36.897 62.9491.00 45.93 C ATOM 6563 OD1 ASP A 436 24.475 36.346 62.465 1.00 50.44 OATOM 6564 OD2 ASP A 436 25.849 36.744 64.188 1.00 48.71 O ATOM 6565 CASP A 436 27.101 38.463 59.884 1.00 35.36 C ATOM 6566 O ASP A 436 28.17138.045 59.505 1.00 34.46 O ATOM 6567 N VAL A 437 26.675 39.699 59.6661.00 34.91 N ATOM 6569 CA VAL A 437 27.539 40.698 59.138 1.00 32.89 CATOM 6571 CB VAL A 437 26.807 41.670 58.331 1.00 33.15 C ATOM 6573 CG1VAL A 437 27.752 42.703 57.809 1.00 33.08 C ATOM 6577 CG2 VAL A 43726.255 40.973 57.202 1.00 34.45 C ATOM 6581 C VAL A 437 28.177 41.42860.248 1.00 32.40 C ATOM 6582 O VAL A 437 27.550 41.789 61.196 1.0033.85 O ATOM 6583 N ILE A 438 29.465 41.596 60.128 1.00 31.56 N ATOM6585 CA ILE A 438 30.196 42.496 60.980 1.00 32.05 C ATOM 6587 CB ILE A438 31.067 41.725 62.017 1.00 31.78 C ATOM 6589 CG1 ILE A 438 31.91742.722 62.782 1.00 33.81 C ATOM 6592 CD1 ILE A 438 31.980 42.501 64.2141.00 34.56 C ATOM 6596 CG2 ILE A 438 31.869 40.711 61.404 1.00 28.81 CATOM 6600 C ILE A 438 31.049 43.403 60.138 1.00 30.73 C ATOM 6601 O ILEA 438 31.771 42.980 59.286 1.00 30.46 O ATOM 6602 N ILE A 439 30.96944.668 60.434 1.00 31.67 N ATOM 6604 CA ILE A 439 31.661 45.697 59.6931.00 31.64 C ATOM 6606 CB ILE A 439 30.627 46.403 58.860 1.00 33.32 CATOM 6608 CG1 ILE A 439 30.097 45.368 57.903 1.00 33.68 C ATOM 6611 CD1ILE A 439 29.445 45.900 56.843 1.00 37.03 C ATOM 6615 CG2 ILE A 43931.173 47.672 58.251 1.00 32.18 C ATOM 6619 C ILE A 439 32.188 46.64260.672 1.00 32.06 C ATOM 6620 O ILE A 439 31.404 47.452 61.174 1.0033.52 O ATOM 6621 N SER A 440 33.472 46.512 60.990 1.00 31.48 N ATOM6623 CA SER A 440 34.064 47.352 61.993 1.00 32.75 C ATOM 6625 CB SER A440 34.033 46.654 63.346 1.00 34.08 C ATOM 6628 OG SER A 440 35.21946.099 63.813 1.00 30.62 O ATOM 6630 C SER A 440 35.423 47.965 61.7101.00 33.20 C ATOM 6631 O SER A 440 36.301 47.431 61.050 1.00 31.65 OATOM 6632 N GLY A 441 35.564 49.154 62.243 1.00 34.51 N ATOM 6634 CA GLYA 441 36.833 49.803 62.243 1.00 35.00 C ATOM 6637 C GLY A 441 37.25750.356 60.936 1.00 34.41 C ATOM 6638 O GLY A 441 38.416 50.475 60.6991.00 36.85 O ATOM 6639 N ASN A 442 36.327 50.764 60.121 1.00 34.47 NATOM 6641 CA ASN A 442 36.633 51.433 58.902 1.00 34.18 C ATOM 6643 CBASN A 442 35.722 50.813 57.889 1.00 32.80 C ATOM 6646 CG ASN A 44235.795 49.277 57.918 1.00 31.45 C ATOM 6647 OD1 ASN A 442 36.767 48.70657.513 1.00 31.51 O ATOM 6648 ND2 ASN A 442 34.759 48.620 58.385 1.0033.37 N ATOM 6651 C ASN A 442 36.483 52.975 59.097 1.00 36.49 C ATOM6652 O ASN A 442 35.399 53.472 58.871 1.00 37.28 O ATOM 6653 N LYS A 44337.537 53.694 59.570 1.00 37.27 N ATOM 6655 CA LYS A 443 37.443 55.11159.920 1.00 40.56 C ATOM 6657 CB LYS A 443 38.759 55.895 59.850 1.0042.83 C ATOM 6660 CG LYS A 443 39.988 55.442 60.495 1.00 45.94 C ATOM6663 CD LYS A 443 41.237 56.329 60.166 1.00 47.16 C ATOM 6666 CE LYS A443 42.546 55.495 60.405 1.00 49.15 C ATOM 6669 NZ LYS A 443 43.70755.709 59.389 1.00 50.56 N ATOM 6673 C LYS A 443 36.582 55.947 58.9451.00 42.61 C ATOM 6674 O LYS A 443 35.994 56.946 59.344 1.00 44.63 OATOM 6675 N ASN A 444 36.652 55.608 57.658 1.00 42.59 N ATOM 6677 CA ASNA 444 36.171 56.418 56.545 1.00 44.01 C ATOM 6679 CB ASN A 444 37.29456.464 55.497 1.00 44.13 C ATOM 6682 CG ASN A 444 38.405 57.361 55.9101.00 46.10 C ATOM 6683 OD1 ASN A 444 38.183 58.301 56.639 1.00 50.68 OATOM 6684 ND2 ASN A 444 39.594 57.100 55.461 1.00 47.38 N ATOM 6687 CASN A 444 34.921 55.847 55.902 1.00 43.68 C ATOM 6688 O ASN A 444 34.54256.270 54.825 1.00 45.84 O ATOM 6689 N LEU A 445 34.283 54.866 56.5391.00 42.24 N ATOM 6691 CA LEU A 445 33.301 54.082 55.849 1.00 41.55 CATOM 6693 CB LEU A 445 33.208 52.701 56.401 1.00 38.97 C ATOM 6696 CGLEU A 445 32.117 51.924 55.680 1.00 39.43 C ATOM 6698 CD1 LEU A 44532.454 51.904 54.221 1.00 41.08 C ATOM 6702 CD2 LEU A 445 31.954 50.48556.169 1.00 37.35 C ATOM 6706 C LEU A 445 31.995 54.746 56.056 1.0044.65 C ATOM 6707 O LEU A 445 31.635 55.160 57.193 1.00 46.34 O ATOM6708 N CYS A 446 31.267 54.879 54.966 1.00 45.65 N ATOM 6710 CA CYS A446 29.956 55.494 55.049 1.00 47.96 C ATOM 6712 CB CYS A 446 29.98056.842 54.346 1.00 51.65 C ATOM 6715 SG CYS A 446 30.690 58.223 55.3231.00 56.94 S ATOM 6716 C CYS A 446 28.930 54.580 54.454 1.00 45.78 CATOM 6717 O CYS A 446 29.247 53.516 53.948 1.00 45.34 O ATOM 6718 N TYRA 447 27.698 54.972 54.622 1.00 46.60 N ATOM 6720 CA TYR A 447 26.53654.438 53.926 1.00 46.93 C ATOM 6722 CB TYR A 447 26.727 54.312 52.3661.00 46.78 C ATOM 6725 CG TYR A 447 27.370 55.536 51.702 1.00 48.48 CATOM 6726 CD1 TYR A 447 28.763 55.661 51.604 1.00 48.29 C ATOM 6728 CE1TYR A 447 29.359 56.796 51.020 1.00 49.65 C ATOM 6730 CZ TYR A 44728.561 57.823 50.584 1.00 53.33 C ATOM 6731 OH TYR A 447 29.156 58.93450.022 1.00 56.47 O ATOM 6733 CE2 TYR A 447 27.188 57.718 50.684 1.0052.55 C ATOM 6735 CD2 TYR A 447 26.603 56.594 51.237 1.00 50.12 C ATOM6737 C TYR A 447 26.006 53.182 54.579 1.00 45.12 C ATOM 6738 O TYR A 44724.828 52.906 54.450 1.00 46.05 O ATOM 6739 N ALA A 448 26.825 52.44155.307 1.00 42.46 N ATOM 6741 CA ALA A 448 26.412 51.097 55.672 1.0042.12 C ATOM 6743 CB ALA A 448 27.486 50.466 56.386 1.00 40.08 C ATOM6747 C ALA A 448 25.164 51.065 56.550 1.00 45.51 C ATOM 6748 O ALA A 44824.377 50.118 56.546 1.00 46.84 O ATOM 6749 N ASN A 449 25.042 52.11657.349 1.00 48.30 N ATOM 6751 CA ASN A 449 24.032 52.298 58.385 1.0050.40 C ATOM 6753 CB ASN A 449 24.550 53.507 59.267 1.00 51.87 C ATOM6756 CG ASN A 449 24.734 54.895 58.395 1.00 57.64 C ATOM 6757 OD1 ASN A449 25.688 55.006 57.531 1.00 53.24 O ATOM 6758 ND2 ASN A 449 23.74755.920 58.585 1.00 59.18 N ATOM 6761 C ASN A 449 22.672 52.509 57.6471.00 52.26 C ATOM 6762 O ASN A 449 21.637 52.128 58.077 1.00 53.29 OATOM 6763 N THR A 450 22.728 53.091 56.469 1.00 53.13 N ATOM 6765 CA THRA 450 21.597 53.268 55.534 1.00 54.99 C ATOM 6767 CB THR A 450 22.26653.742 54.252 1.00 54.62 C ATOM 6769 OG1 THR A 450 22.367 55.152 54.2951.00 55.61 O ATOM 6771 CG2 THR A 450 21.443 53.564 53.124 1.00 57.50 CATOM 6775 C THR A 450 20.713 52.104 55.065 1.00 55.13 C ATOM 6776 O THRA 450 19.534 52.252 54.725 1.00 57.64 O ATOM 6777 N ILE A 451 21.34050.971 54.847 1.00 53.09 N ATOM 6779 CA ILE A 451 20.639 49.838 54.2311.00 52.81 C ATOM 6781 CB ILE A 451 21.672 48.959 53.650 1.00 48.99 CATOM 6783 CG1 ILE A 451 21.964 49.458 52.272 1.00 48.98 C ATOM 6786 CD1ILE A 451 23.287 48.919 51.907 1.00 51.48 C ATOM 6790 CG2 ILE A 45121.238 47.512 53.660 1.00 48.80 C ATOM 6794 C ILE A 451 19.855 49.04155.251 1.00 53.28 C ATOM 6795 O ILE A 451 20.291 48.882 56.403 1.0053.75 O ATOM 6796 N ASN A 452 18.729 48.501 54.859 1.00 54.61 N ATOM6798 CA ASN A 452 18.075 47.564 55.753 1.00 54.85 C ATOM 6800 CB ASN A452 16.582 47.583 55.595 1.00 58.78 C ATOM 6803 CG ASN A 452 15.89846.688 56.573 1.00 60.06 C ATOM 6804 OD1 ASN A 452 16.477 46.247 57.5351.00 60.16 O ATOM 6805 ND2 ASN A 452 14.630 46.447 56.348 1.00 66.13 NATOM 6808 C ASN A 452 18.584 46.161 55.514 1.00 51.88 C ATOM 6809 O ASNA 452 18.079 45.429 54.688 1.00 51.93 O ATOM 6810 N TRP A 453 19.57445.788 56.289 1.00 49.02 N ATOM 6812 CA TRP A 453 20.200 44.509 56.1111.00 47.00 C ATOM 6814 CB TRP A 453 21.380 44.370 57.080 1.00 43.94 CATOM 6817 CG TRP A 453 22.510 45.291 56.788 1.00 42.79 C ATOM 6818 CD1TRP A 453 22.646 46.594 57.203 1.00 43.19 C ATOM 6820 NE1 TRP A 45323.832 47.126 56.749 1.00 42.40 N ATOM 6822 CE2 TRP A 453 24.515 46.16456.055 1.00 41.54 C ATOM 6823 CD2 TRP A 453 23.706 44.986 56.055 1.0040.84 C ATOM 6824 CE3 TRP A 453 24.181 43.846 55.397 1.00 37.49 C ATOM6826 CZ3 TRP A 453 25.422 43.910 54.728 1.00 36.87 C ATOM 6828 CH2 TRP A453 26.216 45.085 54.767 1.00 37.26 C ATOM 6830 CZ2 TRP A 453 25.77146.226 55.419 1.00 40.29 C ATOM 6832 C TRP A 453 19.210 43.347 56.3041.00 48.34 C ATOM 6833 O TRP A 453 19.523 42.225 55.960 1.00 48.61 OATOM 6834 N ALA A 454 18.049 43.569 56.872 1.00 50.12 N ATOM 6836 CA ALAA 454 17.163 42.440 57.046 1.00 52.09 C ATOM 6838 CB ALA A 454 16.10042.742 58.175 1.00 55.94 C ATOM 6842 C ALA A 454 16.497 41.955 55.7311.00 52.76 C ATOM 6843 O ALA A 454 16.033 40.830 55.669 1.00 53.28 OATOM 6844 N ALA A 455 16.438 42.796 54.699 1.00 53.04 N ATOM 6846 CA ALAA 455 15.958 42.371 53.388 1.00 54.61 C ATOM 6848 CB ALA A 455 15.61143.600 52.415 1.00 55.56 C ATOM 6852 C ALA A 455 17.019 41.447 52.7801.00 52.15 C ATOM 6853 O ALA A 455 16.713 40.564 51.986 1.00 53.84 OATOM 6854 N LEU A 456 18.278 41.584 53.144 1.00 48.88 N ATOM 6856 CA LEUA 456 19.207 40.624 52.575 1.00 47.66 C ATOM 6858 CB LEU A 456 20.62941.111 52.554 1.00 44.76 C ATOM 6861 CG LEU A 456 20.822 42.604 52.2991.00 47.13 C ATOM 6863 CD1 LEU A 456 22.273 42.896 52.676 1.00 47.80 CATOM 6867 CD2 LEU A 456 20.538 43.052 50.860 1.00 46.95 C ATOM 6871 CLEU A 456 19.131 39.306 53.285 1.00 47.43 C ATOM 6872 O LEU A 456 19.43338.295 52.722 1.00 48.81 O ATOM 6873 N PHE A 457 18.713 39.299 54.5201.00 48.14 N ATOM 6875 CA PHE A 457 18.752 38.096 55.293 1.00 48.22 CATOM 6877 CB PHE A 457 18.711 38.449 56.766 1.00 48.21 C ATOM 6880 CGPHE A 457 19.963 39.062 57.277 1.00 44.36 C ATOM 6881 CD1 PHE A 45719.934 39.820 58.425 1.00 44.86 C ATOM 6883 CE1 PHE A 457 21.026 40.34658.984 1.00 42.67 C ATOM 6885 CZ PHE A 457 22.226 40.151 58.400 1.0043.38 C ATOM 6887 CE2 PHE A 457 22.294 39.405 57.247 1.00 43.86 C ATOM6889 CD2 PHE A 457 21.148 38.843 56.690 1.00 42.41 C ATOM 6891 C PHE A457 17.647 37.119 54.932 1.00 51.40 C ATOM 6892 O PHE A 457 16.66237.500 54.357 1.00 52.54 O ATOM 6893 N GLY A 458 17.898 35.854 55.2741.00 52.35 N ATOM 6895 CA GLY A 458 17.023 34.744 55.030 1.00 56.05 CATOM 6898 C GLY A 458 16.661 33.924 56.238 1.00 58.52 C ATOM 6899 O GLYA 458 15.591 33.315 56.320 1.00 63.06 O ATOM 6900 N THR A 459 17.59733.823 57.145 1.00 57.90 N ATOM 6902 CA THR A 459 17.361 33.198 58.4471.00 60.11 C ATOM 6904 CB THR A 459 18.698 32.524 59.028 1.00 58.33 CATOM 6906 OG1 THR A 459 19.443 31.758 58.027 1.00 56.59 O ATOM 6908 CG2THR A 459 18.397 31.515 60.156 1.00 61.86 C ATOM 6912 C THR A 459 16.97334.339 59.362 1.00 60.43 C ATOM 6913 O THR A 459 17.504 35.455 59.2931.00 58.76 O ATOM 6914 N SER A 460 16.055 34.063 60.248 1.00 63.77 NATOM 6916 CA SER A 460 15.832 34.971 61.348 1.00 64.47 C ATOM 6918 CBSER A 460 14.427 34.808 61.931 1.00 69.15 C ATOM 6921 OG SER A 46014.550 34.108 63.143 1.00 71.63 O ATOM 6923 C SER A 460 16.934 34.64762.384 1.00 62.22 C ATOM 6924 O SER A 460 17.590 33.555 62.356 1.0061.49 O ATOM 6925 N GLY A 461 17.164 35.602 63.277 1.00 60.59 N ATOM6927 CA GLY A 461 18.316 35.494 64.123 1.00 57.63 C ATOM 6930 C GLY A461 19.585 35.989 63.511 1.00 52.41 C ATOM 6931 O GLY A 461 20.44636.242 64.286 1.00 52.50 O ATOM 6932 N GLN A 462 19.741 36.137 62.1951.00 49.52 N ATOM 6934 CA GLN A 462 20.925 36.822 61.668 1.00 45.64 CATOM 6936 CB GLN A 462 20.952 36.897 60.163 1.00 43.36 C ATOM 6939 CGGLN A 462 21.317 35.605 59.465 1.00 43.36 C ATOM 6942 CD GLN A 46221.144 35.662 57.939 1.00 42.21 C ATOM 6943 OE1 GLN A 462 20.022 35.47757.420 1.00 43.94 O ATOM 6944 NE2 GLN A 462 22.221 35.915 57.237 1.0038.31 N ATOM 6947 C GLN A 462 21.059 38.245 62.227 1.00 46.14 C ATOM6948 O GLN A 462 20.063 38.974 62.410 1.00 47.92 O ATOM 6949 N LYS A 46322.288 38.625 62.523 1.00 44.23 N ATOM 6951 CA LYS A 463 22.533 39.89563.147 1.00 45.46 C ATOM 6953 CB LYS A 463 23.017 39.668 64.596 1.0046.79 C ATOM 6956 CG LYS A 463 21.984 38.954 65.430 1.00 55.05 C ATOM6959 CD LYS A 463 22.139 39.020 67.026 1.00 59.62 C ATOM 6962 CE LYS A463 20.716 38.916 67.717 1.00 64.36 C ATOM 6965 NZ LYS A 463 20.82138.672 69.237 1.00 69.48 N ATOM 6969 C LYS A 463 23.603 40.691 62.3891.00 42.96 C ATOM 6970 O LYS A 463 24.382 40.166 61.581 1.00 39.97 OATOM 6971 N THR A 464 23.730 41.932 62.818 1.00 43.35 N ATOM 6973 CA THRA 464 24.580 42.878 62.188 1.00 42.23 C ATOM 6975 CB THR A 464 23.58343.748 61.509 1.00 44.72 C ATOM 6977 OG1 THR A 464 23.198 43.095 60.2761.00 46.76 O ATOM 6979 CG2 THR A 464 24.182 45.089 61.116 1.00 46.18 CATOM 6983 C THR A 464 25.331 43.693 63.198 1.00 41.03 C ATOM 6984 O THRA 464 24.720 44.166 64.099 1.00 43.87 O ATOM 6985 N LYS A 465 26.61643.918 63.032 1.00 38.29 N ATOM 6987 CA LYS A 465 27.350 44.883 63.8621.00 37.96 C ATOM 6989 CB LYS A 465 28.365 44.234 64.770 1.00 38.00 CATOM 6992 CG LYS A 465 27.843 43.601 66.020 1.00 39.95 C ATOM 6995 CDLYS A 465 29.041 42.928 66.733 1.00 39.30 C ATOM 6998 CE LYS A 46528.550 41.917 67.693 1.00 43.12 C ATOM 7001 NZ LYS A 465 29.446 41.82368.859 1.00 47.34 N ATOM 7005 C LYS A 465 28.107 45.855 62.997 1.0035.71 C ATOM 7006 O LYS A 465 29.066 45.520 62.377 1.00 34.33 O ATOM7007 N ILE A 466 27.686 47.083 63.039 1.00 36.59 N ATOM 7009 CA ILE A466 28.230 48.113 62.287 1.00 36.36 C ATOM 7011 CB ILE A 466 27.14948.658 61.458 1.00 37.62 C ATOM 7013 CG1 ILE A 466 26.638 47.521 60.5751.00 39.37 C ATOM 7016 CD1 ILE A 466 25.425 47.855 59.830 1.00 43.42 CATOM 7020 CG2 ILE A 466 27.645 49.806 60.602 1.00 36.38 C ATOM 7024 CILE A 466 28.660 49.060 63.328 1.00 39.00 C ATOM 7025 O ILE A 466 27.88449.879 63.803 1.00 42.79 O ATOM 7026 N ILE A 467 29.957 49.024 63.5651.00 39.11 N ATOM 7028 CA ILE A 467 30.596 49.432 64.779 1.00 40.37 CATOM 7030 CB ILE A 467 31.219 48.212 65.331 1.00 40.16 C ATOM 7032 CG1ILE A 467 30.370 47.332 66.163 1.00 42.73 C ATOM 7035 CD1 ILE A 46731.377 45.982 66.241 1.00 40.48 C ATOM 7039 CG2 ILE A 467 32.262 48.54966.279 1.00 45.19 C ATOM 7043 C ILE A 467 31.840 50.203 64.366 1.0039.14 C ATOM 7044 O ILE A 467 32.618 49.668 63.547 1.00 36.89 O ATOM7045 N SER A 468 32.116 51.332 65.040 1.00 40.22 N ATOM 7047 CA SER A468 33.370 52.094 64.911 1.00 39.83 C ATOM 7049 CB SER A 468 34.46251.450 65.689 1.00 40.10 C ATOM 7052 OG SER A 468 35.683 52.125 65.5361.00 44.57 O ATOM 7054 C SER A 468 33.775 52.258 63.472 1.00 38.05 CATOM 7055 O SER A 468 34.825 51.854 63.028 1.00 35.32 O ATOM 7056 N ASNA 469 32.855 52.838 62.716 1.00 39.19 N ATOM 7058 CA ASN A 469 33.11653.297 61.394 1.00 38.06 C ATOM 7060 CB ASN A 469 32.120 52.660 60.4731.00 37.00 C ATOM 7063 CG ASN A 469 32.229 51.158 60.463 1.00 32.67 CATOM 7064 OD1 ASN A 469 33.227 50.572 60.068 1.00 31.21 O ATOM 7065 ND2ASN A 469 31.183 50.536 60.930 1.00 33.32 N ATOM 7068 C ASN A 469 33.07254.801 61.447 1.00 40.14 C ATOM 7069 O ASN A 469 33.215 55.332 62.4871.00 41.27 O ATOM 7070 N ARG A 470 32.989 55.479 60.332 1.00 42.08 NATOM 7072 CA ARG A 470 32.665 56.891 60.330 1.00 46.67 C ATOM 7074 CBARG A 470 32.810 57.409 58.920 1.00 47.34 C ATOM 7077 CG ARG A 47032.742 58.880 58.850 1.00 52.09 C ATOM 7080 CD ARG A 470 34.050 59.46458.571 1.00 55.79 C ATOM 7083 NE ARG A 470 33.944 60.651 57.785 1.0061.59 N ATOM 7085 CZ ARG A 470 34.946 61.179 57.104 1.00 64.65 C ATOM7086 NH1 ARG A 470 36.169 60.602 57.129 1.00 61.27 N ATOM 7089 NH2 ARG A470 34.710 62.300 56.374 1.00 67.54 N ATOM 7092 C ARG A 470 31.20557.060 60.710 1.00 49.51 C ATOM 7093 O ARG A 470 30.334 56.385 60.1161.00 51.46 O ATOM 7094 N GLY A 471 30.864 57.940 61.623 1.00 52.32 NATOM 7096 CA GLY A 471 29.444 58.051 61.999 1.00 54.41 C ATOM 7099 C GLYA 471 28.409 58.690 61.044 1.00 56.89 C ATOM 7100 O GLY A 471 28.77159.570 60.204 1.00 58.19 O ATOM 7101 N ALA A 472 27.117 58.276 61.2011.00 57.50 N ATOM 7103 CA ALA A 472 25.991 58.836 60.402 1.00 59.48 CATOM 7105 CB ALA A 472 24.529 58.422 60.926 1.00 59.82 C ATOM 7109 C ALAA 472 26.180 60.340 60.361 1.00 62.54 C ATOM 7110 O ALA A 472 25.93560.936 59.337 1.00 64.71 O ATOM 7111 N ASN A 473 26.708 60.910 61.4481.00 63.09 N ATOM 7113 CA ASN A 473 26.888 62.359 61.610 1.00 66.39 CATOM 7115 CB ASN A 473 27.229 62.615 63.117 1.00 67.84 C ATOM 7118 CGASN A 473 27.465 64.101 63.481 1.00 71.47 C ATOM 7119 OD1 ASN A 47328.533 64.653 63.201 1.00 72.56 O ATOM 7120 ND2 ASN A 473 26.517 64.70264.181 1.00 70.68 N ATOM 7123 C ASN A 473 27.912 62.992 60.665 1.0066.37 C ATOM 7124 O ASN A 473 27.616 63.960 60.011 1.00 68.02 O ATOM7125 N ALA A 474 29.133 62.452 60.621 1.00 65.12 N ATOM 7127 CA ALA A474 30.220 63.060 59.830 1.00 65.88 C ATOM 7129 CB ALA A 474 31.55462.342 60.019 1.00 62.40 C ATOM 7133 C ALA A 474 29.778 62.956 58.4111.00 66.42 C ATOM 7134 O ALA A 474 29.829 63.943 57.670 1.00 69.09 OATOM 7135 N CYS A 475 29.294 61.756 58.068 1.00 64.28 N ATOM 7137 CA CYSA 475 28.846 61.446 56.715 1.00 64.60 C ATOM 7139 CB CYS A 475 28.27660.046 56.655 1.00 61.39 C ATOM 7142 SG CYS A 475 29.609 58.840 57.0051.00 61.67 S ATOM 7143 C CYS A 475 27.823 62.441 56.247 1.00 68.38 CATOM 7144 O CYS A 475 27.945 62.918 55.133 1.00 70.86 O ATOM 7145 N ALAA 476 26.839 62.773 57.096 1.00 69.69 N ATOM 7147 CA ALA A 476 25.73963.659 56.708 1.00 73.44 C ATOM 7149 CB ALA A 476 24.512 63.632 57.7331.00 74.87 C ATOM 7153 C ALA A 476 26.315 65.042 56.588 1.00 76.96 CATOM 7154 O ALA A 476 25.922 65.815 55.746 1.00 80.28 O ATOM 7155 N ALAA 477 27.284 65.326 57.441 1.00 76.83 N ATOM 7157 CA ALA A 477 27.94666.610 57.480 1.00 79.93 C ATOM 7159 CB ALA A 477 28.692 66.746 58.8411.00 79.17 C ATOM 7163 C ALA A 477 28.883 66.854 56.259 1.00 80.17 CATOM 7164 O ALA A 477 29.420 67.924 56.119 1.00 83.71 O ATOM 7165 N THRA 478 29.061 65.887 55.367 1.00 77.44 N ATOM 7167 CA THR A 478 29.85766.103 54.148 1.00 78.09 C ATOM 7169 CB THR A 478 31.207 65.328 54.1841.00 74.61 C ATOM 7171 OG1 THR A 478 31.657 65.181 55.522 1.00 72.75 OATOM 7173 CG2 THR A 478 32.284 66.181 53.526 1.00 77.14 C ATOM 7177 CTHR A 478 29.159 65.664 52.870 1.00 77.93 C ATOM 7178 O THR A 478 29.82165.477 51.834 1.00 78.45 O ATOM 7179 N GLY A 479 27.857 65.436 52.9201.00 77.46 N ATOM 7181 CA GLY A 479 27.162 64.913 51.748 1.00 77.03 CATOM 7184 C GLY A 479 27.510 63.493 51.309 1.00 71.99 C ATOM 7185 O GLYA 479 27.172 63.096 50.232 1.00 71.57 O ATOM 7186 N GLN A 480 28.19762.715 52.127 1.00 68.57 N ATOM 7188 CA GLN A 480 28.453 61.317 51.7861.00 64.64 C ATOM 7190 CB GLN A 480 29.784 60.854 52.334 1.00 61.62 CATOM 7193 CG GLN A 480 30.980 61.814 52.059 1.00 64.83 C ATOM 7196 CDGLN A 480 32.316 61.198 52.592 1.00 64.82 C ATOM 7197 OE1 GLN A 48032.487 61.054 53.819 1.00 64.21 O ATOM 7198 NE2 GLN A 480 33.224 60.78751.671 1.00 62.23 N ATOM 7201 C GLN A 480 27.227 60.525 52.300 1.0063.37 C ATOM 7202 O GLN A 480 27.260 59.788 53.314 1.00 61.12 O ATOM7203 N VAL A 481 26.162 60.692 51.514 1.00 64.68 N ATOM 7205 CA VAL A481 24.809 60.368 51.872 1.00 65.06 C ATOM 7207 CB VAL A 481 24.16761.693 52.392 1.00 69.11 C ATOM 7209 CG1 VAL A 481 22.737 61.873 51.9991.00 71.00 C ATOM 7213 CG2 VAL A 481 24.349 61.727 53.885 1.00 68.55 CATOM 7217 C VAL A 481 24.142 59.795 50.629 1.00 65.55 C ATOM 7218 O VALA 481 24.589 60.047 49.535 1.00 66.48 O ATOM 7219 N CYS A 482 23.05359.055 50.768 1.00 69.26 N ATOM 7221 CA CYS A 482 22.381 58.508 49.5801.00 68.72 C ATOM 7223 CB CYS A 482 21.207 57.639 49.988 1.00 67.54 CATOM 7226 SG CYS A 482 21.874 56.056 50.630 1.00 70.71 S ATOM 7227 C CYSA 482 21.898 59.552 48.623 1.00 69.13 C ATOM 7228 O CYS A 482 21.27060.487 49.030 1.00 70.33 O ATOM 7229 N HIS A 483 22.230 59.344 47.3541.00 68.81 N ATOM 7231 CA HIS A 483 21.865 60.191 46.211 1.00 69.88 CATOM 7233 CB HIS A 483 22.206 59.481 44.903 1.00 68.48 C ATOM 7236 CGHIS A 483 22.273 60.355 43.700 1.00 69.95 C ATOM 7237 ND1 HIS A 48323.344 60.319 42.843 1.00 71.52 N ATOM 7239 CE1 HIS A 483 23.138 61.15441.840 1.00 72.59 C ATOM 7241 NE2 HIS A 483 21.952 61.697 41.998 1.0071.71 N ATOM 7243 CD2 HIS A 483 21.383 61.207 43.144 1.00 70.25 C ATOM7245 C HIS A 483 20.394 60.442 46.219 1.00 70.55 C ATOM 7246 O HIS A 48319.633 59.603 46.639 1.00 69.08 O ATOM 7247 N ALA A 484 20.033 61.64445.777 1.00 73.54 N ATOM 7249 CA ALA A 484 18.667 62.058 45.466 1.0074.84 C ATOM 7251 CB ALA A 484 18.715 63.282 44.604 1.00 77.22 C ATOM7255 C ALA A 484 17.804 60.997 44.766 1.00 73.78 C ATOM 7256 O ALA A 48416.634 60.816 45.150 1.00 74.54 O ATOM 7257 N LEU A 485 18.360 60.29443.758 1.00 72.45 N ATOM 7259 CA LEU A 485 17.549 59.450 42.876 1.0070.78 C ATOM 7261 CB LEU A 485 18.233 59.189 41.526 1.00 69.85 C ATOM7264 CG LEU A 485 18.417 60.352 40.554 1.00 71.18 C ATOM 7266 CD1 LEU A485 19.226 59.942 39.360 1.00 68.77 C ATOM 7270 CD2 LEU A 485 17.08760.885 40.150 1.00 71.99 C ATOM 7274 C LEU A 485 17.292 58.146 43.5721.00 68.77 C ATOM 7275 O LEU A 485 16.758 57.226 42.968 1.00 67.85 OATOM 7276 N CYS A 486 17.658 58.059 44.846 1.00 68.16 N ATOM 7278 CA CYSA 486 17.418 56.844 45.588 1.00 66.85 C ATOM 7280 CB CYS A 486 18.53156.547 46.571 1.00 66.88 C ATOM 7283 SG CYS A 486 20.068 56.462 45.7811.00 68.62 S ATOM 7284 C CYS A 486 16.216 56.889 46.426 1.00 66.34 CATOM 7285 O CYS A 486 15.944 57.829 47.074 1.00 66.83 O ATOM 7286 N SERA 487 15.563 55.767 46.427 1.00 65.87 N ATOM 7288 CA SER A 487 14.60155.373 47.382 1.00 67.61 C ATOM 7290 CB SER A 487 14.455 53.894 47.0961.00 66.72 C ATOM 7293 OG SER A 487 13.753 53.245 48.093 1.00 71.71 OATOM 7295 C SER A 487 15.053 55.580 48.835 1.00 68.27 C ATOM 7296 O SERA 487 16.270 55.700 49.159 1.00 68.64 O ATOM 7297 N PRO A 488 14.09455.577 49.752 1.00 69.67 N ATOM 7298 CA PRO A 488 14.443 55.564 51.1811.00 69.32 C ATOM 7300 CB PRO A 488 13.149 56.052 51.860 1.00 71.17 CATOM 7303 CG PRO A 488 12.071 55.622 50.953 1.00 72.01 C ATOM 7306 CDPRO A 488 12.636 55.635 49.538 1.00 71.29 C ATOM 7309 C PRO A 488 14.86954.179 51.626 1.00 67.39 C ATOM 7310 O PRO A 488 14.883 53.915 52.8041.00 67.71 O ATOM 7311 N GLU A 489 15.262 53.315 50.688 1.00 66.05 NATOM 7313 CA GLU A 489 15.650 51.931 50.990 1.00 64.34 C ATOM 7315 CBGLU A 489 14.944 51.012 49.979 1.00 64.65 C ATOM 7318 CG GLU A 48913.950 49.987 50.564 1.00 66.51 C ATOM 7321 CD GLU A 489 13.583 48.90749.525 1.00 69.58 C ATOM 7322 OE1 GLU A 489 13.820 47.707 49.835 1.0069.93 O ATOM 7323 OE2 GLU A 489 13.131 49.249 48.381 1.00 70.48 O ATOM7324 C GLU A 489 17.197 51.761 50.970 1.00 62.02 C ATOM 7325 O GLU A 48917.725 50.641 50.992 1.00 60.23 O ATOM 7326 N GLY A 490 17.902 52.88550.883 1.00 61.19 N ATOM 7328 CA GLY A 490 19.311 52.942 51.176 1.0060.24 C ATOM 7331 C GLY A 490 20.262 52.839 50.001 1.00 59.52 C ATOM7332 O GLY A 490 19.800 52.615 48.891 1.00 59.65 O ATOM 7333 N CYS A 49121.577 52.973 50.241 1.00 58.69 N ATOM 7335 CA CYS A 491 22.579 52.83449.190 1.00 58.30 C ATOM 7337 CB CYS A 491 23.088 54.159 48.688 1.0059.18 C ATOM 7340 SG CYS A 491 23.678 55.247 49.964 1.00 59.51 S ATOM7341 C CYS A 491 23.768 52.133 49.698 1.00 58.17 C ATOM 7342 O CYS A 49123.906 52.025 50.870 1.00 60.09 O ATOM 7343 N TRP A 492 24.644 51.72248.785 1.00 57.47 N ATOM 7345 CA TRP A 492 25.960 51.167 49.054 1.0057.58 C ATOM 7347 CB TRP A 492 26.198 49.914 48.208 1.00 57.23 C ATOM7350 CG TRP A 492 25.251 48.846 48.427 1.00 56.66 C ATOM 7351 CD1 TRP A492 24.125 48.616 47.769 1.00 56.12 C ATOM 7353 NE1 TRP A 492 23.50447.505 48.257 1.00 56.13 N ATOM 7355 CE2 TRP A 492 24.257 47.030 49.2751.00 56.67 C ATOM 7356 CD2 TRP A 492 25.367 47.843 49.384 1.00 56.95 CATOM 7357 CE3 TRP A 492 26.323 47.539 50.332 1.00 57.68 C ATOM 7359 CZ3TRP A 492 26.133 46.504 51.114 1.00 58.09 C ATOM 7361 CH2 TRP A 49225.012 45.719 50.987 1.00 57.91 C ATOM 7363 CZ2 TRP A 492 24.068 45.96950.056 1.00 57.20 C ATOM 7365 C TRP A 492 26.997 52.155 48.596 1.0058.58 C ATOM 7366 O TRP A 492 28.024 51.764 48.120 1.00 59.09 O ATOM7367 N GLY A 493 26.736 53.443 48.717 1.00 59.23 N ATOM 7369 CA GLY A493 27.584 54.415 48.045 1.00 60.57 C ATOM 7372 C GLY A 493 26.90555.667 47.512 1.00 61.34 C ATOM 7373 O GLY A 493 25.700 55.817 47.5421.00 60.80 O ATOM 7374 N PRO A 494 27.715 56.602 47.067 1.00 63.04 NATOM 7375 CA PRO A 494 27.223 57.926 46.798 1.00 65.24 C ATOM 7377 CBPRO A 494 28.514 58.706 46.562 1.00 67.15 C ATOM 7380 CG PRO A 49429.467 57.738 46.091 1.00 66.26 C ATOM 7383 CD PRO A 494 29.148 56.51646.802 1.00 64.20 C ATOM 7386 C PRO A 494 26.328 57.929 45.573 1.0066.33 C ATOM 7387 O PRO A 494 25.317 58.597 45.559 1.00 68.00 O ATOM7388 N GLU A 495 26.684 57.109 44.592 1.00 66.87 N ATOM 7390 CA GLU A495 26.191 57.194 43.228 1.00 67.29 C ATOM 7392 CB GLU A 495 27.26256.599 42.343 1.00 67.64 C ATOM 7395 CG GLU A 495 28.401 57.573 42.1481.00 71.68 C ATOM 7398 CD GLU A 495 29.577 56.927 41.440 1.00 76.82 CATOM 7399 OE1 GLU A 495 29.470 55.740 40.951 1.00 75.08 O ATOM 7400 OE2GLU A 495 30.632 57.625 41.377 1.00 82.21 O ATOM 7401 C GLU A 495 24.83756.544 42.919 1.00 65.80 C ATOM 7402 O GLU A 495 24.367 55.692 43.6761.00 63.46 O ATOM 7403 N PRO A 496 24.192 56.963 41.810 1.00 67.18 NATOM 7404 CA PRO A 496 22.872 56.413 41.435 1.00 65.83 C ATOM 7406 CBPRO A 496 22.428 57.256 40.256 1.00 66.55 C ATOM 7409 CG PRO A 49623.607 57.978 39.815 1.00 69.03 C ATOM 7412 CD PRO A 496 24.636 58.01340.872 1.00 69.18 C ATOM 7415 C PRO A 496 22.869 54.918 41.127 1.0064.10 C ATOM 7416 O PRO A 496 21.872 54.322 41.478 1.00 64.50 O ATOM7417 N ARG A 497 23.927 54.318 40.585 1.00 63.43 N ATOM 7419 CA ARG A497 23.998 52.856 40.554 1.00 61.81 C ATOM 7421 CB ARG A 497 25.10252.371 39.600 1.00 62.79 C ATOM 7424 CG ARG A 497 26.384 53.144 39.6091.00 64.56 C ATOM 7427 CD ARG A 497 27.644 52.336 39.155 1.00 65.35 CATOM 7430 NE ARG A 497 28.741 52.771 40.030 1.00 68.46 N ATOM 7432 CZARG A 497 30.025 52.441 39.960 1.00 68.79 C ATOM 7433 NH1 ARG A 49730.472 51.636 39.000 1.00 68.43 N ATOM 7436 NH2 ARG A 497 30.864 52.94340.888 1.00 69.25 N ATOM 7439 C ARG A 497 24.213 52.199 41.913 1.0060.94 C ATOM 7440 O ARG A 497 24.213 50.997 42.032 1.00 60.39 O ATOM7441 N ASP A 498 24.436 52.990 42.939 1.00 61.84 N ATOM 7443 CA ASP A498 24.624 52.484 44.285 1.00 60.98 C ATOM 7445 CB ASP A 498 25.57953.410 45.067 1.00 62.53 C ATOM 7448 CG ASP A 498 27.019 53.424 44.5031.00 62.37 C ATOM 7449 OD1 ASP A 498 27.333 52.507 43.754 1.00 63.21 OATOM 7450 OD2 ASP A 498 27.902 54.266 44.765 1.00 61.45 O ATOM 7451 CASP A 498 23.314 52.291 45.059 1.00 60.30 C ATOM 7452 O ASP A 498 23.32451.685 46.104 1.00 58.31 O ATOM 7453 N CYS A 499 22.172 52.740 44.5431.00 61.23 N ATOM 7455 CA CYS A 499 20.943 52.486 45.291 1.00 61.84 CATOM 7457 CB CYS A 499 19.812 53.357 44.872 1.00 62.74 C ATOM 7460 SGCYS A 499 20.331 54.978 44.411 1.00 66.84 S ATOM 7461 C CYS A 499 20.43351.076 45.244 1.00 61.36 C ATOM 7462 O CYS A 499 20.878 50.243 44.4601.00 61.72 O ATOM 7463 N VAL A 500 19.488 50.844 46.136 1.00 61.48 NATOM 7465 CA VAL A 500 18.869 49.574 46.344 1.00 61.04 C ATOM 7467 CBVAL A 500 18.561 49.388 47.868 1.00 61.98 C ATOM 7469 CG1 VAL A 50017.793 48.079 48.131 1.00 63.20 C ATOM 7473 CG2 VAL A 500 19.840 49.43348.728 1.00 60.20 C ATOM 7477 C VAL A 500 17.588 49.573 45.554 1.0061.08 C ATOM 7478 O VAL A 500 17.157 48.532 45.141 1.00 61.21 O ATOM7479 N SER A 501 16.978 50.746 45.391 1.00 61.78 N ATOM 7481 CA SER A501 15.715 50.963 44.651 1.00 62.67 C ATOM 7483 CB SER A 501 14.49650.409 45.457 1.00 63.41 C ATOM 7486 OG SER A 501 14.295 50.992 46.7451.00 62.89 O ATOM 7488 C SER A 501 15.580 52.495 44.276 1.00 64.49 CATOM 7489 O SER A 501 16.205 53.346 44.915 1.00 65.53 O ATOM 7490 N CYSA 502 14.796 52.870 43.271 1.00 65.42 N ATOM 7492 CA CYS A 502 14.82854.267 42.789 1.00 67.75 C ATOM 7494 CB CYS A 502 14.768 54.264 41.2791.00 67.77 C ATOM 7497 SG CYS A 502 16.221 53.363 40.726 1.00 74.29 SATOM 7498 C CYS A 502 13.720 55.123 43.312 1.00 68.44 C ATOM 7499 O CYSA 502 12.717 54.556 43.656 1.00 69.58 O ATOM 7500 N ALA A 503 13.83856.455 43.368 1.00 68.92 N ATOM 7502 CA ALA A 503 12.653 57.227 43.7981.00 71.83 C ATOM 7504 CB ALA A 503 12.941 58.787 44.045 1.00 73.74 CATOM 7508 C ALA A 503 11.611 57.004 42.683 1.00 72.91 C ATOM 7509 O ALAA 503 10.457 56.658 42.934 1.00 72.96 O ATOM 7510 N ASN A 504 12.08957.121 41.445 1.00 72.99 N ATOM 7512 CA ASN A 504 11.256 57.123 40.2431.00 74.36 C ATOM 7514 CB ASN A 504 11.575 58.361 39.406 1.00 75.32 CATOM 7517 CG ASN A 504 11.494 59.602 40.235 1.00 78.00 C ATOM 7518 OD1ASN A 504 10.412 60.228 40.359 1.00 82.73 O ATOM 7519 ND2 ASN A 50412.596 59.937 40.899 1.00 75.00 N ATOM 7522 C ASN A 504 11.434 55.84639.457 1.00 73.02 C ATOM 7523 O ASN A 504 10.662 54.873 39.645 1.0072.93 O ATOM 7524 N VAL A 505 12.501 55.828 38.644 1.00 72.34 N ATOM7526 CA VAL A 505 12.729 54.790 37.645 1.00 70.30 C ATOM 7528 CB VAL A505 12.389 55.347 36.278 1.00 71.79 C ATOM 7530 CG1 VAL A 505 12.52454.251 35.263 1.00 71.94 C ATOM 7534 CG2 VAL A 505 11.011 55.887 36.2451.00 72.79 C ATOM 7538 C VAL A 505 14.158 54.374 37.502 1.00 67.81 CATOM 7539 O VAL A 505 15.046 55.143 37.612 1.00 68.17 O ATOM 7540 N SERA 506 14.376 53.149 37.128 1.00 66.94 N ATOM 7542 CA SER A 506 15.73652.664 36.881 1.00 65.51 C ATOM 7544 CB SER A 506 15.987 51.363 37.6431.00 63.70 C ATOM 7547 OG SER A 506 14.880 50.489 37.521 1.00 63.05 OATOM 7549 C SER A 506 15.894 52.410 35.406 1.00 65.47 C ATOM 7550 O SERA 506 14.922 52.084 34.730 1.00 65.31 O ATOM 7551 N ARG A 507 17.10452.648 34.920 1.00 66.02 N ATOM 7553 CA ARG A 507 17.563 52.198 33.6061.00 66.52 C ATOM 7555 CB ARG A 507 18.321 53.306 32.922 1.00 67.29 CATOM 7558 CG ARG A 507 18.520 53.085 31.458 1.00 67.04 C ATOM 7561 CDARG A 507 19.211 54.254 30.845 1.00 69.49 C ATOM 7564 NE ARG A 50718.350 55.355 30.381 1.00 72.58 N ATOM 7566 CZ ARG A 507 18.876 56.52529.999 1.00 77.80 C ATOM 7567 NH1 ARG A 507 20.241 56.684 30.043 1.0076.65 N ATOM 7570 NH2 ARG A 507 18.076 57.514 29.521 1.00 79.53 N ATOM7573 C ARG A 507 18.500 51.002 33.751 1.00 66.50 C ATOM 7574 O ARG A 50719.747 51.161 33.656 1.00 66.13 O ATOM 7575 N GLY A 508 17.900 49.83334.047 1.00 66.65 N ATOM 7577 CA GLY A 508 18.644 48.603 34.086 1.0065.74 C ATOM 7580 C GLY A 508 19.525 48.460 35.303 1.00 65.94 C ATOM7581 O GLY A 508 19.625 47.337 35.840 1.00 66.96 O ATOM 7582 N ARG A 50920.223 49.516 35.730 1.00 66.56 N ATOM 7584 CA ARG A 509 21.083 49.44536.964 1.00 66.64 C ATOM 7586 CB ARG A 509 22.489 48.881 36.701 1.0066.71 C ATOM 7589 CG ARG A 509 23.298 49.663 35.556 1.00 69.61 C ATOM7592 CD ARG A 509 23.416 48.867 34.185 1.00 70.79 C ATOM 7595 NE ARG A509 24.374 49.468 33.244 1.00 73.28 N ATOM 7597 CZ ARG A 509 25.62848.985 32.971 1.00 75.15 C ATOM 7598 NH1 ARG A 509 26.131 47.881 33.5691.00 71.78 N ATOM 7601 NH2 ARG A 509 26.402 49.636 32.074 1.00 77.07 NATOM 7604 C ARG A 509 21.264 50.782 37.627 1.00 66.73 C ATOM 7605 O ARGA 509 21.410 50.847 38.811 1.00 67.34 O ATOM 7606 N GLU A 510 21.29751.853 36.858 1.00 67.08 N ATOM 7608 CA GLU A 510 21.459 53.183 37.4341.00 67.32 C ATOM 7610 CB GLU A 510 22.246 54.101 36.478 1.00 68.74 CATOM 7613 CG GLU A 510 21.936 55.585 36.586 1.00 70.35 C ATOM 7616 CDGLU A 510 22.933 56.425 35.809 1.00 74.79 C ATOM 7617 OE1 GLU A 51023.986 55.840 35.426 1.00 74.61 O ATOM 7618 OE2 GLU A 510 22.658 57.65235.572 1.00 77.88 O ATOM 7619 C GLU A 510 20.078 53.729 37.693 1.0066.81 C ATOM 7620 O GLU A 510 19.137 53.401 36.977 1.00 66.94 O ATOM7621 N CYS A 511 19.959 54.554 38.719 1.00 66.39 N ATOM 7623 CA CYS A511 18.693 55.135 39.066 1.00 66.14 C ATOM 7625 CB CYS A 511 18.61055.343 40.548 1.00 65.95 C ATOM 7628 SG CYS A 511 18.160 53.799 41.3631.00 62.99 S ATOM 7629 C CYS A 511 18.661 56.414 38.318 1.00 68.45 CATOM 7630 O CYS A 511 19.671 57.145 38.275 1.00 69.88 O ATOM 7631 N VALA 512 17.519 56.652 37.670 1.00 69.26 N ATOM 7633 CA VAL A 512 17.28457.840 36.860 1.00 71.01 C ATOM 7635 CB VAL A 512 17.364 57.499 35.3571.00 70.31 C ATOM 7637 CG1 VAL A 512 17.763 58.724 34.563 1.00 74.73 CATOM 7641 CG2 VAL A 512 18.413 56.495 35.122 1.00 69.40 C ATOM 7645 CVAL A 512 15.961 58.568 37.218 1.00 72.75 C ATOM 7646 O VAL A 512 14.99157.984 37.710 1.00 71.70 O ATOM 7647 N ASP A 513 15.953 59.871 36.9521.00 75.55 N ATOM 7649 CA ASP A 513 14.763 60.722 37.132 1.00 78.34 CATOM 7651 CB ASP A 513 15.195 62.210 37.064 1.00 82.23 C ATOM 7654 CGASP A 513 15.778 62.604 35.666 1.00 86.47 C ATOM 7655 OD1 ASP A 51316.485 61.724 35.028 1.00 85.95 O ATOM 7656 OD2 ASP A 513 15.527 63.75035.143 1.00 89.04 O ATOM 7657 C ASP A 513 13.600 60.486 36.136 1.0078.00 C ATOM 7658 O ASP A 513 12.407 60.618 36.490 1.00 78.71 O ATOM7659 N LYS A 514 13.936 60.184 34.885 1.00 76.63 N ATOM 7661 CA LYS A514 12.907 60.080 33.832 1.00 77.37 C ATOM 7663 CB LYS A 514 12.66161.438 33.090 1.00 79.82 C ATOM 7670 C LYS A 514 13.389 59.087 32.8411.00 74.72 C ATOM 7671 O LYS A 514 14.568 58.916 32.682 1.00 71.86 OATOM 7672 N CYS A 515 12.473 58.478 32.118 1.00 75.49 N ATOM 7674 CA CYSA 515 12.882 57.736 30.931 1.00 75.27 C ATOM 7676 CB CYS A 515 11.95356.576 30.660 1.00 74.23 C ATOM 7679 SG CYS A 515 12.029 55.503 32.0491.00 75.96 S ATOM 7680 C CYS A 515 12.878 58.608 29.723 1.00 77.45 CATOM 7681 O CYS A 515 12.396 59.736 29.762 1.00 80.72 O ATOM 7682 N ASNA 516 13.375 58.047 28.632 1.00 76.28 N ATOM 7684 CA ASN A 516 13.45058.745 27.390 1.00 78.27 C ATOM 7686 CB ASN A 516 14.682 58.263 26.6281.00 76.82 C ATOM 7689 CG ASN A 516 15.962 58.751 27.257 1.00 76.59 CATOM 7690 OD1 ASN A 516 15.913 59.562 28.158 1.00 76.10 O ATOM 7691 ND2ASN A 516 17.118 58.255 26.792 1.00 78.58 N ATOM 7694 C ASN A 516 12.16258.593 26.589 1.00 79.48 C ATOM 7695 O ASN A 516 12.214 58.369 25.3921.00 80.32 O ATOM 7696 N LEU A 517 11.005 58.722 27.247 1.00 80.26 NATOM 7698 CA LEU A 517 9.729 58.866 26.540 1.00 81.89 C ATOM 7700 CB LEUA 517 8.536 58.802 27.508 1.00 82.29 C ATOM 7703 CG LEU A 517 8.47257.763 28.612 1.00 78.11 C ATOM 7705 CD1 LEU A 517 7.256 57.874 29.4931.00 78.46 C ATOM 7709 CD2 LEU A 517 8.494 56.410 27.960 1.00 77.57 CATOM 7713 C LEU A 517 9.787 60.258 25.953 1.00 85.89 C ATOM 7714 O LEU A517 9.879 61.252 26.730 1.00 89.33 O ATOM 7715 N LEU A 518 9.773 60.38924.633 1.00 86.14 N ATOM 7717 CA LEU A 518 9.569 61.731 24.037 1.0089.84 C ATOM 7719 CB LEU A 518 8.620 62.609 24.906 1.00 92.23 C ATOM7722 CG LEU A 518 7.226 62.059 25.263 1.00 91.47 C ATOM 7724 CD1 LEU A518 6.556 62.839 26.352 1.00 93.70 C ATOM 7728 CD2 LEU A 518 6.38262.115 24.048 1.00 93.66 C ATOM 7732 C LEU A 518 10.827 62.542 23.7241.00 90.91 C ATOM 7733 O LEU A 518 10.733 63.588 23.093 1.00 94.73 OATOM 7734 N GLU A 519 11.990 62.050 24.106 1.00 88.21 N ATOM 7736 CA GLUA 519 13.211 62.857 24.134 1.00 90.11 C ATOM 7738 CB GLU A 519 13.10064.031 25.150 1.00 92.09 C ATOM 7745 C GLU A 519 14.289 61.868 24.5791.00 87.46 C ATOM 7746 O GLU A 519 14.162 61.310 25.671 1.00 86.35 OATOM 7747 N GYL A 520 15.305 61.576 23.753 1.00 87.39 N ATOM 7749 CA GYLA 520 16.367 60.664 24.168 1.00 84.28 C ATOM 7752 C GYL A 520 17.18459.916 23.123 1.00 83.49 C ATOM 7753 O GYL A 520 16.762 59.776 21.9621.00 83.56 O ATOM 7754 N GLU A 521 18.343 59.402 23.598 1.00 82.41 NATOM 7756 CA GLU A 521 19.346 58.645 22.811 1.00 81.13 C ATOM 7758 CBGLU A 521 20.537 58.131 23.652 1.00 79.67 C ATOM 7765 C GLU A 521 18.60057.538 22.157 1.00 78.75 C ATOM 7766 O GLU A 521 18.095 57.788 21.0711.00 81.59 O ATOM 7767 N PRO A 522 18.450 56.371 22.786 1.00 75.18 NATOM 7768 CA PRO A 522 17.393 55.446 22.365 1.00 72.91 C ATOM 7770 CBPRO A 522 17.911 54.074 22.846 1.00 70.53 C ATOM 7773 CG PRO A 52218.755 54.376 24.063 1.00 70.29 C ATOM 7776 CD PRO A 522 19.206 55.82223.940 1.00 73.90 C ATOM 7779 C PRO A 522 16.098 55.838 23.085 1.0072.50 C ATOM 7780 O PRO A 522 16.099 56.091 24.277 1.00 71.74 O ATOM7781 N ARG A 523 15.000 55.914 22.354 1.00 73.17 N ATOM 7783 CA ARG A523 13.700 56.209 22.950 1.00 73.74 C ATOM 7785 CB ARG A 523 12.64256.629 21.883 1.00 75.26 C ATOM 7794 C ARG A 523 13.348 54.933 23.7041.00 70.93 C ATOM 7795 O ARG A 523 13.763 53.837 23.330 1.00 68.98 OATOM 7796 N GLU A 524 12.655 55.074 24.817 1.00 71.17 N ATOM 7798 CA GLUA 524 12.390 53.915 25.690 1.00 69.50 C ATOM 7800 CB GLU A 524 13.38153.846 26.934 1.00 67.31 C ATOM 7807 C GLU A 524 10.900 53.981 26.0761.00 70.75 C ATOM 7808 O GLU A 524 10.278 55.027 25.933 1.00 72.03 OATOM 7809 N PHE A 525 10.339 52.834 26.487 1.00 70.41 N ATOM 7811 CA PHEA 525 9.073 52.756 27.238 1.00 71.56 C ATOM 7813 CB PHE A 525 8.07251.852 26.513 1.00 71.53 C ATOM 7816 CG PHE A 525 8.376 50.386 26.6251.00 68.87 C ATOM 7817 CD1 PHE A 525 7.672 49.582 27.527 1.00 66.88 CATOM 7819 CE1 PHE A 525 7.933 48.262 27.624 1.00 65.64 C ATOM 7821 CZPHE A 525 8.923 47.692 26.821 1.00 65.09 C ATOM 7823 CE2 PHE A 525 9.62548.470 25.920 1.00 64.47 C ATOM 7825 CD2 PHE A 525 9.348 49.810 25.8241.00 66.17 C ATOM 7827 C PHE A 525 9.370 52.267 28.663 1.00 70.74 C ATOM7828 O PHE A 525 10.511 52.060 29.014 1.00 69.95 O ATOM 7829 N VAL A 5268.350 52.071 29.478 1.00 72.42 N ATOM 7831 CA VAL A 526 8.512 51.80430.902 1.00 71.94 C ATOM 7833 CB VAL A 526 8.002 52.989 31.696 1.0073.98 C ATOM 7835 CG1 VAL A 526 7.837 52.617 33.185 1.00 75.09 C ATOM7839 CG2 VAL A 526 8.908 54.239 31.481 1.00 74.24 C ATOM 7843 C VAL A526 7.648 50.632 31.327 1.00 73.13 C ATOM 7844 O VAL A 526 6.495 50.50630.870 1.00 75.47 O ATOM 7845 N GLU A 527 8.176 49.785 32.218 1.00 72.37N ATOM 7847 CA GLU A 527 7.356 48.786 32.900 1.00 73.28 C ATOM 7849 CBGLU A 527 7.025 47.568 32.001 1.00 73.10 C ATOM 7852 CG GLU A 527 8.21846.727 31.521 1.00 71.94 C ATOM 7855 CD GLU A 527 7.836 45.371 30.8511.00 72.04 C ATOM 7856 OE1 GLU A 527 6.743 45.307 30.202 1.00 69.38 OATOM 7857 OE2 GLU A 527 8.648 44.377 30.965 1.00 68.38 O ATOM 7858 C GLUA 527 8.000 48.365 34.226 1.00 72.76 C ATOM 7859 O GLU A 527 9.11547.824 34.258 1.00 71.27 O ATOM 7860 N ASN A 528 7.244 48.589 35.3081.00 74.36 N ATOM 7862 CA ASN A 528 7.661 48.313 36.678 1.00 73.60 CATOM 7864 CB ASN A 528 7.986 46.830 36.923 1.00 72.97 C ATOM 7867 CG ASNA 528 7.226 45.878 35.978 1.00 75.77 C ATOM 7868 OD1 ASN A 528 5.99045.973 35.798 1.00 77.45 O ATOM 7869 ND2 ASN A 528 7.978 44.952 35.3531.00 77.81 N ATOM 7872 C ASN A 528 8.833 49.221 36.924 1.00 71.99 C ATOM7873 O ASN A 528 9.871 48.815 37.396 1.00 71.09 O ATOM 7874 N SER A 5298.652 50.478 36.543 1.00 72.85 N ATOM 7876 CA SER A 529 9.608 51.52136.862 1.00 71.65 C ATOM 7878 CB SER A 529 9.699 51.713 38.387 1.0072.07 C ATOM 7881 OG SER A 529 8.447 52.198 38.850 1.00 75.50 O ATOM7883 C SER A 529 10.965 51.223 36.289 1.00 68.41 C ATOM 7884 O SER A 52911.971 51.654 36.838 1.00 67.15 O ATOM 7885 N GLU A 530 11.000 50.52335.172 1.00 66.50 N ATOM 7887 CA GLU A 530 12.270 50.325 34.533 1.0065.30 C ATOM 7889 CB GLU A 530 12.844 48.908 34.841 1.00 64.54 C ATOM7892 CG GLU A 530 12.086 47.695 34.312 1.00 67.37 C ATOM 7895 CD GLU A530 12.640 46.360 34.858 1.00 71.17 C ATOM 7896 OE1 GLU A 530 13.47346.411 35.793 1.00 73.46 O ATOM 7897 OE2 GLU A 530 12.263 45.242 34.3581.00 73.29 O ATOM 7898 C GLU A 530 12.191 50.692 33.060 1.00 64.85 CATOM 7899 O GLU A 530 11.152 50.638 32.500 1.00 65.79 O ATOM 7900 N CYSA 531 13.302 51.128 32.477 1.00 64.45 N ATOM 7902 CA CYS A 531 13.37051.702 31.133 1.00 65.38 C ATOM 7904 CB CYS A 531 14.157 52.986 31.1091.00 66.14 C ATOM 7907 SG CYS A 531 13.296 53.919 32.284 1.00 71.12 SATOM 7908 C CYS A 531 14.000 50.813 30.142 1.00 64.46 C ATOM 7909 O CYSA 531 15.195 50.531 30.187 1.00 63.28 O ATOM 7910 N ILE A 532 13.17850.491 29.167 1.00 65.37 N ATOM 7912 CA ILE A 532 13.468 49.509 28.1871.00 65.17 C ATOM 7914 CB ILE A 532 12.381 48.517 28.302 1.00 65.55 CATOM 7916 CG1 ILE A 532 12.447 47.966 29.713 1.00 66.66 C ATOM 7919 CD1ILE A 532 11.359 47.069 29.980 1.00 70.19 C ATOM 7923 CG2 ILE A 53212.541 47.427 27.274 1.00 65.55 C ATOM 7927 C ILE A 532 13.464 50.13126.825 1.00 65.90 C ATOM 7928 O ILE A 532 12.544 50.839 26.477 1.0066.89 O ATOM 7929 N GLN A 533 14.500 49.835 26.049 1.00 66.08 N ATOM7931 CA GLN A 533 14.651 50.416 24.711 1.00 67.62 C ATOM 7933 CB GLN A533 15.969 49.974 24.060 1.00 67.56 C ATOM 7936 CG GLN A 533 17.23350.681 24.519 1.00 69.80 C ATOM 7939 CD GLN A 533 18.451 49.923 24.0401.00 70.83 C ATOM 7940 OE1 GLN A 533 18.620 49.748 22.845 1.00 72.01 OATOM 7941 NE2 GLN A 533 19.251 49.412 24.962 1.00 71.14 N ATOM 7944 CGLN A 533 13.558 49.968 23.770 1.00 67.44 C ATOM 7945 O GLN A 533 13.11348.818 23.791 1.00 65.57 O ATOM 7946 N CYS A 534 13.183 50.881 22.8951.00 68.65 N ATOM 7948 CA CYS A 534 12.323 50.512 21.786 1.00 69.43 CATOM 7950 CB CYS A 534 11.753 51.740 21.154 1.00 71.08 C ATOM 7953 SGCYS A 534 10.611 52.557 22.300 1.00 73.86 S ATOM 7954 C CYS A 534 13.12649.751 20.777 1.00 68.25 C ATOM 7955 O CYS A 534 14.262 50.108 20.5081.00 68.52 O ATOM 7956 N HIS A 535 12.543 48.707 20.222 1.00 66.84 NATOM 7958 CA HIS A 535 13.212 48.012 19.163 1.00 65.78 C ATOM 7960 CBHIS A 535 12.216 47.085 18.497 1.00 66.02 C ATOM 7963 CG HIS A 53512.824 46.218 17.462 1.00 64.32 C ATOM 7964 ND1 HIS A 535 13.031 46.63816.175 1.00 61.92 N ATOM 7966 CE1 HIS A 535 13.599 45.677 15.489 1.0064.12 C ATOM 7968 NE2 HIS A 535 13.800 44.658 16.299 1.00 65.31 N ATOM7970 CD2 HIS A 535 13.337 44.980 17.543 1.00 64.19 C ATOM 7972 C HIS A535 13.822 49.045 18.165 1.00 66.70 C ATOM 7973 O HIS A 535 13.21750.069 17.907 1.00 68.03 O ATOM 7974 N PRO A 536 15.028 48.800 17.6371.00 66.72 N ATOM 7975 CA PRO A 536 15.804 49.881 16.971 1.00 67.56 CATOM 7977 CB PRO A 536 17.231 49.296 16.821 1.00 67.39 C ATOM 7980 CGPRO A 536 17.085 47.783 16.953 1.00 66.07 C ATOM 7983 CD PRO A 53615.762 47.502 17.657 1.00 65.17 C ATOM 7986 C PRO A 536 15.311 50.17915.631 1.00 68.62 C ATOM 7987 O PRO A 536 15.855 51.051 14.996 1.0070.04 O ATOM 7988 N GLU A 537 14.367 49.374 15.170 1.00 68.61 N ATOM7990 CA GLU A 537 13.650 49.638 13.937 1.00 69.99 C ATOM 7992 CB GLU A537 13.211 48.324 13.277 1.00 68.51 C ATOM 7995 CG GLU A 537 14.32547.611 12.610 1.00 68.09 C ATOM 7998 CD GLU A 537 15.045 48.492 11.6261.00 70.66 C ATOM 7999 OE1 GLU A 537 14.402 49.367 11.003 1.00 74.79 OATOM 8000 OE2 GLU A 537 16.267 48.319 11.485 1.00 72.71 O ATOM 8001 CGLU A 537 12.418 50.521 14.139 1.00 71.72 C ATOM 8002 O GLU A 537 11.67250.711 13.201 1.00 74.11 O ATOM 8003 N CYS A 538 12.169 51.060 15.3251.00 71.85 N ATOM 8005 CA CYS A 538 11.143 52.088 15.421 1.00 73.89 CATOM 8007 CB CYS A 538 10.500 52.152 16.780 1.00 74.04 C ATOM 8010 SGCYS A 538 9.888 50.553 17.320 1.00 72.72 S ATOM 8011 C CYS A 538 11.77053.404 15.135 1.00 75.65 C ATOM 8012 O CYS A 538 12.918 53.645 15.4981.00 74.35 O ATOM 8013 N LEU A 539 10.989 54.235 14.445 1.00 78.81 NATOM 8015 CA LEU A 539 11.368 55.584 14.097 1.00 81.09 C ATOM 8017 CBLEU A 539 10.672 55.993 12.829 1.00 83.53 C ATOM 8020 CG LEU A 53911.126 57.328 12.277 1.00 86.35 C ATOM 8022 CD1 LEU A 539 12.585 57.28711.828 1.00 85.10 C ATOM 8026 CD2 LEU A 539 10.163 57.659 11.175 1.0088.79 C ATOM 8030 C LEU A 539 10.960 56.483 15.249 1.00 82.49 C ATOM8031 O LEU A 539 9.773 56.549 15.611 1.00 82.07 O ATOM 8032 N PRO A 54011.968 57.076 15.893 1.00 83.31 N ATOM 8033 CA PRO A 540 11.736 58.14716.878 1.00 84.93 C ATOM 8035 CB PRO A 540 13.129 58.776 17.104 1.0085.34 C ATOM 8038 CG PRO A 540 14.139 57.881 16.384 1.00 84.21 C ATOM8041 CD PRO A 540 13.398 56.694 15.818 1.00 81.81 C ATOM 8044 C PRO A540 10.784 59.185 16.374 1.00 88.12 C ATOM 8045 O PRO A 540 10.90859.595 15.238 1.00 89.43 O ATOM 8046 N GLN A 541 9.886 59.604 17.2581.00 89.34 N ATOM 8048 CA GLN A 541 8.794 60.495 16.962 1.00 92.72 CATOM 8050 CB GLN A 541 7.463 59.830 17.324 1.00 92.16 C ATOM 8053 CG GLNA 541 7.171 58.527 16.577 1.00 89.77 C ATOM 8056 CD GLN A 541 6.35458.684 15.285 1.00 92.88 C ATOM 8057 OE1 GLN A 541 5.697 59.736 15.0271.00 96.32 O ATOM 8058 NE2 GLN A 541 6.385 57.629 14.462 1.00 88.98 NATOM 8061 C GLN A 541 8.961 61.755 17.791 1.00 95.58 C ATOM 8062 O GLN A541 8.962 61.700 19.017 1.00 93.76 O ATOM 8063 N ALA A 542 9.043 62.89817.103 1.00 100.12 N ATOM 8065 CA ALA A 542 9.171 64.199 17.758 1.00103.21 C ATOM 8067 CB ALA A 542 9.082 65.306 16.720 1.00 107.95 C ATOM8071 C ALA A 542 8.092 64.366 18.819 1.00 104.03 C ATOM 8072 O ALA A 5428.396 64.498 19.999 1.00 103.11 O ATOM 8073 N MET A 543 6.834 64.28118.400 1.00 105.83 N ATOM 8075 CA MET A 543 5.718 64.631 19.277 1.00108.35 C ATOM 8077 CB MET A 543 4.430 64.701 18.477 1.00 111.35 C ATOM8080 CG MET A 543 4.523 65.603 17.241 1.00 116.25 C ATOM 8083 SD MET A543 4.822 67.395 17.470 1.00 123.15 S ATOM 8084 CE MET A 543 6.48667.662 18.473 1.00 119.09 C ATOM 8088 C MET A 543 5.518 63.708 20.4821.00 105.56 C ATOM 8089 O MET A 543 5.645 64.161 21.642 1.00 105.64 OATOM 8090 N ASN A 544 5.215 62.425 20.192 1.00 102.85 N ATOM 8092 CA ASNA 544 4.756 61.436 21.189 1.00 99.69 C ATOM 8094 CB ASN A 544 3.44060.756 20.758 1.00 100.63 C ATOM 8097 CG ASN A 544 2.311 61.737 20.5931.00 106.66 C ATOM 8098 OD1 ASN A 544 2.108 62.599 21.452 1.00 113.63 OATOM 8099 ND2 ASN A 544 1.587 61.647 19.474 1.00 107.70 N ATOM 8102 CASN A 544 5.730 60.329 21.403 1.00 94.33 C ATOM 8103 O ASN A 544 6.73060.230 20.713 1.00 93.08 O ATOM 8104 N ILE A 545 5.400 59.553 22.4331.00 91.45 N ATOM 8106 CA ILE A 545 5.741 58.160 22.629 1.00 86.98 CATOM 8108 CB ILE A 545 4.474 57.465 23.309 1.00 86.92 C ATOM 8110 CG1ILE A 545 4.672 57.482 24.841 1.00 89.02 C ATOM 8113 CD1 ILE A 545 3.52256.919 25.781 1.00 91.04 C ATOM 8117 CG2 ILE A 545 4.136 56.089 22.7681.00 82.26 C ATOM 8121 C ILE A 545 6.144 57.489 21.337 1.00 86.03 C ATOM8122 O ILE A 545 5.452 57.604 20.316 1.00 88.94 O ATOM 8123 N THR A 5467.267 56.788 21.380 1.00 82.71 N ATOM 8125 CA THR A 546 7.828 56.12520.215 1.00 80.76 C ATOM 8127 CB THR A 546 9.312 56.458 20.162 1.0079.71 C ATOM 8129 OG1 THR A 546 9.431 57.779 19.651 1.00 81.40 O ATOM8131 CG2 THR A 546 10.108 55.583 19.160 1.00 77.72 C ATOM 8135 C THR A546 7.623 54.612 20.203 1.00 78.40 C ATOM 8136 O THR A 546 8.110 53.97119.274 1.00 76.95 O ATOM 8137 N CYS A 547 6.944 54.045 21.218 1.00 77.55N ATOM 8139 CA CYS A 547 6.542 52.622 21.189 1.00 76.32 C ATOM 8141 CBCYS A 547 7.766 51.712 21.067 1.00 73.37 C ATOM 8144 SG CYS A 547 8.78951.650 22.513 1.00 73.09 S ATOM 8145 C CYS A 547 5.688 52.116 22.3441.00 75.94 C ATOM 8146 O CYS A 547 5.642 52.743 23.343 1.00 76.38 O ATOM8147 N THR A 548 5.047 50.955 22.188 1.00 76.01 N ATOM 8149 CA THR A 5484.280 50.292 23.254 1.00 76.89 C ATOM 8151 CB THR A 548 3.066 49.53822.668 1.00 78.86 C ATOM 8153 OG1 THR A 548 2.220 50.450 21.967 1.0082.65 O ATOM 8155 CG2 THR A 548 2.142 48.955 23.780 1.00 80.14 C ATOM8159 C THR A 548 5.071 49.259 24.089 1.00 74.79 C ATOM 8160 O THR A 5484.572 48.822 25.099 1.00 75.56 O ATOM 8161 N GYL A 549 6.289 48.87523.701 1.00 72.66 N ATOM 8163 CA GYL A 549 6.888 47.648 24.191 1.0070.37 C ATOM 8166 C GYL A 549 7.998 47.174 23.273 1.00 69.28 C ATOM 8167O GYL A 549 8.481 47.923 22.394 1.00 69.27 O ATOM 8168 N ARG A 550 8.37045.904 23.434 1.00 68.41 N ATOM 8170 CA ARG A 550 9.617 45.393 22.8631.00 66.94 C ATOM 8172 CB ARG A 550 10.066 44.051 23.463 1.00 66.83 CATOM 8175 CG ARG A 550 9.594 43.646 24.804 1.00 67.69 C ATOM 8178 CD ARGA 550 10.696 43.065 25.661 1.00 67.99 C ATOM 8181 NE ARG A 550 10.46743.536 27.012 1.00 68.71 N ATOM 8183 CZ ARG A 550 11.350 43.538 27.9461.00 68.02 C ATOM 8184 NH1 ARG A 550 12.548 43.056 27.689 1.00 71.35 NATOM 8187 NH2 ARG A 550 11.035 43.998 29.154 1.00 67.97 N ATOM 8190 CARG A 550 9.593 45.083 21.401 1.00 67.18 C ATOM 8191 O ARG A 550 10.65445.058 20.759 1.00 65.99 O ATOM 8192 N GYL A 551 8.434 44.712 20.8821.00 68.91 N ATOM 8194 CA GYL A 551 8.428 44.078 19.566 1.00 69.72 CATOM 8197 C GYL A 551 8.984 44.980 18.462 1.00 69.41 C ATOM 8198 O GYL A551 9.184 46.175 18.685 1.00 69.05 O ATOM 8199 N PRO A 552 9.316 44.41717.307 1.00 69.02 N ATOM 8200 CA PRO A 552 9.076 45.130 16.050 1.0070.16 C ATOM 8202 CB PRO A 552 9.704 44.221 14.988 1.00 69.01 C ATOM8205 CG PRO A 552 9.805 42.977 15.585 1.00 68.43 C ATOM 8208 CD PRO A552 10.065 43.179 17.085 1.00 67.57 C ATOM 8211 C PRO A 552 7.584 45.37115.794 1.00 72.55 C ATOM 8212 O PRO A 552 7.216 46.194 14.960 1.00 74.90O ATOM 8213 N ASP A 553 6.708 44.702 16.518 1.00 73.65 N ATOM 8215 CAASP A 553 5.288 44.960 16.308 1.00 76.41 C ATOM 8217 CB ASP A 553 4.48243.789 16.845 1.00 77.64 C ATOM 8220 CG ASP A 553 4.690 42.533 16.0291.00 80.59 C ATOM 8221 OD1 ASP A 553 5.877 42.294 15.647 1.00 83.78 OATOM 8222 OD2 ASP A 553 3.750 41.737 15.698 1.00 84.59 O ATOM 8223 C ASPA 553 4.864 46.275 16.990 1.00 77.13 C ATOM 8224 O ASP A 553 4.01147.012 16.498 1.00 79.38 O ATOM 8225 N ASN A 554 5.493 46.576 18.1171.00 75.22 N ATOM 8227 CA ASN A 554 5.081 47.687 18.953 1.00 75.56 CATOM 8229 CB ASN A 554 5.296 47.312 20.423 1.00 75.01 C ATOM 8232 CG ASNA 554 4.457 46.113 20.854 1.00 76.66 C ATOM 8233 OD1 ASN A 554 3.32145.920 20.378 1.00 79.39 O ATOM 8234 ND2 ASN A 554 5.013 45.299 21.7591.00 76.10 N ATOM 8237 C ASN A 554 5.763 49.021 18.653 1.00 74.89 C ATOM8238 O ASN A 554 5.884 49.859 19.531 1.00 73.74 O ATOM 8239 N CYS A 5556.191 49.225 17.414 1.00 74.76 N ATOM 8241 CA CYS A 555 6.585 50.55316.971 1.00 76.15 C ATOM 8243 CB CYS A 555 7.378 50.459 15.691 1.0075.87 C ATOM 8246 SG CYS A 555 8.888 49.525 15.840 1.00 74.07 S ATOM8247 C CYS A 555 5.378 51.399 16.664 1.00 79.28 C ATOM 8248 O CYS A 5554.303 50.908 16.314 1.00 80.23 O ATOM 8249 N ILE A 556 5.549 52.69016.757 1.00 81.45 N ATOM 8251 CA ILE A 556 4.588 53.558 16.076 1.0086.21 C ATOM 8253 CB ILE A 556 4.217 54.775 16.994 1.00 88.59 C ATOM8255 CG1 ILE A 556 3.285 54.332 18.145 1.00 88.42 C ATOM 8258 CD1 ILE A556 2.945 55.465 19.180 1.00 90.10 C ATOM 8262 CG2 ILE A 556 3.65655.923 16.146 1.00 91.71 C ATOM 8266 C ILE A 556 5.349 54.028 14.8411.00 86.58 C ATOM 8267 O ILE A 556 6.353 54.729 14.990 1.00 89.16 O ATOM8268 N GLN A 557 4.994 53.618 13.653 1.00 85.39 N ATOM 8270 CA GLN A 5575.882 53.937 12.530 1.00 85.32 C ATOM 8272 CB GLN A 557 6.184 55.45612.453 1.00 87.88 C ATOM 8275 CG GLN A 557 6.910 55.832 11.136 1.0089.41 C ATOM 8278 CD GLN A 557 6.557 57.164 10.557 1.00 91.93 C ATOM8279 OE1 GLN A 557 6.459 58.148 11.270 1.00 95.30 O ATOM 8280 NE2 GLN A557 6.423 57.209 9.247 1.00 92.15 N ATOM 8283 C GLN A 557 7.229 53.16512.420 1.00 81.67 C ATOM 8284 O GLN A 557 8.085 53.251 13.261 1.00 80.12O ATOM 8285 N CYS A 558 7.428 52.507 11.295 1.00 81.23 N ATOM 8287 CACYS A 558 8.641 51.768 11.012 1.00 79.48 C ATOM 8289 CB CYS A 558 8.29650.683 10.007 1.00 79.37 C ATOM 8292 SG CYS A 558 7.573 49.169 10.7021.00 81.19 S ATOM 8293 C CYS A 558 9.759 52.580 10.388 1.00 79.80 C ATOM8294 O CYS A 558 9.589 53.173 9.377 1.00 81.16 O ATOM 8295 N ALA A 55910.950 52.512 10.935 1.00 78.94 N ATOM 8297 CA ALA A 559 12.079 53.31310.421 1.00 80.38 C ATOM 8299 CB ALA A 559 13.371 53.087 11.285 1.0078.77 C ATOM 8303 C ALA A 559 12.432 53.046 8.989 1.00 80.70 C ATOM 8304O ALA A 559 12.772 53.965 8.290 1.00 83.71 O ATOM 8305 N HIS A 56012.415 51.785 8.580 1.00 78.83 N ATOM 8307 CA HIS A 560 13.025 51.3777.327 1.00 78.93 C ATOM 8309 CB HIS A 560 14.232 50.473 7.616 1.00 77.41C ATOM 8312 CG HIS A 560 15.521 51.202 7.931 1.00 79.72 C ATOM 8313 ND1HIS A 560 16.068 52.180 7.112 1.00 82.70 N ATOM 8315 CE1 HIS A 56017.212 52.607 7.631 1.00 84.13 C ATOM 8317 NE2 HIS A 560 17.429 51.9398.758 1.00 83.15 N ATOM 8319 CD2 HIS A 560 16.395 51.050 8.962 1.0079.11 C ATOM 8321 C HIS A 560 11.932 50.680 6.503 1.00 78.66 C ATOM 8322O HIS A 560 11.189 51.365 5.825 1.00 81.48 O ATOM 8323 N TYR A 56111.771 49.354 6.575 1.00 76.45 N ATOM 8325 CA TYR A 561 10.666 48.6845.844 1.00 76.16 C ATOM 8327 CB TYR A 561 11.162 47.651 4.814 1.00 75.26C ATOM 8330 CG TYR A 561 12.188 48.263 3.937 1.00 76.43 C ATOM 8331 CD1TYR A 561 13.544 48.158 4.251 1.00 76.49 C ATOM 8333 CE1 TYR A 56114.514 48.770 3.507 1.00 77.50 C ATOM 8335 CZ TYR A 561 14.133 49.5202.438 1.00 81.83 C ATOM 8336 OH TYR A 561 15.079 50.155 1.675 1.00 86.33O ATOM 8338 CE2 TYR A 561 12.789 49.645 2.097 1.00 82.34 C ATOM 8340 CD2TYR A 561 11.824 49.028 2.861 1.00 79.04 C ATOM 8342 C TYR A 561 9.73348.040 6.820 1.00 74.68 C ATOM 8343 O TYR A 561 10.052 47.969 8.013 1.0072.79 O ATOM 8344 N ILE A 562 8.576 47.624 6.285 1.00 75.37 N ATOM 8346CA ILE A 562 7.533 46.899 7.014 1.00 75.42 C ATOM 8348 CB ILE A 5626.207 47.710 7.246 1.00 77.81 C ATOM 8350 CG1 ILE A 562 6.473 49.2357.482 1.00 81.60 C ATOM 8353 CD1 ILE A 562 5.649 50.324 6.529 1.00 83.69C ATOM 8357 CG2 ILE A 562 5.419 47.117 8.432 1.00 75.53 C ATOM 8361 CILE A 562 7.189 45.624 6.263 1.00 75.08 C ATOM 8362 O ILE A 562 6.90445.638 5.077 1.00 75.61 O ATOM 8363 N ASP A 563 7.225 44.529 7.012 1.0073.98 N ATOM 8365 CA ASP A 563 6.927 43.193 6.553 1.00 73.94 C ATOM 8367CB ASP A 563 8.170 42.341 6.827 1.00 72.30 C ATOM 8370 CG ASP A 5638.107 40.945 6.226 1.00 72.50 C ATOM 8371 OD1 ASP A 563 7.372 40.7275.229 1.00 70.35 O ATOM 8372 OD2 ASP A 563 8.822 40.012 6.712 1.00 72.64O ATOM 8373 C ASP A 563 5.760 42.742 7.401 1.00 74.39 C ATOM 8374 O ASPA 563 5.902 42.627 8.612 1.00 73.65 O ATOM 8375 N GLY A 564 4.600 42.5226.796 1.00 75.74 N ATOM 8377 CA GLY A 564 3.414 42.251 7.590 1.00 77.02C ATOM 8380 C GLY A 564 3.269 43.192 8.781 1.00 76.38 C ATOM 8381 O GLYA 564 3.406 44.373 8.626 1.00 75.98 O ATOM 8382 N PRO A 565 2.992 42.6799.966 1.00 76.69 N ATOM 8383 CA PRO A 565 2.937 43.529 11.162 1.00 77.09C ATOM 8385 CB PRO A 565 2.388 42.599 12.264 1.00 77.30 C ATOM 8388 CGPRO A 565 2.710 41.225 11.789 1.00 77.15 C ATOM 8391 CD PRO A 565 2.67341.277 10.276 1.00 77.40 C ATOM 8394 C PRO A 565 4.264 44.083 11.6121.00 75.13 C ATOM 8395 O PRO A 565 4.210 45.061 12.315 1.00 76.23 O ATOM8396 N HIS A 566 5.389 43.477 11.245 1.00 73.76 N ATOM 8398 CA HIS A 5666.707 43.775 11.819 1.00 71.93 C ATOM 8400 CB HIS A 566 7.618 42.55611.660 1.00 70.47 C ATOM 8403 CG HIS A 566 7.029 41.249 12.095 1.0070.87 C ATOM 8404 ND1 HIS A 566 7.119 40.789 13.387 1.00 71.81 N ATOM8406 CE1 HIS A 566 6.566 39.590 13.461 1.00 74.18 C ATOM 8408 NE2 HIS A566 6.133 39.251 12.260 1.00 73.76 N ATOM 8410 CD2 HIS A 566 6.43040.264 11.386 1.00 72.64 C ATOM 8412 C HIS A 566 7.442 44.879 11.0781.00 72.22 C ATOM 8413 O HIS A 566 7.337 44.943 9.859 1.00 74.16 O ATOM8414 N CYS A 567 8.246 45.687 11.769 1.00 71.03 N ATOM 8416 CA CYS A 5679.234 46.549 11.105 1.00 70.86 C ATOM 8418 CB CYS A 567 9.604 47.72611.972 1.00 71.52 C ATOM 8421 SG CYS A 567 8.241 48.666 12.577 1.0073.87 S ATOM 8422 C CYS A 567 10.530 45.832 10.962 1.00 69.04 C ATOM8423 O CYS A 567 11.035 45.332 11.937 1.00 68.08 O ATOM 8424 N VAL A 56811.128 45.862 9.788 1.00 69.34 N ATOM 8426 CA VAL A 568 12.431 45.2849.614 1.00 68.53 C ATOM 8428 CB VAL A 568 12.355 44.035 8.788 1.00 69.32C ATOM 8430 CG1 VAL A 568 13.574 42.972 9.226 1.00 69.18 C ATOM 8434 CG2VAL A 568 10.953 43.396 8.907 1.00 70.17 C ATOM 8438 C VAL A 568 13.38146.205 8.951 1.00 68.70 C ATOM 8439 O VAL A 568 12.953 47.118 8.287 1.0071.27 O ATOM 8440 N LYS A 569 14.673 45.970 9.158 1.00 67.78 N ATOM 8442CA LYS A 569 15.725 46.687 8.455 1.00 69.12 C ATOM 8444 CB LYS A 56917.100 46.328 9.026 1.00 68.55 C ATOM 8447 CG LYS A 569 18.246 47.2138.440 1.00 72.13 C ATOM 8450 CD LYS A 569 19.587 47.155 9.229 1.00 73.34C ATOM 8453 CE LYS A 569 20.258 48.558 9.307 1.00 75.82 C ATOM 8456 NZLYS A 569 21.618 48.573 9.964 1.00 77.31 N ATOM 8460 C LYS A 569 15.73246.425 6.945 1.00 70.04 C ATOM 8461 O LYS A 569 16.006 47.328 6.144 1.0071.03 O ATOM 8462 N THR A 570 15.498 45.170 6.573 1.00 69.61 N ATOM 8464CA THR A 570 15.401 44.774 5.179 1.00 70.80 C ATOM 8466 CB THR A 57016.551 43.874 4.758 1.00 70.64 C ATOM 8468 OG1 THR A 570 17.678 44.1325.574 1.00 69.69 O ATOM 8470 CG2 THR A 570 17.028 44.225 3.290 1.0073.62 C ATOM 8474 C THR A 570 14.147 43.992 4.941 1.00 71.10 C ATOM 8475O THR A 570 13.566 43.417 5.860 1.00 70.34 O ATOM 8476 N CYS A 57113.727 43.956 3.684 1.00 72.17 N ATOM 8478 CA CYS A 571 12.740 42.9923.308 1.00 72.52 C ATOM 8480 CB CYS A 571 12.089 43.404 2.008 1.00 74.33C ATOM 8483 SG CYS A 571 10.724 44.604 2.195 1.00 78.47 S ATOM 8484 CCYS A 571 13.468 41.631 3.216 1.00 71.56 C ATOM 8485 O CYS A 571 14.62441.563 2.831 1.00 71.33 O ATOM 8486 N PRO A 572 12.807 40.570 3.634 1.0071.21 N ATOM 8487 CA PRO A 572 13.365 39.208 3.601 1.00 70.85 C ATOM8489 CB PRO A 572 12.172 38.339 3.923 1.00 71.07 C ATOM 8492 CG PRO A572 11.307 39.225 4.741 1.00 72.16 C ATOM 8495 CD PRO A 572 11.47040.617 4.231 1.00 71.58 C ATOM 8498 C PRO A 572 13.861 38.806 2.253 1.0071.37 C ATOM 8499 O PRO A 572 13.118 38.873 1.309 1.00 71.71 O ATOM 8500N ALA A 573 15.091 38.332 2.192 1.00 71.59 N ATOM 8502 CA ALA A 57315.743 37.986 0.933 1.00 72.60 C ATOM 8504 CB ALA A 573 16.655 39.1030.532 1.00 72.49 C ATOM 8508 C ALA A 573 16.537 36.667 1.074 1.00 72.93C ATOM 8509 O ALA A 573 17.586 36.608 1.717 1.00 73.24 O ATOM 8510 N GLYA 574 16.044 35.603 0.472 1.00 73.55 N ATOM 8512 CA GLY A 574 16.78134.355 0.481 1.00 75.15 C ATOM 8515 C GLY A 574 16.810 33.712 1.853 1.0074.56 C ATOM 8516 O GLY A 574 17.826 33.607 2.501 1.00 74.55 O ATOM 8517N VAL A 575 15.638 33.301 2.271 1.00 74.53 N ATOM 8519 CA VAL A 57515.376 32.861 3.612 1.00 74.16 C ATOM 8521 CB VAL A 575 14.468 33.9304.276 1.00 72.51 C ATOM 8523 CG1 VAL A 575 13.634 33.376 5.319 1.0073.47 C ATOM 8527 CG2 VAL A 575 15.322 34.978 4.860 1.00 70.07 C ATOM8531 C VAL A 575 14.734 31.494 3.412 1.00 75.88 C ATOM 8532 O VAL A 57514.015 31.284 2.455 1.00 76.15 O ATOM 8533 N MET A 576 15.001 30.5174.243 1.00 77.05 N ATOM 8535 CA MET A 576 14.451 29.252 3.827 1.00 79.91C ATOM 8537 CB MET A 576 15.111 28.104 4.533 1.00 81.42 C ATOM 8540 CGMET A 576 14.645 26.801 3.936 1.00 85.73 C ATOM 8543 SD MET A 576 14.96026.651 2.151 1.00 89.21 S ATOM 8544 CE MET A 576 16.879 26.184 2.3711.00 90.57 C ATOM 8548 C MET A 576 12.921 29.212 3.989 1.00 80.55 C ATOM8549 O MET A 576 12.415 29.721 4.978 1.00 79.42 O ATOM 8550 N GLY A 57712.218 28.602 3.012 1.00 82.68 N ATOM 8552 CA GLY A 577 10.765 28.3663.050 1.00 84.07 C ATOM 8555 C GLY A 577 10.277 26.939 2.725 1.00 87.30C ATOM 8556 O GLY A 577 11.075 25.988 2.639 1.00 88.11 O ATOM 8557 N GLUA 578 8.948 26.807 2.560 1.00 89.19 N ATOM 8559 CA GLU A 578 8.27525.574 2.078 1.00 92.83 C ATOM 8561 CB GLU A 578 6.821 25.929 1.572 1.0093.63 C ATOM 8564 CG GLU A 578 5.920 24.741 1.086 1.00 98.88 C ATOM 8567CD GLU A 578 5.383 24.801 −0.403 1.00 100.15 C ATOM 8568 OE1 GLU A 5785.169 25.906 −0.965 1.00 100.10 O ATOM 8569 OE2 GLU A 578 5.120 23.730−1.024 1.00 100.27 O ATOM 8570 C GLU A 578 9.100 24.860 0.942 1.00 94.09C ATOM 8571 O GLU A 578 9.703 25.548 0.100 1.00 92.98 O ATOM 8572 N ASNA 579 9.092 23.509 0.905 1.00 96.70 N ATOM 8574 CA ASN A 579 9.65422.694 −0.210 1.00 97.87 C ATOM 8576 CB ASN A 579 8.673 22.664 −1.4311.00 98.97 C ATOM 8579 CG ASN A 579 8.787 21.320 −2.343 1.00 103.58 CATOM 8580 OD1 ASN A 579 9.375 20.292 −1.934 1.00 107.20 O ATOM 8581 ND2ASN A 579 8.176 21.367 −3.567 1.00 102.91 N ATOM 8584 C ASN A 579 11.08823.139 −0.599 1.00 95.88 C ATOM 8585 O ASN A 579 11.436 23.228 −1.7611.00 95.66 O ATOM 8586 N ASN A 580 11.921 23.436 0.392 1.00 94.91 N ATOM8588 CA ASN A 580 13.261 23.999 0.150 1.00 93.61 C ATOM 8590 CB ASN A580 14.272 22.905 −0.271 1.00 96.16 C ATOM 8593 CG ASN A 580 15.72323.230 0.188 1.00 96.15 C ATOM 8594 OD1 ASN A 580 16.025 24.371 0.4711.00 97.19 O ATOM 8595 ND2 ASN A 580 16.599 22.237 0.248 1.00 96.25 NATOM 8598 C ASN A 580 13.325 25.157 −0.873 1.00 91.65 C ATOM 8599 O ASNA 580 14.368 25.364 −1.497 1.00 91.22 O ATOM 8600 N THR A 581 12.22025.893 −1.049 1.00 90.43 N ATOM 8602 CA THR A 581 12.204 27.090 −1.9011.00 88.39 C ATOM 8604 CB THR A 581 10.888 27.209 −2.798 1.00 89.27 CATOM 8606 OG1 THR A 581 9.764 27.589 −1.994 1.00 89.04 O ATOM 8608 CG2THR A 581 10.466 25.857 −3.437 1.00 92.43 C ATOM 8612 C THR A 581 12.40628.367 −1.034 1.00 84.96 C ATOM 8613 O THR A 581 11.544 28.728 −0.2211.00 83.83 O ATOM 8614 N LEU A 582 13.563 29.011 −1.223 1.00 82.72 NATOM 8616 CA LEU A 582 13.796 30.357 −0.742 1.00 79.94 C ATOM 8618 CBLEU A 582 15.097 30.931 −1.288 1.00 79.24 C ATOM 8621 CG LEU A 58216.381 30.246 −0.893 1.00 80.18 C ATOM 8623 CD1 LEU A 582 17.569 31.154−1.231 1.00 79.77 C ATOM 8627 CD2 LEU A 582 16.366 29.908 0.573 1.0080.16 C ATOM 8631 C LEU A 582 12.669 31.327 −1.083 1.00 78.75 C ATOM8632 O LEU A 582 11.920 31.175 −2.062 1.00 78.56 O ATOM 8633 N VAL A 58312.627 32.351 −0.238 1.00 77.04 N ATOM 8635 CA VAL A 583 11.565 33.320−0.172 1.00 76.73 C ATOM 8637 CB VAL A 583 10.838 33.269 1.201 1.0076.17 C ATOM 8639 CG1 VAL A 583 9.880 34.449 1.387 1.00 75.25 C ATOM8643 CG2 VAL A 583 10.076 31.987 1.302 1.00 78.05 C ATOM 8647 C VAL A583 12.202 34.664 −0.367 1.00 75.52 C ATOM 8648 O VAL A 583 13.12235.011 0.368 1.00 74.49 O ATOM 8649 N TRP A 584 11.705 35.404 −1.3631.00 75.92 N ATOM 8651 CA TRP A 584 12.152 36.769 −1.631 1.00 74.96 CATOM 8653 CB TRP A 584 12.784 36.822 −3.004 1.00 75.84 C ATOM 8656 CGTRP A 584 13.929 35.915 −3.112 1.00 75.22 C ATOM 8657 CD1 TRP A 58413.892 34.622 −3.468 1.00 73.95 C ATOM 8659 NE1 TRP A 584 15.156 34.097−3.430 1.00 72.84 N ATOM 8661 CE2 TRP A 584 16.035 35.062 −3.034 1.0072.12 C ATOM 8662 CD2 TRP A 584 15.298 36.220 −2.810 1.00 73.54 C ATOM8663 CE3 TRP A 584 15.972 37.367 −2.379 1.00 73.41 C ATOM 8665 CZ3 TRP A584 17.340 37.308 −2.209 1.00 74.46 C ATOM 8667 CH2 TRP A 584 18.03536.127 −2.434 1.00 75.07 C ATOM 8669 CZ2 TRP A 584 17.397 35.002 −2.8501.00 73.68 C ATOM 8671 C TRP A 584 11.015 37.767 −1.589 1.00 74.89 CATOM 8672 O TRP A 584 9.889 37.450 −1.907 1.00 75.76 O ATOM 8673 N LYS A585 11.332 38.992 −1.213 1.00 74.03 N ATOM 8675 CA LYS A 585 10.34140.037 −1.097 1.00 73.90 C ATOM 8677 CB LYS A 585 9.857 40.189 0.3691.00 72.96 C ATOM 8680 CG LYS A 585 8.762 39.160 0.785 1.00 72.93 C ATOM8683 CD LYS A 585 7.912 39.538 2.029 1.00 71.79 C ATOM 8686 CE LYS A 5856.856 38.458 2.403 1.00 72.28 C ATOM 8689 NZ LYS A 585 6.373 38.4093.829 1.00 71.42 N ATOM 8693 C LYS A 585 10.947 41.305 −1.619 1.00 73.86C ATOM 8694 O LYS A 585 12.140 41.474 −1.545 1.00 71.84 O ATOM 8695 NTYR A 586 10.104 42.174 −2.184 1.00 75.89 N ATOM 8697 CA TYR A 58610.490 43.531 −2.525 1.00 77.16 C ATOM 8699 CB TYR A 586 10.230 43.846−3.986 1.00 79.32 C ATOM 8702 CG TYR A 586 8.763 43.925 −4.384 1.0081.59 C ATOM 8703 CD1 TYR A 586 8.213 45.101 −4.860 1.00 82.49 C ATOM8705 CE1 TYR A 586 6.859 45.174 −5.239 1.00 86.87 C ATOM 8707 CZ TYR A586 6.024 44.052 −5.144 1.00 87.16 C ATOM 8708 OH TYR A 586 4.674 44.110−5.515 1.00 87.71 O ATOM 8710 CE2 TYR A 586 6.560 42.871 −4.672 1.0085.36 C ATOM 8712 CD2 TYR A 586 7.928 42.812 −4.287 1.00 82.83 C ATOM8714 C TYR A 586 9.748 44.512 −1.639 1.00 77.86 C ATOM 8715 O TYR A 5868.764 44.169 −0.970 1.00 76.82 O ATOM 8716 N ALA A 587 10.264 45.735−1.642 1.00 79.52 N ATOM 8718 CA ALA A 587 9.624 46.881 −1.005 1.0081.22 C ATOM 8720 CB ALA A 587 10.664 47.718 −0.259 1.00 81.30 C ATOM8724 C ALA A 587 8.942 47.760 −2.040 1.00 83.87 C ATOM 8725 O ALA A 5879.587 48.225 −2.966 1.00 85.06 O ATOM 8726 N ASP A 588 7.646 48.003−1.873 1.00 85.42 N ATOM 8728 CA ASP A 588 6.956 49.034 −2.638 1.0087.97 C ATOM 8730 CB ASP A 588 5.453 48.660 −2.823 1.00 89.10 C ATOM8733 CG ASP A 588 4.586 48.846 −1.562 1.00 88.49 C ATOM 8734 OD1 ASP A588 4.972 49.551 −0.614 1.00 88.44 O ATOM 8735 OD2 ASP A 588 3.45348.328 −1.455 1.00 88.07 O ATOM 8736 C ASP A 588 7.209 50.472 −2.0881.00 89.91 C ATOM 8737 O ASP A 588 7.973 50.687 −1.122 1.00 88.35 O ATOM8738 N ALA A 589 6.571 51.439 −2.751 1.00 93.88 N ATOM 8740 CA ALA A 5896.641 52.881 −2.458 1.00 96.73 C ATOM 8742 CB ALA A 589 5.728 53.626−3.421 1.00 100.11 C ATOM 8746 C ALA A 589 6.276 53.241 −1.005 1.0096.86 C ATOM 8747 O ALA A 589 6.805 54.223 −0.437 1.00 98.22 O ATOM 8748N GLY A 590 5.363 52.441 −0.433 1.00 95.88 N ATOM 8750 CA GLY A 5904.993 52.493 0.975 1.00 94.90 C ATOM 8753 C GLY A 590 6.013 51.865 1.9061.00 91.58 C ATOM 8754 O GLY A 590 5.808 51.912 3.111 1.00 90.28 O ATOM8755 N HIS A 591 7.114 51.337 1.348 1.00 90.22 N ATOM 8757 CA HIS A 5918.120 50.545 2.075 1.00 87.77 C ATOM 8759 CB HIS A 591 8.959 51.4393.071 1.00 88.45 C ATOM 8762 CG HIS A 591 9.793 52.510 2.391 1.00 95.05C ATOM 8763 ND1 HIS A 591 9.493 53.860 2.461 1.00 103.48 N ATOM 8765 CE1HIS A 591 10.363 54.550 1.732 1.00 106.24 C ATOM 8767 NE2 HIS A 59111.225 53.702 1.194 1.00 104.71 N ATOM 8769 CD2 HIS A 591 10.895 52.4231.597 1.00 98.92 C ATOM 8771 C HIS A 591 7.502 49.249 2.733 1.00 84.53 CATOM 8772 O HIS A 591 7.962 48.785 3.794 1.00 82.29 O ATOM 8773 N VAL A592 6.486 48.675 2.075 1.00 83.76 N ATOM 8775 CA VAL A 592 5.796 47.4662.544 1.00 81.76 C ATOM 8777 CB VAL A 592 4.215 47.621 2.498 1.00 83.71C ATOM 8779 CG1 VAL A 592 3.457 46.343 2.905 1.00 81.70 C ATOM 8783 CG2VAL A 592 3.769 48.747 3.396 1.00 85.59 C ATOM 8787 C VAL A 592 6.30046.291 1.683 1.00 80.26 C ATOM 8788 O VAL A 592 6.623 46.478 0.512 1.0080.92 O ATOM 8789 N CYS A 593 6.362 45.087 2.259 1.00 77.78 N ATOM 8791CA CYS A 593 7.075 43.998 1.639 1.00 75.78 C ATOM 8793 CB CYS A 5937.847 43.219 2.689 1.00 74.24 C ATOM 8796 SG CYS A 593 9.221 44.0513.477 1.00 73.14 S ATOM 8797 C CYS A 593 6.122 43.052 1.000 1.00 76.03 CATOM 8798 O CYS A 593 5.141 42.647 1.620 1.00 75.39 O ATOM 8799 N HIS A594 6.431 42.645 −0.221 1.00 76.34 N ATOM 8801 CA HIS A 594 5.581 41.688−0.899 1.00 78.01 C ATOM 8803 CB HIS A 594 4.684 42.369 −1.960 1.0080.52 C ATOM 8806 CG HIS A 594 3.723 43.390 −1.407 1.00 81.95 C ATOM8807 ND1 HIS A 594 2.483 43.052 −0.907 1.00 83.85 N ATOM 8809 CE1 HIS A594 1.864 44.144 −0.490 1.00 84.93 C ATOM 8811 NE2 HIS A 594 2.65745.179 −0.700 1.00 84.02 N ATOM 8813 CD2 HIS A 594 3.827 44.736 −1.2711.00 81.36 C ATOM 8815 C HIS A 594 6.429 40.639 −1.555 1.00 77.43 C ATOM8816 O HIS A 594 7.563 40.878 −1.901 1.00 76.36 O ATOM 8817 N LEU A 5955.821 39.480 −1.748 1.00 78.64 N ATOM 8819 CA LEU A 595 6.443 38.324−2.362 1.00 78.53 C ATOM 8821 CB LEU A 595 5.448 37.149 −2.299 1.0079.33 C ATOM 8824 CG LEU A 595 5.801 35.797 −1.684 1.00 78.71 C ATOM8826 CD1 LEU A 595 6.898 35.909 −0.658 1.00 76.77 C ATOM 8830 CD2 LEU A595 4.553 35.115 −1.075 1.00 80.22 C ATOM 8834 C LEU A 595 6.829 38.606−3.822 1.00 80.06 C ATOM 8835 O LEU A 595 6.092 39.243 −4.551 1.00 81.01O ATOM 8836 N CYS A 596 7.989 38.116 −4.238 1.00 80.39 N ATOM 8838 CACYS A 596 8.402 38.165 −5.626 1.00 82.14 C ATOM 8840 CB CYS A 596 9.90737.993 −5.745 1.00 81.09 C ATOM 8843 SG CYS A 596 10.896 39.338 −5.0421.00 82.20 S ATOM 8844 C CYS A 596 7.750 37.016 −6.381 1.00 84.23 C ATOM8845 O CYS A 596 7.182 36.099 −5.758 1.00 84.81 O ATOM 8846 N HIS A 5977.839 37.077 −7.726 1.00 85.98 N ATOM 8848 CA HIS A 597 7.387 35.991−8.602 1.00 86.82 C ATOM 8850 CB HIS A 597 7.815 36.182 −10.084 1.0088.03 C ATOM 8853 CG HIS A 597 6.992 35.395 −11.096 1.00 91.55 C ATOM8854 ND1 HIS A 597 5.695 34.962 −10.863 1.00 94.55 N ATOM 8856 CE1 HIS A597 5.231 34.335 −11.930 1.00 94.09 C ATOM 8858 NE2 HIS A 597 6.17634.338 −12.851 1.00 94.23 N ATOM 8860 CD2 HIS A 597 7.278 35.008 −12.3661.00 92.74 C ATOM 8862 C HIS A 597 8.102 34.818 −8.053 1.00 85.24 C ATOM8863 O HIS A 597 9.227 34.973 −7.601 1.00 82.66 O ATOM 8864 N PRO A 5987.470 33.649 −8.079 1.00 86.55 N ATOM 8865 CA PRO A 598 8.206 32.453−7.664 1.00 86.49 C ATOM 8867 CB PRO A 598 7.109 31.362 −7.590 1.0088.23 C ATOM 8870 CG PRO A 598 5.750 32.113 −7.680 1.00 88.45 C ATOM8873 CD PRO A 598 6.076 33.330 −8.490 1.00 87.86 C ATOM 8876 C PRO A 5989.361 32.186 −8.678 1.00 86.52 C ATOM 8877 O PRO A 598 10.423 31.664−8.294 1.00 85.89 O ATOM 8878 N ASN A 599 9.205 32.641 −9.925 1.00 87.20N ATOM 8880 CA ASN A 599 10.270 32.471 −10.943 1.00 87.60 C ATOM 8882 CBASN A 599 9.669 32.588 −12.365 1.00 88.64 C ATOM 8885 CG ASN A 599 9.38231.218 −13.006 1.00 90.07 C ATOM 8886 OD1 ASN A 599 9.676 31.000 −14.1781.00 92.33 O ATOM 8887 ND2 ASN A 599 8.799 30.307 −12.241 1.00 88.59 NATOM 8890 C ASN A 599 11.524 33.388 −10.788 1.00 86.52 C ATOM 8891 O ASNA 599 12.405 33.364 −11.639 1.00 87.32 O ATOM 8892 N CYS A 600 11.59934.182 −9.712 1.00 84.92 N ATOM 8894 CA CYS A 600 12.739 35.071 −9.4391.00 83.58 C ATOM 8896 CB CYS A 600 12.275 36.331 −8.714 1.00 83.07 CATOM 8899 SG CYS A 600 11.574 37.524 −9.848 1.00 86.34 S ATOM 8900 C CYSA 600 13.757 34.368 −8.590 1.00 82.06 C ATOM 8901 O CYS A 600 13.83834.583 −7.390 1.00 80.61 O ATOM 8902 N THR A 601 14.543 33.532 −9.2401.00 82.20 N ATOM 8904 CA THR A 601 15.540 32.732 −8.580 1.00 81.19 CATOM 8906 CB THR A 601 16.394 31.985 −9.643 1.00 82.55 C ATOM 8908 OG1THR A 601 15.581 31.098 −10.403 1.00 81.59 O ATOM 8910 CG2 THR A 60117.362 31.047 −8.992 1.00 82.82 C ATOM 8914 C THR A 601 16.462 33.557−7.683 1.00 80.12 C ATOM 8915 O THR A 601 17.064 32.984 −6.775 1.0080.18 O ATOM 8916 N TYR A 602 16.626 34.861 −7.927 1.00 79.32 N ATOM8918 CA TYR A 602 17.704 35.596 −7.243 1.00 78.82 C ATOM 8920 CB TYR A602 18.764 35.995 −8.249 1.00 80.35 C ATOM 8923 CG TYR A 602 19.51134.824 −8.832 1.00 81.46 C ATOM 8924 CD1 TYR A 602 19.213 34.362 −10.1171.00 80.69 C ATOM 8926 CE1 TYR A 602 19.887 33.321 −10.666 1.00 81.66 CATOM 8928 CZ TYR A 602 20.870 32.693 −9.952 1.00 82.09 C ATOM 8929 OHTYR A 602 21.510 31.618 −10.515 1.00 83.96 O ATOM 8931 CE2 TYR A 60221.197 33.123 −8.653 1.00 82.70 C ATOM 8933 CD2 TYR A 602 20.518 34.187−8.110 1.00 80.31 C ATOM 8935 C TYR A 602 17.314 36.830 −6.455 1.0077.63 C ATOM 8936 O TYR A 602 18.181 37.605 −6.070 1.00 76.60 O ATOM8937 N GLY A 603 16.021 36.994 −6.190 1.00 77.48 N ATOM 8939 CA GLY A603 15.508 38.166 −5.496 1.00 76.91 C ATOM 8942 C GLY A 603 15.00939.185 −6.473 1.00 77.91 C ATOM 8943 O GLY A 603 15.253 39.045 −7.6631.00 78.71 O ATOM 8944 N CYS A 604 14.312 40.206 −5.982 1.00 78.21 NATOM 8946 CA CYS A 604 13.738 41.210 −6.882 1.00 79.72 C ATOM 8948 CBCYS A 604 12.414 40.701 −7.464 1.00 80.28 C ATOM 8951 SG CYS A 60410.973 40.882 −6.410 1.00 81.56 S ATOM 8952 C CYS A 604 13.558 42.674−6.440 1.00 80.19 C ATOM 8953 O CYS A 604 13.418 43.047 −5.273 1.0077.79 O ATOM 8954 N THR A 605 13.512 43.461 −7.504 1.00 83.00 N ATOM8956 CA THR A 605 13.431 44.905 −7.548 1.00 84.81 C ATOM 8958 CB THR A605 14.006 45.292 −8.941 1.00 87.10 C ATOM 8960 OG1 THR A 605 15.37245.651 −8.743 1.00 89.61 O ATOM 8962 CG2 THR A 605 13.337 46.510 −9.6601.00 90.11 C ATOM 8966 C THR A 605 11.986 45.326 −7.333 1.00 85.27 CATOM 8967 O THR A 605 11.718 46.227 −6.541 1.00 85.22 O ATOM 8968 N GLYA 606 11.069 44.625 −7.999 1.00 85.73 N ATOM 8970 CA GLY A 606 9.64944.898 −7.928 1.00 86.94 C ATOM 8973 C GLY A 606 8.783 43.657 −8.1241.00 86.94 C ATOM 8974 O GLY A 606 9.223 42.537 −7.925 1.00 85.56 O ATOM8975 N PRO A 607 7.534 43.854 −8.515 1.00 89.16 N ATOM 8976 CA PRO A 6076.552 42.772 −8.584 1.00 89.64 C ATOM 8978 CB PRO A 607 5.207 43.521−8.508 1.00 91.72 C ATOM 8981 CG PRO A 607 5.467 44.862 −9.127 1.0093.44 C ATOM 8984 CD PRO A 607 6.939 45.149 −8.880 1.00 92.13 C ATOM8987 C PRO A 607 6.562 41.858 −9.835 1.00 90.94 C ATOM 8988 O PRO A 6076.927 42.251 −10.964 1.00 91.02 O ATOM 8989 N GLY A 608 6.123 40.616−9.558 1.00 91.39 N ATOM 8991 CA GLY A 608 5.924 39.533 −10.509 1.0092.22 C ATOM 8994 C GLY A 608 6.989 39.311 −11.589 1.00 92.72 C ATOM8995 O GLY A 608 8.175 39.081 −11.362 1.00 91.98 O ATOM 8996 N LEU A 6096.506 39.353 −12.807 1.00 94.71 N ATOM 8998 CA LEU A 609 7.270 39.067−14.030 1.00 95.05 C ATOM 9000 CB LEU A 609 6.311 39.435 −15.240 1.0097.40 C ATOM 9003 CG LEU A 609 4.763 39.599 −14.971 1.00 97.53 C ATOM9005 CD1 LEU A 609 4.034 40.291 −16.098 1.00 99.87 C ATOM 9009 CD2 LEU A609 4.038 38.239 −14.601 1.00 96.75 C ATOM 9013 C LEU A 609 8.667 39.823−14.097 1.00 94.70 C ATOM 9014 O LEU A 609 9.722 39.184 −14.227 1.0092.65 O ATOM 9015 N ALA A 610 8.610 41.172 −13.954 1.00 96.08 N ATOM9017 CA ALA A 610 9.684 42.152 −14.257 1.00 96.49 C ATOM 9019 CB ALA A610 9.147 43.190 −15.238 1.00 98.58 C ATOM 9023 C ALA A 610 10.30242.887 −13.030 1.00 95.94 C ATOM 9024 O ALA A 610 10.840 43.987 −13.1571.00 97.11 O ATOM 9025 N GLY A 611 10.220 42.304 −11.844 1.00 94.30 NATOM 9027 CA GLY A 611 11.240 42.583 −10.848 1.00 93.78 C ATOM 9030 CGLY A 611 12.516 41.826 −11.256 1.00 94.52 C ATOM 9031 O GLY A 61113.637 42.114 −10.819 1.00 93.76 O ATOM 9032 N CYS A 612 12.314 40.804−12.087 1.00 96.55 N ATOM 9034 CA CYS A 612 13.377 40.054 −12.743 1.0097.90 C ATOM 9036 CB CYS A 612 12.937 38.613 −12.854 1.00 96.30 C ATOM9039 SG CYS A 612 13.031 37.903 −11.240 1.00 90.82 S ATOM 9040 C CYS A612 13.582 40.653 −14.140 1.00 103.59 C ATOM 9041 O CYS A 612 12.64540.648 −14.971 1.00 103.99 O ATOM 9042 N PRO A 613 14.763 41.243 −14.3701.00 108.80 N ATOM 9043 CA PRO A 613 15.182 41.615 −15.726 1.00 114.87 CATOM 9045 CB PRO A 613 15.737 43.030 −15.521 1.00 114.53 C ATOM 9048 CGPRO A 613 16.295 42.984 −14.088 1.00 110.83 C ATOM 9051 CD PRO A 61315.772 41.685 −13.378 1.00 107.45 C ATOM 9054 C PRO A 613 16.262 40.618−16.273 1.00 122.10 C ATOM 9055 O PRO A 613 16.937 39.895 −15.470 1.00120.24 O ATOM 9056 N THR A 614 16.391 40.617 −17.621 1.00 47.89 N ATOM9058 CA THR A 614 17.198 39.690 −18.467 1.00 53.92 C ATOM 9060 CB THR A614 18.247 38.823 −17.659 1.00 55.51 C ATOM 9062 OG1 THR A 614 19.34039.668 −17.217 1.00 58.77 O ATOM 9064 CG2 THR A 614 18.907 37.587−18.539 1.00 57.00 C ATOM 9068 C THR A 614 16.172 38.798 −19.222 1.0056.93 C ATOM 9069 O THR A 614 15.663 39.166 −20.337 1.00 59.17 O ATOM9070 OXT THR A 614 15.847 37.720 −18.669 1.00 59.96 O ATOM 9071 N ASP C1 33.389 65.342 66.616 1.00 67.77 N ATOM 9073 CA ASP C 1 33.591 64.06067.391 1.00 63.04 C ATOM 9075 CB ASP C 1 34.960 64.034 68.124 1.00 62.38C ATOM 9078 CG ASP C 1 36.160 63.729 67.215 1.00 63.30 C ATOM 9079 OD1ASP C 1 36.329 62.559 66.749 1.00 62.63 O ATOM 9080 OD2 ASP C 1 37.04764.606 67.012 1.00 67.29 O ATOM 9081 C ASP C 1 32.479 63.876 68.450 1.0060.60 C ATOM 9082 O ASP C 1 31.963 64.812 68.966 1.00 63.19 O ATOM 9085N ILE C 2 32.190 62.647 68.811 1.00 56.23 N ATOM 9087 CA ILE C 2 31.11962.338 69.720 1.00 54.21 C ATOM 9089 CB ILE C 2 30.653 60.829 69.4311.00 51.58 C ATOM 9091 CG1 ILE C 2 29.523 60.345 70.377 1.00 50.81 CATOM 9094 CD1 ILE C 2 28.466 59.526 69.644 1.00 49.41 C ATOM 9098 CG2ILE C 2 31.758 59.838 69.497 1.00 46.09 C ATOM 9102 C ILE C 2 31.53862.546 71.167 1.00 52.71 C ATOM 9103 O ILE C 2 32.470 61.928 71.639 1.0050.84 O ATOM 9104 N LEU C 3 30.821 63.383 71.886 1.00 54.32 N ATOM 9106CA LEU C 3 31.006 63.509 73.329 1.00 53.38 C ATOM 9108 CB LEU C 3 30.54764.886 73.785 1.00 57.50 C ATOM 9111 CG LEU C 3 31.316 66.005 73.1231.00 61.79 C ATOM 9113 CD1 LEU C 3 31.128 67.318 73.861 1.00 66.05 CATOM 9117 CD2 LEU C 3 32.806 65.586 73.107 1.00 61.67 C ATOM 9121 C LEUC 3 30.206 62.515 74.091 1.00 50.57 C ATOM 9122 O LEU C 3 29.205 62.07773.632 1.00 50.19 O ATOM 9123 N LEU C 4 30.655 62.200 75.294 1.00 49.48N ATOM 9125 CA LEU C 4 29.977 61.272 76.210 1.00 47.62 C ATOM 9127 CBLEU C 4 30.661 59.899 76.270 1.00 44.26 C ATOM 9130 CG LEU C 4 30.55658.903 75.095 1.00 42.54 C ATOM 9132 CD1 LEU C 4 31.192 57.536 75.4611.00 42.27 C ATOM 9136 CD2 LEU C 4 29.161 58.642 74.668 1.00 41.09 CATOM 9140 C LEU C 4 30.102 61.939 77.564 1.00 49.23 C ATOM 9141 O LEU C4 31.203 62.184 78.046 1.00 50.89 O ATOM 9142 N THR C 5 28.982 62.20678.193 1.00 50.08 N ATOM 9144 CA THR C 5 28.925 63.052 79.340 1.00 51.09C ATOM 9146 CB THR C 5 28.023 64.197 78.914 1.00 54.47 C ATOM 9148 OG1THR C 5 28.669 64.889 77.847 1.00 54.99 O ATOM 9150 CG2 THR C 5 27.84165.257 80.010 1.00 58.10 C ATOM 9154 C THR C 5 28.318 62.222 80.455 1.0050.26 C ATOM 9155 O THR C 5 27.173 61.791 80.329 1.00 52.74 O ATOM 9156N GLN C 6 29.054 61.916 81.509 1.00 48.92 N ATOM 9158 CA GLN C 6 28.47761.131 82.612 1.00 48.41 C ATOM 9160 CB GLN C 6 29.420 60.029 83.1061.00 46.13 C ATOM 9163 CG GLN C 6 29.841 58.951 82.032 1.00 46.01 C ATOM9166 CD GLN C 6 30.748 57.811 82.605 1.00 42.83 C ATOM 9167 OE1 GLN C 630.341 57.108 83.506 1.00 43.11 O ATOM 9168 NE2 GLN C 6 31.931 57.64982.063 1.00 39.15 N ATOM 9171 C GLN C 6 28.086 62.057 83.776 1.00 51.15C ATOM 9172 O GLN C 6 28.575 63.185 83.915 1.00 51.19 O ATOM 9173 N SERC 7 27.195 61.530 84.618 1.00 52.05 N ATOM 9175 CA SER C 7 26.399 62.34485.524 1.00 55.11 C ATOM 9177 CB SER C 7 25.240 62.929 84.689 1.00 57.59C ATOM 9180 OG SER C 7 25.571 64.267 84.306 1.00 63.19 O ATOM 9182 C SERC 7 25.843 61.474 86.652 1.00 54.25 C ATOM 9183 O SER C 7 25.344 60.41986.357 1.00 53.75 O ATOM 9184 N PRO C 8 25.896 61.871 87.925 1.00 55.03N ATOM 9185 CA PRO C 8 26.657 63.025 88.411 1.00 56.11 C ATOM 9187 CBPRO C 8 26.204 63.135 89.865 1.00 57.98 C ATOM 9190 CG PRO C 8 25.66761.770 90.233 1.00 56.40 C ATOM 9193 CD PRO C 8 25.101 61.220 88.9941.00 55.40 C ATOM 9196 C PRO C 8 28.134 62.756 88.412 1.00 54.47 C ATOM9197 O PRO C 8 28.565 61.631 88.075 1.00 52.22 O ATOM 9198 N VAL C 928.908 63.726 88.859 1.00 55.53 N ATOM 9200 CA VAL C 9 30.311 63.45689.017 1.00 55.24 C ATOM 9202 CB VAL C 9 31.120 64.738 89.253 1.00 58.63C ATOM 9204 CG1 VAL C 9 32.588 64.416 89.781 1.00 58.03 C ATOM 9208 CG2VAL C 9 31.166 65.580 87.925 1.00 60.37 C ATOM 9212 C VAL C 9 30.57462.469 90.150 1.00 54.36 C ATOM 9213 O VAL C 9 31.400 61.558 89.968 1.0053.35 O ATOM 9214 N ILE C 10 29.927 62.686 91.302 1.00 55.71 N ATOM 9216CA ILE C 10 29.879 61.722 92.418 1.00 55.79 C ATOM 9218 CB ILE C 1030.485 62.359 93.690 1.00 57.92 C ATOM 9220 CG1 ILE C 10 32.000 62.43093.602 1.00 59.27 C ATOM 9223 CD1 ILE C 10 32.638 63.164 94.791 1.0062.22 C ATOM 9227 CG2 ILE C 10 30.200 61.541 94.922 1.00 58.67 C ATOM9231 C ILE C 10 28.393 61.258 92.677 1.00 57.07 C ATOM 9232 O ILE C 1027.464 62.062 92.664 1.00 60.01 O ATOM 9233 N LEU C 11 28.137 59.98392.929 1.00 55.55 N ATOM 9235 CA LEU C 11 26.769 59.588 93.190 1.0056.88 C ATOM 9237 CB LEU C 11 26.419 58.508 92.202 1.00 54.80 C ATOM9240 CG LEU C 11 25.025 57.907 92.195 1.00 55.67 C ATOM 9242 CD1 LEU C11 24.004 58.957 92.115 1.00 58.93 C ATOM 9246 CD2 LEU C 11 24.91456.991 90.986 1.00 54.73 C ATOM 9250 C LEU C 11 26.688 59.068 94.6201.00 59.06 C ATOM 9251 O LEU C 11 27.287 58.041 94.901 1.00 59.11 O ATOM9252 N SER C 12 26.023 59.782 95.533 1.00 61.71 N ATOM 9254 CA SER C 1226.005 59.382 96.956 1.00 63.27 C ATOM 9256 CB SER C 12 26.214 60.55697.941 1.00 65.33 C ATOM 9259 OG SER C 12 27.431 61.153 97.699 1.0063.03 O ATOM 9261 C SER C 12 24.681 58.744 97.285 1.00 64.64 C ATOM 9262O SER C 12 23.656 59.375 97.191 1.00 66.78 O ATOM 9263 N VAL C 13 24.75057.540 97.814 1.00 64.40 N ATOM 9265 CA VAL C 13 23.657 56.618 97.8101.00 65.81 C ATOM 9267 CB VAL C 13 23.891 55.757 96.586 1.00 63.63 CATOM 9269 CG1 VAL C 13 23.223 54.454 96.715 1.00 66.53 C ATOM 9273 CG2VAL C 13 23.399 56.484 95.355 1.00 64.60 C ATOM 9277 C VAL C 13 23.71255.741 99.037 1.00 66.60 C ATOM 9278 O VAL C 13 24.785 55.268 99.3801.00 64.51 O ATOM 9279 N SER C 14 22.579 55.475 99.680 1.00 69.64 N ATOM9281 CA SER C 14 22.601 54.560 100.836 1.00 72.09 C ATOM 9283 CB SER C14 21.478 54.804 101.839 1.00 76.76 C ATOM 9286 OG SER C 14 20.81056.030 101.609 1.00 79.16 O ATOM 9288 C SER C 14 22.599 53.119 100.3561.00 70.71 C ATOM 9289 O SER C 14 22.149 52.842 99.275 1.00 68.37 O ATOM9290 N PRO C 15 23.152 52.211 101.149 1.00 72.08 N ATOM 9291 CA PRO C 1523.353 50.835 100.735 1.00 71.76 C ATOM 9293 CB PRO C 15 24.297 50.294101.808 1.00 73.08 C ATOM 9296 CG PRO C 15 23.978 51.010 102.986 1.0076.10 C ATOM 9299 CD PRO C 15 23.611 52.399 102.530 1.00 74.92 C ATOM9302 C PRO C 15 22.056 50.082 100.765 1.00 75.00 C ATOM 9303 O PRO C 1521.340 50.172 101.721 1.00 79.23 O ATOM 9304 N GLY C 16 21.755 49.35599.712 1.00 74.43 N ATOM 9306 CA GLY C 16 20.459 48.743 99.583 1.0077.95 C ATOM 9309 C GLY C 16 19.586 49.408 98.540 1.00 77.45 C ATOM 9310O GLY C 16 18.688 48.741 98.034 1.00 80.57 O ATOM 9311 N GLU C 17 19.80950.673 98.194 1.00 75.10 N ATOM 9313 CA GLU C 17 18.992 51.329 97.1581.00 74.75 C ATOM 9315 CB GLU C 17 19.245 52.794 97.143 1.00 73.81 CATOM 9318 CG GLU C 17 18.823 53.497 98.389 1.00 79.22 C ATOM 9321 CD GLUC 17 18.808 54.995 98.145 1.00 79.79 C ATOM 9322 OE1 GLU C 17 19.85155.616 97.710 1.00 69.50 O ATOM 9323 OE2 GLU C 17 17.681 55.505 98.3691.00 88.18 O ATOM 9324 C GLU C 17 19.231 50.930 95.713 1.00 71.55 C ATOM9325 O GLU C 17 20.338 50.462 95.351 1.00 66.99 O ATOM 9326 N ALA C 1818.177 51.167 94.895 1.00 72.93 N ATOM 9328 CA ALA C 18 18.342 51.29793.452 1.00 69.72 C ATOM 9330 CB ALA C 18 17.040 51.182 92.640 1.0070.80 C ATOM 9334 C ALA C 18 19.087 52.642 93.212 1.00 67.33 C ATOM 9335O ALA C 18 18.731 53.667 93.755 1.00 69.28 O ATOM 9336 N VAL C 19 20.15152.542 92.424 1.00 63.49 N ATOM 9338 CA VAL C 19 21.005 53.594 91.9481.00 61.76 C ATOM 9340 CB VAL C 19 22.441 53.202 92.367 1.00 59.76 CATOM 9342 CG1 VAL C 19 23.474 54.131 91.797 1.00 57.51 C ATOM 9346 CG2VAL C 19 22.521 53.203 93.815 1.00 62.73 C ATOM 9350 C VAL C 19 21.05953.596 90.416 1.00 59.34 C ATOM 9351 O VAL C 19 21.188 52.538 89.8321.00 59.40 O ATOM 9352 N SER C 20 21.053 54.764 89.776 1.00 57.96 N ATOM9354 CA SER C 20 21.205 54.860 88.333 1.00 55.03 C ATOM 9356 CB SER C 2020.027 55.545 87.683 1.00 57.01 C ATOM 9359 OG SER C 20 18.851 54.89788.037 1.00 61.60 O ATOM 9361 C SER C 20 22.298 55.767 88.035 1.00 53.24C ATOM 9362 O SER C 20 22.254 56.879 88.497 1.00 54.65 O ATOM 9363 N PHEC 21 23.257 55.326 87.212 1.00 50.84 N ATOM 9365 CA PHE C 21 24.24756.198 86.595 1.00 48.38 C ATOM 9367 CB PHE C 21 25.592 55.519 86.4531.00 46.09 C ATOM 9370 CG PHE C 21 26.047 54.812 87.647 1.00 47.07 CATOM 9371 CD1 PHE C 21 25.631 53.517 87.880 1.00 50.09 C ATOM 9373 CE1PHE C 21 26.041 52.843 88.956 1.00 50.03 C ATOM 9375 CZ PHE C 21 26.87853.444 89.804 1.00 52.96 C ATOM 9377 CE2 PHE C 21 27.326 54.751 89.5761.00 52.36 C ATOM 9379 CD2 PHE C 21 26.921 55.399 88.494 1.00 49.70 CATOM 9381 C PHE C 21 23.797 56.492 85.203 1.00 47.89 C ATOM 9382 O PHE C21 23.140 55.681 84.629 1.00 47.93 O ATOM 9383 N SER C 22 24.198 57.62684.646 1.00 48.25 N ATOM 9385 CA SER C 22 23.802 58.025 83.317 1.0049.61 C ATOM 9387 CB SER C 22 22.694 59.023 83.416 1.00 53.37 C ATOM9390 OG SER C 22 23.123 59.992 84.294 1.00 55.34 O ATOM 9392 C SER C 2224.848 58.684 82.473 1.00 49.38 C ATOM 9393 O SER C 22 25.692 59.45182.980 1.00 51.10 O ATOM 9394 N CYS C 23 24.693 58.465 81.165 1.00 49.64N ATOM 9396 CA CYS C 23 25.639 58.792 80.105 1.00 49.37 C ATOM 9398 CBCYS C 23 26.354 57.470 79.749 1.00 47.09 C ATOM 9401 SG CYS C 23 27.56557.489 78.438 1.00 48.27 S ATOM 9402 C CYS C 23 24.845 59.312 78.8911.00 51.54 C ATOM 9403 O CYS C 23 23.923 58.637 78.433 1.00 51.51 O ATOM9404 N ARG C 24 25.162 60.511 78.383 1.00 53.04 N ATOM 9406 CA ARG C 2424.403 61.116 77.240 1.00 54.66 C ATOM 9408 CB ARG C 24 23.681 62.43477.585 1.00 56.60 C ATOM 9417 C ARG C 24 25.410 61.393 76.163 1.00 53.77C ATOM 9418 O ARG C 24 26.331 62.193 76.410 1.00 55.68 O ATOM 9419 N ALAC 25 25.276 60.747 75.000 1.00 51.76 N ATOM 9421 CA ALA C 25 26.11861.042 73.835 1.00 50.58 C ATOM 9423 CB ALA C 25 26.241 59.816 72.9821.00 48.78 C ATOM 9427 C ALA C 25 25.591 62.193 73.012 1.00 53.60 C ATOM9428 O ALA C 25 24.412 62.317 72.863 1.00 56.32 O ATOM 9429 N SER C 2626.483 63.018 72.497 1.00 54.27 N ATOM 9431 CA SER C 26 26.146 64.19771.725 1.00 59.13 C ATOM 9433 CB SER C 26 27.425 64.981 71.463 1.0059.86 C ATOM 9436 OG SER C 26 28.278 64.302 70.552 1.00 59.91 O ATOM9438 C SER C 26 25.446 63.922 70.377 1.00 61.50 C ATOM 9439 O SER C 2624.883 64.864 69.768 1.00 66.20 O ATOM 9440 N GLN C 27 25.529 62.67069.901 1.00 58.24 N ATOM 9442 CA GLN C 27 24.827 62.225 68.706 1.0060.10 C ATOM 9444 CB GLN C 27 25.688 62.296 67.470 1.00 59.83 C ATOM9447 CG GLN C 27 27.081 62.008 67.716 1.00 58.23 C ATOM 9450 CD GLN C 2727.918 61.992 66.456 1.00 60.02 C ATOM 9451 OE1 GLN C 27 28.552 62.98866.171 1.00 62.47 O ATOM 9452 NE2 GLN C 27 27.924 60.869 65.701 1.0058.88 N ATOM 9455 C GLN C 27 24.312 60.827 68.888 1.00 57.93 C ATOM 9456O GLN C 27 24.902 60.058 69.598 1.00 53.57 O ATOM 9457 N SER C 28 23.16560.527 68.271 1.00 61.55 N ATOM 9459 CA SER C 28 22.408 59.316 68.5821.00 60.90 C ATOM 9461 CB SER C 28 20.945 59.423 68.203 1.00 65.18 CATOM 9464 OG SER C 28 20.591 58.143 67.697 1.00 66.79 O ATOM 9466 C SERC 28 23.004 58.084 67.889 1.00 58.36 C ATOM 9467 O SER C 28 23.25658.074 66.663 1.00 60.09 O ATOM 9468 N ILE C 29 23.131 57.029 68.6911.00 54.91 N ATOM 9470 CA ILE C 29 24.081 55.941 68.499 1.00 50.73 CATOM 9472 CB ILE C 29 24.939 56.025 69.690 1.00 48.76 C ATOM 9474 CG1ILE C 29 26.204 56.799 69.506 1.00 47.90 C ATOM 9477 CD1 ILE C 29 26.78156.887 71.020 1.00 46.20 C ATOM 9481 CG2 ILE C 29 25.406 54.716 70.1401.00 50.42 C ATOM 9485 C ILE C 29 23.419 54.538 68.588 1.00 48.53 C ATOM9486 O ILE C 29 24.082 53.548 68.607 1.00 45.78 O ATOM 9487 N GLY C 3022.128 54.442 68.772 1.00 50.20 N ATOM 9489 CA GLY C 30 21.526 53.15868.932 1.00 49.68 C ATOM 9492 C GLY C 30 21.768 52.584 70.304 1.00 48.73C ATOM 9493 O GLY C 30 21.368 53.115 71.357 1.00 48.59 O ATOM 9494 N THRC 31 22.462 51.467 70.275 1.00 47.96 N ATOM 9496 CA THR C 31 22.65050.599 71.412 1.00 47.77 C ATOM 9498 CB THR C 31 22.033 49.252 71.0081.00 50.14 C ATOM 9500 OG1 THR C 31 20.656 49.459 70.720 1.00 56.14 OATOM 9502 CG2 THR C 31 21.894 48.337 72.170 1.00 52.95 C ATOM 9506 C THRC 31 24.137 50.455 71.595 1.00 44.48 C ATOM 9507 O THR C 31 24.63749.717 72.445 1.00 42.22 O ATOM 9508 N ASN C 32 24.885 51.149 70.7581.00 43.47 N ATOM 9510 CA ASN C 32 26.288 50.870 70.721 1.00 41.11 CATOM 9512 CB ASN C 32 26.825 51.306 69.381 1.00 41.94 C ATOM 9515 CG ASNC 32 26.386 50.392 68.282 1.00 43.35 C ATOM 9516 OD1 ASN C 32 26.17649.129 68.474 1.00 38.32 O ATOM 9517 ND2 ASN C 32 26.245 51.004 67.0901.00 43.19 N ATOM 9520 C ASN C 32 27.059 51.545 71.863 1.00 39.52 C ATOM9521 O ASN C 32 27.910 52.433 71.610 1.00 37.18 O ATOM 9522 N ILE C 3326.740 51.112 73.093 1.00 39.04 N ATOM 9524 CA ILE C 33 27.444 51.54674.289 1.00 38.42 C ATOM 9526 CB ILE C 33 26.556 52.547 75.003 1.0040.72 C ATOM 9528 CG1 ILE C 33 27.221 53.922 74.939 1.00 43.37 C ATOM9531 CD1 ILE C 33 26.172 54.854 74.384 1.00 49.43 C ATOM 9535 CG2 ILE C33 26.295 52.247 76.459 1.00 41.18 C ATOM 9539 C ILE C 33 27.769 50.42575.211 1.00 36.61 C ATOM 9540 O ILE C 33 26.935 49.529 75.421 1.00 38.59O ATOM 9541 N HIS C 34 28.925 50.499 75.846 1.00 34.61 N ATOM 9543 CAHIS C 34 29.162 49.613 76.966 1.00 34.71 C ATOM 9545 CB HIS C 34 30.20048.643 76.574 1.00 33.97 C ATOM 9548 CG HIS C 34 30.194 48.311 75.1411.00 34.26 C ATOM 9549 ND1 HIS C 34 29.367 47.348 74.630 1.00 38.92 NATOM 9551 CE1 HIS C 34 29.607 47.205 73.339 1.00 38.14 C ATOM 9553 NE2HIS C 34 30.540 48.071 72.995 1.00 37.85 N ATOM 9555 CD2 HIS C 34 30.93048.773 74.108 1.00 34.95 C ATOM 9557 C HIS C 34 29.522 50.260 78.3421.00 34.32 C ATOM 9558 O HIS C 34 29.807 51.432 78.392 1.00 33.64 O ATOM9559 N TRP C 35 29.445 49.465 79.426 1.00 34.27 N ATOM 9561 CA TRP C 3529.783 49.896 80.759 1.00 34.35 C ATOM 9563 CB TRP C 35 28.560 49.87981.571 1.00 35.41 C ATOM 9566 CG TRP C 35 27.514 50.870 81.176 1.0038.77 C ATOM 9567 CD1 TRP C 35 26.443 50.635 80.362 1.00 38.77 C ATOM9569 NE1 TRP C 35 25.680 51.764 80.262 1.00 39.07 N ATOM 9571 CE2 TRP C35 26.201 52.740 81.058 1.00 39.78 C ATOM 9572 CD2 TRP C 35 27.35352.211 81.662 1.00 37.48 C ATOM 9573 CE3 TRP C 35 28.075 53.018 82.5011.00 34.96 C ATOM 9575 CZ3 TRP C 35 27.628 54.293 82.738 1.00 38.38 CATOM 9577 CH2 TRP C 35 26.484 54.789 82.138 1.00 41.25 C ATOM 9579 CZ2TRP C 35 25.744 54.022 81.306 1.00 42.46 C ATOM 9581 C TRP C 35 30.80349.082 81.568 1.00 34.40 C ATOM 9582 O TRP C 35 30.787 47.871 81.6431.00 34.68 O ATOM 9583 N TYR C 36 31.619 49.809 82.295 1.00 34.73 N ATOM9585 CA TYR C 36 32.679 49.273 83.080 1.00 34.84 C ATOM 9587 CB TYR C 3633.979 49.790 82.457 1.00 33.85 C ATOM 9590 CG TYR C 36 34.192 49.42881.000 1.00 32.89 C ATOM 9591 CD1 TYR C 36 33.730 50.226 79.935 1.0034.08 C ATOM 9593 CE1 TYR C 36 33.954 49.861 78.569 1.00 30.47 C ATOM9595 CZ TYR C 36 34.628 48.702 78.318 1.00 33.75 C ATOM 9596 OH TYR C 3634.972 48.211 77.099 1.00 32.78 O ATOM 9598 CE2 TYR C 36 35.081 47.93279.350 1.00 36.07 C ATOM 9600 CD2 TYR C 36 34.855 48.298 80.683 1.0034.48 C ATOM 9602 C TYR C 36 32.638 49.720 84.560 1.00 36.53 C ATOM 9603O TYR C 36 32.184 50.821 84.911 1.00 37.45 O ATOM 9604 N GLN C 37 33.18148.875 85.422 1.00 37.01 N ATOM 9606 CA GLN C 37 33.485 49.253 86.7761.00 37.99 C ATOM 9608 CB GLN C 37 32.866 48.245 87.662 1.00 40.20 CATOM 9611 CG GLN C 37 33.024 48.454 89.097 1.00 43.44 C ATOM 9614 CD GLNC 37 32.484 47.260 89.850 1.00 44.50 C ATOM 9615 OE1 GLN C 37 33.09546.188 89.830 1.00 41.97 O ATOM 9616 NE2 GLN C 37 31.341 47.450 90.5191.00 45.99 N ATOM 9619 C GLN C 37 34.971 49.202 86.950 1.00 38.04 C ATOM9620 O GLN C 37 35.576 48.347 86.420 1.00 37.13 O ATOM 9621 N GLN C 3835.532 50.155 87.691 1.00 39.43 N ATOM 9623 CA GLN C 38 36.916 50.23388.006 1.00 40.11 C ATOM 9625 CB GLN C 38 37.572 51.356 87.212 1.0040.00 C ATOM 9628 CG GLN C 38 39.138 51.282 87.328 1.00 41.59 C ATOM9631 CD GLN C 38 39.903 52.189 86.386 1.00 39.71 C ATOM 9632 OE1 GLN C38 40.911 51.749 85.818 1.00 39.37 O ATOM 9633 NE2 GLN C 38 39.48853.456 86.280 1.00 36.17 N ATOM 9636 C GLN C 38 37.025 50.536 89.4901.00 42.44 C ATOM 9637 O GLN C 38 36.535 51.554 89.948 1.00 43.21 O ATOM9638 N ARG C 39 37.659 49.658 90.248 1.00 43.81 N ATOM 9640 CA ARG C 3937.854 49.916 91.649 1.00 46.09 C ATOM 9642 CB ARG C 39 37.775 48.65492.479 1.00 47.38 C ATOM 9645 CG ARG C 39 36.378 48.003 92.388 1.0047.92 C ATOM 9648 CD ARG C 39 36.268 46.636 93.005 1.00 49.95 C ATOM9651 NE ARG C 39 34.888 46.233 93.235 1.00 51.18 N ATOM 9653 CZ ARG C 3934.457 44.976 93.111 1.00 53.33 C ATOM 9654 NH1 ARG C 39 35.280 44.02592.746 1.00 55.36 N ATOM 9657 NH2 ARG C 39 33.198 44.656 93.305 1.0054.57 N ATOM 9660 C ARG C 39 39.227 50.474 91.698 1.00 48.48 C ATOM 9661O ARG C 39 40.076 50.144 90.848 1.00 48.36 O ATOM 9662 N THR C 40 39.44651.325 92.696 1.00 50.49 N ATOM 9664 CA THR C 40 40.767 51.785 93.0541.00 52.37 C ATOM 9666 CB THR C 40 40.743 52.104 94.505 1.00 54.92 CATOM 9668 OG1 THR C 40 39.665 53.023 94.716 1.00 55.56 O ATOM 9670 CG2THR C 40 41.930 52.878 94.904 1.00 57.62 C ATOM 9674 C THR C 40 41.82650.749 92.731 1.00 53.36 C ATOM 9675 O THR C 40 41.665 49.544 93.0251.00 54.89 O ATOM 9676 N ASN C 41 42.870 51.206 92.053 1.00 52.76 N ATOM9678 CA ASN C 41 44.015 50.359 91.762 1.00 54.22 C ATOM 9680 CB ASN C 4144.688 49.980 93.075 1.00 58.44 C ATOM 9683 CG ASN C 41 45.154 51.23093.865 1.00 63.41 C ATOM 9684 OD1 ASN C 41 45.183 52.360 93.337 1.0062.65 O ATOM 9685 ND2 ASN C 41 45.482 51.031 95.136 1.00 66.15 N ATOM9688 C ASN C 41 43.781 49.126 90.892 1.00 51.30 C ATOM 9689 O ASN C 4144.628 48.262 90.811 1.00 52.22 O ATOM 9690 N GLY C 42 42.667 49.10590.189 1.00 47.41 N ATOM 9692 CA GLY C 42 42.301 47.978 89.359 1.0046.02 C ATOM 9695 C GLY C 42 42.014 48.314 87.911 1.00 43.20 C ATOM 9696O GLY C 42 41.863 49.478 87.503 1.00 41.61 O ATOM 9697 N SER C 43 41.94447.296 87.084 1.00 42.43 N ATOM 9699 CA SER C 43 41.710 47.632 85.7151.00 41.19 C ATOM 9701 CB SER C 43 42.475 46.773 84.770 1.00 41.96 CATOM 9704 OG SER C 43 42.809 45.525 85.299 1.00 46.75 O ATOM 9706 C SERC 43 40.215 47.594 85.505 1.00 39.79 C ATOM 9707 O SER C 43 39.48747.122 86.353 1.00 41.05 O ATOM 9708 N PRO C 44 39.700 48.223 84.4761.00 38.34 N ATOM 9709 CA PRO C 44 38.252 48.202 84.306 1.00 37.29 CATOM 9711 CB PRO C 44 37.996 49.170 83.120 1.00 36.21 C ATOM 9714 CG PROC 44 39.228 49.834 82.904 1.00 37.50 C ATOM 9717 CD PRO C 44 40.36349.045 83.467 1.00 38.27 C ATOM 9720 C PRO C 44 37.665 46.810 84.0931.00 35.59 C ATOM 9721 O PRO C 44 38.311 45.834 83.755 1.00 36.62 O ATOM9722 N ARG C 45 36.390 46.753 84.321 1.00 34.62 N ATOM 9724 CA ARG C 4535.656 45.514 84.232 1.00 35.68 C ATOM 9726 CB ARG C 45 35.337 45.06885.609 1.00 37.79 C ATOM 9729 CG ARG C 45 34.555 43.888 85.738 1.0038.23 C ATOM 9732 CD ARG C 45 34.072 43.791 87.116 1.00 42.83 C ATOM9735 NE ARG C 45 33.417 42.512 87.398 1.00 49.92 N ATOM 9737 CZ ARG C 4532.649 42.276 88.464 1.00 48.72 C ATOM 9738 NH1 ARG C 45 32.470 43.24489.332 1.00 42.80 N ATOM 9741 NH2 ARG C 45 32.061 41.070 88.622 1.0053.29 N ATOM 9744 C ARG C 45 34.371 45.749 83.473 1.00 34.81 C ATOM 9745O ARG C 45 33.579 46.617 83.770 1.00 34.72 O ATOM 9746 N LEU C 46 34.17444.950 82.464 1.00 35.29 N ATOM 9748 CA LEU C 46 33.028 45.109 81.6031.00 34.83 C ATOM 9750 CB LEU C 46 33.294 44.349 80.299 1.00 34.21 CATOM 9753 CG LEU C 46 32.122 44.073 79.436 1.00 33.10 C ATOM 9755 CD1LEU C 46 31.697 45.418 78.882 1.00 34.82 C ATOM 9759 CD2 LEU C 46 32.51543.060 78.411 1.00 33.01 C ATOM 9763 C LEU C 46 31.824 44.529 82.3561.00 36.54 C ATOM 9764 O LEU C 46 31.892 43.392 82.806 1.00 38.07 O ATOM9765 N LEU C 47 30.782 45.344 82.478 1.00 36.50 N ATOM 9767 CA LEU C 4729.501 45.034 83.164 1.00 39.21 C ATOM 9769 CB LEU C 47 29.061 46.22783.993 1.00 39.56 C ATOM 9772 CG LEU C 47 30.000 46.623 85.085 1.0039.66 C ATOM 9774 CD1 LEU C 47 29.636 47.995 85.413 1.00 40.73 C ATOM9778 CD2 LEU C 47 29.808 45.699 86.273 1.00 43.21 C ATOM 9782 C LEU C 4728.293 44.773 82.237 1.00 39.13 C ATOM 9783 O LEU C 47 27.510 43.83882.443 1.00 41.74 O ATOM 9784 N ILE C 48 28.172 45.648 81.243 1.00 36.93N ATOM 9786 CA ILE C 48 27.142 45.636 80.277 1.00 37.02 C ATOM 9788 CBILE C 48 26.072 46.575 80.758 1.00 38.96 C ATOM 9790 CG1 ILE C 48 25.46945.944 82.022 1.00 42.23 C ATOM 9793 CD1 ILE C 48 24.088 45.977 82.1631.00 43.44 C ATOM 9797 CG2 ILE C 48 25.048 46.823 79.629 1.00 41.51 CATOM 9801 C ILE C 48 27.663 46.061 78.952 1.00 34.72 C ATOM 9802 O ILE C48 28.368 47.060 78.847 1.00 33.27 O ATOM 9803 N LYS C 49 27.288 45.29677.927 1.00 35.49 N ATOM 9805 CA LYS C 49 27.566 45.597 76.514 1.0033.86 C ATOM 9807 CB LYS C 49 28.333 44.450 75.916 1.00 33.07 C ATOM9810 CG LYS C 49 27.661 43.106 76.022 1.00 38.02 C ATOM 9813 CD LYS C 4928.443 42.066 75.280 1.00 39.19 C ATOM 9816 CE LYS C 49 27.679 41.45574.125 1.00 40.58 C ATOM 9819 NZ LYS C 49 28.697 40.846 73.223 1.0041.24 N ATOM 9823 C LYS C 49 26.249 45.889 75.720 1.00 34.77 C ATOM 9824O LYS C 49 25.183 45.350 75.981 1.00 35.85 O ATOM 9825 N TYR C 50 26.33546.780 74.771 1.00 33.83 N ATOM 9827 CA TYR C 50 25.191 47.100 73.9871.00 37.51 C ATOM 9829 CB TYR C 50 24.878 46.016 72.959 1.00 38.19 CATOM 9832 CG TYR C 50 26.067 45.851 72.028 1.00 38.64 C ATOM 9833 CD1TYR C 50 26.984 44.826 72.216 1.00 37.12 C ATOM 9835 CE1 TYR C 50 28.07644.706 71.409 1.00 33.93 C ATOM 9837 CZ TYR C 50 28.306 45.624 70.4211.00 32.98 C ATOM 9838 OH TYR C 50 29.410 45.521 69.616 1.00 34.60 OATOM 9840 CE2 TYR C 50 27.482 46.665 70.239 1.00 34.65 C ATOM 9842 CD2TYR C 50 26.363 46.797 71.037 1.00 38.98 C ATOM 9844 C TYR C 50 24.01447.451 74.872 1.00 40.75 C ATOM 9845 O TYR C 50 22.900 46.896 74.7661.00 42.82 O ATOM 9846 N ALA C 51 24.282 48.432 75.747 1.00 40.74 N ATOM9848 CA ALA C 51 23.233 49.188 76.446 1.00 41.98 C ATOM 9850 CB ALA C 5122.286 49.720 75.487 1.00 42.55 C ATOM 9854 C ALA C 51 22.556 48.36377.536 1.00 43.53 C ATOM 9855 O ALA C 51 22.440 48.796 78.673 1.00 43.80O ATOM 9856 N SER C 52 22.203 47.139 77.210 1.00 44.89 N ATOM 9858 CASER C 52 21.403 46.352 78.108 1.00 48.67 C ATOM 9860 CB SER C 52 19.95946.450 77.643 1.00 52.04 C ATOM 9863 OG SER C 52 19.845 45.977 76.2941.00 53.55 O ATOM 9865 C SER C 52 21.783 44.880 78.181 1.00 48.92 C ATOM9866 O SER C 52 21.086 44.131 78.910 1.00 50.69 O ATOM 9867 N GLU C 5322.858 44.477 77.491 1.00 46.03 N ATOM 9869 CA GLU C 53 23.166 43.06077.423 1.00 47.67 C ATOM 9871 CB GLU C 53 23.704 42.543 76.064 1.0046.94 C ATOM 9874 CG GLU C 53 22.938 42.960 74.829 1.00 49.55 C ATOM9877 CD GLU C 53 23.501 42.450 73.448 1.00 51.85 C ATOM 9878 OE1 GLU C53 24.687 41.939 73.270 1.00 43.43 O ATOM 9879 OE2 GLU C 53 22.65542.572 72.483 1.00 57.14 O ATOM 9880 C GLU C 53 24.150 42.708 78.5181.00 46.50 C ATOM 9881 O GLU C 53 25.307 43.167 78.557 1.00 42.83 O ATOM9882 N SER C 54 23.689 41.775 79.342 1.00 49.02 N ATOM 9884 CA SER C 5424.458 41.304 80.479 1.00 49.21 C ATOM 9886 CB SER C 54 23.589 40.46781.346 1.00 52.35 C ATOM 9889 OG SER C 54 23.295 39.351 80.585 1.0056.61 O ATOM 9891 C SER C 54 25.636 40.452 80.034 1.00 46.98 C ATOM 9892O SER C 54 25.625 39.895 78.944 1.00 45.39 O ATOM 9893 N ILE C 55 26.61140.392 80.941 1.00 45.65 N ATOM 9895 CA ILE C 55 27.878 39.764 80.7391.00 44.10 C ATOM 9897 CB ILE C 55 28.910 40.806 80.912 1.00 40.90 CATOM 9899 CG1 ILE C 55 29.119 41.482 79.584 1.00 40.37 C ATOM 9902 CD1ILE C 55 29.086 42.819 79.727 1.00 42.31 C ATOM 9906 CG2 ILE C 55 30.19540.224 81.246 1.00 42.13 C ATOM 9910 C ILE C 55 28.092 38.693 81.7481.00 47.09 C ATOM 9911 O ILE C 55 27.684 38.816 82.892 1.00 49.47 O ATOM9912 N SER C 56 28.746 37.611 81.384 1.00 48.71 N ATOM 9914 CA SER C 5628.702 36.538 82.343 1.00 52.52 C ATOM 9916 CB SER C 56 28.994 35.17481.716 1.00 54.74 C ATOM 9919 OG SER C 56 30.317 34.847 82.071 1.0057.29 O ATOM 9921 C SER C 56 29.657 36.960 83.473 1.00 51.73 C ATOM 9922O SER C 56 30.536 37.820 83.277 1.00 48.86 O ATOM 9923 N GLY C 57 29.44236.398 84.659 1.00 54.10 N ATOM 9925 CA GLY C 57 30.238 36.705 85.8301.00 53.98 C ATOM 9928 C GLY C 57 29.779 37.965 86.529 1.00 52.14 C ATOM9929 O GLY C 57 30.328 38.382 87.538 1.00 52.51 O ATOM 9930 N ILE C 5828.756 38.598 86.015 1.00 50.75 N ATOM 9932 CA ILE C 58 28.314 39.79486.658 1.00 49.91 C ATOM 9934 CB ILE C 58 28.314 40.938 85.671 1.0046.82 C ATOM 9936 CG1 ILE C 58 29.765 41.294 85.421 1.00 45.06 C ATOM9939 CD1 ILE C 58 29.908 41.654 84.172 1.00 45.24 C ATOM 9943 CG2 ILE C58 27.517 42.240 86.215 1.00 45.62 C ATOM 9947 C ILE C 58 26.990 39.66487.360 1.00 53.05 C ATOM 9948 O ILE C 58 25.977 39.199 86.799 1.00 53.28O ATOM 9949 N PRO C 59 27.025 40.124 88.607 1.00 54.73 N ATOM 9950 CAPRO C 59 25.850 40.053 89.461 1.00 58.09 C ATOM 9952 CB PRO C 59 26.26240.797 90.748 1.00 58.25 C ATOM 9955 CG PRO C 59 27.651 41.330 90.5601.00 55.53 C ATOM 9958 CD PRO C 59 28.183 40.749 89.287 1.00 53.29 CATOM 9961 C PRO C 59 24.629 40.652 88.749 1.00 57.82 C ATOM 9962 O PRO C59 24.644 41.654 88.035 1.00 53.30 O ATOM 9963 N SER C 60 23.562 39.88788.909 1.00 63.33 N ATOM 9965 CA SER C 60 22.219 40.188 88.390 1.0065.73 C ATOM 9967 CB SER C 60 21.267 39.142 88.972 1.00 71.17 C ATOM9970 OG SER C 60 21.740 38.742 90.265 1.00 74.60 O ATOM 9972 C SER C 6021.779 41.655 88.744 1.00 64.64 C ATOM 9973 O SER C 60 21.114 42.34387.979 1.00 64.25 O ATOM 9974 N ARG C 61 22.185 42.151 89.894 1.00 64.61N ATOM 9976 CA ARG C 61 21.829 43.513 90.261 1.00 63.48 C ATOM 9978 CBARG C 61 22.297 43.845 91.663 1.00 64.21 C ATOM 9981 CG ARG C 61 23.41443.056 92.181 1.00 63.18 C ATOM 9984 CD ARG C 61 24.104 43.802 93.2361.00 63.84 C ATOM 9987 NE ARG C 61 25.537 43.714 93.099 1.00 61.19 NATOM 9989 CZ ARG C 61 26.362 43.963 94.043 1.00 58.51 C ATOM 9990 NH1ARG C 61 25.979 44.372 95.210 1.00 68.13 N ATOM 9993 NH2 ARG C 61 27.59043.835 93.832 1.00 58.31 N ATOM 9996 C ARG C 61 22.316 44.585 89.3091.00 59.40 C ATOM 9997 O ARG C 61 21.757 45.689 89.288 1.00 60.37 O ATOM9998 N PHE C 62 23.370 44.295 88.562 1.00 55.68 N ATOM 10000 CA PHE C 6223.773 45.184 87.492 1.00 51.73 C ATOM 10002 CB PHE C 62 25.226 44.90887.114 1.00 49.74 C ATOM 10005 CG PHE C 62 26.190 45.398 88.121 1.0048.14 C ATOM 10006 CD1 PHE C 62 26.773 44.542 89.009 1.00 49.83 C ATOM10008 CE1 PHE C 62 27.607 44.999 89.940 1.00 50.62 C ATOM 10010 CZ PHE C62 27.859 46.353 90.035 1.00 49.05 C ATOM 10012 CE2 PHE C 62 27.25247.208 89.173 1.00 46.83 C ATOM 10014 CD2 PHE C 62 26.440 46.724 88.2191.00 46.75 C ATOM 10016 C PHE C 62 22.859 45.064 86.262 1.00 51.66 CATOM 10017 O PHE C 62 22.550 43.980 85.814 1.00 52.39 O ATOM 10018 N SERC 63 22.447 46.200 85.726 1.00 50.26 N ATOM 10020 CA SER C 63 21.68146.249 84.502 1.00 51.03 C ATOM 10022 CB SER C 63 20.242 45.917 84.7841.00 55.13 C ATOM 10025 OG SER C 63 19.490 47.066 85.148 1.00 57.69 OATOM 10027 C SER C 63 21.835 47.599 83.758 1.00 49.12 C ATOM 10028 O SERC 63 22.366 48.536 84.265 1.00 47.72 O ATOM 10029 N GLY C 64 21.40547.648 82.513 1.00 49.99 N ATOM 10031 CA GLY C 64 21.517 48.834 81.6941.00 48.78 C ATOM 10034 C GLY C 64 20.311 48.920 80.758 1.00 52.32 CATOM 10035 O GLY C 64 19.752 47.899 80.330 1.00 54.84 O ATOM 10036 N SERC 65 19.880 50.152 80.489 1.00 53.63 N ATOM 10038 CA SER C 65 18.81650.477 79.546 1.00 56.59 C ATOM 10040 CB SER C 65 17.528 50.804 80.2881.00 61.01 C ATOM 10043 OG SER C 65 17.844 51.826 81.211 1.00 63.48 OATOM 10045 C SER C 65 19.200 51.719 78.732 1.00 55.34 C ATOM 10046 O SERC 65 20.157 52.439 79.066 1.00 53.24 O ATOM 10047 N GLY C 66 18.42951.969 77.660 1.00 57.45 N ATOM 10049 CA GLY C 66 18.670 53.097 76.7401.00 56.09 C ATOM 10052 C GLY C 66 18.946 52.775 75.281 1.00 53.82 CATOM 10053 O GLY C 66 19.495 51.716 74.976 1.00 50.48 O ATOM 10054 N SERC 67 18.490 53.659 74.404 1.00 55.01 N ATOM 10056 CA SER C 67 18.99753.730 73.072 1.00 55.14 C ATOM 10058 CB SER C 67 18.520 52.591 72.1051.00 56.95 C ATOM 10061 OG SER C 67 17.150 52.540 71.891 1.00 61.53 OATOM 10063 C SER C 67 18.766 55.098 72.509 1.00 57.64 C ATOM 10064 O SERC 67 17.849 55.760 72.887 1.00 61.04 O ATOM 10065 N GLY C 68 19.65455.501 71.597 1.00 57.28 N ATOM 10067 CA GLY C 68 19.701 56.829 71.0171.00 59.22 C ATOM 10070 C GLY C 68 20.913 57.529 71.590 1.00 56.57 CATOM 10071 O GLY C 68 22.008 57.423 71.141 1.00 53.93 O ATOM 10072 N THRC 69 20.681 58.136 72.712 1.00 58.48 N ATOM 10074 CA THR C 69 21.39859.306 73.137 1.00 59.19 C ATOM 10076 CB THR C 69 20.645 60.517 72.5481.00 64.50 C ATOM 10078 OG1 THR C 69 21.537 61.132 71.613 1.00 67.14 OATOM 10080 CG2 THR C 69 20.230 61.612 73.564 1.00 66.00 C ATOM 10084 CTHR C 69 21.448 59.347 74.621 1.00 57.98 C ATOM 10085 O THR C 69 22.43759.751 75.159 1.00 55.59 O ATOM 10086 N ASP C 70 20.375 58.909 75.2721.00 60.07 N ATOM 10088 CA ASP C 70 20.375 58.727 76.714 1.00 60.09 CATOM 10090 CB ASP C 70 19.133 59.425 77.247 1.00 64.32 C ATOM 10093 CGASP C 70 19.158 60.961 76.992 1.00 70.77 C ATOM 10094 OD1 ASP C 7020.277 61.595 77.042 1.00 67.90 O ATOM 10095 OD2 ASP C 70 18.069 61.61576.776 1.00 79.56 O ATOM 10096 C ASP C 70 20.433 57.271 77.244 1.0057.20 C ATOM 10097 O ASP C 70 19.434 56.565 77.157 1.00 61.34 O ATOM10098 N PHE C 71 21.564 56.871 77.814 1.00 52.43 N ATOM 10100 CA PHE C71 21.775 55.575 78.451 1.00 51.08 C ATOM 10102 CB PHE C 71 23.02054.922 77.855 1.00 48.63 C ATOM 10105 CG PHE C 71 23.070 55.028 76.3881.00 47.77 C ATOM 10106 CD1 PHE C 71 23.558 56.186 75.786 1.00 46.39 CATOM 10108 CE1 PHE C 71 23.531 56.351 74.450 1.00 47.37 C ATOM 10110 CZPHE C 71 23.001 55.340 73.654 1.00 50.56 C ATOM 10112 CE2 PHE C 7122.502 54.172 74.245 1.00 49.84 C ATOM 10114 CD2 PHE C 71 22.531 54.03975.620 1.00 48.19 C ATOM 10116 C PHE C 71 21.950 55.645 79.988 1.0050.97 C ATOM 10117 O PHE C 71 22.106 56.674 80.535 1.00 52.40 O ATOM10118 N THR C 72 21.907 54.515 80.672 1.00 50.66 N ATOM 10120 CA THR C72 21.602 54.430 82.111 1.00 51.41 C ATOM 10122 CB THR C 72 20.09454.686 82.394 1.00 55.42 C ATOM 10124 OG1 THR C 72 19.880 56.096 82.6121.00 58.52 O ATOM 10126 CG2 THR C 72 19.663 54.044 83.737 1.00 55.85 CATOM 10130 C THR C 72 22.009 53.029 82.632 1.00 49.89 C ATOM 10131 O THRC 72 21.515 51.980 82.190 1.00 50.33 O ATOM 10132 N LEU C 73 22.94553.034 83.554 1.00 48.22 N ATOM 10134 CA LEU C 73 23.410 51.850 84.2291.00 47.33 C ATOM 10136 CB LEU C 73 24.898 52.013 84.360 1.00 43.98 CATOM 10139 CG LEU C 73 25.579 50.891 85.084 1.00 43.79 C ATOM 10141 CD1LEU C 73 25.447 49.588 84.285 1.00 43.27 C ATOM 10145 CD2 LEU C 7327.020 51.257 85.309 1.00 39.29 C ATOM 10149 C LEU C 73 22.760 51.82185.616 1.00 50.10 C ATOM 10150 O LEU C 73 22.792 52.823 86.325 1.0051.66 O ATOM 10151 N SER C 74 22.167 50.743 86.071 1.00 51.27 N ATOM10153 CA SER C 74 21.730 50.879 87.435 1.00 54.82 C ATOM 10155 CB SER C74 20.291 51.311 87.436 1.00 57.75 C ATOM 10158 OG SER C 74 19.64550.362 86.713 1.00 60.90 O ATOM 10160 C SER C 74 21.976 49.663 88.3131.00 56.29 C ATOM 10161 O SER C 74 22.286 48.605 87.809 1.00 56.37 OATOM 10162 N ILE C 75 21.872 49.823 89.634 1.00 58.41 N ATOM 10164 CAILE C 75 22.106 48.720 90.561 1.00 59.78 C ATOM 10166 CB ILE C 75 23.35649.038 91.371 1.00 57.98 C ATOM 10168 CG1 ILE C 75 24.460 49.483 90.4381.00 54.60 C ATOM 10171 CD1 ILE C 75 25.843 49.606 91.120 1.00 55.60 CATOM 10175 CG2 ILE C 75 23.802 47.821 92.132 1.00 59.77 C ATOM 10179 CILE C 75 20.937 48.621 91.491 1.00 64.00 C ATOM 10180 O ILE C 75 20.58349.616 92.011 1.00 65.00 O ATOM 10181 N ASN C 76 20.325 47.458 91.7051.00 67.66 N ATOM 10183 CA ASN C 76 19.433 47.273 92.874 1.00 72.86 CATOM 10185 CB ASN C 76 18.573 46.066 92.666 1.00 77.07 C ATOM 10188 CGASN C 76 17.770 46.202 91.447 1.00 80.49 C ATOM 10189 OD1 ASN C 7617.965 47.202 90.704 1.00 80.41 O ATOM 10190 ND2 ASN C 76 16.849 45.24991.198 1.00 83.51 N ATOM 10193 C ASN C 76 20.234 47.037 94.121 1.0073.25 C ATOM 10194 O ASN C 76 21.376 46.588 94.067 1.00 71.87 O ATOM10195 N SER C 77 19.686 47.302 95.282 1.00 75.89 N ATOM 10197 CA SER C77 20.510 47.059 96.480 1.00 76.19 C ATOM 10199 CB SER C 77 20.17945.692 97.115 1.00 80.08 C ATOM 10202 OG SER C 77 21.236 44.803 96.7701.00 81.82 O ATOM 10204 C SER C 77 22.056 47.202 96.231 1.00 70.21 CATOM 10205 O SER C 77 22.780 46.223 95.964 1.00 66.16 O ATOM 10206 N VALC 78 22.515 48.446 96.376 1.00 68.55 N ATOM 10208 CA VAL C 78 23.95848.795 96.322 1.00 65.96 C ATOM 10210 CB VAL C 78 24.263 50.293 96.4641.00 64.03 C ATOM 10212 CG1 VAL C 78 25.675 50.540 96.047 1.00 59.70 CATOM 10216 CG2 VAL C 78 23.367 51.101 95.666 1.00 63.10 C ATOM 10220 CVAL C 78 24.733 48.220 97.475 1.00 68.31 C ATOM 10221 O VAL C 78 24.26948.259 98.604 1.00 70.79 O ATOM 10222 N GLU C 79 25.939 47.756 97.1841.00 67.29 N ATOM 10224 CA GLU C 79 26.747 47.109 98.182 1.00 70.49 CATOM 10226 CB GLU C 79 27.015 45.646 97.772 1.00 71.59 C ATOM 10229 CGGLU C 79 27.567 44.817 98.955 1.00 78.33 C ATOM 10232 CD GLU C 79 27.21743.318 98.941 1.00 81.18 C ATOM 10233 OE1 GLU C 79 27.474 42.734 97.8431.00 73.90 O ATOM 10234 OE2 GLU C 79 26.760 42.776 100.055 1.00 81.77 OATOM 10235 C GLU C 79 28.063 47.841 98.381 1.00 69.03 C ATOM 10236 O GLUC 79 28.525 48.598 97.500 1.00 66.31 O ATOM 10237 N SER C 80 28.68947.602 99.539 1.00 71.62 N ATOM 10239 CA SER C 80 30.037 48.142 99.8221.00 70.15 C ATOM 10241 CB SER C 80 30.613 47.569 101.134 1.00 74.08 CATOM 10244 OG SER C 80 31.587 46.535 100.904 1.00 74.59 O ATOM 10246 CSER C 80 30.987 47.854 98.682 1.00 66.56 C ATOM 10247 O SER C 80 31.83748.668 98.330 1.00 65.25 O ATOM 10248 N GLU C 81 30.846 46.681 98.1191.00 65.84 N ATOM 10250 CA GLU C 81 31.744 46.272 97.084 1.00 64.00 CATOM 10252 CB GLU C 81 31.555 44.781 96.945 1.00 67.28 C ATOM 10255 CGGLU C 81 32.772 43.977 96.520 1.00 70.30 C ATOM 10258 CD GLU C 81 32.32242.601 95.984 1.00 76.21 C ATOM 10259 OE1 GLU C 81 31.393 41.987 96.6731.00 77.86 O ATOM 10260 OE2 GLU C 81 32.876 42.177 94.881 1.00 75.85 OATOM 10261 C GLU C 81 31.451 47.010 95.746 1.00 59.35 C ATOM 10262 O GLUC 81 32.154 46.833 94.764 1.00 57.13 O ATOM 10263 N ASP C 82 30.42247.851 95.702 1.00 57.91 N ATOM 10265 CA ASP C 82 30.121 48.600 94.4881.00 54.01 C ATOM 10267 CB ASP C 82 28.618 48.743 94.296 1.00 54.53 CATOM 10270 CG ASP C 82 27.901 47.367 94.085 1.00 57.28 C ATOM 10271 OD1ASP C 82 28.609 46.391 93.687 1.00 53.65 O ATOM 10272 OD2 ASP C 8226.642 47.201 94.289 1.00 58.60 O ATOM 10273 C ASP C 82 30.766 49.95094.511 1.00 52.01 C ATOM 10274 O ASP C 82 30.626 50.689 93.606 1.0049.44 O ATOM 10275 N ILE C 83 31.480 50.285 95.562 1.00 53.49 N ATOM10277 CA ILE C 83 32.314 51.486 95.551 1.00 52.54 C ATOM 10279 CB ILE C83 32.877 51.678 96.961 1.00 54.86 C ATOM 10281 CG1 ILE C 83 31.81052.202 97.892 1.00 56.48 C ATOM 10284 CD1 ILE C 83 32.220 52.011 99.3071.00 59.82 C ATOM 10288 CG2 ILE C 83 34.042 52.604 96.978 1.00 55.41 CATOM 10292 C ILE C 83 33.434 51.354 94.470 1.00 50.29 C ATOM 10293 O ILEC 83 34.193 50.354 94.456 1.00 49.66 O ATOM 10294 N ALA C 84 33.52852.382 93.610 1.00 48.84 N ATOM 10296 CA ALA C 84 34.175 52.304 92.2631.00 46.44 C ATOM 10298 CB ALA C 84 33.829 50.998 91.537 1.00 44.27 CATOM 10302 C ALA C 84 33.761 53.452 91.360 1.00 45.36 C ATOM 10303 O ALAC 84 32.673 53.978 91.469 1.00 46.26 O ATOM 10304 N ASP C 85 34.62153.824 90.437 1.00 44.56 N ATOM 10306 CA ASP C 85 34.175 54.588 89.2751.00 43.73 C ATOM 10308 CB ASP C 85 35.354 55.295 88.690 1.00 43.97 CATOM 10311 CG ASP C 85 35.925 56.290 89.604 1.00 47.86 C ATOM 10312 OD1ASP C 85 35.213 57.307 89.833 1.00 51.36 O ATOM 10313 OD2 ASP C 8537.066 56.130 90.098 1.00 46.79 O ATOM 10314 C ASP C 85 33.502 53.73588.135 1.00 41.60 C ATOM 10315 O ASP C 85 33.984 52.694 87.751 1.0040.63 O ATOM 10316 N TYR C 86 32.394 54.211 87.600 1.00 40.84 N ATOM10318 CA TYR C 86 31.741 53.554 86.508 1.00 39.46 C ATOM 10320 CB TYR C86 30.278 53.370 86.862 1.00 40.82 C ATOM 10323 CG TYR C 86 30.12852.481 88.089 1.00 41.54 C ATOM 10324 CD1 TYR C 86 30.275 52.972 89.3901.00 40.87 C ATOM 10326 CE1 TYR C 86 30.238 52.105 90.477 1.00 42.12 CATOM 10328 CZ TYR C 86 30.045 50.721 90.274 1.00 43.49 C ATOM 10329 OHTYR C 86 29.967 49.762 91.277 1.00 44.20 O ATOM 10331 CE2 TYR C 8629.911 50.233 88.998 1.00 43.68 C ATOM 10333 CD2 TYR C 86 29.947 51.11187.922 1.00 43.03 C ATOM 10335 C TYR C 86 31.981 54.442 85.282 1.0039.22 C ATOM 10336 O TYR C 86 31.996 55.699 85.428 1.00 39.82 O ATOM10337 N TYR C 87 32.248 53.781 84.121 1.00 37.23 N ATOM 10339 CA TYR C87 32.593 54.411 82.848 1.00 35.32 C ATOM 10341 CB TYR C 87 34.06854.178 82.513 1.00 34.25 C ATOM 10344 CG TYR C 87 35.078 54.824 83.4361.00 32.69 C ATOM 10345 CD1 TYR C 87 35.673 54.085 84.435 1.00 34.43 CATOM 10347 CE1 TYR C 87 36.624 54.622 85.308 1.00 34.35 C ATOM 10349 CZTYR C 87 36.944 55.979 85.221 1.00 35.80 C ATOM 10350 OH TYR C 87 37.86056.518 86.145 1.00 36.98 O ATOM 10352 CE2 TYR C 87 36.313 56.765 84.2171.00 34.38 C ATOM 10354 CD2 TYR C 87 35.427 56.154 83.317 1.00 32.88 CATOM 10356 C TYR C 87 31.659 53.868 81.712 1.00 35.54 C ATOM 10357 O TYRC 87 31.079 52.769 81.798 1.00 33.51 O ATOM 10358 N CYS C 88 31.45154.688 80.674 1.00 36.35 N ATOM 10360 CA CYS C 88 30.675 54.252 79.5001.00 36.73 C ATOM 10362 CB CYS C 88 29.397 55.021 79.326 1.00 38.36 CATOM 10365 SG CYS C 88 29.606 56.785 79.010 1.00 45.26 S ATOM 10366 CCYS C 88 31.526 54.473 78.301 1.00 36.06 C ATOM 10367 O CYS C 88 32.35955.383 78.363 1.00 37.61 O ATOM 10368 N GLN C 89 31.434 53.593 77.2911.00 34.22 N ATOM 10370 CA GLN C 89 32.123 53.844 76.047 1.00 35.12 CATOM 10372 CB GLN C 89 33.376 52.960 75.808 1.00 34.83 C ATOM 10375 CGGLN C 89 33.011 51.589 75.387 1.00 35.80 C ATOM 10378 CD GLN C 89 34.14450.697 75.122 1.00 32.88 C ATOM 10379 OE1 GLN C 89 35.021 50.995 74.3381.00 28.59 O ATOM 10380 NE2 GLN C 89 34.097 49.552 75.751 1.00 34.45 NATOM 10383 C GLN C 89 31.178 53.728 74.916 1.00 35.20 C ATOM 10384 O GLNC 89 30.136 53.113 75.048 1.00 36.60 O ATOM 10385 N GLN C 90 31.51354.370 73.812 1.00 35.36 N ATOM 10387 CA GLN C 90 30.724 54.222 72.6141.00 35.88 C ATOM 10389 CB GLN C 90 30.190 55.561 72.034 1.00 37.15 CATOM 10392 CG GLN C 90 31.160 56.518 71.509 1.00 38.90 C ATOM 10395 CDGLN C 90 31.751 56.167 70.178 1.00 39.85 C ATOM 10396 OE1 GLN C 9031.045 55.686 69.291 1.00 39.79 O ATOM 10397 NE2 GLN C 90 33.055 56.48870.000 1.00 36.83 N ATOM 10400 C GLN C 90 31.541 53.417 71.654 1.0034.21 C ATOM 10401 O GLN C 90 32.721 53.427 71.725 1.00 35.03 O ATOM10402 N ASN C 91 30.827 52.751 70.783 1.00 35.58 N ATOM 10404 CA ASN C91 31.209 51.680 69.873 1.00 35.22 C ATOM 10406 CB ASN C 91 30.30950.451 70.175 1.00 34.54 C ATOM 10409 CG ASN C 91 31.052 49.282 69.9871.00 34.93 C ATOM 10410 OD1 ASN C 91 32.257 49.468 69.874 1.00 37.10 OATOM 10411 ND2 ASN C 91 30.452 48.094 69.806 1.00 34.50 N ATOM 10414 CASN C 91 30.932 52.048 68.387 1.00 36.89 C ATOM 10415 O ASN C 91 31.32751.330 67.449 1.00 35.22 O ATOM 10416 N ASN C 92 30.203 53.164 68.2231.00 37.82 N ATOM 10418 CA ASN C 92 29.658 53.596 66.975 1.00 39.19 CATOM 10420 CB ASN C 92 28.456 54.437 67.328 1.00 42.61 C ATOM 10423 CGASN C 92 27.489 54.658 66.206 1.00 42.89 C ATOM 10424 OD1 ASN C 9227.520 54.082 65.292 1.00 44.19 O ATOM 10425 ND2 ASN C 92 26.568 55.49066.411 1.00 57.14 N ATOM 10428 C ASN C 92 30.602 54.401 66.135 1.0039.91 C ATOM 10429 O ASN C 92 30.717 54.126 64.972 1.00 39.51 O ATOM10430 N ASN C 93 31.291 55.405 66.676 1.00 40.89 N ATOM 10432 CA ASN C93 32.127 56.280 65.792 1.00 43.39 C ATOM 10434 CB ASN C 93 31.93957.785 66.086 1.00 45.26 C ATOM 10437 CG ASN C 93 30.611 58.254 65.7771.00 45.20 C ATOM 10438 OD1 ASN C 93 29.775 57.526 65.177 1.00 44.43 OATOM 10439 ND2 ASN C 93 30.318 59.439 66.265 1.00 49.86 N ATOM 10442 CASN C 93 33.573 55.924 65.885 1.00 42.51 C ATOM 10443 O ASN C 93 33.86755.305 66.862 1.00 43.58 O ATOM 10444 N TRP C 94 34.457 56.343 64.9581.00 43.96 N ATOM 10446 CA TRP C 94 35.670 55.658 64.819 1.00 43.09 CATOM 10448 CB TRP C 94 36.318 55.596 63.431 1.00 45.10 C ATOM 10451 CGTRP C 94 37.929 55.151 63.579 1.00 41.72 C ATOM 10452 CD1 TRP C 9438.440 53.861 63.794 1.00 37.65 C ATOM 10454 NE1 TRP C 94 39.800 53.89363.964 1.00 38.41 N ATOM 10456 CE2 TRP C 94 40.213 55.197 63.962 1.0041.29 C ATOM 10457 CD2 TRP C 94 39.081 56.019 63.735 1.00 42.04 C ATOM10458 CE3 TRP C 94 39.264 57.397 63.732 1.00 44.37 C ATOM 10460 CZ3 TRPC 94 40.504 57.884 63.875 1.00 46.24 C ATOM 10462 CH2 TRP C 94 41.59657.059 64.053 1.00 46.26 C ATOM 10464 CZ2 TRP C 94 41.473 55.715 64.0761.00 44.06 C ATOM 10466 C TRP C 94 36.842 55.984 65.627 1.00 44.73 CATOM 10467 O TRP C 94 37.890 55.418 65.277 1.00 50.14 O ATOM 10468 N PROC 95 36.955 56.786 66.611 1.00 42.69 N ATOM 10469 CA PRO C 95 37.70856.193 67.739 1.00 39.74 C ATOM 10471 CB PRO C 95 38.606 57.326 68.2201.00 40.92 C ATOM 10474 CG PRO C 95 38.406 58.340 67.337 1.00 43.30 CATOM 10477 CD PRO C 95 37.050 58.218 66.504 1.00 45.08 C ATOM 10480 CPRO C 95 36.737 55.730 68.741 1.00 37.51 C ATOM 10481 O PRO C 95 35.82656.513 68.897 1.00 40.73 O ATOM 10482 N THR C 96 36.836 54.564 69.3401.00 35.57 N ATOM 10484 CA THR C 96 36.133 54.302 70.597 1.00 35.67 CATOM 10486 CB THR C 96 36.506 52.995 71.300 1.00 34.47 C ATOM 10488 OG1THR C 96 36.874 52.031 70.376 1.00 40.36 O ATOM 10490 CG2 THR C 9635.298 52.345 71.897 1.00 34.45 C ATOM 10494 C THR C 96 36.545 55.34271.633 1.00 37.15 C ATOM 10495 O THR C 96 37.697 55.771 71.699 1.0038.19 O ATOM 10496 N THR C 97 35.597 55.641 72.520 1.00 37.17 N ATOM10498 CA THR C 97 35.688 56.759 73.381 1.00 37.73 C ATOM 10500 CB THR C97 34.989 57.870 72.675 1.00 39.59 C ATOM 10502 OG1 THR C 97 35.84158.260 71.625 1.00 39.41 O ATOM 10504 CG2 THR C 97 34.957 59.110 73.4541.00 45.48 C ATOM 10508 C THR C 97 35.031 56.368 74.658 1.00 36.93 CATOM 10509 O THR C 97 34.132 55.590 74.698 1.00 36.08 O ATOM 10510 N PHEC 98 35.522 56.933 75.731 1.00 38.65 N ATOM 10512 CA PHE C 98 34.98656.695 77.041 1.00 37.72 C ATOM 10514 CB PHE C 98 36.159 56.124 77.9021.00 37.47 C ATOM 10517 CG PHE C 98 36.606 54.763 77.485 1.00 34.26 CATOM 10518 CD1 PHE C 98 37.578 54.609 76.544 1.00 35.84 C ATOM 10520 CE1PHE C 98 38.002 53.331 76.187 1.00 34.75 C ATOM 10522 CZ PHE C 98 37.42152.229 76.743 1.00 29.78 C ATOM 10524 CE2 PHE C 98 36.491 52.389 77.6681.00 29.34 C ATOM 10526 CD2 PHE C 98 36.090 53.645 78.051 1.00 31.59 CATOM 10528 C PHE C 98 34.422 58.060 77.591 1.00 39.16 C ATOM 10529 O PHEC 98 34.737 59.159 77.062 1.00 40.05 O ATOM 10530 N GLY C 99 33.59857.951 78.645 1.00 38.61 N ATOM 10532 CA GLY C 99 33.116 59.091 79.4231.00 40.58 C ATOM 10535 C GLY C 99 34.047 59.347 80.600 1.00 40.69 CATOM 10536 O GLY C 99 34.881 58.511 80.838 1.00 39.99 O ATOM 10537 N ALAC 100 33.936 60.467 81.318 1.00 42.29 N ATOM 10539 CA ALA C 100 34.92960.800 82.331 1.00 43.08 C ATOM 10541 CB ALA C 100 34.952 62.200 82.5931.00 45.44 C ATOM 10545 C ALA C 100 34.704 60.073 83.615 1.00 43.15 CATOM 10546 O ALA C 100 35.530 60.158 84.533 1.00 46.01 O ATOM 10547 NGLY C 101 33.582 59.386 83.698 1.00 42.22 N ATOM 10549 CA GLY C 10133.303 58.487 84.799 1.00 41.44 C ATOM 10552 C GLY C 101 32.429 59.14185.833 1.00 42.90 C ATOM 10553 O GLY C 101 32.196 60.338 85.710 1.0043.82 O ATOM 10554 N THR C 102 31.927 58.324 86.776 1.00 42.89 N ATOM10556 CA THR C 102 31.102 58.722 87.925 1.00 44.84 C ATOM 10558 CB THR C102 29.615 58.489 87.561 1.00 45.99 C ATOM 10560 OG1 THR C 102 29.16759.579 86.758 1.00 48.49 O ATOM 10562 CG2 THR C 102 28.616 58.548 88.7591.00 48.28 C ATOM 10566 C THR C 102 31.537 57.838 89.083 1.00 44.23 CATOM 10567 O THR C 102 31.749 56.657 88.885 1.00 43.22 O ATOM 10568 NLYS C 103 31.688 58.393 90.278 1.00 45.21 N ATOM 10570 CA LYS C 10332.237 57.643 91.412 1.00 45.48 C ATOM 10572 CB LYS C 103 33.267 58.47592.288 1.00 47.73 C ATOM 10575 CG LYS C 103 34.082 57.608 93.362 1.0048.87 C ATOM 10578 CD LYS C 103 35.298 58.255 93.982 1.00 53.95 C ATOM10581 CE LYS C 103 35.376 58.007 95.634 1.00 64.04 C ATOM 10584 NZ LYS C103 34.907 59.016 96.915 1.00 61.58 N ATOM 10588 C LYS C 103 31.06957.287 92.237 1.00 46.12 C ATOM 10589 O LYS C 103 30.196 58.112 92.4681.00 48.00 O ATOM 10590 N LEU C 104 31.042 56.098 92.776 1.00 46.17 NATOM 10592 CA LEU C 104 29.904 55.784 93.608 1.00 49.29 C ATOM 10594 CBLEU C 104 29.523 54.342 93.380 1.00 49.15 C ATOM 10597 CG LEU C 10428.282 53.863 94.082 1.00 53.47 C ATOM 10599 CD1 LEU C 104 27.166 54.60193.392 1.00 56.73 C ATOM 10603 CD2 LEU C 104 28.068 52.313 94.003 1.0054.16 C ATOM 10607 C LEU C 104 30.351 55.941 94.993 1.00 51.44 C ATOM10608 O LEU C 104 31.362 55.356 95.326 1.00 53.07 O ATOM 10609 N GLU C105 29.662 56.720 95.796 1.00 53.36 N ATOM 10611 CA GLU C 105 29.91456.710 97.228 1.00 56.53 C ATOM 10613 CB GLU C 105 30.270 58.104 97.6971.00 58.68 C ATOM 10616 CG GLU C 105 30.158 58.333 99.212 1.00 63.77 CATOM 10619 CD GLU C 105 30.265 59.803 99.573 1.00 68.90 C ATOM 10620 OE1GLU C 105 29.358 60.563 99.176 1.00 72.30 O ATOM 10621 OE2 GLU C 10531.249 60.206 100.245 1.00 72.61 O ATOM 10622 C GLU C 105 28.705 56.24698.031 1.00 58.76 C ATOM 10623 O GLU C 105 27.599 56.744 97.824 1.0059.09 O ATOM 10624 N LEU C 106 28.930 55.327 98.977 1.00 60.31 N ATOM10626 CA LEU C 106 27.904 54.929 99.963 1.00 62.77 C ATOM 10628 CB LEU C106 28.333 53.678 100.722 1.00 64.45 C ATOM 10631 CG LEU C 106 28.25952.375 99.937 1.00 64.30 C ATOM 10633 CD1 LEU C 106 28.586 51.154100.833 1.00 67.13 C ATOM 10637 CD2 LEU C 106 26.847 52.259 99.368 1.0066.90 C ATOM 10641 C LEU C 106 27.715 55.987 100.994 1.00 64.27 C ATOM10642 O LEU C 106 28.692 56.430 101.558 1.00 63.86 O ATOM 10643 N LYS C107 26.474 56.364 101.274 1.00 65.47 N ATOM 10645 CA LYS C 107 26.24857.151 102.447 1.00 68.21 C ATOM 10647 CB LYS C 107 25.055 58.121102.387 1.00 70.02 C ATOM 10650 CG LYS C 107 24.467 58.503 101.031 1.0069.45 C ATOM 10653 CD LYS C 107 23.340 59.617 101.174 1.00 75.00 C ATOM10656 CE LYS C 107 21.839 59.052 101.327 1.00 80.27 C ATOM 10659 NZ LYSC 107 21.257 58.305 100.105 1.00 78.29 N ATOM 10663 C LYS C 107 26.19156.193 103.612 1.00 70.40 C ATOM 10664 O LYS C 107 26.242 54.991 103.4481.00 69.16 O ATOM 10665 N ARG C 108 26.094 56.784 104.795 1.00 55.67 NATOM 10667 CA ARG C 108 26.552 56.234 106.070 1.00 55.57 C ATOM 10669 CBARG C 108 28.060 56.047 105.949 1.00 55.68 C ATOM 10672 CG ARG C 10828.725 55.336 107.046 1.00 56.83 C ATOM 10675 CD ARG C 108 29.579 56.238107.866 1.00 57.77 C ATOM 10678 NE ARG C 108 29.552 55.864 109.288 1.0057.84 N ATOM 10680 CZ ARG C 108 30.316 54.919 109.761 1.00 60.59 C ATOM10681 NH1 ARG C 108 31.146 54.248 108.965 1.00 62.42 N ATOM 10684 NH2ARG C 108 30.258 54.623 111.020 1.00 64.86 N ATOM 10687 C ARG C 10826.229 57.307 107.130 1.00 54.10 C ATOM 10688 O ARG C 108 26.110 58.500106.783 1.00 52.40 O ATOM 10689 N THR C 109 26.067 56.911 108.401 1.0055.56 N ATOM 10691 CA THR C 109 25.907 57.934 109.458 1.00 56.08 C ATOM10693 CB THR C 109 25.537 57.387 110.847 1.00 58.53 C ATOM 10695 OG1 THRC 109 26.528 56.464 111.278 1.00 58.94 O ATOM 10697 CG2 THR C 109 24.24456.654 110.836 1.00 60.67 C ATOM 10701 C THR C 109 27.167 58.773 109.6551.00 54.85 C ATOM 10702 O THR C 109 28.294 58.337 109.480 1.00 54.01 OATOM 10703 N VAL C 110 26.945 59.997 110.058 1.00 55.32 N ATOM 10705 CAVAL C 110 28.021 60.900 110.341 1.00 55.05 C ATOM 10707 CB VAL C 11027.434 62.253 110.890 1.00 56.58 C ATOM 10709 CG1 VAL C 110 28.52863.180 111.294 1.00 57.91 C ATOM 10713 CG2 VAL C 110 26.507 62.970109.873 1.00 55.27 C ATOM 10717 C VAL C 110 28.999 60.194 111.343 1.0056.38 C ATOM 10718 O VAL C 110 28.608 59.690 112.392 1.00 57.15 O ATOM10719 N ALA C 111 30.277 60.109 110.979 1.00 56.38 N ATOM 10721 CA ALA C111 31.305 59.519 111.847 1.00 57.80 C ATOM 10723 CB ALA C 111 31.85158.283 111.228 1.00 57.81 C ATOM 10727 C ALA C 111 32.433 60.527 112.0641.00 57.43 C ATOM 10728 O ALA C 111 33.114 60.930 111.134 1.00 55.47 OATOM 10729 N ALA C 112 32.619 60.918 113.317 1.00 59.73 N ATOM 10731 CAALA C 112 33.580 61.947 113.670 1.00 59.71 C ATOM 10733 CB ALA C 11233.324 62.564 115.064 1.00 61.97 C ATOM 10737 C ALA C 112 34.938 61.327113.593 1.00 59.10 C ATOM 10738 O ALA C 112 35.109 60.135 113.881 1.0060.02 O ATOM 10739 N PRO C 113 35.869 62.147 113.125 1.00 57.92 N ATOM10740 CA PRO C 113 37.241 61.752 112.972 1.00 57.27 C ATOM 10742 CB PROC 113 37.830 62.929 112.166 1.00 56.41 C ATOM 10745 CG PRO C 113 37.02264.097 112.509 1.00 56.68 C ATOM 10748 CD PRO C 113 35.676 63.541112.663 1.00 57.56 C ATOM 10751 C PRO C 113 37.884 61.697 114.306 1.0059.38 C ATOM 10752 O PRO C 113 37.599 62.541 115.106 1.00 61.02 O ATOM10753 N SER C 114 38.761 60.740 114.498 1.00 59.86 N ATOM 10755 CA SER C114 39.630 60.699 115.606 1.00 62.67 C ATOM 10757 CB SER C 114 39.92359.236 115.876 1.00 64.64 C ATOM 10760 OG SER C 114 38.718 58.528116.164 1.00 66.40 O ATOM 10762 C SER C 114 40.876 61.455 115.164 1.0062.27 C ATOM 10763 O SER C 114 41.536 61.049 114.215 1.00 61.52 O ATOM10764 N VAL C 115 41.212 62.536 115.849 1.00 64.21 N ATOM 10766 CA VAL C115 42.412 63.338 115.568 1.00 64.84 C ATOM 10768 CB VAL C 115 42.11264.867 115.740 1.00 66.16 C ATOM 10770 CG1 VAL C 115 43.187 65.745115.105 1.00 65.30 C ATOM 10774 CG2 VAL C 115 40.751 65.225 115.112 1.0065.65 C ATOM 10778 C VAL C 115 43.656 62.979 116.413 1.00 67.80 C ATOM10779 O VAL C 115 43.555 62.609 117.547 1.00 71.74 O ATOM 10780 N PHE C116 44.834 63.156 115.822 1.00 67.72 N ATOM 10782 CA PHE C 116 46.13062.702 116.329 1.00 69.88 C ATOM 10784 CB PHE C 116 46.381 61.247115.944 1.00 69.43 C ATOM 10787 CG PHE C 116 45.304 60.316 116.387 1.0069.98 C ATOM 10788 CD1 PHE C 116 44.217 60.065 115.575 1.00 66.04 C ATOM10790 CE1 PHE C 116 43.240 59.211 115.989 1.00 68.00 C ATOM 10792 CZ PHEC 116 43.309 58.597 117.221 1.00 71.83 C ATOM 10794 CE2 PHE C 116 44.36758.840 118.040 1.00 75.85 C ATOM 10796 CD2 PHE C 116 45.367 59.710117.630 1.00 74.09 C ATOM 10798 C PHE C 116 47.217 63.542 115.687 1.0069.39 C ATOM 10799 O PHE C 116 47.290 63.629 114.457 1.00 67.03 O ATOM10800 N ILE C 117 48.055 64.175 116.502 1.00 72.96 N ATOM 10802 CA ILE C117 49.120 65.045 115.980 1.00 72.96 C ATOM 10804 CB ILE C 117 49.00066.482 116.565 1.00 74.87 C ATOM 10806 CG1 ILE C 117 50.181 67.350116.111 1.00 76.75 C ATOM 10809 CD1 ILE C 117 49.855 68.819 115.887 1.0077.88 C ATOM 10813 CG2 ILE C 117 48.837 66.451 118.062 1.00 79.54 C ATOM10817 C ILE C 117 50.458 64.376 116.247 1.00 75.27 C ATOM 10818 O ILE C117 50.557 63.617 117.210 1.00 79.55 O ATOM 10819 N PHE C 118 51.45764.596 115.387 1.00 74.30 N ATOM 10821 CA PHE C 118 52.774 63.940115.508 1.00 76.66 C ATOM 10823 CB PHE C 118 52.929 62.877 114.426 1.0074.55 C ATOM 10826 CG PHE C 118 51.971 61.709 114.544 1.00 74.34 C ATOM10827 CD1 PHE C 118 50.831 61.640 113.735 1.00 73.64 C ATOM 10829 CE1PHE C 118 49.942 60.536 113.815 1.00 71.90 C ATOM 10831 CZ PHE C 11850.239 59.516 114.666 1.00 72.99 C ATOM 10833 CE2 PHE C 118 51.38359.572 115.442 1.00 74.93 C ATOM 10835 CD2 PHE C 118 52.232 60.651115.391 1.00 74.47 C ATOM 10837 C PHE C 118 53.975 64.915 115.393 1.0078.41 C ATOM 10838 O PHE C 118 54.268 65.444 114.286 1.00 76.97 O ATOM10839 N PRO C 119 54.675 65.181 116.500 1.00 82.21 N ATOM 10840 CA PRO C119 55.920 65.957 116.393 1.00 84.25 C ATOM 10842 CB PRO C 119 56.54265.838 117.779 1.00 88.82 C ATOM 10845 CG PRO C 119 55.382 65.517118.696 1.00 89.91 C ATOM 10848 CD PRO C 119 54.374 64.797 117.892 1.0085.44 C ATOM 10851 C PRO C 119 56.828 65.320 115.316 1.00 82.79 C ATOM10852 O PRO C 119 56.648 64.125 114.994 1.00 82.06 O ATOM 10853 N PRO C120 57.709 66.107 114.711 1.00 82.76 N ATOM 10854 CA PRO C 120 58.75265.563 113.838 1.00 82.28 C ATOM 10856 CB PRO C 120 59.444 66.815113.282 1.00 82.97 C ATOM 10859 CG PRO C 120 59.057 67.942 114.183 1.0085.25 C ATOM 10862 CD PRO C 120 57.728 67.580 114.747 1.00 84.01 C ATOM10865 C PRO C 120 59.749 64.678 114.568 1.00 85.50 C ATOM 10866 O PRO C120 60.140 64.963 115.715 1.00 90.03 O ATOM 10867 N SER C 121 60.18463.637 113.886 1.00 84.53 N ATOM 10869 CA SER C 121 61.025 62.639114.484 1.00 88.74 C ATOM 10871 CB SER C 121 60.927 61.392 113.675 1.0087.48 C ATOM 10874 OG SER C 121 61.718 61.641 112.529 1.00 88.53 O ATOM10876 C SER C 121 62.513 63.037 114.538 1.00 92.58 C ATOM 10877 O SER C121 62.974 63.943 113.830 1.00 92.02 O ATOM 10878 N ASP C 122 63.25462.310 115.374 1.00 96.87 N ATOM 10880 CA ASP C 122 64.668 62.564115.636 1.00 100.88 C ATOM 10882 CB ASP C 122 65.212 61.403 116.516 1.00106.35 C ATOM 10885 CG ASP C 122 64.930 61.583 118.022 1.00 110.21 CATOM 10886 OD1 ASP C 122 63.991 62.303 118.397 1.00 109.83 O ATOM 10887OD2 ASP C 122 65.610 61.032 118.913 1.00 115.97 O ATOM 10888 C ASP C 12265.523 62.705 114.353 1.00 99.41 C ATOM 10889 O ASP C 122 65.919 63.808113.992 1.00 97.33 O ATOM 10890 N GLU C 123 65.761 61.552 113.698 1.0099.99 N ATOM 10892 CA GLU C 123 66.475 61.402 112.414 1.00 99.67 C ATOM10894 CB GLU C 123 66.175 60.022 111.737 1.00 98.14 C ATOM 10901 C GLU C123 66.137 62.569 111.477 1.00 96.68 C ATOM 10902 O GLU C 123 67.03863.239 110.987 1.00 98.14 O ATOM 10903 N GLN C 124 64.841 62.842 111.2731.00 93.61 N ATOM 10905 CA GLN C 124 64.398 63.880 110.305 1.00 90.64 CATOM 10907 CB GLN C 124 62.846 63.927 110.138 1.00 86.51 C ATOM 10910 CGGLN C 124 62.362 64.800 108.958 1.00 82.22 C ATOM 10913 CD GLN C 12460.869 65.118 108.916 1.00 78.52 C ATOM 10914 OE1 GLN C 124 60.10864.980 109.888 1.00 75.18 O ATOM 10915 NE2 GLN C 124 60.451 65.558107.759 1.00 77.75 N ATOM 10918 C GLN C 124 64.956 65.278 110.658 1.0092.63 C ATOM 10919 O GLN C 124 65.541 65.966 109.784 1.00 92.86 O ATOM10920 N LEU C 125 64.788 65.691 111.917 1.00 94.07 N ATOM 10922 CA LEU C125 65.326 66.981 112.331 1.00 96.57 C ATOM 10924 CB LEU C 125 64.89667.338 113.755 1.00 98.49 C ATOM 10927 CG LEU C 125 63.933 68.526113.913 1.00 97.09 C ATOM 10929 CD1 LEU C 125 62.846 68.157 114.932 1.0096.51 C ATOM 10933 CD2 LEU C 125 64.671 69.836 114.312 1.00 99.62 C ATOM10937 C LEU C 125 66.857 66.986 112.192 1.00 100.24 C ATOM 10938 O LEU C125 67.463 68.054 112.104 1.00 102.53 O ATOM 10939 N LYS C 126 67.46765.794 112.178 1.00 101.49 N ATOM 10941 CA LYS C 126 68.902 65.655111.893 1.00 105.04 C ATOM 10943 CB LYS C 126 69.455 64.271 112.318 1.00107.49 C ATOM 10950 C LYS C 126 69.171 65.943 110.397 1.00 103.41 C ATOM10951 O LYS C 126 70.085 66.726 110.076 1.00 106.04 O ATOM 10952 N SER C127 68.371 65.337 109.510 1.00 99.35 N ATOM 10954 CA SER C 127 68.42365.607 108.082 1.00 97.89 C ATOM 10956 CB SER C 127 67.356 64.775107.347 1.00 95.15 C ATOM 10959 OG SER C 127 66.142 65.501 107.072 1.0092.42 O ATOM 10961 C SER C 127 68.227 67.087 107.758 1.00 97.29 C ATOM10962 O SER C 127 68.571 67.510 106.671 1.00 97.87 O ATOM 10963 N GLY C128 67.655 67.860 108.685 1.00 96.84 N ATOM 10965 CA GLY C 128 67.45169.292 108.505 1.00 97.37 C ATOM 10968 C GLY C 128 66.058 69.738 108.0391.00 94.13 C ATOM 10969 O GLY C 128 65.832 70.917 107.753 1.00 94.42 OATOM 10970 N THR C 129 65.093 68.828 107.976 1.00 91.09 N ATOM 10972 CATHR C 129 63.711 69.278 107.773 1.00 88.29 C ATOM 10974 CB THR C 12963.245 68.917 106.341 1.00 86.24 C ATOM 10976 OG1 THR C 129 64.35369.086 105.439 1.00 88.83 O ATOM 10978 CG2 THR C 129 62.258 69.966105.811 1.00 85.12 C ATOM 10982 C THR C 129 62.732 68.840 108.882 1.0086.18 C ATOM 10983 O THR C 129 63.036 67.960 109.684 1.00 87.16 O ATOM10984 N ALA C 130 61.593 69.530 108.955 1.00 84.15 N ATOM 10986 CA ALA C130 60.525 69.238 109.908 1.00 81.98 C ATOM 10988 CB ALA C 130 60.31870.399 110.827 1.00 84.47 C ATOM 10992 C ALA C 130 59.244 68.958 109.1571.00 78.03 C ATOM 10993 O ALA C 130 58.773 69.810 108.392 1.00 76.36 OATOM 10994 N SER C 131 58.708 67.749 109.369 1.00 76.12 N ATOM 10996 CASER C 131 57.410 67.320 108.816 1.00 72.65 C ATOM 10998 CB SER C 13157.553 66.111 107.877 1.00 70.72 C ATOM 11001 OG SER C 131 57.712 66.485106.501 1.00 70.02 O ATOM 11003 C SER C 131 56.496 66.992 110.011 1.0072.77 C ATOM 11004 O SER C 131 56.814 66.125 110.855 1.00 74.28 O ATOM11005 N VAL C 132 55.378 67.710 110.105 1.00 71.88 N ATOM 11007 CA VAL C132 54.471 67.565 111.239 1.00 72.03 C ATOM 11009 CB VAL C 132 54.17468.881 111.954 1.00 73.84 C ATOM 11011 CG1 VAL C 132 53.490 68.605113.281 1.00 75.05 C ATOM 11015 CG2 VAL C 132 55.443 69.693 112.128 1.0077.41 C ATOM 11019 C VAL C 132 53.191 67.089 110.658 1.00 69.08 C ATOM11020 O VAL C 132 52.743 67.657 109.685 1.00 67.17 O ATOM 11021 N VAL C133 52.591 66.083 111.287 1.00 68.84 N ATOM 11023 CA VAL C 133 51.46565.357 110.700 1.00 66.13 C ATOM 11025 CB VAL C 133 51.861 63.890110.444 1.00 66.16 C ATOM 11027 CG1 VAL C 133 50.771 63.077 109.757 1.0062.31 C ATOM 11031 CG2 VAL C 133 53.162 63.852 109.672 1.00 68.50 C ATOM11035 C VAL C 133 50.262 65.317 111.596 1.00 66.14 C ATOM 11036 O VAL C133 50.346 65.030 112.772 1.00 68.15 O ATOM 11037 N CYS C 134 49.12565.563 110.990 1.00 64.89 N ATOM 11039 CA CYS C 134 47.844 65.261111.575 1.00 64.95 C ATOM 11041 CB CYS C 134 46.938 66.457 111.408 1.0065.26 C ATOM 11044 SG CYS C 134 46.037 66.697 112.941 1.00 72.19 S ATOM11045 C CYS C 134 47.197 64.094 110.858 1.00 62.06 C ATOM 11046 O CYS C134 47.449 63.862 109.674 1.00 61.20 O ATOM 11047 N LEU C 135 46.33763.380 111.568 1.00 61.40 N ATOM 11049 CA LEU C 135 45.617 62.235111.027 1.00 58.71 C ATOM 11051 CB LEU C 135 46.183 60.986 111.655 1.0060.46 C ATOM 11054 CG LEU C 135 45.430 59.670 111.520 1.00 61.31 C ATOM11056 CD1 LEU C 135 45.114 59.308 110.103 1.00 60.36 C ATOM 11060 CD2LEU C 135 46.276 58.559 112.078 1.00 63.76 C ATOM 11064 C LEU C 13544.221 62.435 111.468 1.00 57.46 C ATOM 11065 O LEU C 135 43.984 62.674112.610 1.00 58.68 O ATOM 11066 N LEU C 136 43.282 62.449 110.566 1.0056.07 N ATOM 11068 CA LEU C 136 41.871 62.381 110.951 1.00 56.20 C ATOM11070 CB LEU C 136 41.019 63.385 110.192 1.00 54.74 C ATOM 11073 CG LEUC 136 41.477 64.822 109.904 1.00 55.75 C ATOM 11075 CD1 LEU C 136 40.25265.754 109.846 1.00 56.08 C ATOM 11079 CD2 LEU C 136 42.517 65.363110.864 1.00 57.95 C ATOM 11083 C LEU C 136 41.455 60.970 110.567 1.0056.76 C ATOM 11084 O LEU C 136 41.558 60.579 109.377 1.00 54.98 O ATOM11085 N ASN C 137 41.010 60.175 111.543 1.00 59.04 N ATOM 11087 CA ASN C137 40.813 58.746 111.242 1.00 60.23 C ATOM 11089 CB ASN C 137 41.55157.792 112.223 1.00 63.94 C ATOM 11092 CG ASN C 137 41.899 56.418111.560 1.00 66.89 C ATOM 11093 OD1 ASN C 137 41.856 56.288 110.338 1.0070.32 O ATOM 11094 ND2 ASN C 137 42.199 55.407 112.361 1.00 71.93 N ATOM11097 C ASN C 137 39.365 58.402 111.194 1.00 58.92 C ATOM 11098 O ASN C137 38.607 58.929 111.965 1.00 59.90 O ATOM 11099 N ASN C 138 39.01557.519 110.275 1.00 58.00 N ATOM 11101 CA ASN C 138 37.670 56.976110.095 1.00 57.80 C ATOM 11103 CB ASN C 138 37.502 55.768 110.969 1.0060.82 C ATOM 11106 CG ASN C 138 38.594 54.763 110.761 1.00 63.86 C ATOM11107 OD1 ASN C 138 39.038 54.501 109.625 1.00 64.97 O ATOM 11108 ND2ASN C 138 39.057 54.201 111.853 1.00 67.79 N ATOM 11111 C ASN C 13836.531 57.965 110.296 1.00 56.57 C ATOM 11112 O ASN C 138 35.732 57.824111.235 1.00 57.27 O ATOM 11113 N PHE C 139 36.479 58.985 109.420 1.0054.48 N ATOM 11115 CA PHE C 139 35.331 59.891 109.404 1.00 53.81 C ATOM11117 CB PHE C 139 35.790 61.326 109.616 1.00 53.42 C ATOM 11120 CG PHEC 139 36.608 61.856 108.508 1.00 51.95 C ATOM 11121 CD1 PHE C 139 36.00762.464 107.425 1.00 50.55 C ATOM 11123 CE1 PHE C 139 36.768 62.941106.395 1.00 50.36 C ATOM 11125 CZ PHE C 139 38.144 62.850 106.440 1.0048.23 C ATOM 11127 CE2 PHE C 139 38.739 62.256 107.503 1.00 49.74 C ATOM11129 CD2 PHE C 139 37.976 61.749 108.536 1.00 50.89 C ATOM 11131 C PHEC 139 34.416 59.794 108.162 1.00 52.65 C ATOM 11132 O PHE C 139 34.75159.186 107.164 1.00 50.71 O ATOM 11133 N TYR C 140 33.241 60.391 108.2811.00 52.90 N ATOM 11135 CA TYR C 140 32.274 60.479 107.190 1.00 53.13 CATOM 11137 CB TYR C 140 31.467 59.199 107.034 1.00 54.47 C ATOM 11140 CGTYR C 140 30.597 59.241 105.814 1.00 55.53 C ATOM 11141 CD1 TYR C 14031.066 58.769 104.599 1.00 56.84 C ATOM 11143 CE1 TYR C 140 30.30658.850 103.463 1.00 56.96 C ATOM 11145 CZ TYR C 140 29.054 59.386103.533 1.00 58.04 C ATOM 11146 OH TYR C 140 28.331 59.472 102.372 1.0060.87 O ATOM 11148 CE2 TYR C 140 28.565 59.856 104.720 1.00 57.39 C ATOM11150 CD2 TYR C 140 29.344 59.792 105.851 1.00 56.47 C ATOM 11152 C TYRC 140 31.327 61.564 107.646 1.00 53.37 C ATOM 11153 O TYR C 140 30.97361.600 108.799 1.00 54.87 O ATOM 11154 N PRO C 141 30.932 62.477 106.7991.00 52.72 N ATOM 11155 CA PRO C 141 31.297 62.520 105.408 1.00 52.43 CATOM 11157 CB PRO C 141 30.176 63.388 104.835 1.00 53.29 C ATOM 11160 CGPRO C 141 29.996 64.367 105.828 1.00 53.92 C ATOM 11163 CD PRO C 14130.119 63.638 107.168 1.00 53.63 C ATOM 11166 C PRO C 141 32.700 63.141105.142 1.00 51.46 C ATOM 11167 O PRO C 141 33.371 63.582 106.018 1.0050.16 O ATOM 11168 N ARG C 142 33.106 63.171 103.880 1.00 52.37 N ATOM11170 CA ARG C 142 34.467 63.464 103.538 1.00 52.21 C ATOM 11172 CB ARGC 142 34.734 63.188 102.077 1.00 53.40 C ATOM 11175 CG ARG C 142 36.07863.698 101.630 1.00 56.32 C ATOM 11178 CD ARG C 142 36.554 63.071100.360 1.00 60.42 C ATOM 11181 NE ARG C 142 37.713 63.814 99.826 1.0062.68 N ATOM 11183 CZ ARG C 142 38.378 63.446 98.735 1.00 62.72 C ATOM11184 NH1 ARG C 142 37.965 62.338 98.098 1.00 67.02 N ATOM 11187 NH2 ARGC 142 39.433 64.150 98.286 1.00 59.04 N ATOM 11190 C ARG C 142 34.80364.879 103.799 1.00 52.89 C ATOM 11191 O ARG C 142 35.994 65.178 104.0431.00 52.87 O ATOM 11192 N GLU C 143 33.813 65.776 103.712 1.00 54.26 NATOM 11194 CA GLU C 143 34.158 67.175 103.987 1.00 56.18 C ATOM 11196 CBGLU C 143 33.053 68.169 103.642 1.00 58.86 C ATOM 11199 CG GLU C 14333.596 69.598 103.729 1.00 63.26 C ATOM 11202 CD GLU C 143 32.567 70.696103.455 1.00 70.77 C ATOM 11203 OE1 GLU C 143 31.399 70.575 103.939 1.0072.09 O ATOM 11204 OE2 GLU C 143 32.940 71.714 102.782 1.00 74.74 O ATOM11205 C GLU C 143 34.663 67.386 105.427 1.00 55.52 C ATOM 11206 O GLU C143 33.912 67.386 106.409 1.00 55.37 O ATOM 11207 N ALA C 144 35.97567.507 105.516 1.00 55.94 N ATOM 11209 CA ALA C 144 36.665 67.970106.712 1.00 57.00 C ATOM 11211 CB ALA C 144 37.587 66.852 107.213 1.0055.95 C ATOM 11215 C ALA C 144 37.478 69.253 106.372 1.00 58.66 C ATOM11216 O ALA C 144 37.631 69.622 105.214 1.00 59.65 O ATOM 11217 N LYS C145 38.038 69.884 107.380 1.00 59.98 N ATOM 11219 CA LYS C 145 38.88071.055 107.194 1.00 62.18 C ATOM 11221 CB LYS C 145 37.975 72.309107.181 1.00 65.67 C ATOM 11224 CG LYS C 145 38.627 73.759 107.072 1.0070.00 C ATOM 11227 CD LYS C 145 37.728 74.817 107.895 1.00 74.41 C ATOM11230 CE LYS C 145 37.394 76.202 107.210 1.00 78.41 C ATOM 11233 NZ LYSC 145 37.443 76.330 105.690 1.00 76.16 N ATOM 11237 C LYS C 145 39.94871.077 108.306 1.00 62.49 C ATOM 11238 O LYS C 145 39.714 70.784 109.4931.00 62.13 O ATOM 11239 N VAL C 146 41.152 71.415 107.909 1.00 63.00 NATOM 11241 CA VAL C 146 42.268 71.334 108.824 1.00 63.55 C ATOM 11243 CBVAL C 146 43.183 70.193 108.431 1.00 61.33 C ATOM 11245 CG1 VAL C 14644.510 70.267 109.248 1.00 63.03 C ATOM 11249 CG2 VAL C 146 42.44668.892 108.609 1.00 58.25 C ATOM 11253 C VAL C 146 43.060 72.595 108.7301.00 66.29 C ATOM 11254 O VAL C 146 43.628 72.875 107.681 1.00 66.84 OATOM 11255 N GLN C 147 43.095 73.350 109.817 1.00 68.87 N ATOM 11257 CAGLN C 147 43.905 74.536 109.882 1.00 72.37 C ATOM 11259 CB GLN C 14743.099 75.734 110.396 1.00 76.83 C ATOM 11262 CG GLN C 147 42.317 76.514109.337 1.00 77.62 C ATOM 11265 CD GLN C 147 41.165 77.347 109.930 1.0080.53 C ATOM 11266 OE1 GLN C 147 41.367 78.499 110.283 1.00 88.62 O ATOM11267 NE2 GLN C 147 39.980 76.775 110.015 1.00 74.96 N ATOM 11270 C GLNC 147 45.058 74.207 110.804 1.00 72.82 C ATOM 11271 O GLN C 147 44.92073.510 111.778 1.00 71.65 O ATOM 11272 N TRP C 148 46.224 74.684 110.4431.00 74.99 N ATOM 11274 CA TRP C 148 47.392 74.550 111.287 1.00 76.89 CATOM 11276 CB TRP C 148 48.588 74.068 110.465 1.00 74.83 C ATOM 11279 CGTRP C 148 48.711 72.619 110.138 1.00 70.59 C ATOM 11280 CD1 TRP C 14848.353 72.042 108.978 1.00 67.59 C ATOM 11282 NE1 TRP C 148 48.67670.711 108.984 1.00 63.05 N ATOM 11284 CE2 TRP C 148 49.305 70.418110.155 1.00 65.79 C ATOM 11285 CD2 TRP C 148 49.343 71.584 110.905 1.0069.46 C ATOM 11286 CE3 TRP C 148 49.938 71.526 112.141 1.00 72.82 C ATOM11288 CZ3 TRP C 148 50.457 70.314 112.584 1.00 71.92 C ATOM 11290 CH2TRP C 148 50.410 69.202 111.822 1.00 68.74 C ATOM 11292 CZ2 TRP C 14849.838 69.223 110.603 1.00 67.06 C ATOM 11294 C TRP C 148 47.705 75.955111.937 1.00 82.80 C ATOM 11295 O TRP C 148 47.740 77.001 111.243 1.0084.38 O ATOM 11296 N LYS C 149 47.929 75.943 113.262 1.00 85.63 N ATOM11298 CA LYS C 149 48.203 77.147 114.050 1.00 91.54 C ATOM 11300 CB LYSC 149 47.065 77.424 115.063 1.00 94.11 C ATOM 11303 CG LYS C 149 45.65777.643 114.457 1.00 92.57 C ATOM 11306 CD LYS C 149 44.608 77.959115.522 1.00 95.47 C ATOM 11309 CE LYS C 149 43.170 77.612 115.088 1.0093.07 C ATOM 11312 NZ LYS C 149 42.369 76.679 116.029 1.00 90.06 N ATOM11316 C LYS C 149 49.548 76.978 114.773 1.00 93.58 C ATOM 11317 O LYS C149 49.876 75.896 115.279 1.00 91.51 O ATOM 11318 N VAL C 150 50.31578.062 114.807 1.00 97.73 N ATOM 11320 CA VAL C 150 51.624 78.061115.384 1.00 100.07 C ATOM 11322 CB VAL C 150 52.631 78.262 114.275 1.0099.22 C ATOM 11324 CG1 VAL C 150 54.029 78.444 114.828 1.00 104.37 CATOM 11328 CG2 VAL C 150 52.601 77.096 113.333 1.00 93.65 C ATOM 11332 CVAL C 150 51.629 79.233 116.329 1.00 107.01 C ATOM 11333 O VAL C 15051.874 80.369 115.916 1.00 111.28 O ATOM 11334 N ASP C 151 51.334 78.985117.600 1.00 109.29 N ATOM 11336 CA ASP C 151 51.128 80.083 118.573 1.00116.46 C ATOM 11338 CB ASP C 151 52.361 81.004 118.708 1.00 121.70 CATOM 11341 CG ASP C 151 53.612 80.265 119.111 1.00 119.58 C ATOM 11342OD1 ASP C 151 53.619 79.651 120.194 1.00 118.15 O ATOM 11343 OD2 ASP C151 54.640 80.248 118.410 1.00 116.55 O ATOM 11344 C ASP C 151 49.92780.929 118.156 1.00 118.10 C ATOM 11345 O ASP C 151 49.762 82.048118.615 1.00 124.53 O ATOM 11346 N ASN C 152 49.106 80.368 117.273 1.00112.89 N ATOM 11348 CA ASN C 152 47.884 80.991 116.737 1.00 113.81 CATOM 11350 CB ASN C 152 46.964 81.550 117.853 1.00 119.38 C ATOM 11353CG ASN C 152 46.467 80.472 118.794 1.00 117.08 C ATOM 11354 OD1 ASN C152 45.498 79.741 118.489 1.00 111.65 O ATOM 11355 ND2 ASN C 152 47.13380.356 119.948 1.00 119.53 N ATOM 11358 C ASN C 152 48.039 82.015115.598 1.00 115.75 C ATOM 11359 O ASN C 152 47.197 82.882 115.467 1.00119.93 O ATOM 11360 N ALA C 153 49.086 81.916 114.773 1.00 113.90 N ATOM11362 CA ALA C 153 49.016 82.419 113.383 1.00 112.97 C ATOM 11364 CB ALAC 153 50.362 83.049 112.914 1.00 115.78 C ATOM 11368 C ALA C 153 48.58281.215 112.489 1.00 105.40 C ATOM 11369 O ALA C 153 49.190 80.118112.536 1.00 100.44 O ATOM 11370 N LEU C 154 47.490 81.404 111.738 1.00104.22 N ATOM 11372 CA LEU C 154 47.062 80.433 110.725 1.00 98.09 C ATOM11374 CB LEU C 154 45.803 80.913 109.980 1.00 99.06 C ATOM 11377 CG LEUC 154 44.449 80.931 110.712 1.00 100.59 C ATOM 11379 CD1 LEU C 15444.035 82.369 111.263 1.00 107.76 C ATOM 11383 CD2 LEU C 154 43.37680.317 109.788 1.00 96.43 C ATOM 11387 C LEU C 154 48.178 80.250 109.7061.00 96.18 C ATOM 11388 O LEU C 154 48.764 81.229 109.238 1.00 99.72 OATOM 11389 N GLN C 155 48.466 78.997 109.357 1.00 90.49 N ATOM 11391 CAGLN C 155 49.477 78.703 108.346 1.00 88.65 C ATOM 11393 CB GLN C 15550.264 77.418 108.660 1.00 84.72 C ATOM 11396 CG GLN C 155 51.045 77.407109.970 1.00 85.90 C ATOM 11399 CD GLN C 155 51.946 78.589 110.099 1.0091.43 C ATOM 11400 OE1 GLN C 155 52.738 78.847 109.204 1.00 93.14 O ATOM11401 NE2 GLN C 155 51.820 79.336 111.198 1.00 95.40 N ATOM 11404 C GLNC 155 48.752 78.564 107.025 1.00 86.54 C ATOM 11405 O GLN C 155 47.59978.120 106.959 1.00 84.02 O ATOM 11406 N SER C 156 49.404 78.988 105.9661.00 87.95 N ATOM 11408 CA SER C 156 48.872 78.684 104.665 1.00 86.39 CATOM 11410 CB SER C 156 47.818 79.707 104.245 1.00 89.74 C ATOM 11413 OGSER C 156 48.427 80.797 103.581 1.00 95.70 O ATOM 11415 C SER C 15650.039 78.564 103.698 1.00 86.84 C ATOM 11416 O SER C 156 51.075 79.207103.873 1.00 88.72 O ATOM 11417 N GLY C 157 49.867 77.656 102.735 1.0084.26 N ATOM 11419 CA GLY C 157 50.836 77.421 101.684 1.00 85.21 C ATOM11422 C GLY C 157 52.001 76.541 102.070 1.00 82.75 C ATOM 11423 O GLY C157 52.857 76.304 101.247 1.00 83.43 O ATOM 11424 N ASN C 158 52.01976.050 103.302 1.00 80.64 N ATOM 11426 CA ASN C 158 53.087 75.180103.820 1.00 79.04 C ATOM 11428 CB ASN C 158 53.786 75.891 104.976 1.0081.79 C ATOM 11431 CG ASN C 158 52.797 76.357 106.077 1.00 84.07 C ATOM11432 OD1 ASN C 158 51.593 76.497 105.840 1.00 85.42 O ATOM 11433 ND2ASN C 158 53.315 76.578 107.292 1.00 87.62 N ATOM 11436 C ASN C 15852.554 73.770 104.259 1.00 74.13 C ATOM 11437 O ASN C 158 53.185 73.076105.074 1.00 72.30 O ATOM 11438 N SER C 159 51.392 73.365 103.719 1.0071.66 N ATOM 11440 CA SER C 159 50.788 72.052 104.073 1.00 67.90 C ATOM11442 CB SER C 159 49.729 72.128 105.214 1.00 66.13 C ATOM 11445 OG SERC 159 48.749 73.114 105.020 1.00 64.64 O ATOM 11447 C SER C 159 50.18371.335 102.905 1.00 66.31 C ATOM 11448 O SER C 159 49.609 71.959 102.0301.00 68.14 O ATOM 11449 N GLN C 160 50.291 70.012 102.916 1.00 64.19 NATOM 11451 CA GLN C 160 49.644 69.174 101.896 1.00 62.64 C ATOM 11453 CBGLN C 160 50.677 68.532 100.993 1.00 63.54 C ATOM 11456 CG GLN C 16051.374 69.456 100.096 1.00 65.64 C ATOM 11459 CD GLN C 160 52.390 68.73199.259 1.00 68.21 C ATOM 11460 OE1 GLN C 160 52.193 68.544 98.030 1.0070.43 O ATOM 11461 NE2 GLN C 160 53.480 68.295 99.904 1.00 66.25 N ATOM11464 C GLN C 160 48.905 68.054 102.548 1.00 59.52 C ATOM 11465 O GLN C160 49.353 67.499 103.546 1.00 58.40 O ATOM 11466 N GLU C 161 47.79467.673 101.945 1.00 58.74 N ATOM 11468 CA GLU C 161 47.020 66.559102.487 1.00 56.88 C ATOM 11470 CB GLU C 161 45.748 67.079 103.199 1.0057.07 C ATOM 11473 CG GLU C 161 44.936 68.196 102.543 1.00 59.02 C ATOM11476 CD GLU C 161 43.833 68.709 103.487 1.00 61.54 C ATOM 11477 OE1 GLUC 161 44.130 69.229 104.606 1.00 63.55 O ATOM 11478 OE2 GLU C 161 42.64768.567 103.133 1.00 61.99 O ATOM 11479 C GLU C 161 46.653 65.492 101.4971.00 55.11 C ATOM 11480 O GLU C 161 46.532 65.801 100.352 1.00 55.99 OATOM 11481 N SER C 162 46.556 64.230 101.937 1.00 53.99 N ATOM 11483 CASER C 162 45.689 63.253 101.252 1.00 54.45 C ATOM 11485 CB SER C 16246.338 61.980 100.687 1.00 54.88 C ATOM 11488 OG SER C 162 47.640 61.877100.980 1.00 54.80 O ATOM 11490 C SER C 162 44.599 62.743 102.111 1.0053.51 C ATOM 11491 O SER C 162 44.721 62.768 103.346 1.00 53.28 O ATOM11492 N VAL C 163 43.602 62.185 101.394 1.00 53.67 N ATOM 11494 CA VAL C163 42.504 61.396 101.915 1.00 52.73 C ATOM 11496 CB VAL C 163 41.16261.948 101.478 1.00 52.14 C ATOM 11498 CG1 VAL C 163 40.071 61.623102.477 1.00 52.07 C ATOM 11502 CG2 VAL C 163 41.242 63.407 101.328 1.0053.45 C ATOM 11506 C VAL C 163 42.564 60.049 101.289 1.00 54.59 C ATOM11507 O VAL C 163 43.085 59.875 100.212 1.00 56.88 O ATOM 11508 N THR C164 41.975 59.088 101.948 1.00 55.77 N ATOM 11510 CA THR C 164 41.85157.795 101.389 1.00 58.56 C ATOM 11512 CB THR C 164 41.900 56.737102.484 1.00 59.66 C ATOM 11514 OG1 THR C 164 42.914 57.079 103.426 1.0059.99 O ATOM 11516 CG2 THR C 164 42.467 55.366 101.889 1.00 64.68 C ATOM11520 C THR C 164 40.566 57.687 100.624 1.00 59.35 C ATOM 11521 O THR C164 39.597 58.310 100.908 1.00 58.00 O ATOM 11522 N GLU C 165 40.57956.823 99.639 1.00 62.70 N ATOM 11524 CA GLU C 165 39.368 56.246 99.1081.00 63.98 C ATOM 11526 CB GLU C 165 39.764 55.246 98.035 1.00 68.42 CATOM 11529 CG GLU C 165 40.394 55.913 96.779 1.00 74.03 C ATOM 11532 CDGLU C 165 39.509 57.028 96.100 1.00 78.67 C ATOM 11533 OE1 GLU C 16538.238 56.972 96.180 1.00 81.40 O ATOM 11534 OE2 GLU C 165 40.078 57.97895.467 1.00 80.96 O ATOM 11535 C GLU C 165 38.537 55.561 100.192 1.0062.40 C ATOM 11536 O GLU C 165 39.094 55.035 101.158 1.00 62.62 O ATOM11537 N GLN C 166 37.206 55.570 100.001 1.00 61.60 N ATOM 11539 CA GLN C166 36.190 55.023 100.958 1.00 60.28 C ATOM 11541 CB GLN C 166 34.78955.255 100.390 1.00 60.22 C ATOM 11544 CG GLN C 166 33.671 54.930101.352 1.00 60.01 C ATOM 11547 CD GLN C 166 32.343 55.571 101.001 1.0057.99 C ATOM 11548 OE1 GLN C 166 31.947 55.629 99.846 1.00 60.56 O ATOM11549 NE2 GLN C 166 31.631 55.984 102.008 1.00 56.87 N ATOM 11552 C GLNC 166 36.369 53.544 101.355 1.00 61.82 C ATOM 11553 O GLN C 166 36.66852.732 100.536 1.00 63.96 O ATOM 11554 N ASP C 167 36.172 53.205 102.6111.00 61.44 N ATOM 11556 CA ASP C 167 36.546 51.900 103.107 1.00 65.73 CATOM 11558 CB ASP C 167 36.746 51.988 104.586 1.00 65.19 C ATOM 11561 CGASP C 167 37.345 50.724 105.181 1.00 72.04 C ATOM 11562 OD1 ASP C 16736.669 49.640 105.326 1.00 75.74 O ATOM 11563 OD2 ASP C 167 38.52950.768 105.587 1.00 76.75 O ATOM 11564 C ASP C 167 35.428 50.923 102.9041.00 69.41 C ATOM 11565 O ASP C 167 34.325 51.175 103.348 1.00 68.59 OATOM 11566 N SER C 168 35.692 49.784 102.272 1.00 74.58 N ATOM 11568 CASER C 168 34.612 48.829 101.949 1.00 78.10 C ATOM 11570 CB SER C 16835.157 47.618 101.188 1.00 83.31 C ATOM 11573 OG SER C 168 36.431 47.235101.689 1.00 84.86 O ATOM 11575 C SER C 168 33.831 48.435 103.227 1.0078.77 C ATOM 11576 O SER C 168 32.616 48.748 103.318 1.00 78.19 O ATOM11577 N LYS C 169 34.533 47.857 104.227 1.00 80.20 N ATOM 11579 CA LYS C169 33.923 47.466 105.543 1.00 81.36 C ATOM 11581 CB LYS C 169 34.97646.844 106.508 1.00 84.06 C ATOM 11584 CG LYS C 169 35.667 45.526106.043 1.00 90.82 C ATOM 11587 CD LYS C 169 37.176 45.430 106.502 1.0092.25 C ATOM 11590 CE LYS C 169 37.919 44.219 105.925 1.00 98.14 C ATOM11593 NZ LYS C 169 37.925 43.042 106.880 1.00 104.47 N ATOM 11597 C LYSC 169 33.080 48.578 106.300 1.00 76.62 C ATOM 11598 O LYS C 169 31.88048.420 106.429 1.00 77.24 O ATOM 11599 N ASP C 170 33.703 49.652 106.8061.00 72.36 N ATOM 11601 CA ASP C 170 32.992 50.745 107.525 1.00 68.94 CATOM 11603 CB ASP C 170 33.753 51.190 108.779 1.00 68.28 C ATOM 11606 CGASP C 170 35.172 51.717 108.499 1.00 68.33 C ATOM 11607 OD1 ASP C 17035.669 51.859 107.357 1.00 68.00 O ATOM 11608 OD2 ASP C 170 35.90352.067 109.425 1.00 71.49 O ATOM 11609 C ASP C 170 32.608 51.977 106.6621.00 65.16 C ATOM 11610 O ASP C 170 32.043 52.960 107.137 1.00 61.37 OATOM 11611 N SER C 171 32.914 51.881 105.374 1.00 65.83 N ATOM 11613 CASER C 171 32.547 52.884 104.369 1.00 63.62 C ATOM 11615 CB SER C 17131.104 52.585 103.921 1.00 64.50 C ATOM 11618 OG SER C 171 30.278 53.545104.481 1.00 62.30 O ATOM 11620 C SER C 171 32.857 54.392 104.719 1.0059.93 C ATOM 11621 O SER C 171 32.140 55.332 104.368 1.00 58.66 O ATOM11622 N THR C 172 34.017 54.602 105.330 1.00 59.37 N ATOM 11624 CA THR C172 34.528 55.938 105.707 1.00 55.85 C ATOM 11626 CB THR C 172 34.67455.962 107.198 1.00 55.89 C ATOM 11628 OG1 THR C 172 35.487 57.071107.513 1.00 59.13 O ATOM 11630 CG2 THR C 172 35.511 54.826 107.712 1.0057.10 C ATOM 11634 C THR C 172 35.897 56.403 105.084 1.00 53.92 C ATOM11635 O THR C 172 36.617 55.676 104.436 1.00 54.08 O ATOM 11636 N TYR C173 36.228 57.655 105.324 1.00 52.30 N ATOM 11638 CA TYR C 173 37.47958.291 104.859 1.00 51.46 C ATOM 11640 CB TYR C 173 37.166 59.643104.193 1.00 49.71 C ATOM 11643 CG TYR C 173 36.218 59.481 103.061 1.0049.79 C ATOM 11644 CD1 TYR C 173 34.872 59.517 103.254 1.00 49.00 C ATOM11646 CE1 TYR C 173 34.033 59.333 102.222 1.00 52.19 C ATOM 11648 CZ TYRC 173 34.545 59.096 100.980 1.00 53.46 C ATOM 11649 OH TYR C 173 33.72758.910 99.884 1.00 58.02 O ATOM 11651 CE2 TYR C 173 35.868 59.059100.794 1.00 52.66 C ATOM 11653 CD2 TYR C 173 36.680 59.236 101.810 1.0051.00 C ATOM 11655 C TYR C 173 38.513 58.493 105.961 1.00 51.35 C ATOM11656 O TYR C 173 38.240 58.326 107.138 1.00 51.36 O ATOM 11657 N SER C174 39.701 58.907 105.547 1.00 51.83 N ATOM 11659 CA SER C 174 40.79959.144 106.484 1.00 52.31 C ATOM 11661 CB SER C 174 41.538 57.809106.747 1.00 54.03 C ATOM 11664 OG SER C 174 41.293 57.287 108.023 1.0052.58 O ATOM 11666 C SER C 174 41.742 60.193 105.881 1.00 51.52 C ATOM11667 O SER C 174 42.203 60.034 104.801 1.00 52.07 O ATOM 11668 N LEU C175 42.048 61.249 106.587 1.00 51.86 N ATOM 11670 CA LEU C 175 42.87462.315 106.019 1.00 52.36 C ATOM 11672 CB LEU C 175 42.244 63.649106.309 1.00 51.94 C ATOM 11675 CG LEU C 175 42.542 64.815 105.400 1.0051.62 C ATOM 11677 CD1 LEU C 175 41.344 65.221 104.572 1.00 50.59 C ATOM11681 CD2 LEU C 175 42.946 65.915 106.230 1.00 52.90 C ATOM 11685 C LEUC 175 44.220 62.353 106.658 1.00 54.29 C ATOM 11686 O LEU C 175 44.42661.809 107.718 1.00 55.77 O ATOM 11687 N SER C 176 45.160 63.032 106.0291.00 55.63 N ATOM 11689 CA SER C 176 46.416 63.293 106.700 1.00 56.66 CATOM 11691 CB SER C 176 47.413 62.207 106.400 1.00 57.54 C ATOM 11694 OGSER C 176 48.503 62.771 105.728 1.00 61.11 O ATOM 11696 C SER C 17646.915 64.623 106.226 1.00 57.20 C ATOM 11697 O SER C 176 46.943 64.902105.017 1.00 56.36 O ATOM 11698 N SER C 177 47.292 65.468 107.193 1.0058.72 N ATOM 11700 CA SER C 177 47.898 66.776 106.878 1.00 59.21 C ATOM11702 CB SER C 177 47.171 67.915 107.543 1.00 59.79 C ATOM 11705 OG SERC 177 47.283 69.028 106.687 1.00 61.45 O ATOM 11707 C SER C 177 49.29566.763 107.325 1.00 59.52 C ATOM 11708 O SER C 177 49.564 66.372 108.4081.00 59.47 O ATOM 11709 N THR C 178 50.183 67.147 106.438 1.00 60.76 NATOM 11711 CA THR C 178 51.600 67.208 106.743 1.00 62.63 C ATOM 11713 CBTHR C 178 52.400 66.234 105.865 1.00 62.33 C ATOM 11715 OG1 THR C 17852.028 64.884 106.194 1.00 62.25 O ATOM 11717 CG2 THR C 178 53.83666.288 106.225 1.00 63.69 C ATOM 11721 C THR C 178 52.063 68.655 106.6301.00 64.52 C ATOM 11722 O THR C 178 52.212 69.231 105.532 1.00 65.27 OATOM 11723 N LEU C 179 52.186 69.261 107.800 1.00 66.36 N ATOM 11725 CALEU C 179 52.856 70.552 107.944 1.00 69.87 C ATOM 11727 CB LEU C 17952.540 71.183 109.294 1.00 71.47 C ATOM 11730 CG LEU C 179 53.257 72.492109.522 1.00 75.84 C ATOM 11732 CD1 LEU C 179 52.876 73.551 108.468 1.0078.63 C ATOM 11736 CD2 LEU C 179 52.886 72.972 110.888 1.00 79.77 C ATOM11740 C LEU C 179 54.370 70.431 107.757 1.00 71.38 C ATOM 11741 O LEU C179 55.035 69.600 108.367 1.00 71.08 O ATOM 11742 N THR C 180 54.89271.257 106.871 1.00 73.42 N ATOM 11744 CA THR C 180 56.279 71.148106.515 1.00 75.49 C ATOM 11746 CB THR C 180 56.400 70.535 105.098 1.0074.91 C ATOM 11748 OG1 THR C 180 55.394 69.499 104.878 1.00 70.42 O ATOM11750 CG2 THR C 180 57.757 69.818 104.953 1.00 76.14 C ATOM 11754 C THRC 180 57.016 72.488 106.671 1.00 79.35 C ATOM 11755 O THR C 180 56.49973.558 106.316 1.00 80.35 O ATOM 11756 N LEU C 181 58.218 72.376 107.2381.00 81.53 N ATOM 11758 CA LEU C 181 59.046 73.493 107.698 1.00 86.10 CATOM 11760 CB LEU C 181 58.626 73.845 109.107 1.00 87.52 C ATOM 11763 CGLEU C 181 57.270 74.495 109.258 1.00 88.57 C ATOM 11765 CD1 LEU C 18157.123 74.780 110.767 1.00 91.29 C ATOM 11769 CD2 LEU C 181 57.12475.802 108.372 1.00 92.28 C ATOM 11773 C LEU C 181 60.531 73.127 107.7901.00 87.89 C ATOM 11774 O LEU C 181 60.834 72.002 108.185 1.00 87.01 OATOM 11775 N SER C 182 61.451 74.058 107.498 1.00 90.99 N ATOM 11777 CASER C 182 62.872 73.750 107.637 1.00 92.84 C ATOM 11779 CB SER C 18263.746 74.837 107.014 1.00 96.46 C ATOM 11782 OG SER C 182 64.103 75.790107.977 1.00 99.90 O ATOM 11784 C SER C 182 63.126 73.614 109.129 1.0094.76 C ATOM 11785 O SER C 182 62.526 74.368 109.888 1.00 96.46 O ATOM11786 N LYS C 183 63.973 72.665 109.562 1.00 95.19 N ATOM 11788 CA LYS C183 64.345 72.530 111.001 1.00 97.89 C ATOM 11790 CB LYS C 183 65.60371.666 111.218 1.00 99.64 C ATOM 11797 C LYS C 183 64.651 73.848 111.6701.00 102.52 C ATOM 11798 O LYS C 183 64.684 73.922 112.904 1.00 105.22 OATOM 11799 N ALA C 184 64.965 74.851 110.850 1.00 104.32 N ATOM 11801 CAALA C 184 65.255 76.202 111.322 1.00 109.49 C ATOM 11803 CB ALA C 18465.910 76.997 110.192 1.00 111.80 C ATOM 11807 C ALA C 184 64.015 76.946111.857 1.00 109.86 C ATOM 11808 O ALA C 184 64.043 77.545 112.937 1.00113.60 O ATOM 11809 N ASP C 185 62.940 76.921 111.075 1.00 106.51 N ATOM11811 CA ASP C 185 61.677 77.545 111.468 1.00 106.54 C ATOM 11813 CB ASPC 185 60.662 77.485 110.312 1.00 103.12 C ATOM 11816 CG ASP C 185 61.10578.269 109.052 1.00 106.46 C ATOM 11817 OD1 ASP C 185 61.944 79.204109.095 1.00 110.53 O ATOM 11818 OD2 ASP C 185 60.608 78.007 107.9351.00 108.38 O ATOM 11819 C ASP C 185 61.087 76.833 112.689 1.00 104.72 CATOM 11820 O ASP C 185 60.448 77.451 113.547 1.00 107.05 O ATOM 11821 NTYR C 186 61.307 75.525 112.758 1.00 100.91 N ATOM 11823 CA TYR C 18660.650 74.704 113.761 1.00 99.44 C ATOM 11825 CB TYR C 186 60.821 73.215113.428 1.00 95.52 C ATOM 11828 CG TYR C 186 60.182 72.269 114.423 1.0094.50 C ATOM 11829 CD1 TYR C 186 58.820 72.302 114.676 1.00 92.95 C ATOM11831 CE1 TYR C 186 58.228 71.416 115.611 1.00 92.00 C ATOM 11833 CZ TYRC 186 59.018 70.511 116.287 1.00 92.21 C ATOM 11834 OH TYR C 186 58.47569.656 117.188 1.00 90.68 O ATOM 11836 CE2 TYR C 186 60.364 70.460116.052 1.00 95.55 C ATOM 11838 CD2 TYR C 186 60.948 71.339 115.126 1.0096.74 C ATOM 11840 C TYR C 186 61.198 75.043 115.143 1.00 104.67 C ATOM11841 O TYR C 186 60.414 75.165 116.098 1.00 106.10 O ATOM 11842 N GLU C187 62.532 75.225 115.226 1.00 107.76 N ATOM 11844 CA GLU C 187 63.22775.577 116.466 1.00 112.95 C ATOM 11846 CB GLU C 187 64.703 75.893116.196 1.00 115.75 C ATOM 11853 C GLU C 187 62.516 76.763 117.096 1.00116.87 C ATOM 11854 O GLU C 187 62.133 76.705 118.270 1.00 119.20 O ATOM11855 N LYS C 188 62.254 77.785 116.272 1.00 117.68 N ATOM 11857 CA LYSC 188 61.806 79.119 116.728 1.00 123.34 C ATOM 11859 CB LYS C 188 62.25880.186 115.693 1.00 125.15 C ATOM 11866 C LYS C 188 60.293 79.334117.137 1.00 122.83 C ATOM 11867 O LYS C 188 59.870 80.480 117.337 1.00127.37 O ATOM 11868 N HIS C 189 59.498 78.271 117.295 1.00 118.14 N ATOM11870 CA HIS C 189 58.118 78.401 117.838 1.00 118.23 C ATOM 11872 CB HISC 189 57.039 78.402 116.701 1.00 113.37 C ATOM 11875 CG HIS C 189 57.19779.528 115.718 1.00 115.83 C ATOM 11876 ND1 HIS C 189 56.933 80.841116.040 1.00 122.53 N ATOM 11878 CE1 HIS C 189 57.218 81.617 115.0111.00 123.27 C ATOM 11880 NE2 HIS C 189 57.650 80.854 114.025 1.00 118.61N ATOM 11882 CD2 HIS C 189 57.647 79.542 114.440 1.00 114.31 C ATOM11884 C HIS C 189 57.835 77.295 118.865 1.00 116.94 C ATOM 11885 O HIS C189 58.396 76.204 118.757 1.00 114.30 O ATOM 11886 N LYS C 190 56.96577.557 119.843 1.00 119.39 N ATOM 11888 CA LYS C 190 56.663 76.554120.870 1.00 119.33 C ATOM 11890 CB LYS C 190 56.311 77.194 122.220 1.00126.70 C ATOM 11897 C LYS C 190 55.537 75.659 120.451 1.00 113.38 C ATOM11898 O LYS C 190 55.777 74.497 120.119 1.00 109.64 O ATOM 11899 N VAL C191 54.318 76.222 120.457 1.00 113.48 N ATOM 11901 CA VAL C 191 53.05575.504 120.222 1.00 108.33 C ATOM 11903 CB VAL C 191 51.789 76.364120.601 1.00 110.82 C ATOM 11905 CG1 VAL C 191 50.492 75.634 120.2791.00 106.29 C ATOM 11909 CG2 VAL C 191 51.761 76.701 122.048 1.00 117.81C ATOM 11913 C VAL C 191 52.932 75.172 118.762 1.00 102.06 C ATOM 11914O VAL C 191 53.386 75.958 117.927 1.00 101.58 O ATOM 11915 N TYR C 19252.284 74.024 118.493 1.00 97.43 N ATOM 11917 CA TYR C 192 51.969 73.511117.156 1.00 91.95 C ATOM 11919 CB TYR C 192 53.046 72.561 116.731 1.0089.41 C ATOM 11922 CG TYR C 192 54.216 73.257 116.212 1.00 90.56 C ATOM11923 CD1 TYR C 192 55.338 73.417 116.990 1.00 97.01 C ATOM 11925 CE1TYR C 192 56.440 74.109 116.506 1.00 99.63 C ATOM 11927 CZ TYR C 19256.404 74.640 115.220 1.00 96.17 C ATOM 11928 OH TYR C 192 57.487 75.340114.715 1.00 99.78 O ATOM 11930 CE2 TYR C 192 55.283 74.479 114.450 1.0090.48 C ATOM 11932 CD2 TYR C 192 54.194 73.817 114.961 1.00 87.27 C ATOM11934 C TYR C 192 50.653 72.713 117.135 1.00 89.66 C ATOM 11935 O TYR C192 50.545 71.644 117.772 1.00 89.20 O ATOM 11936 N ALA C 193 49.68473.192 116.352 1.00 88.28 N ATOM 11938 CA ALA C 193 48.281 72.900116.635 1.00 87.68 C ATOM 11940 CB ALA C 193 47.569 74.139 117.180 1.0091.96 C ATOM 11944 C ALA C 193 47.588 72.431 115.403 1.00 83.46 C ATOM11945 O ALA C 193 47.920 72.887 114.312 1.00 83.57 O ATOM 11946 N CYS C194 46.602 71.551 115.588 1.00 81.07 N ATOM 11948 CA CYS C 194 45.91270.929 114.502 1.00 76.76 C ATOM 11950 CB CYS C 194 46.244 69.455114.509 1.00 74.32 C ATOM 11953 SG CYS C 194 45.544 68.692 113.051 1.0076.90 S ATOM 11954 C CYS C 194 44.444 71.168 114.783 1.00 76.26 C ATOM11955 O CYS C 194 43.916 70.603 115.720 1.00 77.18 O ATOM 11956 N GLU C195 43.790 72.021 113.991 1.00 75.58 N ATOM 11958 CA GLU C 195 42.37672.394 114.203 1.00 75.90 C ATOM 11960 CB GLU C 195 42.230 73.907114.332 1.00 80.39 C ATOM 11963 CG GLU C 195 40.824 74.381 114.736 1.0083.63 C ATOM 11966 CD GLU C 195 40.380 75.689 114.059 1.00 87.24 C ATOM11967 OE1 GLU C 195 41.166 76.308 113.301 1.00 87.78 O ATOM 11968 OE2GLU C 195 39.230 76.118 114.284 1.00 89.97 O ATOM 11969 C GLU C 19541.369 71.845 113.145 1.00 71.74 C ATOM 11970 O GLU C 195 41.127 72.413112.070 1.00 70.64 O ATOM 11971 N VAL C 196 40.744 70.741 113.531 1.0069.55 N ATOM 11973 CA VAL C 196 39.805 70.023 112.708 1.00 65.72 C ATOM11975 CB VAL C 196 39.792 68.572 113.122 1.00 63.49 C ATOM 11977 CG1 VALC 196 38.864 67.812 112.277 1.00 60.95 C ATOM 11981 CG2 VAL C 196 41.19567.993 113.025 1.00 62.64 C ATOM 11985 C VAL C 196 38.388 70.591 112.8301.00 66.93 C ATOM 11986 O VAL C 196 37.907 70.990 113.890 1.00 68.84 OATOM 11987 N THR C 197 37.727 70.587 111.693 1.00 65.22 N ATOM 11989 CATHR C 197 36.375 71.068 111.555 1.00 66.67 C ATOM 11991 CB THR C 19736.395 72.420 110.849 1.00 68.91 C ATOM 11993 OG1 THR C 197 37.26873.302 111.567 1.00 73.48 O ATOM 11995 CG2 THR C 197 35.026 73.088110.862 1.00 70.65 C ATOM 11999 C THR C 197 35.623 70.042 110.718 1.0064.04 C ATOM 12000 O THR C 197 36.033 69.666 109.600 1.00 62.98 O ATOM12001 N HIS C 198 34.511 69.574 111.243 1.00 64.16 N ATOM 12003 CA HIS C198 33.842 68.464 110.617 1.00 61.33 C ATOM 12005 CB HIS C 198 34.56267.151 110.973 1.00 59.74 C ATOM 12008 CG HIS C 198 33.971 65.964110.287 1.00 58.02 C ATOM 12009 ND1 HIS C 198 34.128 65.750 108.936 1.0057.39 N ATOM 12011 CE1 HIS C 198 33.441 64.677 108.594 1.00 56.71 C ATOM12013 NE2 HIS C 198 32.826 64.208 109.663 1.00 54.74 N ATOM 12015 CD2HIS C 198 33.140 64.993 110.736 1.00 55.73 C ATOM 12017 C HIS C 19832.439 68.464 111.115 1.00 62.12 C ATOM 12018 O HIS C 198 32.191 68.978112.181 1.00 65.48 O ATOM 12019 N GLN C 199 31.529 67.905 110.337 1.0060.45 N ATOM 12021 CA GLN C 199 30.113 67.879 110.673 1.00 61.89 C ATOM12023 CB GLN C 199 29.321 67.205 109.531 1.00 60.84 C ATOM 12026 CG GLNC 199 27.791 67.469 109.465 1.00 62.62 C ATOM 12029 CD GLN C 199 27.11866.758 108.272 1.00 62.17 C ATOM 12030 OE1 GLN C 199 27.603 66.780107.132 1.00 62.44 O ATOM 12031 NE2 GLN C 199 26.021 66.130 108.541 1.0062.82 N ATOM 12034 C GLN C 199 29.881 67.134 111.977 1.00 62.72 C ATOM12035 O GLN C 199 28.947 67.431 112.702 1.00 64.57 O ATOM 12036 N GLY C200 30.759 66.186 112.294 1.00 61.62 N ATOM 12038 CA GLY C 200 30.55365.315 113.435 1.00 62.79 C ATOM 12041 C GLY C 200 31.172 65.785 114.7301.00 65.81 C ATOM 12042 O GLY C 200 31.463 64.929 115.553 1.00 68.31 OATOM 12043 N LEU C 201 31.378 67.103 114.910 1.00 67.08 N ATOM 12045 CALEU C 201 32.111 67.693 116.042 1.00 69.26 C ATOM 12047 CB LEU C 20133.565 67.903 115.686 1.00 67.39 C ATOM 12050 CG LEU C 201 34.388 66.703115.257 1.00 64.11 C ATOM 12052 CD1 LEU C 201 35.552 67.128 114.421 1.0062.77 C ATOM 12056 CD2 LEU C 201 34.886 65.911 116.436 1.00 66.42 C ATOM12060 C LEU C 201 31.490 69.063 116.339 1.00 73.17 C ATOM 12061 O LEU C201 31.436 69.928 115.455 1.00 72.65 O ATOM 12062 N SER C 202 31.01769.270 117.568 1.00 77.26 N ATOM 12064 CA SER C 202 30.015 70.328117.787 1.00 81.12 C ATOM 12066 CB SER C 202 29.362 70.258 119.187 1.0085.90 C ATOM 12069 OG SER C 202 29.672 69.042 119.838 1.00 85.41 O ATOM12071 C SER C 202 30.667 71.668 117.561 1.00 82.89 C ATOM 12072 O SER C202 30.102 72.570 116.969 1.00 83.10 O ATOM 12073 N SER C 203 31.86871.774 118.085 1.00 84.21 N ATOM 12075 CA SER C 203 32.746 72.851117.732 1.00 86.10 C ATOM 12077 CB SER C 203 32.963 73.783 118.912 1.0092.36 C ATOM 12080 OG SER C 203 33.402 73.025 120.003 1.00 93.55 O ATOM12082 C SER C 203 34.044 72.186 117.323 1.00 83.05 C ATOM 12083 O SER C203 34.262 70.983 117.626 1.00 81.22 O ATOM 12084 N PRO C 204 34.87372.948 116.593 1.00 82.81 N ATOM 12085 CA PRO C 204 36.239 72.533116.233 1.00 79.98 C ATOM 12087 CB PRO C 204 36.927 73.854 115.863 1.0082.52 C ATOM 12090 CG PRO C 204 35.815 74.803 115.476 1.00 85.07 C ATOM12093 CD PRO C 204 34.522 74.253 115.995 1.00 85.30 C ATOM 12096 C PRO C204 37.021 71.856 117.358 1.00 80.67 C ATOM 12097 O PRO C 204 36.88072.153 118.548 1.00 85.19 O ATOM 12098 N VAL C 205 37.859 70.933 116.9501.00 76.65 N ATOM 12100 CA VAL C 205 38.675 70.224 117.872 1.00 77.69 CATOM 12102 CB VAL C 205 38.367 68.781 117.787 1.00 74.45 C ATOM 12104CG1 VAL C 205 39.541 67.929 118.243 1.00 74.59 C ATOM 12108 CG2 VAL C205 37.123 68.551 118.602 1.00 76.84 C ATOM 12112 C VAL C 205 40.10170.505 117.535 1.00 77.92 C ATOM 12113 O VAL C 205 40.492 70.477 116.3911.00 75.11 O ATOM 12114 N THR C 206 40.873 70.789 118.566 1.00 82.28 NATOM 12116 CA THR C 206 42.253 71.122 118.415 1.00 82.99 C ATOM 12118 CBTHR C 206 42.454 72.498 118.958 1.00 88.12 C ATOM 12120 OG1 THR C 20641.528 73.357 118.281 1.00 89.49 O ATOM 12122 CG2 THR C 206 43.88073.065 118.602 1.00 88.94 C ATOM 12126 C THR C 206 43.102 70.134 119.1411.00 83.61 C ATOM 12127 O THR C 206 42.741 69.648 120.193 1.00 86.65 OATOM 12128 N LYS C 207 44.257 69.863 118.563 1.00 82.04 N ATOM 12130 CALYS C 207 45.180 68.869 119.060 1.00 82.54 C ATOM 12132 CB LYS C 20745.015 67.583 118.263 1.00 78.30 C ATOM 12135 CG LYS C 207 43.851 66.746118.747 1.00 79.34 C ATOM 12138 CD LYS C 207 44.253 65.776 119.859 1.0083.48 C ATOM 12141 CE LYS C 207 43.082 65.543 120.827 1.00 87.11 C ATOM12144 NZ LYS C 207 43.103 64.157 121.312 1.00 89.42 N ATOM 12148 C LYS C207 46.566 69.432 118.866 1.00 83.38 C ATOM 12149 O LYS C 207 46.95069.716 117.727 1.00 79.79 O ATOM 12150 N SER C 208 47.307 69.585 119.9741.00 88.00 N ATOM 12152 CA SER C 208 48.616 70.245 119.940 1.00 89.86 CATOM 12154 CB SER C 208 48.480 71.696 120.405 1.00 94.01 C ATOM 12157 OGSER C 208 48.739 71.839 121.786 1.00 101.12 O ATOM 12159 C SER C 20849.701 69.477 120.706 1.00 92.09 C ATOM 12160 O SER C 208 49.485 68.338121.104 1.00 91.27 O ATOM 12161 N PHE C 209 50.881 70.092 120.841 1.0094.82 N ATOM 12163 CA PHE C 209 52.047 69.472 121.487 1.00 97.65 C ATOM12165 CB PHE C 209 52.583 68.375 120.587 1.00 93.33 C ATOM 12168 CG PHEC 209 53.213 68.915 119.352 1.00 90.96 C ATOM 12169 CD1 PHE C 209 54.54269.293 119.354 1.00 92.49 C ATOM 12171 CE1 PHE C 209 55.156 69.817118.232 1.00 90.22 C ATOM 12173 CZ PHE C 209 54.445 69.986 117.093 1.0086.31 C ATOM 12175 CE2 PHE C 209 53.081 69.625 117.063 1.00 85.26 C ATOM12177 CD2 PHE C 209 52.471 69.103 118.197 1.00 87.32 C ATOM 12179 C PHEC 209 53.203 70.469 121.743 1.00 101.51 C ATOM 12180 O PHE C 209 53.16971.618 121.266 1.00 101.04 O ATOM 12181 N ASN C 210 54.241 69.987122.454 1.00 105.05 N ATOM 12183 CA ASN C 210 55.489 70.740 122.698 1.00109.04 C ATOM 12185 CB ASN C 210 56.296 70.878 121.379 1.00 104.70 CATOM 12188 CG ASN C 210 57.652 71.550 121.525 1.00 107.23 C ATOM 12189OD1 ASN C 210 58.002 72.407 120.710 1.00 103.98 O ATOM 12190 ND2 ASN C210 58.447 71.118 122.493 1.00 110.21 N ATOM 12193 C ASN C 210 55.02472.070 123.298 1.00 113.97 C ATOM 12194 O ASN C 210 55.282 73.132122.742 1.00 115.08 O ATOM 12195 N ARG C 211 54.328 71.954 124.444 1.00118.00 N ATOM 12197 CA ARG C 211 53.444 72.976 125.069 1.00 121.86 CATOM 12199 CB ARG C 211 54.110 74.377 125.154 1.00 126.69 C ATOM 12208 CARG C 211 52.005 73.001 124.427 1.00 117.02 C ATOM 12209 O ARG C 21151.034 73.584 124.925 1.00 119.42 O ATOM 12210 OXT ARG C 211 51.61872.421 123.385 1.00 109.85 O ATOM 12211 N ALA D 1 41.982 30.461 82.2771.00 57.00 N ATOM 12213 CA ALA D 1 41.459 31.172 81.013 1.00 55.46 CATOM 12215 CB ALA D 1 39.904 31.400 81.090 1.00 56.48 C ATOM 12219 C ALAD 1 42.126 32.481 80.527 1.00 50.69 C ATOM 12220 O ALA D 1 43.285 32.66980.747 1.00 52.53 O ATOM 12223 N VAL D 2 41.421 33.378 79.851 1.00 47.38N ATOM 12225 CA VAL D 2 42.079 34.564 79.219 1.00 44.48 C ATOM 12227 CBVAL D 2 41.096 35.532 78.483 1.00 41.76 C ATOM 12229 CG1 VAL D 2 41.90536.738 77.915 1.00 40.38 C ATOM 12233 CG2 VAL D 2 40.388 34.848 77.3551.00 39.69 C ATOM 12237 C VAL D 2 42.842 35.498 80.122 1.00 44.26 C ATOM12238 O VAL D 2 42.298 36.058 81.022 1.00 44.63 O ATOM 12239 N GLN D 344.102 35.758 79.839 1.00 45.24 N ATOM 12241 CA GLN D 3 44.919 36.57880.772 1.00 45.86 C ATOM 12243 CB GLN D 3 45.720 35.704 81.745 1.0048.64 C ATOM 12246 CG GLN D 3 44.864 34.972 82.827 1.00 51.62 C ATOM12249 CD GLN D 3 45.710 34.463 84.014 1.00 59.14 C ATOM 12250 OE1 GLN D3 46.947 34.642 84.062 1.00 62.63 O ATOM 12251 NE2 GLN D 3 45.053 33.84084.973 1.00 62.87 N ATOM 12254 C GLN D 3 45.815 37.442 79.938 1.00 43.72C ATOM 12255 O GLN D 3 46.250 36.962 78.925 1.00 44.39 O ATOM 12256 NLEU D 4 46.002 38.713 80.310 1.00 42.40 N ATOM 12258 CA LEU D 4 46.97739.641 79.686 1.00 40.47 C ATOM 12260 CB LEU D 4 46.256 40.846 79.0831.00 37.49 C ATOM 12263 CG LEU D 4 45.152 40.660 78.040 1.00 36.95 CATOM 12265 CD1 LEU D 4 45.432 41.577 76.858 1.00 36.62 C ATOM 12269 CD2LEU D 4 45.043 39.356 77.504 1.00 39.31 C ATOM 12273 C LEU D 4 47.96940.192 80.723 1.00 41.49 C ATOM 12274 O LEU D 4 47.599 40.842 81.6651.00 41.51 O ATOM 12275 N LYS D 5 49.250 39.970 80.549 1.00 43.23 N ATOM12277 CA LYS D 5 50.217 40.446 81.543 1.00 45.14 C ATOM 12279 CB LYS D 550.892 39.284 82.282 1.00 48.88 C ATOM 12282 CG LYS D 5 49.903 38.53683.266 1.00 54.47 C ATOM 12285 CD LYS D 5 50.560 37.297 83.990 1.0060.79 C ATOM 12288 CE LYS D 5 49.635 36.013 83.904 1.00 63.31 C ATOM12291 NZ LYS D 5 50.408 34.721 84.358 1.00 69.55 N ATOM 12295 C LYS D 551.231 41.305 80.900 1.00 43.29 C ATOM 12296 O LYS D 5 51.789 40.93179.897 1.00 43.73 O ATOM 12297 N GLN D 6 51.474 42.461 81.495 1.00 42.41N ATOM 12299 CA GLN D 6 52.383 43.434 80.924 1.00 41.52 C ATOM 12301 CBGLN D 6 51.796 44.835 81.003 1.00 40.15 C ATOM 12304 CG GLN D 6 50.40644.997 80.357 1.00 39.53 C ATOM 12307 CD GLN D 6 49.771 46.341 80.6161.00 38.13 C ATOM 12308 OE1 GLN D 6 50.442 47.334 80.783 1.00 39.92 OATOM 12309 NE2 GLN D 6 48.468 46.370 80.597 1.00 40.10 N ATOM 12312 CGLN D 6 53.668 43.410 81.676 1.00 43.59 C ATOM 12313 O GLN D 6 53.67543.182 82.887 1.00 43.49 O ATOM 12314 N SER D 7 54.749 43.568 80.9201.00 44.87 N ATOM 12316 CA SER D 7 56.016 44.080 81.435 1.00 48.01 CATOM 12318 CB SER D 7 57.107 42.989 81.406 1.00 51.52 C ATOM 12321 OGSER D 7 57.386 42.519 80.095 1.00 51.53 O ATOM 12323 C SER D 7 56.52145.303 80.675 1.00 47.70 C ATOM 12324 O SER D 7 56.324 45.395 79.4691.00 46.37 O ATOM 12325 N GLY D 8 57.216 46.210 81.364 1.00 50.18 N ATOM12327 CA GLY D 8 57.911 47.315 80.713 1.00 50.86 C ATOM 12330 C GLY D 858.393 48.422 81.619 1.00 52.58 C ATOM 12331 O GLY D 8 57.780 48.76382.605 1.00 51.07 O ATOM 12332 N PRO D 9 59.516 49.021 81.266 1.00 56.53N ATOM 12333 CA PRO D 9 60.030 50.159 82.043 1.00 58.30 C ATOM 12335 CBPRO D 9 61.288 50.586 81.284 1.00 61.09 C ATOM 12338 CG PRO D 9 61.82449.267 80.591 1.00 62.53 C ATOM 12341 CD PRO D 9 60.435 48.657 80.1621.00 58.96 C ATOM 12344 C PRO D 9 59.005 51.228 82.035 1.00 56.45 C ATOM12345 O PRO D 9 58.635 51.619 80.919 1.00 55.51 O ATOM 12346 N GLY D 1058.485 51.541 83.237 1.00 56.24 N ATOM 12348 CA GLY D 10 57.666 52.71483.525 1.00 54.81 C ATOM 12351 C GLY D 10 58.271 54.154 83.662 1.0055.43 C ATOM 12352 O GLY D 10 57.660 55.095 83.144 1.00 53.90 O ATOM12353 N LEU D 11 59.401 54.365 84.340 1.00 56.80 N ATOM 12355 CA LEU D11 60.044 55.699 84.289 1.00 57.96 C ATOM 12357 CB LEU D 11 61.14855.834 85.329 1.00 61.18 C ATOM 12360 CG LEU D 11 61.792 57.218 85.4061.00 62.40 C ATOM 12362 CD1 LEU D 11 60.836 58.390 85.187 1.00 61.71 CATOM 12366 CD2 LEU D 11 62.429 57.397 86.726 1.00 63.46 C ATOM 12370 CLEU D 11 60.627 55.983 82.904 1.00 57.05 C ATOM 12371 O LEU D 11 61.34755.208 82.383 1.00 58.70 O ATOM 12372 N VAL D 12 60.292 57.085 82.2911.00 55.69 N ATOM 12374 CA VAL D 12 60.629 57.284 80.914 1.00 55.00 CATOM 12376 CB VAL D 12 59.409 57.062 80.020 1.00 52.03 C ATOM 12378 CG1VAL D 12 59.667 57.583 78.591 1.00 54.04 C ATOM 12382 CG2 VAL D 1259.123 55.658 79.921 1.00 50.83 C ATOM 12386 C VAL D 12 61.019 58.70180.732 1.00 56.49 C ATOM 12387 O VAL D 12 60.264 59.589 81.020 1.0055.45 O ATOM 12388 N GLN D 13 62.182 58.916 80.163 1.00 59.59 N ATOM12390 CA GLN D 13 62.707 60.278 80.045 1.00 62.52 C ATOM 12392 CB GLN D13 64.212 60.305 79.899 1.00 65.71 C ATOM 12395 CG GLN D 13 64.77660.399 81.258 1.00 69.08 C ATOM 12398 CD GLN D 13 66.219 60.422 81.2711.00 77.09 C ATOM 12399 OE1 GLN D 13 66.874 60.460 80.225 1.00 81.75 OATOM 12400 NE2 GLN D 13 66.770 60.414 82.464 1.00 82.68 N ATOM 12403 CGLN D 13 62.064 60.980 78.931 1.00 61.31 C ATOM 12404 O GLN D 13 61.77560.374 77.918 1.00 60.31 O ATOM 12405 N PRO D 14 61.769 62.245 79.1371.00 62.39 N ATOM 12406 CA PRO D 14 61.018 62.986 78.155 1.00 61.94 CATOM 12408 CB PRO D 14 60.741 64.296 78.849 1.00 63.94 C ATOM 12411 CGPRO D 14 61.829 64.410 79.730 1.00 66.71 C ATOM 12414 CD PRO D 14 62.07063.082 80.291 1.00 64.87 C ATOM 12417 C PRO D 14 61.835 63.107 76.8881.00 63.56 C ATOM 12418 O PRO D 14 63.036 63.175 76.841 1.00 63.90 OATOM 12419 N SER D 15 61.050 62.965 75.841 1.00 62.98 N ATOM 12421 CASER D 15 61.451 62.904 74.452 1.00 64.41 C ATOM 12423 CB SER D 15 62.32464.072 74.064 1.00 67.55 C ATOM 12426 OG SER D 15 63.444 63.478 73.5901.00 66.46 O ATOM 12428 C SER D 15 62.057 61.533 74.072 1.00 64.44 CATOM 12429 O SER D 15 62.277 61.275 72.902 1.00 65.45 O ATOM 12430 N GLND 16 62.212 60.620 75.032 1.00 64.20 N ATOM 12432 CA GLN D 16 62.56159.213 74.717 1.00 63.39 C ATOM 12434 CB GLN D 16 63.626 58.733 75.7041.00 65.81 C ATOM 12437 CG GLN D 16 64.952 58.300 75.040 1.00 71.75 CATOM 12440 CD GLN D 16 65.920 58.044 76.159 1.00 80.91 C ATOM 12441 OE1GLN D 16 65.494 58.154 77.339 1.00 85.18 O ATOM 12442 NE2 GLN D 1667.191 57.708 75.856 1.00 83.89 N ATOM 12445 C GLN D 16 61.346 58.24174.614 1.00 57.84 C ATOM 12446 O GLN D 16 60.221 58.667 74.789 1.0056.16 O ATOM 12447 N SER D 17 61.557 56.958 74.323 1.00 56.20 N ATOM12449 CA SER D 17 60.435 56.035 74.025 1.00 53.11 C ATOM 12451 CB SER D17 60.826 55.185 72.839 1.00 53.56 C ATOM 12454 OG SER D 17 61.34753.954 73.336 1.00 55.78 O ATOM 12456 C SER D 17 59.885 55.054 75.1521.00 50.62 C ATOM 12457 O SER D 17 60.571 54.565 75.997 1.00 53.47 OATOM 12458 N LEU D 18 58.624 54.752 75.101 1.00 46.73 N ATOM 12460 CALEU D 18 57.978 53.917 76.046 1.00 44.77 C ATOM 12462 CB LEU D 18 56.56754.511 76.298 1.00 42.30 C ATOM 12465 CG LEU D 18 55.563 53.620 76.9861.00 40.07 C ATOM 12467 CD1 LEU D 18 56.090 53.066 78.283 1.00 41.41 CATOM 12471 CD2 LEU D 18 54.332 54.437 77.255 1.00 41.25 C ATOM 12475 CLEU D 18 57.806 52.599 75.327 1.00 43.93 C ATOM 12476 O LEU D 18 57.14852.565 74.292 1.00 42.76 O ATOM 12477 N SER D 19 58.323 51.506 75.8791.00 44.90 N ATOM 12479 CA SER D 19 58.085 50.145 75.341 1.00 43.56 CATOM 12481 CB SER D 19 59.401 49.524 74.816 1.00 46.48 C ATOM 12484 OGSER D 19 59.933 50.140 73.634 1.00 46.71 O ATOM 12486 C SER D 19 57.44849.240 76.426 1.00 42.19 C ATOM 12487 O SER D 19 57.952 49.152 77.5621.00 44.56 O ATOM 12488 N ILE D 20 56.343 48.596 76.071 1.00 39.20 NATOM 12490 CA ILE D 20 55.610 47.698 76.923 1.00 38.53 C ATOM 12492 CBILE D 20 54.240 48.329 77.293 1.00 37.18 C ATOM 12494 CG1 ILE D 2054.377 49.567 78.173 1.00 37.34 C ATOM 12497 CD1 ILE D 20 53.211 50.44978.017 1.00 39.17 C ATOM 12501 CG2 ILE D 20 53.280 47.309 78.017 1.0037.55 C ATOM 12505 C ILE D 20 55.324 46.437 76.164 1.00 38.06 C ATOM12506 O ILE D 20 54.932 46.471 75.000 1.00 36.64 O ATOM 12507 N THR D 2155.441 45.303 76.835 1.00 40.37 N ATOM 12509 CA THR D 21 55.088 44.00176.249 1.00 41.04 C ATOM 12511 CB THR D 21 56.261 43.068 76.450 1.0043.74 C ATOM 12513 OG1 THR D 21 57.415 43.589 75.748 1.00 46.48 O ATOM12515 CG2 THR D 21 55.958 41.774 75.812 1.00 45.01 C ATOM 12519 C THR D21 53.813 43.430 76.933 1.00 40.58 C ATOM 12520 O THR D 21 53.626 43.56778.162 1.00 41.40 O ATOM 12521 N CYS D 22 52.939 42.816 76.145 1.0039.61 N ATOM 12523 CA CYS D 22 51.711 42.179 76.631 1.00 39.65 C ATOM12525 CB CYS D 22 50.514 42.703 75.891 1.00 36.18 C ATOM 12528 SG CYS D22 48.888 42.439 76.557 1.00 40.37 S ATOM 12529 C CYS D 22 51.943 40.71976.274 1.00 41.94 C ATOM 12530 O CYS D 22 51.961 40.359 75.089 1.0042.48 O ATOM 12531 N THR D 23 52.199 39.891 77.285 1.00 43.68 N ATOM12533 CA THR D 23 52.093 38.468 77.096 1.00 45.36 C ATOM 12535 CB THR D23 53.107 37.752 77.925 1.00 48.80 C ATOM 12537 OG1 THR D 23 54.34838.483 77.823 1.00 53.25 O ATOM 12539 CG2 THR D 23 53.391 36.405 77.3281.00 48.29 C ATOM 12543 C THR D 23 50.749 37.970 77.417 1.00 44.01 CATOM 12544 O THR D 23 50.309 38.115 78.469 1.00 45.58 O ATOM 12545 N VALD 24 50.189 37.240 76.505 1.00 44.18 N ATOM 12547 CA VAL D 24 48.80136.874 76.441 1.00 43.47 C ATOM 12549 CB VAL D 24 48.356 37.223 74.9831.00 41.96 C ATOM 12551 CG1 VAL D 24 47.387 36.320 74.500 1.00 46.10 CATOM 12555 CG2 VAL D 24 47.785 38.612 74.857 1.00 38.96 C ATOM 12559 CVAL D 24 48.716 35.342 76.633 1.00 45.93 C ATOM 12560 O VAL D 24 49.55534.625 76.140 1.00 47.90 O ATOM 12561 N SER D 25 47.696 34.840 77.3201.00 46.33 N ATOM 12563 CA SER D 25 47.435 33.388 77.384 1.00 48.67 CATOM 12565 CB SER D 25 48.043 32.805 78.617 1.00 51.18 C ATOM 12568 OGSER D 25 47.357 33.326 79.724 1.00 50.94 O ATOM 12570 C SER D 25 45.93233.060 77.394 1.00 47.97 C ATOM 12571 O SER D 25 45.123 33.821 77.8501.00 46.72 O ATOM 12572 N GLY D 26 45.566 31.903 76.896 1.00 49.61 NATOM 12574 CA GLY D 26 44.195 31.497 76.922 1.00 49.63 C ATOM 12577 CGLY D 26 43.485 31.917 75.682 1.00 47.39 C ATOM 12578 O GLY D 26 42.28931.683 75.579 1.00 48.65 O ATOM 12579 N PHE D 27 44.175 32.578 74.7661.00 44.85 N ATOM 12581 CA PHE D 27 43.678 32.695 73.407 1.00 42.48 CATOM 12583 CB PHE D 27 42.750 33.823 73.310 1.00 38.91 C ATOM 12586 CGPHE D 27 43.398 35.137 73.470 1.00 37.97 C ATOM 12587 CD1 PHE D 2743.723 35.946 72.327 1.00 36.52 C ATOM 12589 CE1 PHE D 27 44.286 37.24472.465 1.00 32.40 C ATOM 12591 CZ PHE D 27 44.529 37.730 73.713 1.0033.39 C ATOM 12593 CE2 PHE D 27 44.200 36.928 74.876 1.00 36.37 C ATOM12595 CD2 PHE D 27 43.631 35.636 74.733 1.00 37.60 C ATOM 12597 C PHE D27 44.849 32.968 72.521 1.00 42.29 C ATOM 12598 O PHE D 27 45.885 33.25373.043 1.00 43.18 O ATOM 12599 N SER D 28 44.701 32.894 71.199 1.0041.48 N ATOM 12601 CA SER D 28 45.787 33.229 70.284 1.00 41.06 C ATOM12603 CB SER D 28 46.052 32.076 69.303 1.00 43.62 C ATOM 12606 OG SER D28 45.379 32.165 68.103 1.00 42.29 O ATOM 12608 C SER D 28 45.579 34.55769.592 1.00 38.22 C ATOM 12609 O SER D 28 44.467 34.940 69.333 1.0036.54 O ATOM 12610 N LEU D 29 46.675 35.275 69.369 1.00 38.34 N ATOM12612 CA LEU D 29 46.673 36.543 68.643 1.00 36.43 C ATOM 12614 CB LEU D29 48.007 37.269 68.769 1.00 35.93 C ATOM 12617 CG LEU D 29 48.34037.596 70.229 1.00 37.34 C ATOM 12619 CD1 LEU D 29 49.853 37.698 70.4361.00 42.57 C ATOM 12623 CD2 LEU D 29 47.767 38.823 70.769 1.00 35.50 CATOM 12627 C LEU D 29 46.360 36.329 67.182 1.00 36.97 C ATOM 12628 O LEUD 29 46.087 37.243 66.425 1.00 36.62 O ATOM 12629 N THR D 30 46.35135.089 66.796 1.00 39.55 N ATOM 12631 CA THR D 30 45.918 34.679 65.4731.00 39.97 C ATOM 12633 CB THR D 30 46.294 33.210 65.329 1.00 43.13 CATOM 12635 OG1 THR D 30 47.406 33.151 64.447 1.00 45.16 O ATOM 12637 CG2THR D 30 45.192 32.267 64.762 1.00 43.76 C ATOM 12641 C THR D 30 44.45434.936 65.221 1.00 38.74 C ATOM 12642 O THR D 30 44.112 35.136 64.0631.00 39.61 O ATOM 12643 N ASN D 31 43.611 34.983 66.267 1.00 37.45 NATOM 12645 CA ASN D 31 42.163 35.188 66.094 1.00 36.67 C ATOM 12647 CBASN D 31 41.384 34.034 66.706 1.00 38.21 C ATOM 12650 CG ASN D 31 41.83932.691 66.202 1.00 40.54 C ATOM 12651 OD1 ASN D 31 42.034 32.490 64.9931.00 41.36 O ATOM 12652 ND2 ASN D 31 42.022 31.763 67.125 1.00 40.98 NATOM 12655 C ASN D 31 41.563 36.434 66.711 1.00 34.82 C ATOM 12656 O ASND 31 40.386 36.809 66.403 1.00 34.97 O ATOM 12657 N TYR D 32 42.32837.047 67.606 1.00 33.79 N ATOM 12659 CA TYR D 32 41.897 38.238 68.3861.00 31.32 C ATOM 12661 CB TYR D 32 41.680 37.931 69.881 1.00 30.94 CATOM 12664 CG TYR D 32 40.436 37.197 70.158 1.00 31.75 C ATOM 12665 CD1TYR D 32 40.437 35.834 70.261 1.00 35.96 C ATOM 12667 CE1 TYR D 3239.263 35.109 70.544 1.00 37.48 C ATOM 12669 CZ TYR D 32 38.076 35.76270.634 1.00 38.25 C ATOM 12670 OH TYR D 32 36.944 35.006 70.814 1.0042.78 O ATOM 12672 CE2 TYR D 32 38.032 37.152 70.457 1.00 36.56 C ATOM12674 CD2 TYR D 32 39.225 37.857 70.249 1.00 33.48 C ATOM 12676 C TYR D32 42.934 39.293 68.222 1.00 29.57 C ATOM 12677 O TYR D 32 44.098 38.98368.095 1.00 32.81 O ATOM 12678 N GLY D 33 42.505 40.521 68.175 1.0027.55 N ATOM 12680 CA GLY D 33 43.339 41.698 68.179 1.00 27.54 C ATOM12683 C GLY D 33 43.622 42.083 69.643 1.00 28.10 C ATOM 12684 O GLY D 3342.841 41.699 70.478 1.00 28.48 O ATOM 12685 N VAL D 34 44.747 42.75369.946 1.00 28.42 N ATOM 12687 CA VAL D 34 44.978 43.335 71.246 1.0028.37 C ATOM 12689 CB VAL D 34 46.329 42.870 71.774 1.00 29.29 C ATOM12691 CG1 VAL D 34 46.618 43.435 73.133 1.00 29.09 C ATOM 12695 CG2 VALD 34 46.332 41.434 71.903 1.00 31.00 C ATOM 12699 C VAL D 34 44.95844.866 71.101 1.00 28.37 C ATOM 12700 O VAL D 34 45.624 45.432 70.2311.00 28.84 O ATOM 12701 N HIS D 35 44.195 45.528 71.940 1.00 28.35 NATOM 12703 CA HIS D 35 44.057 46.977 71.908 1.00 29.07 C ATOM 12705 CBHIS D 35 42.582 47.405 72.135 1.00 28.80 C ATOM 12708 CG HIS D 35 41.62946.857 71.124 1.00 28.13 C ATOM 12709 ND1 HIS D 35 41.245 47.557 70.0181.00 28.65 N ATOM 12711 CE1 HIS D 35 40.387 46.852 69.309 1.00 28.35 CATOM 12713 NE2 HIS D 35 40.220 45.689 69.902 1.00 29.20 N ATOM 12715 CD2HIS D 35 40.962 45.687 71.062 1.00 30.52 C ATOM 12717 C HIS D 35 44.91447.588 72.996 1.00 30.05 C ATOM 12718 O HIS D 35 45.252 46.902 73.9601.00 31.00 O ATOM 12719 N TRP D 36 45.191 48.891 72.888 1.00 30.37 NATOM 12721 CA TRP D 36 45.968 49.637 73.896 1.00 30.27 C ATOM 12723 CBTRP D 36 47.309 50.002 73.310 1.00 30.97 C ATOM 12726 CG TRP D 36 48.15048.741 73.152 1.00 33.79 C ATOM 12727 CD1 TRP D 36 48.170 47.889 72.0861.00 35.19 C ATOM 12729 NE1 TRP D 36 49.026 46.835 72.340 1.00 35.82 NATOM 12731 CE2 TRP D 36 49.551 46.981 73.589 1.00 34.05 C ATOM 12732 CD2TRP D 36 49.040 48.169 74.124 1.00 33.66 C ATOM 12733 CE3 TRP D 3649.467 48.562 75.374 1.00 33.15 C ATOM 12735 CZ3 TRP D 36 50.354 47.79676.024 1.00 37.51 C ATOM 12737 CH2 TRP D 36 50.881 46.636 75.451 1.0038.07 C ATOM 12739 CZ2 TRP D 36 50.470 46.216 74.235 1.00 37.73 C ATOM12741 C TRP D 36 45.246 50.892 74.309 1.00 30.62 C ATOM 12742 O TRP D 3644.780 51.687 73.485 1.00 31.69 O ATOM 12743 N VAL D 37 45.089 51.07775.591 1.00 30.38 N ATOM 12745 CA VAL D 37 44.250 52.184 76.057 1.0030.87 C ATOM 12747 CB VAL D 37 42.965 51.664 76.601 1.00 30.04 C ATOM12749 CG1 VAL D 37 42.249 52.681 77.266 1.00 29.29 C ATOM 12753 CG2 VALD 37 42.196 51.029 75.509 1.00 29.91 C ATOM 12757 C VAL D 37 45.00152.685 77.207 1.00 32.03 C ATOM 12758 O VAL D 37 45.581 51.865 77.8981.00 33.02 O ATOM 12759 N ARG D 38 44.997 53.987 77.438 1.00 32.94 NATOM 12761 CA ARG D 38 45.661 54.526 78.606 1.00 34.28 C ATOM 12763 CBARG D 38 46.875 55.319 78.163 1.00 35.74 C ATOM 12766 CG ARG D 38 46.55756.678 77.574 1.00 36.42 C ATOM 12769 CD ARG D 38 47.776 57.442 77.2511.00 36.01 C ATOM 12772 NE ARG D 38 47.459 58.672 76.558 1.00 38.09 NATOM 12774 CZ ARG D 38 48.345 59.511 76.121 1.00 36.79 C ATOM 12775 NH1ARG D 38 49.623 59.276 76.303 1.00 39.89 N ATOM 12778 NH2 ARG D 3847.960 60.562 75.501 1.00 38.50 N ATOM 12781 C ARG D 38 44.763 55.36979.527 1.00 34.80 C ATOM 12782 O ARG D 38 43.781 55.900 79.125 1.0033.76 O ATOM 12783 N GLN D 39 45.159 55.528 80.755 1.00 35.60 N ATOM12785 CA GLN D 39 44.335 56.277 81.633 1.00 38.73 C ATOM 12787 CB GLN D39 43.724 55.284 82.598 1.00 39.56 C ATOM 12790 CG GLN D 39 42.74355.887 83.573 1.00 41.47 C ATOM 12793 CD GLN D 39 42.015 54.861 84.3461.00 40.76 C ATOM 12794 OE1 GLN D 39 42.588 53.843 84.731 1.00 40.61 OATOM 12795 NE2 GLN D 39 40.736 55.120 84.599 1.00 45.06 N ATOM 12798 CGLN D 39 45.148 57.376 82.371 1.00 41.44 C ATOM 12799 O GLN D 39 46.19957.117 82.951 1.00 41.23 O ATOM 12800 N SER D 40 44.701 58.612 82.2941.00 43.95 N ATOM 12802 CA SER D 40 45.297 59.665 83.117 1.00 48.33 CATOM 12804 CB SER D 40 45.996 60.801 82.338 1.00 49.57 C ATOM 12807 OGSER D 40 45.266 61.127 81.159 1.00 48.49 O ATOM 12809 C SER D 40 44.16260.222 83.917 1.00 51.39 C ATOM 12810 O SER D 40 43.005 60.374 83.4201.00 53.29 O ATOM 12811 N PRO D 41 44.470 60.547 85.153 1.00 53.68 NATOM 12812 CA PRO D 41 43.423 60.996 86.069 1.00 57.08 C ATOM 12814 CBPRO D 41 44.192 61.252 87.364 1.00 58.57 C ATOM 12817 CG PRO D 41 45.52861.522 86.889 1.00 57.21 C ATOM 12820 CD PRO D 41 45.811 60.620 85.7361.00 53.85 C ATOM 12823 C PRO D 41 42.753 62.260 85.443 1.00 59.94 CATOM 12824 O PRO D 41 41.491 62.335 85.416 1.00 60.69 O ATOM 12825 N GLYD 42 43.616 63.113 84.835 1.00 61.45 N ATOM 12827 CA GLY D 42 43.26964.364 84.131 1.00 64.05 C ATOM 12830 C GLY D 42 42.483 64.364 82.8051.00 63.41 C ATOM 12831 O GLY D 42 41.364 64.858 82.825 1.00 65.45 OATOM 12832 N LYS D 43 43.023 63.893 81.661 1.00 60.97 N ATOM 12834 CALYS D 43 42.118 63.505 80.546 1.00 59.80 C ATOM 12836 CB LYS D 43 42.85163.131 79.232 1.00 57.52 C ATOM 12843 C LYS D 43 41.186 62.352 81.0781.00 58.39 C ATOM 12844 O LYS D 43 40.305 62.593 82.000 1.00 63.11 OATOM 12845 N GLY D 44 41.315 61.144 80.548 1.00 53.00 N ATOM 12847 CAGLY D 44 40.557 60.047 81.120 1.00 51.14 C ATOM 12850 C GLY D 44 41.02758.728 80.530 1.00 47.33 C ATOM 12851 O GLY D 44 42.277 58.557 80.3661.00 46.03 O ATOM 12852 N LEU D 45 40.088 57.808 80.217 1.00 44.05 NATOM 12854 CA LEU D 45 40.455 56.553 79.559 1.00 40.18 C ATOM 12856 CBLEU D 45 39.386 55.575 79.824 1.00 39.67 C ATOM 12859 CG LEU D 45 39.60154.171 80.329 1.00 38.63 C ATOM 12861 CD1 LEU D 45 40.898 53.853 80.8631.00 37.61 C ATOM 12865 CD2 LEU D 45 38.510 54.020 81.401 1.00 42.06 CATOM 12869 C LEU D 45 40.553 56.808 78.075 1.00 38.78 C ATOM 12870 O LEUD 45 39.585 57.217 77.474 1.00 42.37 O ATOM 12871 N GLU D 46 41.68356.616 77.442 1.00 36.39 N ATOM 12873 CA GLU D 46 41.756 56.917 76.0231.00 36.08 C ATOM 12875 CB GLU D 46 42.482 58.195 75.876 1.00 38.06 CATOM 12878 CG GLU D 46 42.640 58.660 74.466 1.00 43.17 C ATOM 12881 CDGLU D 46 43.757 59.721 74.236 1.00 49.47 C ATOM 12882 OE1 GLU D 4644.654 59.993 75.192 1.00 44.91 O ATOM 12883 OE2 GLU D 46 43.686 60.24873.037 1.00 46.97 O ATOM 12884 C GLU D 46 42.359 55.793 75.169 1.0032.98 C ATOM 12885 O GLU D 46 43.347 55.226 75.508 1.00 31.48 O ATOM12886 N TRP D 47 41.679 55.438 74.096 1.00 32.53 N ATOM 12888 CA TRP D47 42.154 54.391 73.191 1.00 32.16 C ATOM 12890 CB TRP D 47 41.00153.746 72.467 1.00 31.08 C ATOM 12893 CG TRP D 47 41.254 52.697 71.4391.00 30.69 C ATOM 12894 CD1 TRP D 47 41.205 51.356 71.611 1.00 30.28 CATOM 12896 NE1 TRP D 47 41.413 50.701 70.416 1.00 29.31 N ATOM 12898 CE2TRP D 47 41.587 51.627 69.432 1.00 29.06 C ATOM 12899 CD2 TRP D 4741.481 52.897 70.034 1.00 33.41 C ATOM 12900 CE3 TRP D 47 41.626 54.03569.212 1.00 36.15 C ATOM 12902 CZ3 TRP D 47 41.836 53.864 67.825 1.0032.52 C ATOM 12904 CH2 TRP D 47 41.916 52.607 67.285 1.00 30.16 C ATOM12906 CZ2 TRP D 47 41.785 51.466 68.079 1.00 29.39 C ATOM 12908 C TRP D47 43.269 54.825 72.197 1.00 32.70 C ATOM 12909 O TRP D 47 43.190 55.88571.523 1.00 32.87 O ATOM 12910 N LEU D 48 44.322 53.995 72.178 1.0031.73 N ATOM 12912 CA LEU D 48 45.556 54.317 71.463 1.00 32.99 C ATOM12914 CB LEU D 48 46.776 53.933 72.280 1.00 32.64 C ATOM 12917 CG LEU D48 46.758 54.648 73.611 1.00 32.13 C ATOM 12919 CD1 LEU D 48 47.95754.186 74.392 1.00 32.17 C ATOM 12923 CD2 LEU D 48 46.771 56.119 73.4141.00 32.53 C ATOM 12927 C LEU D 48 45.631 53.665 70.121 1.00 32.70 CATOM 12928 O LEU D 48 45.921 54.298 69.140 1.00 32.71 O ATOM 12929 N GLYD 49 45.363 52.376 70.092 1.00 32.34 N ATOM 12931 CA GLY D 49 45.22551.704 68.809 1.00 32.63 C ATOM 12934 C GLY D 49 45.081 50.210 68.9621.00 31.13 C ATOM 12935 O GLY D 49 44.752 49.728 70.032 1.00 30.55 OATOM 12936 N VAL D 50 45.357 49.499 67.880 1.00 30.69 N ATOM 12938 CAVAL D 50 45.234 48.071 67.858 1.00 29.69 C ATOM 12940 CB VAL D 50 43.92147.569 67.214 1.00 30.33 C ATOM 12942 CG1 VAL D 50 43.191 46.659 68.1681.00 29.69 C ATOM 12946 CG2 VAL D 50 43.087 48.640 66.687 1.00 30.44 CATOM 12950 C VAL D 50 46.227 47.452 66.954 1.00 29.44 C ATOM 12951 O VALD 50 46.492 47.957 65.895 1.00 28.43 O ATOM 12952 N ILE D 51 46.70446.296 67.352 1.00 29.83 N ATOM 12954 CA ILE D 51 47.217 45.344 66.3821.00 31.60 C ATOM 12956 CB ILE D 51 48.621 44.854 66.705 1.00 32.32 CATOM 12958 CG1 ILE D 51 49.185 44.059 65.511 1.00 36.70 C ATOM 12961 CD1ILE D 51 50.707 43.620 65.590 1.00 32.82 C ATOM 12965 CG2 ILE D 5148.644 43.931 67.879 1.00 32.72 C ATOM 12969 C ILE D 51 46.179 44.21866.317 1.00 31.06 C ATOM 12970 O ILE D 51 46.002 43.445 67.231 1.0030.75 O ATOM 12971 N TRP D 52 45.429 44.247 65.242 1.00 31.60 N ATOM12973 CA TRP D 52 44.467 43.230 64.869 1.00 31.36 C ATOM 12975 CB TRP D52 43.712 43.639 63.636 1.00 30.90 C ATOM 12978 CG TRP D 52 42.95344.914 63.709 1.00 29.08 C ATOM 12979 CD1 TRP D 52 43.219 46.097 63.0331.00 28.04 C ATOM 12981 NE1 TRP D 52 42.243 47.006 63.289 1.00 26.54 NATOM 12983 CE2 TRP D 52 41.321 46.397 64.086 1.00 25.66 C ATOM 12984 CD2TRP D 52 41.738 45.097 64.333 1.00 26.15 C ATOM 12985 CE3 TRP D 5240.927 44.278 65.103 1.00 29.06 C ATOM 12987 CZ3 TRP D 52 39.779 44.80365.625 1.00 26.64 C ATOM 12989 CH2 TRP D 52 39.410 46.068 65.353 1.0027.20 C ATOM 12991 CZ2 TRP D 52 40.166 46.880 64.583 1.00 28.98 C ATOM12993 C TRP D 52 45.108 41.895 64.531 1.00 32.27 C ATOM 12994 O TRP D 5246.307 41.779 64.320 1.00 32.72 O ATOM 12995 N SER D 53 44.227 40.91564.488 1.00 32.74 N ATOM 12997 CA SER D 53 44.580 39.525 64.425 1.0034.75 C ATOM 12999 CB SER D 53 43.298 38.681 64.426 1.00 35.90 C ATOM13002 OG SER D 53 42.764 38.516 63.151 1.00 37.74 O ATOM 13004 C SER D53 45.454 39.204 63.274 1.00 35.30 C ATOM 13005 O SER D 53 46.503 38.64663.451 1.00 37.19 O ATOM 13006 N GLY D 54 45.092 39.637 62.083 1.0035.49 N ATOM 13008 CA GLY D 54 45.992 39.425 60.943 1.00 35.48 C ATOM13011 C GLY D 54 47.220 40.303 60.835 1.00 34.39 C ATOM 13012 O GLY D 5447.807 40.343 59.768 1.00 36.25 O ATOM 13013 N GLY D 55 47.614 40.99161.899 1.00 32.23 N ATOM 13015 CA GLY D 55 48.901 41.684 61.913 1.0033.48 C ATOM 13018 C GLY D 55 48.859 43.138 61.531 1.00 33.28 C ATOM13019 O GLY D 55 49.752 43.862 61.701 1.00 33.23 O ATOM 13020 N ASN D 5647.752 43.574 61.012 1.00 33.55 N ATOM 13022 CA ASN D 56 47.664 44.92460.574 1.00 35.11 C ATOM 13024 CB ASN D 56 46.626 45.025 59.499 1.0034.70 C ATOM 13027 CG ASN D 56 45.305 44.633 59.959 1.00 35.37 C ATOM13028 OD1 ASN D 56 44.385 45.451 59.883 1.00 40.28 O ATOM 13029 ND2 ASND 56 45.122 43.357 60.343 1.00 36.56 N ATOM 13032 C ASN D 56 47.34745.795 61.765 1.00 34.36 C ATOM 13033 O ASN D 56 46.820 45.268 62.7501.00 33.78 O ATOM 13034 N THR D 57 47.669 47.100 61.710 1.00 34.41 NATOM 13036 CA THR D 57 47.319 47.969 62.842 1.00 32.78 C ATOM 13038 CBTHR D 57 48.563 48.487 63.562 1.00 32.50 C ATOM 13040 OG1 THR D 5749.303 49.334 62.711 1.00 34.26 O ATOM 13042 CG2 THR D 57 49.505 47.39263.858 1.00 33.15 C ATOM 13046 C THR D 57 46.377 49.127 62.532 1.0032.96 C ATOM 13047 O THR D 57 46.016 49.401 61.417 1.00 34.56 O ATOM13048 N ASP D 58 45.957 49.794 63.572 1.00 32.56 N ATOM 13050 CA ASP D58 45.262 51.043 63.418 1.00 33.53 C ATOM 13052 CB ASP D 58 43.80550.801 63.352 1.00 32.81 C ATOM 13055 CG ASP D 58 43.086 51.930 62.8051.00 35.44 C ATOM 13056 OD1 ASP D 58 43.702 52.786 62.201 1.00 39.99 OATOM 13057 OD2 ASP D 58 41.850 52.052 62.880 1.00 44.18 O ATOM 13058 CASP D 58 45.555 51.858 64.639 1.00 34.20 C ATOM 13059 O ASP D 58 45.60151.348 65.789 1.00 33.15 O ATOM 13060 N TYR D 59 45.757 53.139 64.4131.00 36.15 N ATOM 13062 CA TYR D 59 46.178 54.024 65.491 1.00 35.91 CATOM 13064 CB TYR D 59 47.573 54.426 65.247 1.00 36.57 C ATOM 13067 CGTYR D 59 48.572 53.328 65.088 1.00 37.04 C ATOM 13068 CD1 TYR D 5949.590 53.425 64.103 1.00 40.41 C ATOM 13070 CE1 TYR D 59 50.555 52.50563.961 1.00 38.26 C ATOM 13072 CZ TYR D 59 50.592 51.439 64.807 1.0036.55 C ATOM 13073 OH TYR D 59 51.546 50.524 64.623 1.00 38.64 O ATOM13075 CE2 TYR D 59 49.668 51.275 65.780 1.00 36.05 C ATOM 13077 CD2 TYRD 59 48.620 52.260 65.935 1.00 36.55 C ATOM 13079 C TYR D 59 45.33555.284 65.529 1.00 36.81 C ATOM 13080 O TYR D 59 45.092 55.899 64.5241.00 38.49 O ATOM 13081 N ASN D 60 44.888 55.660 66.710 1.00 36.57 NATOM 13083 CA ASN D 60 44.107 56.894 66.906 1.00 38.17 C ATOM 13085 CBASN D 60 43.885 57.030 68.383 1.00 37.59 C ATOM 13088 CG ASN D 60 42.74257.873 68.742 1.00 39.27 C ATOM 13089 OD1 ASN D 60 42.025 58.492 67.9281.00 42.52 O ATOM 13090 ND2 ASN D 60 42.533 57.895 70.029 1.00 40.55 NATOM 13093 C ASN D 60 44.905 58.075 66.418 1.00 39.85 C ATOM 13094 O ASND 60 46.085 58.121 66.619 1.00 40.65 O ATOM 13095 N THR D 61 44.25559.004 65.783 1.00 41.38 N ATOM 13097 CA THR D 61 44.885 60.081 65.0891.00 45.06 C ATOM 13099 CB THR D 61 43.838 61.144 64.787 1.00 48.42 CATOM 13101 OG1 THR D 61 42.731 60.516 64.121 1.00 47.87 O ATOM 13103 CG2THR D 61 44.366 62.233 63.789 1.00 52.40 C ATOM 13107 C THR D 61 46.02760.733 65.763 1.00 46.36 C ATOM 13108 O THR D 61 47.011 60.937 65.1521.00 48.83 O ATOM 13109 N PRO D 62 45.936 61.148 66.995 1.00 47.67 NATOM 13110 CA PRO D 62 47.106 61.814 67.621 1.00 49.35 C ATOM 13112 CBPRO D 62 46.538 62.388 68.924 1.00 49.55 C ATOM 13115 CG PRO D 62 45.38761.448 69.263 1.00 47.57 C ATOM 13118 CD PRO D 62 44.769 61.089 67.9001.00 47.33 C ATOM 13121 C PRO D 62 48.301 60.936 67.935 1.00 47.56 CATOM 13122 O PRO D 62 49.297 61.412 68.435 1.00 49.85 O ATOM 13123 N PHED 63 48.225 59.660 67.661 1.00 45.89 N ATOM 13125 CA PHE D 63 49.35458.776 67.922 1.00 45.48 C ATOM 13127 CB PHE D 63 48.991 57.694 69.0221.00 42.86 C ATOM 13130 CG PHE D 63 48.348 58.264 70.261 1.00 41.77 CATOM 13131 CD1 PHE D 63 46.985 58.211 70.441 1.00 37.08 C ATOM 13133 CE1PHE D 63 46.398 58.790 71.575 1.00 38.67 C ATOM 13135 CZ PHE D 63 47.14559.418 72.527 1.00 37.15 C ATOM 13137 CE2 PHE D 63 48.487 59.515 72.3461.00 41.21 C ATOM 13139 CD2 PHE D 63 49.109 58.935 71.211 1.00 41.81 CATOM 13141 C PHE D 63 49.802 58.127 66.601 1.00 46.08 C ATOM 13142 O PHED 63 50.622 57.230 66.587 1.00 46.42 O ATOM 13143 N THR D 64 49.30058.568 65.480 1.00 47.62 N ATOM 13145 CA THR D 64 49.712 57.961 64.2401.00 49.13 C ATOM 13147 CB THR D 64 48.972 58.633 63.160 1.00 51.36 CATOM 13149 OG1 THR D 64 47.638 58.085 63.156 1.00 50.94 O ATOM 13151 CG2THR D 64 49.591 58.313 61.782 1.00 54.91 C ATOM 13155 C THR D 64 51.21058.114 63.990 1.00 52.42 C ATOM 13156 O THR D 64 51.907 57.193 63.5321.00 53.42 O ATOM 13157 N SER D 65 51.737 59.289 64.303 1.00 54.78 NATOM 13159 CA SER D 65 53.053 59.604 63.833 1.00 56.59 C ATOM 13161 CBSER D 65 53.251 61.158 63.765 1.00 60.91 C ATOM 13164 OG SER D 65 53.28361.827 65.066 1.00 60.68 O ATOM 13166 C SER D 65 54.083 58.943 64.7161.00 54.95 C ATOM 13167 O SER D 65 55.308 59.151 64.511 1.00 58.96 OATOM 13168 N ARG D 66 53.650 58.240 65.753 1.00 50.49 N ATOM 13170 CAARG D 66 54.617 57.976 66.852 1.00 50.01 C ATOM 13172 CB ARG D 66 54.71659.163 67.832 1.00 50.28 C ATOM 13175 CG ARG D 66 53.473 59.338 68.6811.00 49.71 C ATOM 13178 CD ARG D 66 53.310 60.748 69.279 1.00 52.47 CATOM 13181 NE ARG D 66 53.856 60.823 70.640 1.00 51.78 N ATOM 13183 CZARG D 66 53.150 60.998 71.750 1.00 50.52 C ATOM 13184 NH1 ARG D 6651.848 61.166 71.744 1.00 52.35 N ATOM 13187 NH2 ARG D 66 53.760 61.06472.902 1.00 52.82 N ATOM 13190 C ARG D 66 54.356 56.697 67.597 1.0046.69 C ATOM 13191 O ARG D 66 55.145 56.247 68.434 1.00 46.16 O ATOM13192 N LEU D 67 53.265 56.067 67.250 1.00 44.55 N ATOM 13194 CA LEU D67 52.930 54.840 67.913 1.00 42.69 C ATOM 13196 CB LEU D 67 51.44454.918 68.365 1.00 40.49 C ATOM 13199 CG LEU D 67 50.806 53.736 69.0491.00 39.68 C ATOM 13201 CD1 LEU D 67 51.766 53.114 70.010 1.00 41.91 CATOM 13205 CD2 LEU D 67 49.535 54.112 69.731 1.00 39.30 C ATOM 13209 CLEU D 67 53.301 53.694 66.939 1.00 42.23 C ATOM 13210 O LEU D 67 53.18753.803 65.722 1.00 41.99 O ATOM 13211 N SER D 68 53.814 52.615 67.4841.00 41.73 N ATOM 13213 CA SER D 68 53.956 51.426 66.679 1.00 42.24 CATOM 13215 CB SER D 68 55.369 51.322 66.097 1.00 44.65 C ATOM 13218 OGSER D 68 56.007 50.216 66.719 1.00 44.64 O ATOM 13220 C SER D 68 53.67050.202 67.537 1.00 40.14 C ATOM 13221 O SER D 68 54.406 49.959 68.4581.00 41.75 O ATOM 13222 N ILE D 69 52.646 49.430 67.192 1.00 38.16 NATOM 13224 CA ILE D 69 52.444 48.115 67.777 1.00 37.76 C ATOM 13226 CBILE D 69 51.042 47.962 68.094 1.00 35.22 C ATOM 13228 CG1 ILE D 6950.542 49.253 68.763 1.00 35.84 C ATOM 13231 CD1 ILE D 69 49.059 49.37469.024 1.00 34.14 C ATOM 13235 CG2 ILE D 69 50.941 46.834 69.044 1.0036.27 C ATOM 13239 C ILE D 69 52.930 46.915 66.909 1.00 39.46 C ATOM13240 O ILE D 69 52.799 46.952 65.673 1.00 41.51 O ATOM 13241 N ASN D 7053.501 45.877 67.523 1.00 39.23 N ATOM 13243 CA ASN D 70 53.977 44.71566.762 1.00 41.63 C ATOM 13245 CB ASN D 70 55.460 44.779 66.533 1.0044.84 C ATOM 13248 CG ASN D 70 55.800 45.718 65.434 1.00 49.17 C ATOM13249 OD1 ASN D 70 55.575 45.399 64.289 1.00 55.81 O ATOM 13250 ND2 ASND 70 56.256 46.927 65.763 1.00 52.56 N ATOM 13253 C ASN D 70 53.63143.453 67.469 1.00 40.86 C ATOM 13254 O ASN D 70 53.133 43.517 68.5481.00 40.73 O ATOM 13255 N LYS D 71 53.824 42.299 66.872 1.00 41.57 NATOM 13257 CA LYS D 71 53.571 41.114 67.652 1.00 41.77 C ATOM 13259 CBLYS D 71 52.089 40.784 67.647 1.00 39.31 C ATOM 13262 CG LYS D 71 51.53240.227 66.385 1.00 38.04 C ATOM 13265 CD LYS D 71 49.962 40.233 66.4021.00 37.00 C ATOM 13268 CE LYS D 71 49.309 39.359 65.314 1.00 34.15 CATOM 13271 NZ LYS D 71 47.935 39.378 65.457 1.00 32.61 N ATOM 13275 CLYS D 71 54.304 39.898 67.162 1.00 45.31 C ATOM 13276 O LYS D 71 54.64439.819 66.008 1.00 47.02 O ATOM 13277 N ASP D 72 54.499 38.940 68.0611.00 46.92 N ATOM 13279 CA ASP D 72 54.911 37.579 67.731 1.00 49.86 CATOM 13281 CB ASP D 72 56.252 37.312 68.418 1.00 52.20 C ATOM 13284 CGASP D 72 56.857 36.047 67.966 1.00 58.26 C ATOM 13285 OD1 ASP D 7256.033 35.215 67.531 1.00 59.63 O ATOM 13286 OD2 ASP D 72 58.108 35.77467.965 1.00 67.49 O ATOM 13287 C ASP D 72 53.816 36.496 68.102 1.0048.55 C ATOM 13288 O ASP D 72 53.706 36.125 69.270 1.00 48.20 O ATOM13289 N ASN D 73 53.015 36.002 67.142 1.00 47.65 N ATOM 13291 CA ASN D73 51.975 35.023 67.542 1.00 47.21 C ATOM 13293 CB ASN D 73 50.97834.570 66.476 1.00 45.48 C ATOM 13296 CG ASN D 73 50.327 35.684 65.7131.00 43.16 C ATOM 13297 OD1 ASN D 73 49.630 36.539 66.293 1.00 47.44 OATOM 13298 ND2 ASN D 73 50.408 35.612 64.406 1.00 39.25 N ATOM 13301 CASN D 73 52.598 33.748 68.083 1.00 51.12 C ATOM 13302 O ASN D 73 51.98733.107 68.883 1.00 52.43 O ATOM 13303 N SER D 74 53.773 33.318 67.6431.00 54.87 N ATOM 13305 CA SER D 74 54.397 32.122 68.317 1.00 58.74 CATOM 13307 CB SER D 74 55.773 31.817 67.787 1.00 62.13 C ATOM 13310 OGSER D 74 55.629 31.667 66.404 1.00 65.94 O ATOM 13312 C SER D 74 54.54332.307 69.802 1.00 58.18 C ATOM 13313 O SER D 74 54.129 31.462 70.5311.00 60.18 O ATOM 13314 N LYS D 75 55.131 33.421 70.238 1.00 56.43 NATOM 13316 CA LYS D 75 55.368 33.665 71.639 1.00 56.60 C ATOM 13318 CBLYS D 75 56.566 34.600 71.806 1.00 57.02 C ATOM 13321 CG LYS D 75 57.81633.999 71.324 1.00 62.21 C ATOM 13324 CD LYS D 75 58.969 34.990 71.0791.00 65.08 C ATOM 13327 CE LYS D 75 60.071 34.308 70.161 1.00 69.37 CATOM 13330 NZ LYS D 75 61.327 33.664 70.861 1.00 75.58 N ATOM 13334 CLYS D 75 54.153 34.295 72.277 1.00 53.67 C ATOM 13335 O LYS D 75 54.25434.800 73.361 1.00 53.73 O ATOM 13336 N SER D 76 52.997 34.249 71.6211.00 52.05 N ATOM 13338 CA SER D 76 51.836 35.122 71.941 1.00 48.62 CATOM 13340 CB SER D 76 50.739 34.328 72.636 1.00 48.74 C ATOM 13343 OGSER D 76 51.376 33.677 73.649 1.00 52.34 O ATOM 13345 C SER D 76 52.22436.397 72.744 1.00 46.65 C ATOM 13346 O SER D 76 51.862 36.571 73.9151.00 45.12 O ATOM 13347 N GLN D 77 52.938 37.285 72.056 1.00 45.21 NATOM 13349 CA GLN D 77 53.433 38.479 72.656 1.00 43.66 C ATOM 13351 CBGLN D 77 54.970 38.339 72.814 1.00 46.88 C ATOM 13354 CG GLN D 77 55.41337.830 74.223 1.00 47.53 C ATOM 13357 CD GLN D 77 56.927 37.700 74.3971.00 49.35 C ATOM 13358 OE1 GLN D 77 57.662 37.900 73.452 1.00 49.14 OATOM 13359 NE2 GLN D 77 57.377 37.335 75.607 1.00 49.80 N ATOM 13362 CGLN D 77 53.046 39.686 71.801 1.00 40.90 C ATOM 13363 O GLN D 77 53.11839.637 70.599 1.00 39.78 O ATOM 13364 N VAL D 78 52.621 40.767 72.4411.00 39.44 N ATOM 13366 CA VAL D 78 52.391 42.018 71.747 1.00 38.83 CATOM 13368 CB VAL D 78 51.002 42.480 71.899 1.00 36.73 C ATOM 13370 CG1VAL D 78 50.881 43.889 71.317 1.00 36.47 C ATOM 13374 CG2 VAL D 7850.060 41.533 71.152 1.00 36.98 C ATOM 13378 C VAL D 78 53.269 43.13272.259 1.00 39.68 C ATOM 13379 O VAL D 78 53.417 43.313 73.430 1.0041.11 O ATOM 13380 N PHE D 79 53.852 43.887 71.350 1.00 41.21 N ATOM13382 CA PHE D 79 54.922 44.885 71.657 1.00 42.91 C ATOM 13384 CB PHE D79 56.198 44.576 70.873 1.00 44.00 C ATOM 13387 CG PHE D 79 56.68543.209 71.048 1.00 44.41 C ATOM 13388 CD1 PHE D 79 56.809 42.361 69.9861.00 44.33 C ATOM 13390 CE1 PHE D 79 57.312 41.097 70.146 1.00 44.84 CATOM 13392 CZ PHE D 79 57.692 40.655 71.360 1.00 46.86 C ATOM 13394 CE2PHE D 79 57.625 41.481 72.428 1.00 47.48 C ATOM 13396 CD2 PHE D 7957.110 42.779 72.274 1.00 47.39 C ATOM 13398 C PHE D 79 54.451 46.31571.284 1.00 41.27 C ATOM 13399 O PHE D 79 54.445 46.684 70.135 1.0041.52 O ATOM 13400 N PHE D 80 54.052 47.086 72.266 1.00 40.35 N ATOM13402 CA PHE D 80 53.562 48.422 72.037 1.00 39.60 C ATOM 13404 CB PHE D80 52.521 48.721 73.090 1.00 38.21 C ATOM 13407 CG PHE D 80 52.21650.165 73.261 1.00 37.90 C ATOM 13408 CD1 PHE D 80 51.021 50.680 72.8211.00 35.78 C ATOM 13410 CE1 PHE D 80 50.725 51.977 73.032 1.00 34.24 CATOM 13412 CZ PHE D 80 51.553 52.761 73.706 1.00 33.92 C ATOM 13414 CE2PHE D 80 52.672 52.283 74.183 1.00 37.81 C ATOM 13416 CD2 PHE D 8053.045 50.982 73.964 1.00 37.72 C ATOM 13418 C PHE D 80 54.725 49.30372.235 1.00 41.55 C ATOM 13419 O PHE D 80 55.430 49.157 73.215 1.0042.98 O ATOM 13420 N LYS D 81 54.956 50.208 71.309 1.00 42.00 N ATOM13422 CA LYS D 81 56.094 51.126 71.444 1.00 43.52 C ATOM 13424 CB LYS D81 57.243 50.693 70.573 1.00 45.25 C ATOM 13427 CG LYS D 81 58.51951.595 70.732 1.00 48.35 C ATOM 13430 CD LYS D 81 59.776 51.198 69.9031.00 49.70 C ATOM 13433 CE LYS D 81 60.773 52.392 69.816 1.00 53.14 CATOM 13436 NZ LYS D 81 62.159 52.008 69.543 1.00 55.94 N ATOM 13440 CLYS D 81 55.604 52.514 71.033 1.00 43.91 C ATOM 13441 O LYS D 81 54.94052.640 69.988 1.00 44.59 O ATOM 13442 N MET D 82 55.837 53.535 71.8611.00 44.38 N ATOM 13444 CA MET D 82 55.448 54.904 71.496 1.00 45.09 CATOM 13446 CB MET D 82 54.343 55.408 72.393 1.00 44.28 C ATOM 13449 CGMET D 82 54.024 56.895 72.173 1.00 45.85 C ATOM 13452 SD MET D 82 52.32957.187 72.824 1.00 47.44 S ATOM 13453 CE MET D 82 52.586 57.665 74.4891.00 46.84 C ATOM 13457 C MET D 82 56.604 55.815 71.643 1.00 47.35 CATOM 13458 O MET D 82 57.299 55.728 72.615 1.00 47.79 O ATOM 13459 N ASND 83 56.792 56.728 70.704 1.00 49.56 N ATOM 13461 CA ASN D 83 58.00957.562 70.660 1.00 52.90 C ATOM 13463 CB ASN D 83 58.447 57.777 69.2021.00 55.93 C ATOM 13466 CG ASN D 83 58.932 56.492 68.511 1.00 58.70 CATOM 13467 OD1 ASN D 83 59.525 55.600 69.150 1.00 60.92 O ATOM 13468 ND2ASN D 83 58.724 56.428 67.175 1.00 62.10 N ATOM 13471 C ASN D 83 57.82858.935 71.279 1.00 53.16 C ATOM 13472 O ASN D 83 56.723 59.418 71.4281.00 50.57 O ATOM 13473 N SER D 84 58.938 59.578 71.592 1.00 56.13 NATOM 13475 CA SER D 84 58.927 60.981 72.007 1.00 58.85 C ATOM 13477 CBSER D 84 58.743 61.821 70.818 1.00 60.49 C ATOM 13480 OG SER D 84 59.65061.296 69.902 1.00 66.30 O ATOM 13482 C SER D 84 57.859 61.347 72.9911.00 57.53 C ATOM 13483 O SER D 84 56.903 62.028 72.657 1.00 57.77 OATOM 13484 N LEU D 85 58.044 60.895 74.219 1.00 56.64 N ATOM 13486 CALEU D 85 57.070 61.114 75.227 1.00 55.13 C ATOM 13488 CB LEU D 85 57.16160.009 76.274 1.00 53.82 C ATOM 13491 CG LEU D 85 56.234 58.846 75.9101.00 50.98 C ATOM 13493 CD1 LEU D 85 56.953 57.991 74.900 1.00 52.48 CATOM 13497 CD2 LEU D 85 55.847 58.046 77.151 1.00 49.77 C ATOM 13501 CLEU D 85 57.320 62.484 75.826 1.00 57.61 C ATOM 13502 O LEU D 85 58.42362.985 75.802 1.00 60.21 O ATOM 13503 N GLN D 86 56.247 63.093 76.2981.00 56.61 N ATOM 13505 CA GLN D 86 56.287 64.342 77.012 1.00 58.88 CATOM 13507 CB GLN D 86 55.661 65.449 76.174 1.00 60.42 C ATOM 13510 CGGLN D 86 56.455 65.786 74.922 1.00 62.18 C ATOM 13513 CD GLN D 86 57.88666.248 75.220 1.00 64.34 C ATOM 13514 OE1 GLN D 86 58.158 66.968 76.2141.00 62.43 O ATOM 13515 NE2 GLN D 86 58.800 65.806 74.377 1.00 62.47 NATOM 13518 C GLN D 86 55.487 64.077 78.249 1.00 56.98 C ATOM 13519 O GLND 86 55.039 62.988 78.450 1.00 53.19 O ATOM 13520 N SER D 87 55.32365.069 79.089 1.00 59.59 N ATOM 13522 CA SER D 87 54.745 64.812 80.3811.00 59.57 C ATOM 13524 CB SER D 87 55.036 65.975 81.289 1.00 63.01 CATOM 13527 OG SER D 87 54.389 67.041 80.689 1.00 67.52 O ATOM 13529 CSER D 87 53.258 64.544 80.272 1.00 57.33 C ATOM 13530 O SER D 87 52.76763.721 81.021 1.00 55.78 O ATOM 13531 N ASN D 88 52.563 65.209 79.3291.00 58.66 N ATOM 13533 CA ASN D 88 51.256 64.748 78.718 1.00 56.25 CATOM 13535 CB ASN D 88 51.180 65.170 77.247 1.00 57.45 C ATOM 13538 CGASN D 88 50.876 66.580 77.067 1.00 62.84 C ATOM 13539 OD1 ASN D 8850.883 67.306 78.041 1.00 74.09 O ATOM 13540 ND2 ASN D 88 50.533 67.01275.831 1.00 63.95 N ATOM 13543 C ASN D 88 51.038 63.237 78.581 1.0052.90 C ATOM 13544 O ASN D 88 49.916 62.814 78.417 1.00 52.43 O ATOM13545 N ASP D 89 52.092 62.440 78.501 1.00 51.41 N ATOM 13547 CA ASP D89 51.949 61.018 78.388 1.00 49.06 C ATOM 13549 CB ASP D 89 52.92660.536 77.355 1.00 49.14 C ATOM 13552 CG ASP D 89 52.744 61.234 76.0461.00 51.56 C ATOM 13553 OD1 ASP D 89 51.627 61.127 75.481 1.00 51.32 OATOM 13554 OD2 ASP D 89 53.661 61.899 75.486 1.00 54.26 O ATOM 13555 CASP D 89 52.113 60.193 79.688 1.00 49.01 C ATOM 13556 O ASP D 89 52.11958.945 79.650 1.00 47.85 O ATOM 13557 N THR D 90 52.206 60.851 80.8471.00 51.07 N ATOM 13559 CA THR D 90 52.121 60.112 82.141 1.00 49.85 CATOM 13561 CB THR D 90 52.273 61.030 83.288 1.00 51.99 C ATOM 13563 OG1THR D 90 53.571 61.636 83.183 1.00 57.36 O ATOM 13565 CG2 THR D 9052.303 60.281 84.588 1.00 51.56 C ATOM 13569 C THR D 90 50.773 59.57782.214 1.00 47.11 C ATOM 13570 O THR D 90 49.808 60.323 81.988 1.0047.64 O ATOM 13571 N ALA D 91 50.695 58.289 82.502 1.00 45.03 N ATOM13573 CA ALA D 91 49.405 57.551 82.488 1.00 42.38 C ATOM 13575 CB ALA D91 48.762 57.590 81.130 1.00 41.09 C ATOM 13579 C ALA D 91 49.640 56.14782.851 1.00 40.25 C ATOM 13580 O ALA D 91 50.767 55.723 82.869 1.0041.74 O ATOM 13581 N ILE D 92 48.576 55.431 83.165 1.00 38.65 N ATOM13583 CA ILE D 92 48.616 53.982 83.189 1.00 36.52 C ATOM 13585 CB ILE D92 47.692 53.500 84.265 1.00 37.41 C ATOM 13587 CG1 ILE D 92 48.31853.873 85.587 1.00 39.88 C ATOM 13590 CD1 ILE D 92 47.426 54.065 86.6041.00 43.89 C ATOM 13594 CG2 ILE D 92 47.526 52.047 84.213 1.00 36.13 CATOM 13598 C ILE D 92 48.310 53.461 81.803 1.00 33.73 C ATOM 13599 O ILED 92 47.290 53.775 81.214 1.00 32.00 O ATOM 13600 N TYR D 93 49.24852.737 81.244 1.00 33.28 N ATOM 13602 CA TYR D 93 49.012 52.153 79.9481.00 32.94 C ATOM 13604 CB TYR D 93 50.261 52.260 79.101 1.00 32.51 CATOM 13607 CG TYR D 93 50.564 53.690 78.742 1.00 35.57 C ATOM 13608 CD1TYR D 93 50.996 54.606 79.683 1.00 38.55 C ATOM 13610 CE1 TYR D 9351.271 55.942 79.320 1.00 40.44 C ATOM 13612 CZ TYR D 93 51.095 56.35378.008 1.00 38.75 C ATOM 13613 OH TYR D 93 51.301 57.632 77.620 1.0036.83 O ATOM 13615 CE2 TYR D 93 50.676 55.468 77.070 1.00 37.22 C ATOM13617 CD2 TYR D 93 50.386 54.151 77.450 1.00 37.91 C ATOM 13619 C TYR D93 48.527 50.698 80.099 1.00 32.47 C ATOM 13620 O TYR D 93 49.158 49.90680.771 1.00 33.93 O ATOM 13621 N TYR D 94 47.412 50.374 79.461 1.0031.81 N ATOM 13623 CA TYR D 94 46.790 49.071 79.509 1.00 31.89 C ATOM13625 CB TYR D 94 45.316 49.180 79.927 1.00 31.43 C ATOM 13628 CG TYR D94 45.044 49.623 81.317 1.00 34.26 C ATOM 13629 CD1 TYR D 94 44.72250.933 81.611 1.00 34.32 C ATOM 13631 CE1 TYR D 94 44.471 51.333 82.9551.00 37.87 C ATOM 13633 CZ TYR D 94 44.541 50.406 83.981 1.00 40.08 CATOM 13634 OH TYR D 94 44.302 50.719 85.322 1.00 44.06 O ATOM 13636 CE2TYR D 94 44.840 49.120 83.681 1.00 39.37 C ATOM 13638 CD2 TYR D 9445.065 48.720 82.362 1.00 37.60 C ATOM 13640 C TYR D 94 46.766 48.45878.114 1.00 31.19 C ATOM 13641 O TYR D 94 46.595 49.162 77.134 1.0028.84 O ATOM 13642 N CYS D 95 46.803 47.114 78.094 1.00 32.31 N ATOM13644 CA CYS D 95 46.343 46.326 76.978 1.00 31.63 C ATOM 13646 CB CYS D95 47.407 45.367 76.555 1.00 32.86 C ATOM 13649 SG CYS D 95 47.83744.087 77.682 1.00 36.32 S ATOM 13650 C CYS D 95 45.043 45.595 77.2291.00 31.81 C ATOM 13651 O CYS D 95 44.543 45.489 78.338 1.00 32.84 OATOM 13652 N ALA D 96 44.415 45.138 76.170 1.00 31.66 N ATOM 13654 CAALA D 96 43.065 44.613 76.333 1.00 31.98 C ATOM 13656 CB ALA D 96 42.06745.738 76.560 1.00 31.73 C ATOM 13660 C ALA D 96 42.610 43.789 75.1891.00 31.15 C ATOM 13661 O ALA D 96 43.109 43.916 74.113 1.00 30.28 OATOM 13662 N ARG D 97 41.644 42.929 75.459 1.00 31.57 N ATOM 13664 CAARG D 97 41.056 42.132 74.424 1.00 31.04 C ATOM 13666 CB ARG D 97 41.40340.657 74.529 1.00 31.65 C ATOM 13669 CG ARG D 97 41.364 39.961 73.2521.00 30.26 C ATOM 13672 CD ARG D 97 41.106 38.522 73.380 1.00 33.63 CATOM 13675 NE ARG D 97 39.673 38.270 73.544 1.00 35.37 N ATOM 13677 CZARG D 97 39.119 37.052 73.723 1.00 37.21 C ATOM 13678 NH1 ARG D 9739.855 35.971 73.753 1.00 39.36 N ATOM 13681 NH2 ARG D 97 37.797 36.90573.786 1.00 38.08 N ATOM 13684 C ARG D 97 39.632 42.302 74.578 1.0030.96 C ATOM 13685 O ARG D 97 39.130 42.243 75.686 1.00 31.79 O ATOM13686 N ALA D 98 38.981 42.482 73.441 1.00 30.39 N ATOM 13688 CA ALA D98 37.540 42.481 73.374 1.00 30.35 C ATOM 13690 CB ALA D 98 37.14142.731 71.958 1.00 30.65 C ATOM 13694 C ALA D 98 36.991 41.140 73.7691.00 31.90 C ATOM 13695 O ALA D 98 37.675 40.141 73.670 1.00 31.68 OATOM 13696 N LEU D 99 35.719 41.124 74.134 1.00 33.49 N ATOM 13698 CALEU D 99 34.995 39.875 74.405 1.00 35.36 C ATOM 13700 CB LEU D 99 33.71940.195 75.166 1.00 36.53 C ATOM 13703 CG LEU D 99 32.855 39.064 75.6321.00 37.57 C ATOM 13705 CD1 LEU D 99 33.465 38.470 76.786 1.00 39.95 CATOM 13709 CD2 LEU D 99 31.538 39.533 75.980 1.00 38.23 C ATOM 13713 CLEU D 99 34.636 39.123 73.129 1.00 34.97 C ATOM 13714 O LEU D 99 34.37637.955 73.165 1.00 38.11 O ATOM 13715 N THR D 100 34.604 39.801 72.0071.00 33.14 N ATOM 13717 CA THR D 100 34.004 39.285 70.772 1.00 32.28 CATOM 13719 CB THR D 100 32.617 39.874 70.631 1.00 33.08 C ATOM 13721 OG1THR D 100 31.693 39.072 71.380 1.00 32.58 O ATOM 13723 CG2 THR D 10032.098 39.948 69.118 1.00 37.21 C ATOM 13727 C THR D 100 34.873 39.70269.604 1.00 31.13 C ATOM 13728 O THR D 100 35.471 40.785 69.620 1.0030.37 O ATOM 13729 N TYR D 101 34.993 38.833 68.611 1.00 31.37 N ATOM13731 CA TYR D 101 35.703 39.160 67.419 1.00 30.84 C ATOM 13733 CB TYR D101 35.437 38.137 66.314 1.00 32.08 C ATOM 13736 CG TYR D 101 35.62936.729 66.805 1.00 34.25 C ATOM 13737 CD1 TYR D 101 34.583 35.941 67.0971.00 38.88 C ATOM 13739 CE1 TYR D 101 34.750 34.707 67.562 1.00 39.52 CATOM 13741 CZ TYR D 101 35.946 34.269 67.763 1.00 38.52 C ATOM 13742 OHTYR D 101 36.095 33.043 68.238 1.00 44.46 O ATOM 13744 CE2 TYR D 10136.986 34.992 67.497 1.00 36.82 C ATOM 13746 CD2 TYR D 101 36.835 36.23167.048 1.00 35.53 C ATOM 13748 C TYR D 101 35.277 40.529 66.932 1.0030.86 C ATOM 13749 O TYR D 101 34.084 40.893 66.955 1.00 33.11 O ATOM13750 N TYR D 102 36.280 41.279 66.517 1.00 29.81 N ATOM 13752 CA TYR D102 36.191 42.562 65.853 1.00 29.45 C ATOM 13754 CB TYR D 102 35.56542.386 64.481 1.00 30.72 C ATOM 13757 CG TYR D 102 36.154 41.295 63.6981.00 28.52 C ATOM 13758 CD1 TYR D 102 35.328 40.351 63.085 1.00 32.83 CATOM 13760 CE1 TYR D 102 35.834 39.306 62.287 1.00 32.70 C ATOM 13762 CZTYR D 102 37.178 39.172 62.157 1.00 29.94 C ATOM 13763 OH TYR D 10237.581 38.164 61.424 1.00 30.00 O ATOM 13765 CE2 TYR D 102 38.019 40.07662.744 1.00 29.21 C ATOM 13767 CD2 TYR D 102 37.461 41.196 63.511 1.0026.98 C ATOM 13769 C TYR D 102 35.564 43.702 66.606 1.00 29.34 C ATOM13770 O TYR D 102 35.211 44.753 65.993 1.00 31.06 O ATOM 13771 N ASP D103 35.453 43.560 67.911 1.00 29.51 N ATOM 13773 CA ASP D 103 34.62144.510 68.693 1.00 31.57 C ATOM 13775 CB ASP D 103 33.523 43.743 69.3921.00 32.31 C ATOM 13778 CG ASP D 103 32.231 44.541 69.603 1.00 35.50 CATOM 13779 OD1 ASP D 103 32.229 45.811 69.699 1.00 37.86 O ATOM 13780OD2 ASP D 103 31.147 43.932 69.760 1.00 33.03 O ATOM 13781 C ASP D 10335.493 45.285 69.688 1.00 31.31 C ATOM 13782 O ASP D 103 36.726 45.13069.654 1.00 30.80 O ATOM 13783 N TYR D 104 34.867 46.062 70.572 1.0032.47 N ATOM 13785 CA TYR D 104 35.564 47.042 71.419 1.00 33.02 C ATOM13787 CB TYR D 104 35.387 48.429 70.847 1.00 32.52 C ATOM 13790 CG TYR D104 35.855 48.529 69.452 1.00 32.49 C ATOM 13791 CD1 TYR D 104 35.05148.168 68.386 1.00 34.38 C ATOM 13793 CE1 TYR D 104 35.511 48.235 67.0601.00 36.47 C ATOM 13795 CZ TYR D 104 36.784 48.661 66.851 1.00 40.26 CATOM 13796 OH TYR D 104 37.335 48.820 65.555 1.00 42.04 O ATOM 13798 CE2TYR D 104 37.581 48.984 67.959 1.00 36.79 C ATOM 13800 CD2 TYR D 10437.121 48.927 69.194 1.00 32.46 C ATOM 13802 C TYR D 104 35.042 47.07972.872 1.00 35.19 C ATOM 13803 O TYR D 104 35.119 48.144 73.559 1.0036.99 O ATOM 13804 N GLU D 105 34.624 45.896 73.331 1.00 35.25 N ATOM13806 CA GLU D 105 33.892 45.637 74.609 1.00 37.05 C ATOM 13808 CB GLU D105 32.653 44.759 74.311 1.00 38.39 C ATOM 13811 CG GLU D 105 33.16243.726 73.210 1.00 39.20 C ATOM 13814 CD GLU D 105 32.119 42.797 72.8001.00 43.24 C ATOM 13815 OE1 GLU D 105 30.967 43.102 73.166 1.00 50.60 OATOM 13816 OE2 GLU D 105 32.424 41.815 72.145 1.00 41.17 O ATOM 13817 CGLU D 105 34.955 44.885 75.449 1.00 34.79 C ATOM 13818 O GLU D 10535.096 43.674 75.450 1.00 33.21 O ATOM 13819 N PHE D 106 35.794 45.66376.079 1.00 34.74 N ATOM 13821 CA PHE D 106 36.971 45.106 76.719 1.0033.56 C ATOM 13823 CB PHE D 106 37.941 46.202 76.907 1.00 32.11 C ATOM13826 CG PHE D 106 38.218 46.917 75.658 1.00 32.00 C ATOM 13827 CD1 PHED 106 38.095 48.287 75.563 1.00 36.38 C ATOM 13829 CE1 PHE D 106 38.44048.935 74.393 1.00 34.66 C ATOM 13831 CZ PHE D 106 38.862 48.191 73.3041.00 30.31 C ATOM 13833 CE2 PHE D 106 38.918 46.865 73.389 1.00 29.09 CATOM 13835 CD2 PHE D 106 38.605 46.234 74.565 1.00 30.59 C ATOM 13837 CPHE D 106 36.657 44.375 78.016 1.00 34.43 C ATOM 13838 O PHE D 10636.441 44.995 79.034 1.00 36.37 O ATOM 13839 N ALA D 107 36.649 43.05077.934 1.00 33.57 N ATOM 13841 CA ALA D 107 36.320 42.181 79.035 1.0035.28 C ATOM 13843 CB ALA D 107 35.614 40.888 78.539 1.00 35.86 C ATOM13847 C ALA D 107 37.554 41.780 79.759 1.00 35.97 C ATOM 13848 O ALA D107 37.409 41.351 80.903 1.00 38.66 O ATOM 13849 N TYR D 108 38.71641.898 79.101 1.00 33.76 N ATOM 13851 CA TYR D 108 39.993 41.378 79.5671.00 34.96 C ATOM 13853 CB TYR D 108 40.460 40.163 78.709 1.00 34.47 CATOM 13856 CG TYR D 108 39.440 39.099 78.601 1.00 35.04 C ATOM 13857 CD1TYR D 108 38.726 38.850 77.407 1.00 35.31 C ATOM 13859 CE1 TYR D 10837.743 37.862 77.365 1.00 35.79 C ATOM 13861 CZ TYR D 108 37.474 37.18278.535 1.00 38.03 C ATOM 13862 OH TYR D 108 36.533 36.206 78.654 1.0044.30 O ATOM 13864 CE2 TYR D 108 38.152 37.435 79.680 1.00 38.12 C ATOM13866 CD2 TYR D 108 39.139 38.355 79.697 1.00 37.41 C ATOM 13868 C TYR D108 41.038 42.466 79.377 1.00 34.37 C ATOM 13869 O TYR D 108 41.15642.969 78.276 1.00 33.58 O ATOM 13870 N TRP D 109 41.817 42.778 80.4311.00 35.51 N ATOM 13872 CA TRP D 109 42.755 43.898 80.499 1.00 33.04 CATOM 13874 CB TRP D 109 42.188 45.019 81.373 1.00 33.12 C ATOM 13877 CGTRP D 109 40.965 45.716 80.852 1.00 33.03 C ATOM 13878 CD1 TRP D 10939.735 45.182 80.686 1.00 35.04 C ATOM 13880 NE1 TRP D 109 38.877 46.10580.136 1.00 35.58 N ATOM 13882 CE2 TRP D 109 39.559 47.266 79.932 1.0033.94 C ATOM 13883 CD2 TRP D 109 40.878 47.049 80.343 1.00 33.28 C ATOM13884 CE3 TRP D 109 41.789 48.075 80.166 1.00 33.80 C ATOM 13886 CZ3 TRPD 109 41.349 49.277 79.611 1.00 33.42 C ATOM 13888 CH2 TRP D 109 40.05149.447 79.228 1.00 33.69 C ATOM 13890 CZ2 TRP D 109 39.129 48.465 79.4011.00 33.31 C ATOM 13892 C TRP D 109 43.970 43.405 81.176 1.00 34.87 CATOM 13893 O TRP D 109 43.919 42.614 82.081 1.00 37.35 O ATOM 13894 NGLY D 110 45.108 43.904 80.769 1.00 35.09 N ATOM 13896 CA GLY D 11046.304 43.773 81.543 1.00 35.48 C ATOM 13899 C GLY D 110 46.167 44.50982.858 1.00 36.71 C ATOM 13900 O GLY D 110 45.170 45.206 83.165 1.0035.65 O ATOM 13901 N GLN D 111 47.194 44.292 83.674 1.00 38.41 N ATOM13903 CA GLN D 111 47.290 44.909 84.986 1.00 39.88 C ATOM 13905 CB GLN D111 48.241 44.104 85.886 1.00 42.53 C ATOM 13908 CG GLN D 111 49.72544.447 85.776 1.00 42.86 C ATOM 13911 CD GLN D 111 50.463 43.616 84.7771.00 41.89 C ATOM 13912 OE1 GLN D 111 51.637 43.438 84.917 1.00 44.32 OATOM 13913 NE2 GLN D 111 49.790 43.179 83.713 1.00 41.71 N ATOM 13916 CGLN D 111 47.694 46.381 84.902 1.00 38.77 C ATOM 13917 O GLN D 11147.649 47.095 85.877 1.00 40.58 O ATOM 13918 N GLY D 112 48.078 46.84583.738 1.00 36.79 N ATOM 13920 CA GLY D 112 48.429 48.224 83.606 1.0037.21 C ATOM 13923 C GLY D 112 49.899 48.474 83.858 1.00 39.24 C ATOM13924 O GLY D 112 50.520 47.788 84.674 1.00 42.52 O ATOM 13925 N THR D113 50.463 49.436 83.139 1.00 38.68 N ATOM 13927 CA THR D 113 51.78549.879 83.417 1.00 41.03 C ATOM 13929 CB THR D 113 52.612 49.719 82.1801.00 40.97 C ATOM 13931 OG1 THR D 113 52.785 48.325 81.891 1.00 40.85 OATOM 13933 CG2 THR D 113 54.036 50.254 82.416 1.00 42.53 C ATOM 13937 CTHR D 113 51.750 51.353 83.870 1.00 42.14 C ATOM 13938 O THR D 11351.250 52.198 83.134 1.00 40.31 O ATOM 13939 N LEU D 114 52.270 51.63785.076 1.00 44.50 N ATOM 13941 CA LEU D 114 52.295 52.984 85.606 1.0045.15 C ATOM 13943 CB LEU D 114 52.560 52.927 87.087 1.00 47.24 C ATOM13946 CG LEU D 114 52.578 54.312 87.753 1.00 48.79 C ATOM 13948 CD1 LEUD 114 51.232 54.921 87.733 1.00 49.87 C ATOM 13952 CD2 LEU D 114 53.08754.296 89.213 1.00 51.70 C ATOM 13956 C LEU D 114 53.444 53.717 84.9561.00 46.43 C ATOM 13957 O LEU D 114 54.584 53.494 85.359 1.00 48.45 OATOM 13958 N VAL D 115 53.174 54.617 84.008 1.00 44.80 N ATOM 13960 CAVAL D 115 54.248 55.285 83.274 1.00 45.32 C ATOM 13962 CB VAL D 11553.999 55.303 81.781 1.00 43.97 C ATOM 13964 CG1 VAL D 115 55.038 56.09281.076 1.00 45.37 C ATOM 13968 CG2 VAL D 115 54.011 53.915 81.240 1.0045.06 C ATOM 13972 C VAL D 115 54.332 56.717 83.635 1.00 46.21 C ATOM13973 O VAL D 115 53.342 57.421 83.507 1.00 46.25 O ATOM 13974 N THR D116 55.549 57.149 83.931 1.00 47.39 N ATOM 13976 CA THR D 116 55.87658.442 84.504 1.00 49.19 C ATOM 13978 CB THR D 116 56.559 58.139 85.8261.00 51.28 C ATOM 13980 OG1 THR D 116 55.851 57.040 86.446 1.00 49.66 OATOM 13982 CG2 THR D 116 56.561 59.345 86.814 1.00 52.90 C ATOM 13986 CTHR D 116 56.870 59.154 83.611 1.00 50.16 C ATOM 13987 O THR D 11657.880 58.600 83.330 1.00 50.46 O ATOM 13988 N VAL D 117 56.626 60.38283.209 1.00 50.68 N ATOM 13990 CA VAL D 117 57.511 61.021 82.292 1.0052.90 C ATOM 13992 CB VAL D 117 56.786 61.424 81.067 1.00 52.02 C ATOM13994 CG1 VAL D 117 57.669 62.056 80.124 1.00 54.34 C ATOM 13998 CG2 VALD 117 56.235 60.219 80.389 1.00 51.45 C ATOM 14002 C VAL D 117 58.16962.215 82.941 1.00 57.15 C ATOM 14003 O VAL D 117 57.575 63.264 83.1391.00 59.15 O ATOM 14004 N SER D 118 59.443 62.064 83.257 1.00 59.82 NATOM 14006 CA SER D 118 60.162 63.096 83.950 1.00 63.47 C ATOM 14008 CBSER D 118 59.855 62.996 85.452 1.00 63.79 C ATOM 14011 OG SER D 11860.736 63.764 86.268 1.00 66.67 O ATOM 14013 C SER D 118 61.614 62.83483.640 1.00 66.29 C ATOM 14014 O SER D 118 62.005 61.685 83.390 1.0064.91 O ATOM 14015 N ALA D 119 62.406 63.899 83.602 1.00 54.31 N ATOM14017 CA ALA D 119 63.822 63.741 83.347 1.00 55.75 C ATOM 14019 CB ALA D119 64.349 64.894 82.555 1.00 57.76 C ATOM 14023 C ALA D 119 64.54963.610 84.672 1.00 55.45 C ATOM 14024 O ALA D 119 65.775 63.529 84.7291.00 56.97 O ATOM 14025 N ALA D 120 63.807 63.582 85.753 1.00 53.85 NATOM 14027 CA ALA D 120 64.453 63.464 87.038 1.00 53.86 C ATOM 14029 CBALA D 120 63.469 63.824 88.155 1.00 53.59 C ATOM 14033 C ALA D 12064.930 62.055 87.236 1.00 53.49 C ATOM 14034 O ALA D 120 64.510 61.09186.561 1.00 52.47 O ATOM 14035 N SER D 121 65.770 61.966 88.241 1.0054.49 N ATOM 14037 CA SER D 121 66.445 60.753 88.607 1.00 55.63 C ATOM14039 CB SER D 121 67.839 61.096 89.074 1.00 58.28 C ATOM 14042 OG SER D121 67.715 61.672 90.340 1.00 57.66 O ATOM 14044 C SER D 121 65.72360.084 89.756 1.00 54.50 C ATOM 14045 O SER D 121 65.234 60.737 90.6671.00 54.17 O ATOM 14046 N THR D 122 65.671 58.761 89.676 1.00 54.53 NATOM 14048 CA THR D 122 65.177 57.902 90.720 1.00 53.23 C ATOM 14050 CBTHR D 122 65.387 56.504 90.241 1.00 54.78 C ATOM 14052 OG1 THR D 12264.463 56.273 89.190 1.00 52.62 O ATOM 14054 CG2 THR D 122 65.040 55.50191.265 1.00 55.87 C ATOM 14058 C THR D 122 65.900 58.103 92.036 1.0054.14 C ATOM 14059 O THR D 122 67.082 58.370 92.070 1.00 57.74 O ATOM14060 N LYS D 123 65.155 57.970 93.101 1.00 52.70 N ATOM 14062 CA LYS D123 65.617 58.079 94.434 1.00 54.77 C ATOM 14064 CB LYS D 123 65.60259.545 94.866 1.00 55.21 C ATOM 14067 CG LYS D 123 65.630 59.764 96.4211.00 58.84 C ATOM 14070 CD LYS D 123 66.294 61.098 96.875 1.00 62.89 CATOM 14073 CE LYS D 123 66.371 61.121 98.457 1.00 68.82 C ATOM 14076 NZLYS D 123 67.102 62.300 99.097 1.00 74.24 N ATOM 14080 C LYS D 12364.761 57.241 95.373 1.00 54.21 C ATOM 14081 O LYS D 123 63.536 57.23595.342 1.00 52.84 O ATOM 14082 N GLY D 124 65.417 56.518 96.234 1.0057.38 N ATOM 14084 CA GLY D 124 64.733 55.809 97.291 1.00 58.45 C ATOM14087 C GLY D 124 64.316 56.758 98.400 1.00 58.43 C ATOM 14088 O GLY D124 64.894 57.864 98.560 1.00 58.61 O ATOM 14089 N PRO D 125 63.31056.315 99.155 1.00 58.47 N ATOM 14090 CA PRO D 125 62.713 57.103 100.2301.00 58.38 C ATOM 14092 CB PRO D 125 61.436 56.350 100.539 1.00 57.92 CATOM 14095 CG PRO D 125 61.782 54.878 100.208 1.00 59.26 C ATOM 14098 CDPRO D 125 62.690 54.979 99.035 1.00 59.00 C ATOM 14101 C PRO D 12563.552 57.038 101.469 1.00 62.83 C ATOM 14102 O PRO D 125 64.321 56.073101.644 1.00 64.70 O ATOM 14103 N SER D 126 63.389 58.069 102.297 1.0063.66 N ATOM 14105 CA SER D 126 63.821 58.051 103.670 1.00 68.27 C ATOM14107 CB SER D 126 64.670 59.277 104.016 1.00 71.00 C ATOM 14110 OG SERD 126 63.979 60.445 103.680 1.00 70.40 O ATOM 14112 C SER D 126 62.52057.927 104.480 1.00 67.10 C ATOM 14113 O SER D 126 61.438 58.220 103.9601.00 63.05 O ATOM 14114 N VAL D 127 62.644 57.394 105.709 1.00 70.81 NATOM 14116 CA VAL D 127 61.531 56.782 106.473 1.00 70.08 C ATOM 14118 CBVAL D 127 61.577 55.231 106.423 1.00 71.07 C ATOM 14120 CG1 VAL D 12760.469 54.669 107.223 1.00 72.19 C ATOM 14124 CG2 VAL D 127 61.48254.719 105.003 1.00 66.98 C ATOM 14128 C VAL D 127 61.614 57.164 107.9351.00 73.31 C ATOM 14129 O VAL D 127 62.406 56.660 108.598 1.00 76.86 OATOM 14130 N PHE D 128 60.795 58.080 108.402 1.00 72.76 N ATOM 14132 CAPHE D 128 60.755 58.481 109.789 1.00 77.52 C ATOM 14134 CB PHE D 12860.660 60.012 109.858 1.00 77.44 C ATOM 14137 CG PHE D 128 61.762 60.709109.068 1.00 78.35 C ATOM 14138 CD1 PHE D 128 61.473 61.588 108.023 1.0074.99 C ATOM 14140 CE1 PHE D 128 62.471 62.155 107.297 1.00 73.17 C ATOM14142 CZ PHE D 128 63.765 61.868 107.582 1.00 77.82 C ATOM 14144 CE2 PHED 128 64.074 61.016 108.582 1.00 80.68 C ATOM 14146 CD2 PHE D 128 63.08960.430 109.318 1.00 80.90 C ATOM 14148 C PHE D 128 59.576 57.790 110.4611.00 78.03 C ATOM 14149 O PHE D 128 58.667 57.365 109.780 1.00 74.02 OATOM 14150 N PRO D 129 59.604 57.611 111.781 1.00 84.09 N ATOM 14151 CAPRO D 129 58.457 57.042 112.494 1.00 85.22 C ATOM 14153 CB PRO D 12959.078 56.527 113.776 1.00 91.56 C ATOM 14156 CG PRO D 129 60.132 57.546114.071 1.00 94.86 C ATOM 14159 CD PRO D 129 60.703 57.940 112.717 1.0090.22 C ATOM 14162 C PRO D 129 57.522 58.179 112.818 1.00 85.06 C ATOM14163 O PRO D 129 57.900 59.302 112.572 1.00 85.76 O ATOM 14164 N LEU D130 56.343 57.890 113.342 1.00 85.59 N ATOM 14166 CA LEU D 130 55.39458.881 113.824 1.00 85.82 C ATOM 14168 CB LEU D 130 54.239 59.068112.847 1.00 80.81 C ATOM 14171 CG LEU D 130 54.384 59.615 111.434 1.0076.34 C ATOM 14173 CD1 LEU D 130 53.028 59.517 110.732 1.00 73.31 C ATOM14177 CD2 LEU D 130 54.855 61.068 111.414 1.00 77.79 C ATOM 14181 C LEUD 130 54.860 58.224 115.070 1.00 90.47 C ATOM 14182 O LEU D 130 53.81557.574 115.037 1.00 89.75 O ATOM 14183 N ALA D 131 55.601 58.344 116.1621.00 96.32 N ATOM 14185 CA ALA D 131 55.347 57.554 117.353 1.00 101.04 CATOM 14187 CB ALA D 131 56.545 57.608 118.237 1.00 107.25 C ATOM 14191 CALA D 131 54.118 58.036 118.109 1.00 102.96 C ATOM 14192 O ALA D 13153.813 59.224 118.068 1.00 101.97 O ATOM 14193 N PRO D 132 53.447 57.125118.830 1.00 106.22 N ATOM 14194 CA PRO D 132 52.215 57.439 119.582 1.00108.61 C ATOM 14196 CB PRO D 132 51.637 56.027 119.870 1.00 109.88 CATOM 14199 CG PRO D 132 52.854 55.128 120.013 1.00 111.73 C ATOM 14202CD PRO D 132 53.831 55.703 119.007 1.00 108.34 C ATOM 14205 C PRO D 13252.484 58.180 120.916 1.00 115.60 C ATOM 14206 O PRO D 132 51.947 57.773121.972 1.00 120.74 O ATOM 14207 N SER D 133 53.261 59.267 120.859 1.00116.62 N ATOM 14209 CA SER D 133 54.103 59.666 122.000 1.00 124.00 CATOM 14211 CB SER D 133 55.207 60.712 121.636 1.00 124.54 C ATOM 14214OG SER D 133 54.848 61.677 120.645 1.00 118.70 O ATOM 14216 C SER D 13353.234 60.103 123.172 1.00 129.46 C ATOM 14217 O SER D 133 52.147 60.677122.931 1.00 127.35 O ATOM 14218 N SER D 134 53.726 59.793 124.396 1.00136.79 N ATOM 14220 CA SER D 134 52.982 59.796 125.685 1.00 143.02 CATOM 14222 CB SER D 134 53.599 60.774 126.704 1.00 150.95 C ATOM 14225OG SER D 134 53.463 62.111 126.259 1.00 149.72 O ATOM 14227 C SER D 13451.470 60.022 125.546 1.00 140.00 C ATOM 14228 O SER D 134 50.863 60.833126.267 1.00 144.16 O ATOM 14229 N LYS D 135 50.881 59.254 124.626 1.00133.42 N ATOM 14231 CA LYS D 135 49.472 59.353 124.290 1.00 130.16 CATOM 14233 CB LYS D 135 49.180 58.611 122.963 1.00 122.30 C ATOM 14240 CLYS D 135 48.725 58.746 125.472 1.00 135.96 C ATOM 14241 O LYS D 13548.452 57.551 125.475 1.00 135.99 O ATOM 14242 N SER D 136 48.443 59.541126.506 1.00 141.90 N ATOM 14244 CA SER D 136 47.762 58.997 127.683 1.00148.08 C ATOM 14246 CB SER D 136 48.003 59.872 128.938 1.00 156.17 CATOM 14249 OG SER D 136 47.204 59.449 130.043 1.00 160.68 O ATOM 14251 CSER D 136 46.252 58.781 127.358 1.00 145.76 C ATOM 14252 O SER D 13645.478 59.749 127.277 1.00 145.97 O ATOM 14253 N THR D 137 45.887 57.508127.105 1.00 143.97 N ATOM 14255 CA THR D 137 44.495 57.012 126.990 1.00142.86 C ATOM 14257 CB THR D 137 43.968 56.999 125.484 1.00 134.89 CATOM 14259 OG1 THR D 137 44.846 57.734 124.605 1.00 129.83 O ATOM 14261CG2 THR D 137 42.567 57.671 125.358 1.00 134.26 C ATOM 14265 C THR D 13744.440 55.570 127.549 1.00 146.23 C ATOM 14266 O THR D 137 44.505 54.608126.769 1.00 142.87 O ATOM 14267 N SER D 138 44.364 55.417 128.874 1.00153.23 N ATOM 14269 CA SER D 138 44.243 54.088 129.508 1.00 157.67 CATOM 14271 CB SER D 138 43.834 54.215 131.017 1.00 166.65 C ATOM 14274OG SER D 138 42.567 53.646 131.354 1.00 167.36 O ATOM 14276 C SER D 13843.278 53.162 128.739 1.00 154.58 C ATOM 14277 O SER D 138 43.711 52.177128.126 1.00 151.95 O ATOM 14278 N GLY D 139 41.984 53.513 128.758 1.00155.39 N ATOM 14280 CA GLY D 139 40.916 52.737 128.132 1.00 153.62 CATOM 14283 C GLY D 139 40.310 53.374 126.872 1.00 147.16 C ATOM 14284 OGLY D 139 39.078 53.540 126.851 1.00 148.77 O ATOM 14285 N GLY D 14041.159 53.757 125.887 1.00 140.58 N ATOM 14287 CA GLY D 140 40.78554.070 124.501 1.00 133.65 C ATOM 14290 C GLY D 140 41.900 53.685123.488 1.00 128.29 C ATOM 14291 O GLY D 140 43.034 53.341 123.877 1.00129.62 O ATOM 14292 N THR D 141 41.622 53.770 122.181 1.00 122.35 N ATOM14294 CA THR D 141 42.543 53.206 121.174 1.00 117.27 C ATOM 14296 CB THRD 141 41.749 52.518 120.026 1.00 114.37 C ATOM 14298 OG1 THR D 14141.283 51.237 120.468 1.00 118.95 O ATOM 14300 CG2 THR D 141 42.64052.107 118.885 1.00 110.43 C ATOM 14304 C THR D 141 43.460 54.289120.658 1.00 112.42 C ATOM 14305 O THR D 141 43.007 55.385 120.437 1.00110.84 O ATOM 14306 N ALA D 142 44.744 53.980 120.495 1.00 110.72 N ATOM14308 CA ALA D 142 45.741 54.969 120.088 1.00 107.63 C ATOM 14310 CB ALAD 142 46.854 55.047 121.088 1.00 111.82 C ATOM 14314 C ALA D 142 46.30854.630 118.726 1.00 102.27 C ATOM 14315 O ALA D 142 46.122 53.503118.238 1.00 101.65 O ATOM 14316 N ALA D 143 47.020 55.610 118.149 1.0098.80 N ATOM 14318 CA ALA D 143 47.476 55.602 116.748 1.00 93.39 C ATOM14320 CB ALA D 143 46.600 56.585 115.878 1.00 89.96 C ATOM 14324 C ALA D143 48.970 55.943 116.551 1.00 92.18 C ATOM 14325 O ALA D 143 49.56856.769 117.278 1.00 93.80 O ATOM 14326 N LEU D 144 49.547 55.316 115.5291.00 88.87 N ATOM 14328 CA LEU D 144 50.950 55.507 115.213 1.00 88.48 CATOM 14330 CB LEU D 144 51.793 54.604 116.101 1.00 93.10 C ATOM 14333 CGLEU D 144 51.319 53.166 116.222 1.00 94.60 C ATOM 14335 CD1 LEU D 14451.776 52.328 115.026 1.00 91.71 C ATOM 14339 CD2 LEU D 144 51.84952.610 117.557 1.00 101.82 C ATOM 14343 C LEU D 144 51.243 55.237113.737 1.00 84.16 C ATOM 14344 O LEU D 144 50.331 54.826 112.998 1.0081.75 O ATOM 14345 N GLY D 145 52.504 55.438 113.316 1.00 83.52 N ATOM14347 CA GLY D 145 52.856 55.270 111.913 1.00 79.91 C ATOM 14350 C GLY D145 54.282 55.538 111.367 1.00 79.57 C ATOM 14351 O GLY D 145 55.30455.437 112.066 1.00 83.32 O ATOM 14352 N CYS D 146 54.312 55.893 110.0751.00 75.22 N ATOM 14354 CA CYS D 146 55.508 55.855 109.206 1.00 73.84 CATOM 14356 CB CYS D 146 55.664 54.503 108.451 1.00 73.43 C ATOM 14359 SGCYS D 146 56.308 53.216 109.520 1.00 81.52 S ATOM 14360 C CYS D 14655.384 56.912 108.144 1.00 69.05 C ATOM 14361 O CYS D 146 54.402 56.950107.391 1.00 65.38 O ATOM 14362 N LEU D 147 56.406 57.747 108.065 1.0068.91 N ATOM 14364 CA LEU D 147 56.432 58.804 107.109 1.00 65.13 C ATOM14366 CB LEU D 147 56.963 60.025 107.764 1.00 67.65 C ATOM 14369 CG LEUD 147 57.069 61.227 106.873 1.00 67.06 C ATOM 14371 CD1 LEU D 147 55.72461.483 106.297 1.00 65.61 C ATOM 14375 CD2 LEU D 147 57.559 62.440107.688 1.00 71.20 C ATOM 14379 C LEU D 147 57.370 58.331 106.083 1.0063.16 C ATOM 14380 O LEU D 147 58.552 58.304 106.328 1.00 64.33 O ATOM14381 N VAL D 148 56.830 57.899 104.943 1.00 60.56 N ATOM 14383 CA VAL D148 57.671 57.588 103.762 1.00 59.44 C ATOM 14385 CB VAL D 148 57.17056.371 103.022 1.00 57.55 C ATOM 14387 CG1 VAL D 148 58.149 56.036101.950 1.00 56.88 C ATOM 14391 CG2 VAL D 148 57.071 55.207 103.985 1.0060.14 C ATOM 14395 C VAL D 148 57.880 58.789 102.783 1.00 57.27 C ATOM14396 O VAL D 148 56.988 59.143 102.012 1.00 56.19 O ATOM 14397 N LYS D149 59.063 59.372 102.818 1.00 57.66 N ATOM 14399 CA LYS D 149 59.29360.687 102.272 1.00 56.80 C ATOM 14401 CB LYS D 149 59.604 61.579103.479 1.00 60.19 C ATOM 14404 CG LYS D 149 60.038 63.016 103.218 1.0062.14 C ATOM 14407 CD LYS D 149 59.519 63.986 104.319 1.00 64.95 C ATOM14410 CE LYS D 149 59.517 65.451 103.856 1.00 66.61 C ATOM 14413 NZ LYSD 149 60.933 65.996 103.508 1.00 69.35 N ATOM 14417 C LYS D 149 60.43560.715 101.246 1.00 56.13 C ATOM 14418 O LYS D 149 61.365 59.926 101.2681.00 58.22 O ATOM 14419 N ASP D 150 60.363 61.652 100.340 1.00 54.55 NATOM 14421 CA ASP D 150 61.444 61.929 99.384 1.00 54.34 C ATOM 14423 CBASP D 150 62.629 62.585 100.090 1.00 58.17 C ATOM 14426 CG ASP D 15062.264 63.912 100.695 1.00 60.09 C ATOM 14427 OD1 ASP D 150 62.98264.376 101.590 1.00 69.14 O ATOM 14428 OD2 ASP D 150 61.267 64.570100.383 1.00 58.91 O ATOM 14429 C ASP D 150 61.896 60.772 98.527 1.0052.77 C ATOM 14430 O ASP D 150 63.026 60.348 98.599 1.00 54.66 O ATOM14431 N TYR D 151 60.981 60.295 97.682 1.00 50.75 N ATOM 14433 CA TYR D151 61.252 59.228 96.706 1.00 49.16 C ATOM 14435 CB TYR D 151 60.72357.880 97.179 1.00 49.80 C ATOM 14438 CG TYR D 151 59.222 57.790 97.2521.00 48.09 C ATOM 14439 CD1 TYR D 151 58.483 57.376 96.154 1.00 46.12 CATOM 14441 CE1 TYR D 151 57.135 57.321 96.171 1.00 45.49 C ATOM 14443 CZTYR D 151 56.438 57.658 97.307 1.00 45.19 C ATOM 14444 OH TYR D 15155.092 57.521 97.328 1.00 43.36 O ATOM 14446 CE2 TYR D 151 57.101 58.07798.410 1.00 49.83 C ATOM 14448 CD2 TYR D 151 58.545 58.130 98.391 1.0049.84 C ATOM 14450 C TYR D 151 60.657 59.567 95.382 1.00 46.65 C ATOM14451 O TYR D 151 59.792 60.426 95.271 1.00 44.77 O ATOM 14452 N PHE D152 61.155 58.867 94.379 1.00 46.98 N ATOM 14454 CA PHE D 152 60.72459.046 93.020 1.00 46.06 C ATOM 14456 CB PHE D 152 61.221 60.378 92.5321.00 46.70 C ATOM 14459 CG PHE D 152 60.649 60.766 91.240 1.00 46.30 CATOM 14460 CD1 PHE D 152 61.258 60.423 90.090 1.00 47.89 C ATOM 14462CE1 PHE D 152 60.726 60.772 88.909 1.00 47.13 C ATOM 14464 CZ PHE D 15259.636 61.473 88.857 1.00 43.58 C ATOM 14466 CE2 PHE D 152 59.024 61.81189.990 1.00 45.67 C ATOM 14468 CD2 PHE D 152 59.510 61.472 91.174 1.0044.91 C ATOM 14470 C PHE D 152 61.265 57.933 92.107 1.00 47.13 C ATOM14471 O PHE D 152 62.368 57.460 92.281 1.00 46.91 O ATOM 14472 N PRO D153 60.458 57.446 91.172 1.00 47.74 N ATOM 14473 CA PRO D 153 59.06457.821 91.009 1.00 46.84 C ATOM 14475 CB PRO D 153 58.855 57.629 89.5191.00 47.99 C ATOM 14478 CG PRO D 153 59.782 56.422 89.160 1.00 49.21 CATOM 14481 CD PRO D 153 60.823 56.380 90.221 1.00 49.16 C ATOM 14484 CPRO D 153 58.259 56.813 91.759 1.00 46.89 C ATOM 14485 O PRO D 15358.853 56.011 92.434 1.00 46.53 O ATOM 14486 N GLU D 154 56.945 56.87791.635 1.00 47.75 N ATOM 14488 CA GLU D 154 56.045 55.904 92.262 1.0049.53 C ATOM 14490 CB GLU D 154 54.615 56.391 92.071 1.00 49.61 C ATOM14493 CG GLU D 154 54.229 57.558 92.949 1.00 48.55 C ATOM 14496 CD GLU D154 53.234 57.082 94.005 1.00 51.59 C ATOM 14497 OE1 GLU D 154 53.67256.795 95.160 1.00 50.24 O ATOM 14498 OE2 GLU D 154 52.016 56.961 93.6501.00 52.02 O ATOM 14499 C GLU D 154 56.182 54.533 91.593 1.00 51.99 CATOM 14500 O GLU D 154 56.757 54.438 90.491 1.00 52.94 O ATOM 14501 NPRO D 155 55.706 53.469 92.229 1.00 54.47 N ATOM 14502 CA PRO D 15555.067 53.470 93.560 1.00 55.09 C ATOM 14504 CB PRO D 155 53.979 52.48093.367 1.00 56.62 C ATOM 14507 CG PRO D 155 54.662 51.449 92.460 1.0058.94 C ATOM 14510 CD PRO D 155 55.738 52.112 91.677 1.00 57.37 C ATOM14513 C PRO D 155 55.902 52.909 94.714 1.00 56.44 C ATOM 14514 O PRO D155 56.987 52.293 94.496 1.00 57.94 O ATOM 14515 N VAL D 156 55.35653.104 95.921 1.00 55.95 N ATOM 14517 CA VAL D 156 55.900 52.510 97.1101.00 58.09 C ATOM 14519 CB VAL D 156 56.074 53.534 98.199 1.00 57.30 CATOM 14521 CG1 VAL D 156 56.640 52.887 99.512 1.00 60.92 C ATOM 14525CG2 VAL D 156 57.072 54.513 97.769 1.00 57.85 C ATOM 14529 C VAL D 15654.907 51.505 97.595 1.00 60.29 C ATOM 14530 O VAL D 156 53.748 51.61297.316 1.00 61.45 O ATOM 14531 N THR D 157 55.373 50.518 98.313 1.0062.28 N ATOM 14533 CA THR D 157 54.531 49.596 98.993 1.00 64.84 C ATOM14535 CB THR D 157 55.070 48.221 98.666 1.00 68.70 C ATOM 14537 OG1 THRD 157 54.767 47.907 97.300 1.00 68.61 O ATOM 14539 CG2 THR D 157 54.37747.166 99.467 1.00 74.43 C ATOM 14543 C THR D 157 54.791 49.880 100.4321.00 65.43 C ATOM 14544 O THR D 157 55.929 50.121 100.772 1.00 67.18 OATOM 14545 N VAL D 158 53.792 49.826 101.297 1.00 66.13 N ATOM 14547 CAVAL D 158 54.027 49.793 102.753 1.00 67.84 C ATOM 14549 CB VAL D 15853.496 51.066 103.435 1.00 65.69 C ATOM 14551 CG1 VAL D 158 53.81251.053 104.905 1.00 67.82 C ATOM 14555 CG2 VAL D 158 54.053 52.331102.774 1.00 61.61 C ATOM 14559 C VAL D 158 53.277 48.599 103.351 1.0072.19 C ATOM 14560 O VAL D 158 52.314 48.156 102.776 1.00 73.95 O ATOM14561 N SER D 159 53.681 48.090 104.507 1.00 75.68 N ATOM 14563 CA SER D159 52.984 46.954 105.155 1.00 80.05 C ATOM 14565 CB SER D 159 53.23145.659 104.387 1.00 83.26 C ATOM 14568 OG SER D 159 54.603 45.300104.525 1.00 84.89 O ATOM 14570 C SER D 159 53.544 46.773 106.546 1.0083.51 C ATOM 14571 O SER D 159 54.718 47.089 106.775 1.00 83.52 O ATOM14572 N TRP D 160 52.768 46.211 107.471 1.00 87.04 N ATOM 14574 CA TRP D160 53.284 46.101 108.846 1.00 90.70 C ATOM 14576 CB TRP D 160 52.37846.873 109.763 1.00 89.83 C ATOM 14579 CG TRP D 160 52.246 48.303109.409 1.00 84.69 C ATOM 14580 CD1 TRP D 160 51.543 48.842 108.352 1.0079.29 C ATOM 14582 NE1 TRP D 160 51.623 50.213 108.391 1.00 73.78 N ATOM14584 CE2 TRP D 160 52.373 50.592 109.470 1.00 76.63 C ATOM 14585 CD2TRP D 160 52.788 49.408 110.131 1.00 83.36 C ATOM 14586 CE3 TRP D 16053.560 49.524 111.289 1.00 87.07 C ATOM 14588 CZ3 TRP D 160 53.91050.795 111.732 1.00 86.68 C ATOM 14590 CH2 TRP D 160 53.494 51.947111.041 1.00 80.65 C ATOM 14592 CZ2 TRP D 160 52.723 51.864 109.916 1.0075.76 C ATOM 14594 C TRP D 160 53.529 44.669 109.400 1.00 97.32 C ATOM14595 O TRP D 160 52.681 43.805 109.261 1.00 100.42 O ATOM 14596 N ASN D161 54.708 44.447 110.002 1.00 100.50 N ATOM 14598 CA ASN D 161 55.10743.189 110.664 1.00 107.59 C ATOM 14600 CB ASN D 161 54.168 42.853111.837 1.00 111.38 C ATOM 14603 CG ASN D 161 54.071 43.990 112.867 1.00109.86 C ATOM 14604 OD1 ASN D 161 53.451 43.837 113.914 1.00 113.63 OATOM 14605 ND2 ASN D 161 54.700 45.122 112.572 1.00 104.12 N ATOM 14608C ASN D 161 55.201 42.031 109.686 1.00 109.80 C ATOM 14609 O ASN D 16154.581 40.995 109.890 1.00 113.89 O ATOM 14610 N SER D 162 56.001 42.232108.633 1.00 107.26 N ATOM 14612 CA SER D 162 55.962 41.418 107.389 1.00108.05 C ATOM 14614 CB SER D 162 56.905 40.169 107.464 1.00 115.28 CATOM 14617 OG SER D 162 56.533 39.196 108.446 1.00 122.27 O ATOM 14619 CSER D 162 54.515 41.104 106.843 1.00 106.92 C ATOM 14620 O SER D 16254.284 40.170 106.071 1.00 109.12 O ATOM 14621 N GLY D 163 53.558 41.941107.206 1.00 103.43 N ATOM 14623 CA GLY D 163 52.218 41.849 106.659 1.00102.77 C ATOM 14626 C GLY D 163 51.214 41.161 107.561 1.00 107.96 C ATOM14627 O GLY D 163 50.140 40.801 107.100 1.00 109.21 O ATOM 14628 N ALA D164 51.541 40.998 108.842 1.00 111.31 N ATOM 14630 CA ALA D 164 50.64140.355 109.775 1.00 116.24 C ATOM 14632 CB ALA D 164 51.422 39.829110.979 1.00 121.90 C ATOM 14636 C ALA D 164 49.498 41.278 110.236 1.00113.12 C ATOM 14637 O ALA D 164 48.523 40.774 110.836 1.00 117.66 O ATOM14638 N LEU D 165 49.610 42.594 109.985 1.00 106.18 N ATOM 14640 CA LEUD 165 48.572 43.596 110.366 1.00 103.35 C ATOM 14642 CB LEU D 165 49.21344.841 111.017 1.00 100.01 C ATOM 14645 CG LEU D 165 49.884 44.675112.393 1.00 104.07 C ATOM 14647 CD1 LEU D 165 49.895 46.010 113.1401.00 100.25 C ATOM 14651 CD2 LEU D 165 49.215 43.516 113.304 1.00 113.44C ATOM 14655 C LEU D 165 47.666 44.060 109.206 1.00 99.38 C ATOM 14656 OLEU D 165 48.126 44.281 108.107 1.00 95.88 O ATOM 14657 N THR D 16646.382 44.244 109.481 1.00 100.31 N ATOM 14659 CA THR D 166 45.38644.436 108.428 1.00 98.64 C ATOM 14661 CB THR D 166 44.681 43.068108.100 1.00 104.71 C ATOM 14663 OG1 THR D 166 45.324 42.495 106.9611.00 104.16 O ATOM 14665 CG2 THR D 166 43.167 43.212 107.657 1.00 105.79C ATOM 14669 C THR D 166 44.388 45.506 108.810 1.00 96.21 C ATOM 14670 OTHR D 166 44.421 46.562 108.235 1.00 91.40 O ATOM 14671 N SER D 16743.492 45.242 109.755 1.00 100.00 N ATOM 14673 CA SER D 167 42.55246.277 110.121 1.00 98.66 C ATOM 14675 CB SER D 167 41.333 45.736110.879 1.00 103.89 C ATOM 14678 OG SER D 167 41.735 45.120 112.053 1.00106.75 O ATOM 14680 C SER D 167 43.307 47.389 110.895 1.00 95.73 C ATOM14681 O SER D 167 44.117 47.131 111.821 1.00 96.71 O ATOM 14682 N GLY D168 43.027 48.623 110.464 1.00 91.77 N ATOM 14684 CA GLY D 168 43.65549.807 110.982 1.00 89.03 C ATOM 14687 C GLY D 168 44.604 50.335 109.9361.00 84.96 C ATOM 14688 O GLY D 168 45.059 51.438 110.086 1.00 83.18 OATOM 14689 N VAL D 169 44.892 49.580 108.871 1.00 84.50 N ATOM 14691 CAVAL D 169 45.986 49.932 107.935 1.00 80.36 C ATOM 14693 CB VAL D 16946.696 48.697 107.290 1.00 82.08 C ATOM 14695 CG1 VAL D 169 47.82949.109 106.355 1.00 76.99 C ATOM 14699 CG2 VAL D 169 47.248 47.793108.385 1.00 87.51 C ATOM 14703 C VAL D 169 45.440 50.853 106.859 1.0076.27 C ATOM 14704 O VAL D 169 44.763 50.448 105.886 1.00 75.78 O ATOM14705 N HIS D 170 45.770 52.104 107.099 1.00 72.66 N ATOM 14707 CA HIS D170 45.447 53.183 106.249 1.00 69.38 C ATOM 14709 CB HIS D 170 44.78654.234 107.116 1.00 70.06 C ATOM 14712 CG HIS D 170 43.316 54.039107.318 1.00 71.85 C ATOM 14713 ND1 HIS D 170 42.431 53.891 106.277 1.0070.83 N ATOM 14715 CE1 HIS D 170 41.200 53.816 106.759 1.00 75.91 C ATOM14717 NE2 HIS D 170 41.258 53.904 108.075 1.00 76.31 N ATOM 14719 CD2HIS D 170 42.571 54.040 108.449 1.00 74.79 C ATOM 14721 C HIS D 17046.730 53.740 105.599 1.00 65.87 C ATOM 14722 O HIS D 170 47.590 54.326106.240 1.00 64.33 O ATOM 14723 N THR D 171 46.813 53.616 104.287 1.0064.92 N ATOM 14725 CA THR D 171 48.045 53.890 103.569 1.00 61.85 C ATOM14727 CB THR D 171 48.525 52.618 102.809 1.00 63.26 C ATOM 14729 OG1 THRD 171 48.681 51.525 103.768 1.00 68.52 O ATOM 14731 CG2 THR D 171 49.92252.775 102.220 1.00 60.74 C ATOM 14735 C THR D 171 48.066 55.083 102.7011.00 57.66 C ATOM 14736 O THR D 171 49.097 55.421 102.275 1.00 59.99 OATOM 14737 N PHE D 172 47.052 55.841 102.493 1.00 56.24 N ATOM 14739 CAPHE D 172 47.309 57.278 102.015 1.00 53.44 C ATOM 14741 CB PHE D 17247.980 58.182 103.068 1.00 52.85 C ATOM 14744 CG PHE D 172 47.131 58.461104.272 1.00 56.06 C ATOM 14745 CD1 PHE D 172 47.421 57.886 105.494 1.0057.70 C ATOM 14747 CE1 PHE D 172 46.598 58.125 106.593 1.00 61.30 C ATOM14749 CZ PHE D 172 45.466 58.949 106.488 1.00 61.98 C ATOM 14751 CE2 PHED 172 45.158 59.512 105.286 1.00 61.46 C ATOM 14753 CD2 PHE D 172 46.00259.285 104.175 1.00 58.64 C ATOM 14755 C PHE D 172 48.040 57.484 100.6841.00 50.18 C ATOM 14756 O PHE D 172 49.188 57.152 100.499 1.00 48.95 OATOM 14757 N PRO D 173 47.323 57.960 99.703 1.00 51.03 N ATOM 14758 CAPRO D 173 47.966 58.259 98.437 1.00 50.61 C ATOM 14760 CB PRO D 17346.828 58.841 97.589 1.00 51.50 C ATOM 14763 CG PRO D 173 45.802 59.11298.483 1.00 53.99 C ATOM 14766 CD PRO D 173 45.876 58.146 99.622 1.0052.80 C ATOM 14769 C PRO D 173 49.105 59.258 98.568 1.00 49.69 C ATOM14770 O PRO D 173 49.007 60.262 99.263 1.00 50.24 O ATOM 14771 N ALA D174 50.192 58.982 97.865 1.00 49.12 N ATOM 14773 CA ALA D 174 51.33359.885 97.868 1.00 48.07 C ATOM 14775 CB ALA D 174 52.374 59.344 96.9691.00 47.30 C ATOM 14779 C ALA D 174 50.988 61.267 97.411 1.00 48.33 CATOM 14780 O ALA D 174 49.996 61.501 96.760 1.00 48.62 O ATOM 14781 NVAL D 175 51.863 62.181 97.732 1.00 48.93 N ATOM 14783 CA VAL D 17551.693 63.544 97.311 1.00 50.08 C ATOM 14785 CB VAL D 175 51.278 64.39698.464 1.00 52.47 C ATOM 14787 CG1 VAL D 175 51.091 65.789 98.004 1.0056.48 C ATOM 14791 CG2 VAL D 175 49.992 63.925 99.000 1.00 53.12 C ATOM14795 C VAL D 175 53.009 64.056 96.790 1.00 49.12 C ATOM 14796 O VAL D175 54.031 63.730 97.308 1.00 48.44 O ATOM 14797 N LEU D 176 52.96564.862 95.747 1.00 49.70 N ATOM 14799 CA LEU D 176 54.162 65.349 95.1251.00 49.52 C ATOM 14801 CB LEU D 176 53.854 65.602 93.685 1.00 50.20 CATOM 14804 CG LEU D 176 54.982 66.015 92.758 1.00 51.28 C ATOM 14806 CD1LEU D 176 56.160 65.079 92.906 1.00 51.18 C ATOM 14810 CD2 LEU D 17654.408 65.949 91.360 1.00 51.54 C ATOM 14814 C LEU D 176 54.528 66.63195.771 1.00 51.36 C ATOM 14815 O LEU D 176 53.750 67.559 95.800 1.0053.28 O ATOM 14816 N GLN D 177 55.703 66.664 96.348 1.00 52.30 N ATOM14818 CA GLN D 177 56.173 67.852 97.072 1.00 55.83 C ATOM 14820 CB GLN D177 57.242 67.468 98.109 1.00 56.07 C ATOM 14823 CG GLN D 177 56.88566.367 99.070 1.00 53.77 C ATOM 14826 CD GLN D 177 58.093 65.861 99.8211.00 55.31 C ATOM 14827 OE1 GLN D 177 59.134 66.373 99.640 1.00 67.15 OATOM 14828 NE2 GLN D 177 57.940 64.937 100.701 1.00 56.54 N ATOM 14831 CGLN D 177 56.753 68.909 96.092 1.00 57.83 C ATOM 14832 O GLN D 17756.895 68.652 94.905 1.00 57.07 O ATOM 14833 N SER D 178 57.105 70.08696.594 1.00 61.86 N ATOM 14835 CA SER D 178 57.698 71.128 95.747 1.0064.24 C ATOM 14837 CB SER D 178 57.821 72.425 96.515 1.00 68.85 C ATOM14840 OG SER D 178 56.592 73.127 96.433 1.00 70.78 O ATOM 14842 C SER D178 59.054 70.760 95.178 1.00 63.76 C ATOM 14843 O SER D 178 59.47471.301 94.193 1.00 64.54 O ATOM 14844 N SER D 179 59.735 69.827 95.8201.00 63.67 N ATOM 14846 CA SER D 179 61.005 69.276 95.324 1.00 63.08 CATOM 14848 CB SER D 179 61.691 68.545 96.476 1.00 63.84 C ATOM 14851 OGSER D 179 60.849 67.484 97.003 1.00 62.76 O ATOM 14853 C SER D 17960.897 68.260 94.149 1.00 60.11 C ATOM 14854 O SER D 179 61.972 67.79593.639 1.00 60.04 O ATOM 14855 N GLY D 180 59.651 67.856 93.788 1.0056.93 N ATOM 14857 CA GLY D 180 59.442 66.838 92.771 1.00 53.61 C ATOM14860 C GLY D 180 59.604 65.423 93.306 1.00 51.38 C ATOM 14861 O GLY D180 59.592 64.412 92.557 1.00 49.29 O ATOM 14862 N LEU D 181 59.72865.348 94.623 1.00 51.34 N ATOM 14864 CA LEU D 181 59.769 64.068 95.2881.00 50.39 C ATOM 14866 CB LEU D 181 60.814 64.149 96.347 1.00 52.46 CATOM 14869 CG LEU D 181 62.218 64.303 95.845 1.00 53.18 C ATOM 14871 CD1LEU D 181 63.179 64.532 97.017 1.00 53.74 C ATOM 14875 CD2 LEU D 18162.516 63.006 95.073 1.00 51.26 C ATOM 14879 C LEU D 181 58.437 63.75695.964 1.00 49.42 C ATOM 14880 O LEU D 181 57.823 64.632 96.590 1.0050.84 O ATOM 14881 N TYR D 182 57.995 62.517 95.866 1.00 47.37 N ATOM14883 CA TYR D 182 56.805 62.099 96.625 1.00 47.21 C ATOM 14885 CB TYR D182 56.283 60.780 96.092 1.00 46.17 C ATOM 14888 CG TYR D 182 55.76760.930 94.708 1.00 45.87 C ATOM 14889 CD1 TYR D 182 56.557 60.615 93.6331.00 46.82 C ATOM 14891 CE1 TYR D 182 56.098 60.809 92.348 1.00 48.35 CATOM 14893 CZ TYR D 182 54.813 61.268 92.138 1.00 47.09 C ATOM 14894 OHTYR D 182 54.417 61.435 90.868 1.00 45.62 O ATOM 14896 CE2 TYR D 18254.012 61.607 93.185 1.00 45.99 C ATOM 14898 CD2 TYR D 182 54.494 61.46194.465 1.00 46.47 C ATOM 14900 C TYR D 182 57.045 61.914 98.120 1.0048.05 C ATOM 14901 O TYR D 182 58.117 61.576 98.545 1.00 48.45 O ATOM14902 N SER D 183 56.034 62.171 98.915 1.00 48.87 N ATOM 14904 CA SER D183 55.925 61.467 100.149 1.00 51.41 C ATOM 14906 CB SER D 183 56.47462.252 101.324 1.00 53.74 C ATOM 14909 OG SER D 183 55.445 62.952101.902 1.00 57.05 O ATOM 14911 C SER D 183 54.518 60.978 100.430 1.0051.30 C ATOM 14912 O SER D 183 53.558 61.281 99.726 1.00 50.46 O ATOM14913 N LEU D 184 54.452 60.236 101.521 1.00 53.32 N ATOM 14915 CA LEU D184 53.409 59.260 101.805 1.00 54.25 C ATOM 14917 CB LEU D 184 53.94857.905 101.387 1.00 54.63 C ATOM 14920 CG LEU D 184 53.018 56.728101.250 1.00 54.80 C ATOM 14922 CD1 LEU D 184 52.219 56.950 100.076 1.0053.73 C ATOM 14926 CD2 LEU D 184 53.879 55.526 101.028 1.00 57.84 C ATOM14930 C LEU D 184 53.275 59.190 103.308 1.00 56.22 C ATOM 14931 O LEU D184 54.094 59.680 104.021 1.00 57.29 O ATOM 14932 N SER D 185 52.27258.516 103.800 1.00 57.35 N ATOM 14934 CA SER D 185 52.379 58.007105.174 1.00 59.70 C ATOM 14936 CB SER D 185 52.049 59.067 106.224 1.0061.87 C ATOM 14939 OG SER D 185 50.921 59.813 105.836 1.00 63.92 O ATOM14941 C SER D 185 51.474 56.865 105.319 1.00 58.54 C ATOM 14942 O SER D185 50.405 56.906 104.803 1.00 55.56 O ATOM 14943 N SER D 186 51.95555.837 105.977 1.00 60.18 N ATOM 14945 CA SER D 186 51.078 54.790106.428 1.00 63.53 C ATOM 14947 CB SER D 186 51.565 53.439 105.983 1.0064.38 C ATOM 14950 OG SER D 186 51.306 52.536 107.024 1.00 69.79 O ATOM14952 C SER D 186 50.824 54.828 107.946 1.00 66.75 C ATOM 14953 O SER D186 51.600 55.365 108.716 1.00 68.12 O ATOM 14954 N VAL D 187 49.70054.263 108.364 1.00 69.09 N ATOM 14956 CA VAL D 187 49.165 54.560109.697 1.00 72.02 C ATOM 14958 CB VAL D 187 48.374 55.912 109.640 1.0070.96 C ATOM 14960 CG1 VAL D 187 47.059 55.856 110.271 1.00 72.97 C ATOM14964 CG2 VAL D 187 49.184 57.018 110.284 1.00 72.15 C ATOM 14968 C VALD 187 48.375 53.380 110.180 1.00 74.57 C ATOM 14969 O VAL D 187 47.76552.687 109.388 1.00 73.67 O ATOM 14970 N VAL D 188 48.480 53.089 111.4671.00 78.78 N ATOM 14972 CA VAL D 188 47.669 52.026 112.060 1.00 83.05 CATOM 14974 CB VAL D 188 48.424 50.763 112.506 1.00 86.25 C ATOM 14976CG1 VAL D 188 47.620 49.558 112.107 1.00 88.84 C ATOM 14980 CG2 VAL D188 49.766 50.672 111.881 1.00 86.59 C ATOM 14984 C VAL D 188 46.95452.550 113.272 1.00 86.01 C ATOM 14985 O VAL D 188 47.492 53.373 114.0271.00 87.50 O ATOM 14986 N THR D 189 45.717 52.090 113.409 1.00 87.42 NATOM 14988 CA THR D 189 45.015 52.183 114.633 1.00 90.97 C ATOM 14990 CBTHR D 189 43.536 52.320 114.347 1.00 91.22 C ATOM 14992 OG1 THR D 18943.307 53.207 113.261 1.00 85.40 O ATOM 14994 CG2 THR D 189 42.84252.982 115.480 1.00 95.29 C ATOM 14998 C THR D 189 45.331 50.835 115.3041.00 95.78 C ATOM 14999 O THR D 189 45.260 49.755 114.672 1.00 96.14 OATOM 15000 N VAL D 190 45.746 50.884 116.561 1.00 99.65 N ATOM 15002 CAVAL D 190 45.807 49.661 117.344 1.00 105.40 C ATOM 15004 CB VAL D 19047.212 48.949 117.308 1.00 106.50 C ATOM 15006 CG1 VAL D 190 47.11247.459 117.879 1.00 113.44 C ATOM 15010 CG2 VAL D 190 47.766 48.880115.927 1.00 101.20 C ATOM 15014 C VAL D 190 45.413 49.955 118.791 1.00110.32 C ATOM 15015 O VAL D 190 45.707 51.074 119.275 1.00 109.76 O ATOM15016 N PRO D 191 44.744 48.985 119.460 1.00 114.97 N ATOM 15017 CA PROD 191 44.542 49.062 120.915 1.00 120.91 C ATOM 15019 CB PRO D 191 44.04347.643 121.300 1.00 125.96 C ATOM 15022 CG PRO D 191 44.151 46.807120.045 1.00 123.19 C ATOM 15025 CD PRO D 191 44.102 47.772 118.900 1.00115.97 C ATOM 15028 C PRO D 191 45.853 49.394 121.632 1.00 122.98 C ATOM15029 O PRO D 191 46.839 48.659 121.471 1.00 123.92 O ATOM 15030 N SER D192 45.865 50.488 122.396 1.00 124.39 N ATOM 15032 CA SER D 192 47.08450.948 123.089 1.00 126.95 C ATOM 15034 CB SER D 192 46.777 52.111124.075 1.00 129.91 C ATOM 15037 OG SER D 192 45.532 51.972 124.740 1.00133.29 O ATOM 15039 C SER D 192 47.947 49.817 123.741 1.00 132.43 C ATOM15040 O SER D 192 49.151 49.762 123.488 1.00 131.87 O ATOM 15041 N SER D193 47.354 48.897 124.509 1.00 137.70 N ATOM 15043 CA SER D 193 48.12647.756 125.053 1.00 143.45 C ATOM 15045 CB SER D 193 47.327 46.438125.055 1.00 146.12 C ATOM 15048 OG SER D 193 46.031 46.630 125.549 1.00145.50 O ATOM 15050 C SER D 193 49.469 47.537 124.314 1.00 141.77 C ATOM15051 O SER D 193 50.505 48.003 124.802 1.00 144.72 O ATOM 15052 N SER D194 49.431 46.911 123.120 1.00 137.58 N ATOM 15054 CA SER D 194 50.57646.172 122.505 1.00 137.39 C ATOM 15056 CB SER D 194 51.823 47.067122.336 1.00 134.79 C ATOM 15059 OG SER D 194 51.599 48.394 122.757 1.00130.77 O ATOM 15061 C SER D 194 50.904 44.805 123.248 1.00 146.68 C ATOM15062 O SER D 194 52.066 44.543 123.660 1.00 150.94 O ATOM 15063 N LEU D195 49.851 43.974 123.443 1.00 150.16 N ATOM 15065 CA LEU D 195 49.92542.548 123.927 1.00 158.06 C ATOM 15067 CB LEU D 195 48.727 42.204124.827 1.00 162.41 C ATOM 15073 C LEU D 195 49.952 41.592 122.701 1.00156.29 C ATOM 15074 O LEU D 195 49.549 42.026 121.607 1.00 149.95 O ATOM15075 N GLY D 196 50.425 40.340 122.842 1.00 162.68 N ATOM 15077 CA GLYD 196 50.727 39.497 121.675 1.00 161.42 C ATOM 15080 C GLY D 196 51.31840.257 120.455 1.00 153.51 C ATOM 15081 O GLY D 196 50.581 40.655119.512 1.00 147.54 O ATOM 15082 N THR D 197 52.642 40.478 120.464 1.00153.86 N ATOM 15084 CA THR D 197 53.368 41.350 119.480 1.00 146.39 CATOM 15086 CB THR D 197 53.254 40.820 117.993 1.00 142.49 C ATOM 15088OG1 THR D 197 54.045 39.617 117.882 1.00 149.06 O ATOM 15090 CG2 THR D197 53.887 41.806 116.926 1.00 133.52 C ATOM 15094 C THR D 197 53.13842.899 119.643 1.00 140.17 C ATOM 15095 O THR D 197 52.525 43.607118.818 1.00 132.05 O ATOM 15096 N GLN D 198 53.709 43.363 120.759 1.00144.11 N ATOM 15098 CA GLN D 198 53.825 44.764 121.116 1.00 140.43 CATOM 15100 CB GLN D 198 54.450 44.898 122.532 1.00 147.96 C ATOM 15107 CGLN D 198 54.697 45.496 120.114 1.00 134.16 C ATOM 15108 O GLN D 19854.789 46.710 120.188 1.00 130.78 O ATOM 15109 N THR D 199 55.332 44.766119.190 1.00 133.07 N ATOM 15111 CA THR D 199 56.296 45.351 118.244 1.00128.45 C ATOM 15113 CB THR D 199 57.444 44.346 117.891 1.00 132.44 CATOM 15115 OG1 THR D 199 57.295 43.134 118.631 1.00 139.60 O ATOM 15117CG2 THR D 199 58.814 44.873 118.344 1.00 135.37 C ATOM 15121 C THR D 19955.626 45.857 116.943 1.00 120.09 C ATOM 15122 O THR D 199 55.024 45.084116.183 1.00 118.92 O ATOM 15123 N TYR D 200 55.751 47.155 116.680 1.00115.03 N ATOM 15125 CA TYR D 200 55.213 47.730 115.454 1.00 107.62 CATOM 15127 CB TYR D 200 54.281 48.908 115.795 1.00 104.46 C ATOM 15130CG TYR D 200 53.147 48.489 116.711 1.00 106.68 C ATOM 15131 CD1 TYR D200 52.975 49.070 117.970 1.00 109.12 C ATOM 15133 CE1 TYR D 200 51.96348.664 118.811 1.00 111.35 C ATOM 15135 CZ TYR D 200 51.115 47.661118.401 1.00 111.91 C ATOM 15136 OH TYR D 200 50.096 47.221 119.207 1.00115.71 O ATOM 15138 CE2 TYR D 200 51.271 47.068 117.166 1.00 109.67 CATOM 15140 CD2 TYR D 200 52.277 47.479 116.333 1.00 106.06 C ATOM 15142C TYR D 200 56.346 48.132 114.499 1.00 104.92 C ATOM 15143 O TYR D 20057.050 49.105 114.738 1.00 104.47 O ATOM 15144 N ILE D 201 56.521 47.366113.424 1.00 103.81 N ATOM 15146 CA ILE D 201 57.545 47.671 112.429 1.00102.21 C ATOM 15148 CB ILE D 201 58.684 46.590 112.496 1.00 107.75 CATOM 15150 CG1 ILE D 201 59.393 46.656 113.856 1.00 113.72 C ATOM 15153CD1 ILE D 201 60.523 45.656 114.048 1.00 119.86 C ATOM 15157 CG2 ILE D201 59.717 46.792 111.336 1.00 105.63 C ATOM 15161 C ILE D 201 56.99747.807 110.980 1.00 96.83 C ATOM 15162 O ILE D 201 56.436 46.849 110.4361.00 97.98 O ATOM 15163 N CYS D 202 57.184 48.959 110.330 1.00 92.25 NATOM 15165 CA CYS D 202 56.695 49.076 108.944 1.00 87.63 C ATOM 15167 CBCYS D 202 56.006 50.398 108.708 1.00 83.22 C ATOM 15170 SG CYS D 20257.133 51.729 108.422 1.00 81.91 S ATOM 15171 C CYS D 202 57.728 48.846107.836 1.00 86.17 C ATOM 15172 O CYS D 202 58.868 49.308 107.923 1.0086.56 O ATOM 15173 N ASN D 203 57.254 48.177 106.780 1.00 84.31 N ATOM15175 CA ASN D 203 58.079 47.615 105.732 1.00 84.05 C ATOM 15177 CB ASND 203 57.692 46.171 105.447 1.00 87.34 C ATOM 15180 CG ASN D 203 57.40045.402 106.715 1.00 93.02 C ATOM 15181 OD1 ASN D 203 58.163 45.443107.705 1.00 94.19 O ATOM 15182 ND2 ASN D 203 56.273 44.708 106.709 1.0095.69 N ATOM 15185 C ASN D 203 57.828 48.450 104.543 1.00 78.21 C ATOM15186 O ASN D 203 56.798 48.349 103.918 1.00 77.07 O ATOM 15187 N VAL D204 58.774 49.310 104.262 1.00 75.80 N ATOM 15189 CA VAL D 204 58.72850.161 103.109 1.00 71.12 C ATOM 15191 CB VAL D 204 59.273 51.551103.467 1.00 69.36 C ATOM 15193 CG1 VAL D 204 58.892 52.562 102.404 1.0064.60 C ATOM 15197 CG2 VAL D 204 58.753 51.967 104.837 1.00 69.88 C ATOM15201 C VAL D 204 59.544 49.533 101.980 1.00 71.71 C ATOM 15202 O VAL D204 60.760 49.405 102.076 1.00 73.45 O ATOM 15203 N ASN D 205 58.86749.133 100.912 1.00 70.66 N ATOM 15205 CA ASN D 205 59.554 48.715 99.6971.00 71.49 C ATOM 15207 CB ASN D 205 59.047 47.351 99.229 1.00 74.94 CATOM 15210 CG ASN D 205 59.923 46.761 98.143 1.00 78.41 C ATOM 15211 OD1ASN D 205 60.868 46.022 98.437 1.00 84.36 O ATOM 15212 ND2 ASN D 20559.661 47.141 96.874 1.00 77.11 N ATOM 15215 C ASN D 205 59.436 49.74598.564 1.00 66.99 C ATOM 15216 O ASN D 205 58.335 50.165 98.188 1.0065.08 O ATOM 15217 N HIS D 206 60.575 50.160 98.031 1.00 66.16 N ATOM15219 CA HIS D 206 60.573 51.013 96.867 1.00 63.53 C ATOM 15221 CB HIS D206 61.317 52.331 97.165 1.00 62.70 C ATOM 15224 CG HIS D 206 61.16853.375 96.096 1.00 59.74 C ATOM 15225 ND1 HIS D 206 62.041 53.481 95.0381.00 60.76 N ATOM 15227 CE1 HIS D 206 61.660 54.482 94.258 1.00 60.76 CATOM 15229 NE2 HIS D 206 60.570 55.028 94.772 1.00 56.00 N ATOM 15231CD2 HIS D 206 60.261 54.371 95.937 1.00 57.75 C ATOM 15233 C HIS D 20661.213 50.257 95.718 1.00 65.17 C ATOM 15234 O HIS D 206 62.419 50.37395.513 1.00 66.55 O ATOM 15235 N LYS D 207 60.399 49.504 94.963 1.0065.74 N ATOM 15237 CA LYS D 207 60.878 48.605 93.893 1.00 67.90 C ATOM15239 CB LYS D 207 59.738 47.730 93.323 1.00 69.51 C ATOM 15246 C LYS D207 61.623 49.304 92.746 1.00 65.87 C ATOM 15247 O LYS D 207 62.59148.740 92.218 1.00 69.15 O ATOM 15248 N PRO D 208 61.243 50.518 92.3511.00 61.80 N ATOM 15249 CA PRO D 208 61.943 51.167 91.206 1.00 60.92 CATOM 15251 CB PRO D 208 61.030 52.336 90.824 1.00 56.74 C ATOM 15254 CGPRO D 208 60.162 52.553 91.983 1.00 55.16 C ATOM 15257 CD PRO D 20860.202 51.389 92.929 1.00 58.46 C ATOM 15260 C PRO D 208 63.412 51.63091.492 1.00 61.31 C ATOM 15261 O PRO D 208 64.183 51.824 90.547 1.0061.70 O ATOM 15262 N SER D 209 63.764 51.760 92.771 1.00 61.75 N ATOM15264 CA SER D 209 65.107 52.100 93.230 1.00 63.81 C ATOM 15266 CB SER D209 65.067 53.338 94.118 1.00 61.67 C ATOM 15269 OG SER D 209 64.72953.003 95.435 1.00 61.97 O ATOM 15271 C SER D 209 65.706 51.015 94.0781.00 68.74 C ATOM 15272 O SER D 209 66.705 51.256 94.740 1.00 71.24 OATOM 15273 N ASN D 210 65.085 49.836 94.113 1.00 70.96 N ATOM 15275 CAASN D 210 65.640 48.698 94.851 1.00 75.73 C ATOM 15277 CB ASN D 21067.009 48.338 94.275 1.00 79.41 C ATOM 15280 CG ASN D 210 67.493 47.00994.735 1.00 85.45 C ATOM 15281 OD1 ASN D 210 66.693 46.147 95.042 1.0086.85 O ATOM 15282 ND2 ASN D 210 68.826 46.840 94.825 1.00 91.76 N ATOM15285 C ASN D 210 65.746 48.906 96.367 1.00 76.54 C ATOM 15286 O ASN D210 66.441 48.163 97.027 1.00 81.20 O ATOM 15287 N THR D 211 65.04349.891 96.915 1.00 73.00 N ATOM 15289 CA THR D 211 65.020 50.089 98.3601.00 75.11 C ATOM 15291 CB THR D 211 64.668 51.546 98.732 1.00 71.89 CATOM 15293 OG1 THR D 211 64.896 52.438 97.628 1.00 70.10 O ATOM 15295CG2 THR D 211 65.666 52.070 99.782 1.00 76.24 C ATOM 15299 C THR D 21164.044 49.148 99.040 1.00 76.40 C ATOM 15300 O THR D 211 62.956 48.90298.516 1.00 74.76 O ATOM 15301 N LYS D 212 64.432 48.605 100.193 1.0080.57 N ATOM 15303 CA LYS D 212 63.545 47.720 100.946 1.00 82.72 C ATOM15305 CB LYS D 212 63.730 46.229 100.569 1.00 87.28 C ATOM 15312 C LYS D212 63.809 47.921 102.405 1.00 85.46 C ATOM 15313 O LYS D 212 64.25847.015 103.062 1.00 91.69 O ATOM 15314 N VAL D 213 63.489 49.105 102.9001.00 82.31 N ATOM 15316 CA VAL D 213 63.725 49.519 104.291 1.00 85.17 CATOM 15318 CB VAL D 213 63.756 51.057 104.298 1.00 82.29 C ATOM 15320CG1 VAL D 213 63.512 51.666 105.713 1.00 84.73 C ATOM 15324 CG2 VAL D213 65.083 51.527 103.696 1.00 84.19 C ATOM 15328 C VAL D 213 62.71149.064 105.372 1.00 86.25 C ATOM 15329 O VAL D 213 61.532 49.006 105.1291.00 82.68 O ATOM 15330 N ASP D 214 63.192 48.774 106.586 1.00 91.59 NATOM 15332 CA ASP D 214 62.311 48.532 107.749 1.00 92.98 C ATOM 15334 CBASP D 214 62.506 47.092 108.271 1.00 98.93 C ATOM 15337 CG ASP D 21462.194 46.035 107.204 1.00 97.80 C ATOM 15338 OD1 ASP D 214 61.38546.349 106.310 1.00 92.43 O ATOM 15339 OD2 ASP D 214 62.686 44.884107.157 1.00 100.35 O ATOM 15340 C ASP D 214 62.580 49.592 108.846 1.0094.11 C ATOM 15341 O ASP D 214 63.738 50.011 109.018 1.00 97.04 O ATOM15342 N LYS D 215 61.519 50.079 109.507 1.00 91.96 N ATOM 15344 CA LYS D215 61.627 50.915 110.722 1.00 94.21 C ATOM 15346 CB LYS D 215 61.44052.411 110.394 1.00 88.82 C ATOM 15353 C LYS D 215 60.643 50.460 111.8491.00 96.87 C ATOM 15354 O LYS D 215 59.545 50.002 111.586 1.00 94.60 OATOM 15355 N ARG D 216 61.060 50.595 113.105 1.00 102.63 N ATOM 15357 CAARG D 216 60.210 50.347 114.279 1.00 105.91 C ATOM 15359 CB ARG D 21661.002 49.578 115.347 1.00 114.01 C ATOM 15368 C ARG D 216 59.655 51.654114.900 1.00 104.92 C ATOM 15369 O ARG D 216 60.344 52.686 114.955 1.00104.73 O ATOM 15370 N VAL D 217 58.416 51.599 115.392 1.00 104.77 N ATOM15372 CA VAL D 217 57.769 52.766 116.007 1.00 104.59 C ATOM 15374 CB VALD 217 56.461 53.206 115.224 1.00 98.42 C ATOM 15376 CG1 VAL D 217 55.93954.582 115.703 1.00 97.76 C ATOM 15380 CG2 VAL D 217 56.697 53.270113.726 1.00 92.68 C ATOM 15384 C VAL D 217 57.468 52.519 117.502 1.00111.16 C ATOM 15385 O VAL D 217 56.318 52.305 117.890 1.00 111.38 O ATOM15386 N GLU D 218 58.506 52.549 118.337 1.00 117.44 N ATOM 15388 CA GLUD 218 58.321 52.507 119.788 1.00 124.37 C ATOM 15390 CB GLU D 218 59.67052.285 120.523 1.00 132.09 C ATOM 15393 CG GLU D 218 60.454 51.010120.158 1.00 134.04 C ATOM 15396 CD GLU D 218 61.880 51.285 119.658 1.00134.59 C ATOM 15397 OE1 GLU D 218 62.817 51.026 120.429 1.00 140.64 OATOM 15398 OE2 GLU D 218 62.079 51.756 118.499 1.00 128.11 O ATOM 15399C GLU D 218 57.741 53.874 120.171 1.00 123.49 C ATOM 15400 O GLU D 21857.926 54.837 119.434 1.00 119.12 O ATOM 15401 N PRO D 219 57.050 53.982121.306 1.00 128.14 N ATOM 15402 CA PRO D 219 56.704 55.312 121.852 1.00129.40 C ATOM 15404 CB PRO D 219 55.714 54.997 122.995 1.00 133.43 CATOM 15407 CG PRO D 219 55.987 53.558 123.371 1.00 137.50 C ATOM 15410CD PRO D 219 56.555 52.876 122.145 1.00 132.81 C ATOM 15413 C PRO D 21957.965 56.083 122.345 1.00 134.98 C ATOM 15414 O PRO D 219 59.093 55.751121.941 1.00 136.16 O ATOM 15415 N LYS D 220 57.773 57.114 123.171 1.00138.92 N ATOM 15417 CA LYS D 220 58.896 57.870 123.769 1.00 144.98 CATOM 15419 CB LYS D 220 59.535 58.834 122.740 1.00 140.79 C ATOM 15426 CLYS D 220 58.390 58.627 125.010 1.00 151.08 C ATOM 15427 O LYS D 22057.270 59.161 124.935 1.00 147.70 O ATOM 15428 OXT LYS D 220 59.05558.684 126.069 1.00 159.07 O ATOM 15429 C1 NAG E 321 29.462 −7.12422.592 1.00 106.85 C ATOM 15432 C2 NAG E 321 28.616 −8.080 23.433 1.00108.34 C ATOM 15434 N2 NAG E 321 27.778 −7.288 24.383 1.00 103.56 N ATOM15436 C7 NAG E 321 26.642 −6.621 24.066 1.00 100.08 C ATOM 15437 O7 NAGE 321 25.925 −6.934 23.152 1.00 101.12 O ATOM 15438 C8 NAG E 321 26.201−5.421 24.839 1.00 96.46 C ATOM 15442 C3 NAG E 321 29.493 −9.202 24.1021.00 112.92 C ATOM 15444 O3 NAG E 321 28.990 −10.588 23.960 1.00 118.55O ATOM 15446 C4 NAG E 321 31.051 −9.069 23.931 1.00 113.06 C ATOM 15448O4 NAG E 321 31.842 −9.641 24.956 1.00 113.90 O ATOM 15450 C5 NAG E 32131.401 −7.591 23.904 1.00 108.70 C ATOM 15452 C6 NAG E 321 32.887 −7.23824.154 1.00 106.46 C ATOM 15455 O6 NAG E 321 33.769 −8.115 23.495 1.00106.75 O ATOM 15457 O5 NAG E 321 30.883 −7.285 22.627 1.00 108.92 O ATOM15458 C1 NAG E 322 29.267 −9.662 26.756 1.00 110.31 C ATOM 15461 C2 NAGE 322 28.521 −10.967 26.426 1.00 114.38 C ATOM 15463 N2 NAG E 322 28.052−10.913 25.020 1.00 116.92 N ATOM 15465 C7 NAG E 322 28.385 −11.78024.057 1.00 119.42 C ATOM 15466 O7 NAG E 322 29.320 −11.475 23.340 1.00121.28 O ATOM 15467 C8 NAG E 322 27.607 −13.054 23.839 1.00 120.01 CATOM 15471 C3 NAG E 322 27.408 −11.226 27.470 1.00 113.49 C ATOM 15473O3 NAG E 322 26.898 −12.548 27.431 1.00 115.37 O ATOM 15475 C4 NAG E 32227.936 −10.952 28.884 1.00 112.48 C ATOM 15477 O4 NAG E 322 26.846−11.144 29.763 1.00 111.54 O ATOM 15479 C5 NAG E 322 28.645 −9.56828.956 1.00 109.09 C ATOM 15481 C6 NAG E 322 29.263 −9.135 30.280 1.00107.46 C ATOM 15484 O6 NAG E 322 28.277 −8.551 31.092 1.00 105.99 O ATOM15486 O5 NAG E 322 29.744 −9.611 28.071 1.00 109.51 O ATOM 15487 C1 MANE 323 27.558 −13.638 31.168 1.00 118.90 C ATOM 15490 C2 MAN E 323 26.564−13.183 32.294 1.00 117.77 C ATOM 15492 O2 MAN E 323 26.868 −11.91732.907 1.00 116.43 O ATOM 15494 C3 MAN E 323 25.081 −13.205 31.860 1.00117.73 C ATOM 15496 O3 MAN E 323 24.400 −11.977 32.023 1.00 112.67 OATOM 15498 C4 MAN E 323 24.976 −13.765 30.434 1.00 119.97 C ATOM 15500O4 MAN E 323 23.637 −13.872 30.008 1.00 121.73 O ATOM 15502 C5 MAN E 32325.750 −15.104 30.461 1.00 122.58 C ATOM 15504 C6 MAN E 323 25.209−16.307 29.627 1.00 125.63 C ATOM 15507 O6 MAN E 323 24.816 −16.08728.285 1.00 125.42 O ATOM 15509 O5 MAN E 323 27.124 −14.727 30.312 1.00121.55 O ATOM 15510 C1 MAN E 324 25.902 −11.845 35.755 1.00 115.15 CATOM 15513 C2 MAN E 324 27.196 −11.304 35.140 1.00 112.82 C ATOM 15515O2 MAN E 324 26.996 −11.188 33.736 1.00 113.36 O ATOM 15517 C3 MAN E 32427.691 −9.982 35.758 1.00 109.46 C ATOM 15519 O3 MAN E 324 28.466 −9.35434.763 1.00 107.10 O ATOM 15521 C4 MAN E 324 26.596 −8.988 36.246 1.00108.78 C ATOM 15523 O4 MAN E 324 27.023 −8.082 37.287 1.00 103.92 O ATOM15525 C5 MAN E 324 25.275 −9.715 36.643 1.00 112.59 C ATOM 15527 C6 MANE 324 24.102 −8.722 36.842 1.00 110.06 C ATOM 15530 O6 MAN E 324 23.750−8.085 35.622 1.00 108.11 O ATOM 15532 O5 MAN E 324 24.926 −10.81235.755 1.00 114.60 O ATOM 15533 C1 NAG E 881 51.524 67.218 74.770 1.0082.89 C ATOM 15536 C2 NAG E 881 50.338 68.025 74.160 1.00 83.13 C ATOM15538 N2 NAG E 881 49.032 67.353 73.995 1.00 82.71 N ATOM 15540 C7 NAG E881 47.991 67.386 74.866 1.00 82.73 C ATOM 15541 O7 NAG E 881 47.38066.346 75.237 1.00 78.34 O ATOM 15542 C8 NAG E 881 47.603 68.758 75.3851.00 84.08 C ATOM 15546 C3 NAG E 881 50.819 68.571 72.803 1.00 83.44 CATOM 15548 O3 NAG E 881 49.657 69.047 72.125 1.00 81.68 O ATOM 15550 C4NAG E 881 52.075 69.513 72.964 1.00 84.89 C ATOM 15552 O4 NAG E 88152.660 69.876 71.736 1.00 84.61 O ATOM 15554 C5 NAG E 881 53.218 68.84873.783 1.00 83.76 C ATOM 15556 C6 NAG E 881 54.566 69.652 74.031 1.0085.43 C ATOM 15559 O6 NAG E 881 54.704 71.055 74.263 1.00 83.52 O ATOM15561 O5 NAG E 881 52.665 68.147 74.940 1.00 86.69 O ATOM 15562 C1 NAG E3281 49.375 31.629 48.905 1.00 52.84 C ATOM 15565 C2 NAG E 3281 49.48231.018 50.297 1.00 51.74 C ATOM 15567 N2 NAG E 3281 50.091 31.941 51.2491.00 51.34 N ATOM 15569 C7 NAG E 3281 49.384 32.526 52.211 1.00 50.13 CATOM 15570 O7 NAG E 3281 48.435 32.032 52.749 1.00 53.22 O ATOM 15571 C8NAG E 3281 49.756 33.856 52.704 1.00 50.66 C ATOM 15575 C3 NAG E 328150.226 29.684 50.255 1.00 52.62 C ATOM 15577 O3 NAG E 3281 50.116 29.05451.488 1.00 52.27 O ATOM 15579 C4 NAG E 3281 49.732 28.723 49.174 1.0054.50 C ATOM 15581 O4 NAG E 3281 50.703 27.716 48.931 1.00 54.62 O ATOM15582 C5 NAG E 3281 49.375 29.441 47.856 1.00 54.70 C ATOM 15584 C6 NAGE 3281 48.447 28.552 47.010 1.00 55.71 C ATOM 15587 O6 NAG E 3281 47.27828.100 47.717 1.00 53.23 O ATOM 15589 O5 NAG E 3281 48.735 30.686 48.0781.00 51.91 O ATOM 15590 C1 NAG E 3282 50.357 26.487 49.573 1.00 54.61 CATOM 15592 C2 NAG E 3282 51.035 25.314 48.888 1.00 56.44 C ATOM 15594 N2NAG E 3282 50.443 25.157 47.600 1.00 56.42 N ATOM 15596 C7 NAG E 328250.897 25.560 46.412 1.00 57.36 C ATOM 15597 O7 NAG E 3282 51.890 26.17646.141 1.00 58.44 O ATOM 15598 C8 NAG E 3282 50.036 25.176 45.269 1.0058.52 C ATOM 15602 C3 NAG E 3282 50.703 24.044 49.639 1.00 56.65 C ATOM15604 O3 NAG E 3282 51.439 22.899 49.223 1.00 60.43 O ATOM 15606 C4 NAGE 3282 51.144 24.227 51.060 1.00 59.24 C ATOM 15608 O4 NAG E 3282 50.92822.982 51.702 1.00 59.30 O ATOM 15609 C5 NAG E 3282 50.469 25.441 51.7181.00 57.25 C ATOM 15611 C6 NAG E 3282 51.087 25.744 53.078 1.00 55.87 CATOM 15614 O6 NAG E 3282 52.436 26.070 52.833 1.00 56.35 O ATOM 15616 O5NAG E 3282 50.700 26.585 50.922 1.00 56.55 O ATOM 15617 C1 MAN E 328352.049 22.569 52.475 1.00 60.80 C ATOM 15619 C2 MAN E 3283 51.547 22.10353.804 1.00 59.65 C ATOM 15621 O2 MAN E 3283 50.445 21.312 53.451 1.0058.83 O ATOM 15623 C3 MAN E 3283 52.518 21.233 54.574 1.00 61.41 C ATOM15625 O3 MAN E 3283 51.787 20.219 55.195 1.00 63.34 O ATOM 15626 C4 MANE 3283 53.562 20.456 53.794 1.00 64.14 C ATOM 15628 O4 MAN E 3283 54.59220.336 54.757 1.00 65.32 O ATOM 15630 C5 MAN E 3283 53.906 21.186 52.4841.00 64.35 C ATOM 15632 C6 MAN E 3283 54.827 20.559 51.427 1.00 66.91 CATOM 15635 O6 MAN E 3283 54.336 19.397 50.755 1.00 68.16 O ATOM 15636 O5MAN E 3283 52.651 21.452 51.873 1.00 66.18 O ATOM 15637 C1 MAN E 328455.217 18.249 50.742 1.00 72.30 C ATOM 15639 C2 MAN E 3284 55.266 17.68452.167 1.00 74.79 C ATOM 15641 O2 MAN E 3284 53.926 17.897 52.622 1.0075.61 O ATOM 15643 C3 MAN E 3284 55.505 16.199 52.355 1.00 77.19 C ATOM15645 O3 MAN E 3284 55.980 15.970 53.712 1.00 78.27 O ATOM 15646 C4 MANE 3284 54.050 15.999 51.891 1.00 74.76 C ATOM 15648 O4 MAN E 3284 53.36314.913 52.491 1.00 74.26 O ATOM 15650 C5 MAN E 3284 54.093 16.166 50.3111.00 75.13 C ATOM 15652 C6 MAN E 3284 52.766 16.286 49.596 1.00 71.00 CATOM 15655 O6 MAN E 3284 51.789 16.197 50.591 1.00 67.75 O ATOM 15656 O5MAN E 3284 54.772 17.312 49.795 1.00 71.66 O ATOM 15657 C1 MAN E 328756.557 14.726 54.281 1.00 82.57 C ATOM 15659 C2 MAN E 3287 57.357 13.79753.289 1.00 86.35 C ATOM 15661 O2 MAN E 3287 58.723 13.344 53.449 1.0090.50 O ATOM 15662 C3 MAN E 3287 56.672 12.482 52.944 1.00 89.09 C ATOM15664 O3 MAN E 3287 57.659 11.558 52.507 1.00 90.57 O ATOM 15666 C4 MANE 3287 55.887 11.911 54.115 1.00 89.40 C ATOM 15668 O4 MAN E 3287 55.29410.689 53.706 1.00 92.89 O ATOM 15670 C5 MAN E 3287 54.863 12.927 54.6211.00 83.20 C ATOM 15672 C6 MAN E 3287 54.074 12.364 55.791 1.00 82.64 CATOM 15675 O6 MAN E 3287 53.440 11.149 55.398 1.00 86.10 O ATOM 15677 O5MAN E 3287 55.586 14.035 55.127 1.00 82.62 O ATOM 15678 C1 MAN E 328859.546 13.176 54.658 1.00 92.52 C ATOM 15680 C2 MAN E 3288 59.349 14.27255.676 1.00 89.65 C ATOM 15682 O2 MAN E 3288 58.271 13.854 56.471 1.0091.69 O ATOM 15684 C3 MAN E 3288 60.452 14.356 56.660 1.00 90.23 C ATOM15686 O3 MAN E 3288 59.890 15.181 57.619 1.00 85.18 O ATOM 15688 C4 MANE 3288 60.741 13.016 57.331 1.00 94.39 C ATOM 15690 O4 MAN E 3288 62.02513.205 57.964 1.00 93.03 O ATOM 15692 C5 MAN E 3288 60.590 11.833 56.3151.00 97.46 C ATOM 15694 C6 MAN E 3288 60.604 10.434 56.978 1.00 101.20 CATOM 15697 O6 MAN E 3288 59.305 9.870 57.154 1.00 102.55 O ATOM 15699 O5MAN E 3288 59.440 12.000 55.444 1.00 94.57 O ATOM 15700 C1 MAN E 328552.312 20.696 57.165 1.00 71.22 C ATOM 15702 C2 MAN E 3285 51.852 19.51258.022 1.00 72.51 C ATOM 15704 O2 MAN E 3285 52.078 19.647 59.410 1.0075.71 O ATOM 15705 C3 MAN E 3285 50.367 19.348 57.867 1.00 68.59 C ATOM15707 O3 MAN E 3285 50.001 18.467 58.884 1.00 72.03 O ATOM 15709 C4 MANE 3285 49.651 20.659 58.121 1.00 64.77 C ATOM 15711 O4 MAN E 3285 48.26320.485 57.943 1.00 65.10 O ATOM 15713 C5 MAN E 3285 50.145 21.664 57.1341.00 62.44 C ATOM 15715 C6 MAN E 3285 49.441 22.972 57.332 1.00 57.64 CATOM 15718 O6 MAN E 3285 49.509 23.586 56.085 1.00 54.72 O ATOM 15720 O5MAN E 3285 51.537 21.875 57.328 1.00 68.41 O ATOM 15721 C1 MAN E 328652.667 20.955 59.763 1.00 77.35 C ATOM 15723 C2 MAN E 3286 52.629 21.16461.302 1.00 76.62 C ATOM 15725 O2 MAN E 3286 52.926 19.916 61.946 1.0081.48 O ATOM 15727 C3 MAN E 3286 53.567 22.287 61.783 1.00 73.66 C ATOM15729 O3 MAN E 3286 54.478 21.668 62.617 1.00 73.03 O ATOM 15731 C4 MANE 3286 54.473 23.006 60.754 1.00 75.14 C ATOM 15733 O4 MAN E 3286 54.44924.416 61.021 1.00 71.56 O ATOM 15735 C5 MAN E 3286 54.173 22.670 59.2601.00 76.43 C ATOM 15737 C6 MAN E 3286 55.208 23.365 58.290 1.00 76.78 CATOM 15740 O6 MAN E 3286 55.328 23.003 56.888 1.00 76.61 O ATOM 15742 O5MAN E 3286 54.002 21.227 59.234 1.00 77.45 O ATOM 15743 C1 MAN E 328950.258 15.461 49.783 1.00 75.63 C ATOM 15745 C2 MAN E 3289 50.034 14.26748.872 1.00 75.77 C ATOM 15747 O2 MAN E 3289 48.660 14.201 48.764 1.0072.18 O ATOM 15749 C3 MAN E 3289 50.526 14.452 47.437 1.00 78.29 C ATOM15751 O3 MAN E 3289 49.933 13.510 46.572 1.00 79.15 O ATOM 15753 C4 MANE 3289 50.081 15.789 46.882 1.00 77.40 C ATOM 15755 O4 MAN E 3289 50.52115.836 45.541 1.00 77.75 O ATOM 15757 C5 MAN E 3289 50.659 16.920 47.7721.00 76.35 C ATOM 15759 C6 MAN E 3289 50.230 18.330 47.313 1.00 71.38 CATOM 15762 O6 MAN E 3289 51.375 19.128 47.137 1.00 68.05 O ATOM 15764 O5MAN E 3289 50.198 16.752 49.136 1.00 76.70 O ATOM 15765 C1 NAG E 337138.544 32.137 31.287 1.00 73.74 C ATOM 15768 C2 NAG E 3371 39.910 31.52430.912 1.00 72.50 C ATOM 15770 N2 NAG E 3371 40.864 31.546 32.013 1.0071.87 N ATOM 15772 C7 NAG E 3371 41.239 30.472 32.757 1.00 70.84 C ATOM15773 O7 NAG E 3371 40.476 29.555 33.102 1.00 70.45 O ATOM 15774 C8 NAGE 3371 42.672 30.426 33.238 1.00 70.39 C ATOM 15778 C3 NAG E 3371 40.65632.193 29.783 1.00 75.42 C ATOM 15780 O3 NAG E 3371 41.791 31.359 29.4401.00 77.30 O ATOM 15782 C4 NAG E 3371 39.730 32.463 28.602 1.00 76.98 CATOM 15784 O4 NAG E 3371 40.419 33.182 27.568 1.00 80.73 O ATOM 15785 C5NAG E 3371 38.541 33.295 29.072 1.00 77.51 C ATOM 15787 C6 NAG E 337137.559 33.426 27.908 1.00 79.31 C ATOM 15790 O6 NAG E 3371 36.679 34.49628.177 1.00 80.38 O ATOM 15792 O5 NAG E 3371 37.813 32.803 30.226 1.0077.42 O ATOM 15793 C1 NAG E 3372 41.583 32.516 26.923 1.00 81.06 C ATOM15795 C2 NAG E 3372 42.328 33.443 25.948 1.00 82.94 C ATOM 15797 N2 NAGE 3372 41.740 34.767 25.838 1.00 82.97 N ATOM 15799 C7 NAG E 3372 42.23335.902 26.335 1.00 82.90 C ATOM 15800 O7 NAG E 3372 41.520 36.914 26.2481.00 82.64 O ATOM 15801 C8 NAG E 3372 43.607 35.961 26.991 1.00 82.07 CATOM 15805 C3 NAG E 3372 42.419 32.829 24.547 1.00 85.35 C ATOM 15807 O3NAG E 3372 43.207 33.591 23.635 1.00 87.85 O ATOM 15809 C4 NAG E 337243.054 31.472 24.780 1.00 84.91 C ATOM 15811 O4 NAG E 3372 43.723 30.92023.637 1.00 91.00 O ATOM 15812 C5 NAG E 3372 41.959 30.586 25.314 1.0082.11 C ATOM 15814 C6 NAG E 3372 42.432 29.260 25.924 1.00 80.32 C ATOM15817 O6 NAG E 3372 43.839 29.217 26.026 1.00 82.02 O ATOM 15819 O5 NAGE 3372 41.168 31.317 26.251 1.00 83.28 O ATOM 15820 C1 MAN E 3373 43.19331.163 22.297 1.00 90.26 C ATOM 15822 C2 MAN E 3373 43.289 29.790 21.5721.00 89.29 C ATOM 15824 O2 MAN E 3373 42.106 29.541 20.822 1.00 88.30 OATOM 15826 C3 MAN E 3373 44.594 29.551 20.798 1.00 90.57 C ATOM 15828 O3MAN E 3373 44.458 28.528 19.795 1.00 92.13 O ATOM 15829 C4 MAN E 337345.145 30.855 20.206 1.00 93.50 C ATOM 15831 O4 MAN E 3373 46.449 30.56619.675 1.00 97.00 O ATOM 15833 C5 MAN E 3373 45.156 32.027 21.232 1.0091.21 C ATOM 15835 C6 MAN E 3373 45.845 33.348 20.765 1.00 92.87 C ATOM15838 O6 MAN E 3373 45.180 34.027 19.709 1.00 91.50 O ATOM 15840 O5 MANE 3373 43.831 32.276 21.657 1.00 90.06 O ATOM 15841 C1 MAN E 3374 45.29927.327 19.975 1.00 91.45 C ATOM 15843 C2 MAN E 3374 44.665 25.926 19.5731.00 90.43 C ATOM 15845 O2 MAN E 3374 43.307 25.675 19.923 1.00 85.56 OATOM 15847 C3 MAN E 3374 44.958 25.484 18.106 1.00 93.36 C ATOM 15849 O3MAN E 3374 43.909 25.879 17.264 1.00 92.46 O ATOM 15851 C4 MAN E 337446.346 25.944 17.578 1.00 95.44 C ATOM 15853 O4 MAN E 3374 47.038 24.92916.892 1.00 96.98 O ATOM 15855 C5 MAN E 3374 47.209 26.363 18.774 1.0094.63 C ATOM 15857 C6 MAN E 3374 48.726 26.471 18.535 1.00 95.51 C ATOM15860 O6 MAN E 3374 49.041 26.392 17.176 1.00 99.02 O ATOM 15862 O5 MANE 3374 46.576 27.526 19.340 1.00 94.07 O ATOM 15863 C1 NAG E 3891 45.80853.754 43.706 1.00 74.28 C ATOM 15866 C2 NAG E 3891 45.380 54.293 42.3351.00 76.79 C ATOM 15868 N2 NAG E 3891 43.931 54.439 42.244 1.00 77.53 NATOM 15870 C7 NAG E 3891 43.082 53.652 41.542 1.00 79.46 C ATOM 15871 O7NAG E 3891 42.117 54.113 40.922 1.00 80.77 O ATOM 15872 C8 NAG E 389143.269 52.147 41.487 1.00 77.83 C ATOM 15876 C3 NAG E 3891 45.958 53.51841.171 1.00 79.74 C ATOM 15878 O3 NAG E 3891 45.933 54.287 39.941 1.0085.15 O ATOM 15880 C4 NAG E 3891 47.366 53.013 41.512 1.00 79.56 C ATOM15882 O4 NAG E 3891 47.766 52.108 40.515 1.00 81.56 O ATOM 15884 C5 NAGE 3891 47.547 52.327 42.862 1.00 74.77 C ATOM 15886 C6 NAG E 3891 49.03851.935 43.162 1.00 76.89 C ATOM 15889 O6 NAG E 3891 50.128 52.559 42.4361.00 78.59 O ATOM 15891 O5 NAG E 3891 47.051 53.133 43.897 1.00 71.16 OATOM 15892 C1 NAG E 3892 49.560 50.560 39.673 1.00 85.54 C ATOM 15895 C2NAG E 3892 51.079 50.372 39.365 1.00 87.01 C ATOM 15897 N2 NAG E 389251.830 49.743 40.498 1.00 86.01 N ATOM 15899 C7 NAG E 3892 53.058 50.16841.010 1.00 88.55 C ATOM 15900 O7 NAG E 3892 54.106 50.400 40.348 1.0092.23 O ATOM 15901 C8 NAG E 3892 53.194 50.394 42.509 1.00 85.72 C ATOM15905 C3 NAG E 3892 51.752 51.651 38.791 1.00 89.93 C ATOM 15907 O3 NAGE 3892 53.012 51.322 38.204 1.00 93.75 O ATOM 15909 C4 NAG E 3892 50.81652.383 37.790 1.00 92.19 C ATOM 15911 O4 NAG E 3892 51.469 53.394 36.9801.00 97.04 O ATOM 15913 C5 NAG E 3892 49.621 52.861 38.652 1.00 90.09 CATOM 15915 C6 NAG E 3892 48.688 53.957 38.073 1.00 91.72 C ATOM 15918 O6NAG E 3892 49.232 54.724 36.977 1.00 93.72 O ATOM 15920 O5 NAG E 389248.877 51.689 39.028 1.00 88.11 O ATOM 15921 C1 NAG E 4201 42.244 56.85252.671 1.00 63.81 C ATOM 15924 C2 NAG E 4201 43.345 57.207 51.711 1.0065.17 C ATOM 15926 N2 NAG E 4201 44.591 56.697 52.209 1.00 64.00 N ATOM15928 C7 NAG E 4201 45.518 56.163 51.423 1.00 64.41 C ATOM 15929 O7 NAGE 4201 45.413 56.030 50.212 1.00 65.04 O ATOM 15930 C8 NAG E 4201 46.79555.727 52.065 1.00 64.60 C ATOM 15934 C3 NAG E 4201 43.381 58.699 51.6171.00 68.66 C ATOM 15936 O3 NAG E 4201 44.262 58.910 50.571 1.00 74.46 OATOM 15938 C4 NAG E 4201 42.044 59.335 51.220 1.00 71.76 C ATOM 15940 O4NAG E 4201 41.985 60.760 51.475 1.00 76.53 O ATOM 15941 C5 NAG E 420140.915 58.632 51.980 1.00 68.94 C ATOM 15943 C6 NAG E 4201 39.614 58.83051.256 1.00 70.71 C ATOM 15946 O6 NAG E 4201 38.706 58.151 52.076 1.0070.23 O ATOM 15948 O5 NAG E 4201 41.037 57.234 52.120 1.00 65.06 O ATOM15949 C1 NAG E 4202 42.056 61.718 50.372 1.00 81.14 C ATOM 15951 C2 NAGE 4202 41.295 63.019 50.736 1.00 83.23 C ATOM 15953 N2 NAG E 4202 40.15862.736 51.611 1.00 81.14 N ATOM 15955 C7 NAG E 4202 40.195 62.977 52.9381.00 81.55 C ATOM 15956 O7 NAG E 4202 40.397 62.106 53.790 1.00 75.71 OATOM 15957 C8 NAG E 4202 39.997 64.413 53.403 1.00 84.96 C ATOM 15961 C3NAG E 4202 40.871 63.865 49.497 1.00 87.52 C ATOM 15963 O3 NAG E 420240.860 65.241 49.801 1.00 91.09 O ATOM 15965 C4 NAG E 4202 41.751 63.57148.257 1.00 88.70 C ATOM 15967 O4 NAG E 4202 41.562 64.296 46.993 1.0092.75 O ATOM 15968 C5 NAG E 4202 41.445 62.067 48.006 1.00 86.08 C ATOM15970 C6 NAG E 4202 42.113 61.443 46.760 1.00 86.81 C ATOM 15973 O6 NAGE 4202 43.309 60.781 47.074 1.00 86.56 O ATOM 15975 O5 NAG E 4202 41.55561.202 49.146 1.00 82.49 O ATOM 15976 C1 MAN E 4203 41.597 65.753 46.7581.00 96.52 C ATOM 15978 C2 MAN E 4203 42.878 66.374 46.086 1.00 98.52 CATOM 15980 O2 MAN E 4203 43.726 65.559 45.284 1.00 94.95 O ATOM 15982 C3MAN E 4203 42.475 67.691 45.329 1.00 104.12 C ATOM 15984 O3 MAN E 420342.359 67.581 43.900 1.00 106.03 O ATOM 15986 C4 MAN E 4203 41.18568.311 45.942 1.00 105.60 C ATOM 15988 O4 MAN E 4203 41.065 69.69845.630 1.00 108.12 O ATOM 15990 C5 MAN E 4203 41.097 68.015 47.482 1.00102.96 C ATOM 15992 C6 MAN E 4203 39.839 68.676 48.110 1.00 104.13 CATOM 15995 O6 MAN E 4203 39.443 67.969 49.283 1.00 100.82 O ATOM 15997O5 MAN E 4203 41.313 66.623 47.864 1.00 97.25 O ATOM 15998 C1 NAG E 504112.333 62.275 39.325 1.00 137.11 C ATOM 16001 C2 NAG E 5041 12.98663.604 39.616 1.00 138.53 C ATOM 16003 N2 NAG E 5041 13.364 63.66041.044 1.00 136.10 N ATOM 16005 C7 NAG E 5041 14.433 63.080 41.645 1.00128.39 C ATOM 16006 O7 NAG E 5041 14.366 62.041 42.320 1.00 122.17 OATOM 16007 C8 NAG E 5041 15.723 63.845 41.521 1.00 127.26 C ATOM 16011C3 NAG E 5041 12.054 64.733 39.116 1.00 144.44 C ATOM 16013 O3 NAG E5041 12.354 64.855 37.737 1.00 145.80 O ATOM 16015 C4 NAG E 5041 10.51564.539 39.222 1.00 148.10 C ATOM 16017 O4 NAG E 5041 9.929 65.156 40.3701.00 149.99 O ATOM 16019 C5 NAG E 5041 10.130 63.058 39.106 1.00 144.50C ATOM 16021 C6 NAG E 5041 8.913 62.764 38.230 1.00 147.36 C ATOM 16024O6 NAG E 5041 7.864 63.649 38.544 1.00 153.22 O ATOM 16026 O5 NAG E 504111.210 62.427 38.472 1.00 141.22 O ATOM 16027 C1 NAG E 5441 0.234 62.12719.661 1.00 208.01 C ATOM 16030 C2 NAG E 5441 −0.771 60.962 19.723 1.00206.40 C ATOM 16032 N2 NAG E 5441 −1.608 60.874 18.514 1.00 211.28 NATOM 16034 C7 NAG E 5441 −2.489 59.886 18.295 1.00 210.66 C ATOM 16035O7 NAG E 5441 −2.188 58.694 18.394 1.00 203.38 O ATOM 16036 C8 NAG E5441 −3.897 60.288 17.910 1.00 217.87 C ATOM 16040 C3 NAG E 5441 −1.61961.139 20.977 1.00 207.06 C ATOM 16042 O3 NAG E 5441 −0.826 60.94122.134 1.00 198.40 O ATOM 16044 C4 NAG E 5441 −2.284 62.530 20.945 1.00213.89 C ATOM 16046 O4 NAG E 5441 −3.220 62.583 19.875 1.00 218.05 OATOM 16048 C5 NAG E 5441 −1.247 63.664 20.825 1.00 214.53 C ATOM 16050C6 NAG E 5441 −1.248 64.554 22.067 1.00 214.73 C ATOM 16053 O6 NAG E5441 −2.440 65.317 22.081 1.00 221.76 O ATOM 16055 O5 NAG E 5441 0.07463.184 20.624 1.00 209.23 O ATOM 16056 C1 NAG E 5791 8.755 20.579 −4.6591.00 160.24 C ATOM 16059 C2 NAG E 5791 10.058 20.624 −5.492 1.00 160.36C ATOM 16061 N2 NAG E 5791 10.855 21.828 −5.207 1.00 160.00 N ATOM 16063C7 NAG E 5791 12.120 21.841 −4.740 1.00 156.65 C ATOM 16064 O7 NAG E5791 12.480 22.620 −3.870 1.00 154.63 O ATOM 16065 C8 NAG E 5791 13.17520.917 −5.291 1.00 156.27 C ATOM 16069 C3 NAG E 5791 9.820 20.532 −7.0081.00 164.24 C ATOM 16071 O3 NAG E 5791 11.069 20.293 −7.622 1.00 162.89O ATOM 16073 C4 NAG E 5791 8.760 19.484 −7.413 1.00 166.62 C ATOM 16075O4 NAG E 5791 8.408 19.503 −8.803 1.00 169.76 O ATOM 16077 C5 NAG E 57917.504 19.627 −6.540 1.00 165.87 C ATOM 16079 C6 NAG E 5791 6.460 18.548−6.894 1.00 167.55 C ATOM 16082 O6 NAG E 5791 6.356 18.315 −8.298 1.00169.02 O ATOM 16084 O5 NAG E 5791 7.861 19.573 −5.156 1.00 161.26 O END

REFERENCES

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1. A crystal of a receptor-antibody complex comprising areceptor-antibody complex of an epidermal growth factor receptor (EGFR)extracellular domain and cetuximab Fab, wherein the crystal has aresolution determined by X-ray crystallography of better than about 5.0Angstroms.
 2. The crystal of claim 1, wherein the crystal has aresolution determined by X-ray crystallography of better than about 4.0Angstroms.
 3. The crystal of claim 2, wherein the crystal has aresolution determined by X-ray crystallography of better than about 3.0Angstroms.
 4. The crystal of claim 1, wherein the crystal belongs tospace group P2₁ and has unit cell dimensions a=77.8 Å, b=70.9 Å, c=147.1Å, and β=102.5°.
 5. The crystal of claim 1, having atomic coordinatesprovided in Table
 2. 6. A method for preparing a crystal of a complex ofan epidermal growth factor receptor (EGFR) extracellular domain andcetuximab Fab comprising preparing a solution containing theextracellular domain of EGFR and cetuximab Fab fragment, and growing thecrystal.
 7. The method of claim 6, wherein the pH of the solution isabout 6.0 to about 8.0.
 8. A method of identifying a mimetic ofcetuximab comprising comparing a three-dimensional structure of themimetic with a three-dimensional structure determined for the complex ofclaim
 1. 9. The method of claim 8, wherein the three dimensionalstructure of the mimetic is compared with at least a subset of thecoordinates provided in Table
 2. 10. The method of claim 8, whereinidentifying a mimetic is carried out by comparing the three-dimensionalstructure of the mimetic against the coordinates of at least one EGFRamino acid bound by cetuximab Fab.
 11. The method of claim 9, whereinthe EGFR amino acid is selected from the group consisting of Gln 384,Gln 408, Ser 418, Ser 440, Lys 465, Ser 468, and Asn
 469. 12. The methodof claim 8, wherein the locations of atoms of the mimetic that contactEGFR correspond to atoms of cetuximab that contact EGFR.
 13. The methodof claim 8, wherein identifying a mimetic comprises comparing a threedimensional structure of a mimetic with the atomic coordinates of aregion of EGFR selected from the group consisting of about amino acidresidue 350 to about amino acid residue 354, about amino acid residue380 to about amino acid residue 385, about amino acid residue 405 toabout amino acid residue 420, about amino acid residue 435 to aboutamino acid residue 475 and combinations thereof.
 14. The method of claim8, wherein the mimetic is a small molecule.
 15. The method of claim 8,wherein the mimetic is a peptide.
 16. The method of claim [0014],wherein the peptide is an antibody or a fragment thereof.
 17. The methodof claim 8, wherein the method is carried out with use of a computer.18. The method of claim 8, further comprising synthesizing the mimeticand assaying its binding or physiological activity.
 19. The method ofclaim [0017], wherein the mimetic binds to EGFR with similar affinity ascetuximab Fab.
 20. The method of claim [0017], wherein the mimeticinhibits dimerization of EGFR expressed by a cell.
 21. The method ofclaim [0017], wherein the mimetic inhibits tyrosine kinase activity ofthe receptor.
 22. The method of claim [0017], wherein the mimetic blocksbinding of EGF to EGFR.
 23. A method for identifying a mimetic ofcetuximab, comprising: (a) introducing in silico substitutions in atleast a single CDR region of cetuximab to obtain a pool of variants; and(b) using a computer and at least a subset of the EGFR coordinatesprovided in Table 2 to select a variant with improved EGFR bindingcharacteristics.
 24. The method of claim 23, further comprisingdetermining the biological activity of the mimetic.
 25. The method ofclaim 23, wherein at most a single substitution is made in each CDR. 26.The method of claim 23, wherein substitutions are made solely in a CDR3region.
 27. A computer-assisted method for identifying a potentialantagonist mimetic that binds the extracellular domain of EGFRcomprising a processor, a data storage system, an input device, and anoutput device, comprising: (a) inputting into the programmed computerthrough said input device data comprising the three-dimensionalcoordinates of a subset of the atoms of EGFR as set out in Table 2; (a)providing a database of chemical and peptide structures stored in saidcomputer data storage system; (b) selecting from said database, usingcomputer methods, structures having a portion that is structurallysimilar to said criteria data set; and (b) outputting to said outputdevice the selected chemical structures having a portion similar to saidcriteria data set.
 28. A machine-readable medium having stored thereon aplurality of executable instructions to perform a method to identify amimetic of cetuximab using a crystal of a receptor-antibody complexcomprising a receptor-antibody complex of an epidermal growth factorreceptor (EGFR) extracellular domain and cetuximab Fab, the methodcomprising: comparing a three-dimensional structure of a mimetic with athree dimensional structure an epidermal growth factor receptor (EGFR)extracellular domain and cetuximab Fab having an X-ray crystallographyresolution of better than about 5.0 Angstroms.
 29. The machine-readablemedium of claim [0019], wherein the EGFR coordinates comprise at least asubset of the atomic coordinates of Table
 2. 30. The machine-readablemedium of claim [0019], wherein the three-dimensional structure of themimetic is compared with at least a subset of the atomic coordinates ofTable
 2. 31. The machine-readable medium of claim [0019], whereinidentifying a mimetic comprises comparing the three-dimensionalstructure of a mimetic with a three-dimensional structure of at leastone EGFR amino acid bound by cetuximab Fab.
 32. The machine-readablemedium of claim [0019], wherein identifying a mimetic comprisescomparing a three dimensional structure of a mimetic with the atomiccoordinates of a region of EGFR selected from the group consisting ofabout amino acid residue 350 to about amino acid residue 354, aboutamino acid residue 380 to about amino acid residue 385, about amino acidresidue 405 to about amino acid residue 420, about amino acid residue435 to about amino acid residue 475 and combinations thereof.
 33. Amachine-readable medium having stored thereon a plurality of executableinstructions to perform a method for identifying a mimetic of cetuximab,the method comprising: (a) introducing in silico substitutions in atleast a single CDR region of cetuximab to obtain a pool of variants; and(b) using a computer and at least a subset of the EGFR coordinatesprovided in Table 2 to select a variant with improved EGFR bindingcharacteristics.
 34. A cetuximab mimetic identified by the method of anyone of claims 8 to
 27. 35. A method of inhibiting EGFR comprisingadministering a mimetic of claim [0022].
 36. A method of inhibitingtumor growth in a mammal comprising administering a therapeuticallyeffective amount of a cetuximab mimetic of claim [0022].
 37. The methodof claim 36, wherein the tumor expresses EGFR.
 38. The method of claim36, wherein the tumor overexpresses EGFR.
 39. The method of claim 36,wherein the tumor is a primary tumor.
 40. The method of claim 36,wherein the tumor is a metastatic tumor.
 41. The method of claim 36,wherein the tumor is a refractory tumor.
 42. The method of claim 36,wherein the tumor is a vascularized tumor.
 43. The method of claim 36,wherein the tumor is selected from the group consisting of a colorectaltumor, a head and neck tumor, a pancreatic tumor, a lung tumor, a breasttumor, a renal cell carcinoma, and a glioblastoma.
 44. The method ofclaim 36, wherein the cetuximab mimetic is administered in combinationwith an anti-neoplastic agent.
 45. The method of claim 44, wherein theantineoplastic agent is a chemotherapeutic agent.
 46. The method ofclaim 44, wherein the antineoplastic agent is irinotecan (CPT-11). 47.The method of claim 44, wherein the antineoplastic agent is radiation.48. The method of claim 36, wherein the cetuximab mimetic isadministered in combination with an EGFR antagonist.
 49. The method ofclaim 48, wherein the EGFR antagonist is an intracellular EGFRantagonist.
 50. The method of claim 36, wherein the cetuximab mimetic isadministered in combination with a VEGFR antagonist.
 51. The method ofclaim 36, wherein the cetuximab mimetic is administered in combinationwith an insulin like growth factor receptor (IGFR) antagonist.
 52. Amethod of treating a hyperproliferative disease comprising administeringa therapeutically effective amount of a cetuximab mimetic of claim[0022].
 53. The method of claim 52, wherein the hyperproliferativedisease is psoriasis.
 54. The method of claim 52, wherein the cetuximabmimetic is administered in combination with a topical or systemic agentfor psoriasis.
 55. The method of claim 52, wherein the cetuximab mimeticis administered in combination with a corticosteroid.
 56. The method ofclaim 52, wherein the cetuximab mimetic is administered in combinationwith a retinoid.